Article
Oncology
Yucheng Liu, Xinyan Wang, Wucheng Zhu, Zhongheng Sui, Xiangqing Wei, Yang Zhang, Jiansong Qi, Yanhong Xing, Wuyang Wang
Summary: This study reveals the mechanism by which TRPML1 inhibits autophagy to regulate apoptosis, involving disrupted mitochondrial turnover, elevated ROS, DNA damage, and p53 activation. These findings have potential clinical implications for treating melanoma and glioblastoma.
Article
Environmental Sciences
Shuwei Yao, Xintong Chen, Ningdong Hu, Nan Zhang, Miaoyun Qiu, Yangyang Jia, Han Zhang, Jihuan Liang, Zehao Chen, Liting Zheng, Jialu Zhu, Rulin Mao, Yiguo Jiang
Summary: In this study, it was found that the environmental pollutant benzo[a]pyrene (B[a]P) upregulated the expression of circular RNA circ_0003552 through m6A modification, leading to DNA damage. These findings revealed the key role of epigenetics in carcinogen-induced DNA damage and suggested that quantifiable changes in circ_0003552 expression could serve as an early biomarker for genetic-related diseases.
ENVIRONMENTAL POLLUTION
(2023)
Article
Neurosciences
Kyra Ungerleider, Jessica A. Beck, Delphine Lissa, Sebastien Joruiz, Izumi Horikawa, Curtis C. Harris
Summary: Cellular senescence is closely associated with aging and age-related diseases such as Alzheimer's disease (AD). The protein isoform Delta 133p53 alpha has been found to be decreased in cellular senescence and brain tissues of AD patients. Amyloid-beta oligomers (Aβ) induce cellular senescence and proinflammatory cytokine secretion in astrocytes, involving accelerated DNA damage, upregulation of full-length p53 and its target gene p21WAF1. Enhancing the expression of Delta 133p53 alpha can rescue astrocytes from Aβ-induced senescence and proinflammatory cytokine secretion, inhibiting neurotoxicity.
Article
Pharmacology & Pharmacy
Yanting Yang, Xiuhong Zhu, Guohua Yu, Jinbo Ma
Summary: This study demonstrates that Pyxinol can mitigate cisplatin-induced renal injury by attenuating DNA damage response and tubular cell apoptosis. Furthermore, Pyxinol can enhance the in vivo anti-tumor efficacy of cisplatin against xenograft tumors in nude mice. The combination of Pyxinol with cisplatin may represent a beneficial adjunct therapy for cisplatin-based chemotherapeutic regimens in the clinic.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Dong Li, Ying Ge, Ze Zhao, Rui Zhu, Xiang Wang, Xiaolin Bi
Summary: The study analyzed the expression profiles of miRNAs and piRNAs in Drosophila during development and DNA damage response, revealing dynamic expression patterns and the key roles of E2f1 and p53 in regulating small ncRNAs. E2f1 may play a major role in modulating miRNAs during development and after X-ray irradiation, showcasing new insights into small ncRNA biology.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Fisheries
Xuan Lihui, Qiu Xiaojie, Yu Hao, Chu Jialiang, Guo Jinming, Chang Ying
Summary: The organophosphorus pesticide profenofos (PFF) induces genotoxicity in fish hepatocytes, while the sesquiterpenoid Albicanol can reduce oxidative stress and the activation of the p53 signaling pathway in this process.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Oncology
Meiling Zhou, Liang Xiao, Jing Jin, Yin Wang, Peiyu Guo, Jinhua Luo, Magdalena Skonieczna, Ruixue Huang
Summary: This study revealed the epigenetic mechanisms underlying Nano-ZnO-induced DNA damage and EMT. The effect of Nano-ZnO-induced DNA damage through the p53/circRNA_0085439/Ku70 pathway likely contributes to Nano-ZnO-induced cell cytotoxicity and apoptosis. These findings provide important information to further elucidate the molecular mechanisms of Nano-ZnO-induced cytotoxicity and genotoxicity.
CANCER NANOTECHNOLOGY
(2023)
Review
Cell Biology
Maria Gonzalez-Amor, Beatriz Dorado, Vicente Andres
Summary: Population aging and age-related cardiovascular disease (CVD) are widespread and burdensome worldwide. Cellular stress responses play a crucial role in the complex regulation and interaction between aging and CVD. The ubiquitin-like protein ISG15 and its pathway have been found to have implications in age-related telomere shortening, genomic instability, DNA damage accumulation, as well as in major CVD risk factors prevalent in the elderly population such as hypertension, diabetes, and obesity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Chunyun Zhang, Yingjie Guan, Jianan Zou, Xu Yang, Georgia Bayliss, Shougang Zhuang
Summary: This study reveals the role of MLL1 in acute kidney injury (AKI) induced by cisplatin. The inhibition of the MLL1/WDR5 complex using MM102 improved renal function, attenuated tubular injury and apoptosis, and suppressed the phosphorylation of p53 and the decrease of E-cadherin expression. MM102 also effectively inhibited the DNA damage response triggered by cisplatin.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Jorge Canar, Prima Manandhar-Sasaki, Jill Bargonetti
Summary: The TP53 gene is frequently mutated in human cancers, leading to dysfunctional p53-induced cell death pathway. In this study, we used C. elegans as a model to test for ways to induce p53-independent cancer cell death. We found that two p53-independent death inducers were able to induce cell death in C. elegans germline tumor cells, suggesting the potential of testing targeted drugs in this model for p53-independent cancer cell killing.
Article
Biotechnology & Applied Microbiology
Luying Lai, Yongwei Wang, Shenghui Peng, Wenjing Guo, Fengxian Li, Shiyuan Xu
Summary: This research aimed to explore the biological role of p53 protein and long non-coding RNA (lncRNA) TUG1 in bupivacaine-induced neurotoxicity. The results showed that p53 and TUG1 promote the repair of DNA damage induced by bupivacaine in murine dorsal root ganglion cells.
Article
Neurosciences
Songwang Xie, Zhen Hong, Yan Li, Junyong Wang, Jian Wang, Shaoquan Li, Yongchang Liu
Summary: The study found that RNF216 is overexpressed in GBM and is associated with a poor prognosis. Overexpression of RNF216 promotes GBM cell growth and inhibits apoptosis, while knockdown of RNF216 has the opposite effects. RNF216 overexpression also degrades the p53 protein and negatively regulates the p53 pathway.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sandeep Kaur, Manabu Kurokawa
Summary: Apoptosis is a crucial process in maintaining cellular balance and development in the ovarian reserve. While a large number of oocytes are generated in the fetal ovary, most of them undergo apoptosis before birth. During puberty, primordial follicles develop into mature follicles, but only one dominant follicle is selected for ovulation, while smaller ones undergo apoptosis. The molecular mechanism of oocyte death is still not fully understood, despite extensive studies. This review discusses the roles of apoptosis regulators and the transcription factor p63 in oocyte death and survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Toxicology
Xiaohu Ren, Jiawen Ruan, Xuerao Lan, Sixia Yang, Desheng Wu, Xinfeng Huang, Hongyu Zhang, Jianjun Liu, Haiyan Huang
Summary: This study identified SET-H3K79me3-p53 as a critical regulatory axis involved in the DNA damage response to TCE exposure.
TOXICOLOGY LETTERS
(2023)
Article
Cell Biology
Lei Sang, Rui Dong, Rui Liu, Qinggang Hao, Weiyu Bai, Jianwei Sun
Summary: Our study reveals that NHR-14/HNF4 alpha cooperates with CEP-1/p53 to regulate DNA damage-induced apoptosis.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Seung Wook Yang, Lei Li, Jon P. Connelly, Shaina N. Porter, Kiran Kodali, Haiyun Gan, Jung Mi Park, Klementina Fon Tacer, Heather Tillman, Junmin Peng, Shondra M. Pruett-Miller, Wei Li, Patrick Ryan Potts
Article
Neurosciences
Jaehyun Lee, Ki-Jun Yoon, Pojeong Park, Chaery Lee, Min Jung Kim, Dae Hee Han, Ji-il Kim, Somi Kim, Hye-Ryeon Lee, Yeseul Lee, Eun-Hae Jang, Hyoung-Gon Ko, Young-Yun Kong, Bong-Kiun Kaang
Review
Biochemistry & Molecular Biology
Ji An Kang, Young Joo Jeon
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Multidisciplinary Sciences
Seung Wook Yang, Xin Huang, Wenwei Lin, Jaeki Min, Darcie J. Miller, Anand Mayasundari, Patrick Rodrigues, Elizabeth C. Griffith, Clifford T. Gee, Lei Li, Wei Li, Richard E. Lee, Zoran Rankovic, Taosheng Chen, Patrick Ryan Potts
NATURE COMMUNICATIONS
(2020)
Article
Geriatrics & Gerontology
Ji-Hoon Kim, Inkuk Park, Hijai R. Shin, Joonwoo Rhee, Ji-Yun Seo, Young-Woo Jo, Kyusang Yoo, Sang-Hyeon Hann, Jong-Seol Kang, Jieon Park, Ye Lynne Kim, Ju-Yeon Moon, Man Ho Choi, Young-Yun Kong
Summary: Disrupting the HPG axis impairs muscle regeneration, increases DNA damage marker expression and senescence-related gene expression in MuSCs, indicating that the absence of sex hormone signaling accelerates the aging process of MuSCs.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Review
Biochemistry & Molecular Biology
Ji An Kang, Young Joo Jeon
Summary: The endoplasmic reticulum (ER) is crucial for protein synthesis and quality control, requiring significant resources to maintain protein homeostasis. Misfolded proteins pose a threat to proteostasis, which can be regulated through ERAD and ER-phagy processes in the ER.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Ji-Yun Seo, Jong-Seol Kang, Ye Lynne Kim, Young-Woo Jo, Ji-Hoon Kim, Sang-Hyeon Hann, Jieon Park, Inkuk Park, Hyerim Park, Kyusang Yoo, Joonwoo Rhee, Jung-Wee Park, Yong Chan Ha, Young-Yun Kong
Summary: The study reveals that Mind bomb-1 is important for skeletal muscle maintenance with age by regulating Actn3, and that disruption of Mib1 leads to muscle atrophy, which can be rescued by downregulating Actn3 expression.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Jung Mi Park, Seung Wook Yang, Wei Zhuang, Asim K. Bera, Yan Liu, Deepak Gurbani, Sergei J. von Hoyningen-Huene, Sadie Miki Sakurada, Haiyun Gan, Shondra M. Pruett-Miller, Kenneth D. Westover, Malia B. Potts
Summary: Nutrient-responsive protein kinase SRMS inhibits autophagy and promotes growth in vertebrates, and is amplified in human cancers. Inhibition of SRMS kinase activates autophagy, inhibits cancer growth, and can be achieved using the FDA-approved tyrosine kinase inhibitor ibrutinib.
Article
Chemistry, Multidisciplinary
Jaeki Min, Anand Mayasundari, Fatemeh Keramatnia, Barbara Jonchere, Seung Wook Yang, Jamie Jarusiewicz, Marisa Actis, Sourav Das, Brandon Young, Jake Slavish, Lei Yang, Yong Li, Xiang Fu, Shalandus H. Garrett, Mi-Kyung Yun, Zhenmei Li, Stanley Nithianantham, Sergio Chai, Taosheng Chen, Anang Shelat, Richard E. Lee, Gisele Nishiguchi, Stephen W. White, Martine F. Roussel, Patrick Ryan Potts, Marcus Fischer, Zoran Rankovic
Summary: IMiDs and IMiD-based PROTACs rapidly hydrolyze in commonly utilized cell media, affecting their efficacy; Novel CRBN binders, phenyl glutarimide (PG) analogues, were designed with high affinity and improved stability; Discovery of PG PROTAC 4c as a potent degrader of BET proteins, supporting the utility of PG derivatives in CRBN-directed PROTACs design.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Rheumatology
Jin-Sil Park, SeungCheon Yang, Sun-Hee Hwang, JeongWon Choi, Seung-Ki Kwok, Young-Yun Kong, Jeehee Youn, Mi-La Cho, Sung-Hwan Park
Summary: This study found that the loss of CRIF1 in B cells promotes the development of autoimmune lupus, while overexpression of CRIF1 improves disease severity. These results suggest that CRIF1 is crucial for maintaining self tolerance in B cells.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Medicine, Research & Experimental
Ji-Hoon Kim, Jong-Seol Kang, Kyusang Yoo, Jinguk Jeong, Inkuk Park, Jong Ho Park, Joonwoo Rhee, Shin Jeon, Young-Woo Jo, Sang-Hyeon Hann, Minji Seo, Seungtae Moon, Soo-Jong Um, Rho Hyun Seong, Young-Yun Kong
Summary: This study reveals the crucial role of Bap1-mediated SMN stabilization in Dpp4* FAPs for the neuromuscular system. Inactivation of Bap1 decreases SMN levels and leads to degeneration of the neuromuscular junction. Transplantation of Dpp4* FAPs rescues neuromuscular defects. These findings provide insights into potential cell-based therapeutics for treating neuromuscular diseases.
Article
Cell & Tissue Engineering
Young-Woo Jo, Inkuk Park, Kyusang Yoo, Hyun-Young Woo, Ye Lynne Kim, Yea-Eun Kim, Ji-Hoon Kim, Young-Yun Kong
Summary: This study found that Notch1 and Notch2 play distinct roles in maintaining the population of myogenic progenitors (MPs) during fetal myogenesis, with Notch1 inducing cell cycle exit and Notch2 suppressing premature differentiation. The activation of Notch1 and Notch2 signaling in MPs is also shown to be distinctively regulated by interactions with Notch ligand-expressing myofibers and MP-lineage cells, respectively.
Article
Biochemistry & Molecular Biology
Jong-Seol Kang, Dongha Kim, Joonwoo Rhee, Ji-Yun Seo, Inkuk Park, Ji-Hoon Kim, Daewon Lee, WonUk Lee, Ye Lynne Kim, Kyusang Yoo, Sunghwan Bae, Jongkyeong Chung, Rho Hyun Seong, Young-Yun Kong
Summary: During exercise, skeletal muscle undergoes low oxygen conditions, which triggers the stabilization of the hypoxia-inducible factor-1α (HIF-1α) transcription factor and the expression of genes regulating glycolytic metabolism. This study demonstrates that Brg1/Brm-associated factor 155 (Baf155), a core subunit of the SWI/SNF complex, is crucial for HIF-1α signaling in skeletal muscle. Muscle-specific ablation of Baf155 increases oxidative metabolism, decreases lactate production, and enhances endurance exercise capacity. Baf155 modulates DNA-binding activity of HIF-1α and requires the coactivator complex formed by phospho-signal transducer and activator of transcription 3 (pSTAT3) and HIF-1α for its regulatory function.
Review
Biochemistry & Molecular Biology
Ji An Kang, Yoon Jung Kim, Young Joo Jeon
Summary: ISG15, a ubiquitin-like protein found only in vertebrates, plays diverse roles in cellular processes and has potential therapeutic implications in human diseases, including cancer. However, the mechanisms and consequences of ISG15 and its conjugation remain poorly understood.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Inyoung Park, Myongsun Son, Eunseon Ahn, Young-Woong Kim, Young-Yun Kong, Yungdae Yun
MOLECULES AND CELLS
(2020)
