Journal
CELL RESEARCH
Volume 23, Issue 3, Pages 320-322Publisher
INST BIOCHEMISTRY & CELL BIOLOGY
DOI: 10.1038/cr.2012.155
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Human immunodeficiency virus type 1 (HIV-1) is the cause of AIDS. In recent years it has emerged that cellular interferon-stimulated genes (ISG), play important roles in cell-intrinsic restriction of HIV replication. A publication now describes a novel strategy employed by HIV-infected cells to restrict viral replication, which involves inhibition of viral mRNA translation by the ISG Schlafen 11.
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