Article
Endocrinology & Metabolism
Myat Win, Rowan Beckett, Lynn Thomson, Ajay Thankamony, Kathryn Beardsall
Summary: This retrospective study introduces the use of real-time CGM in monitoring persistent neonatal hypoglycemia. The study found significant fluctuations in glucose levels in babies with congenital hyperinsulinism, highlighting the challenges of preventing hypoglycemia. The results also suggest the potential application of CGM as an adjunct to clinical care in managing neonatal hypoglycemia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Chris Worth, Lucy Hoskyns, Maria Salomon-Estebanez, Paul W. Nutter, Simon Harper, Terry G. J. Derks, Kathy Beardsall, Indraneel Banerjee
Summary: Childhood hypoglycemia remains a major health problem and risk factor for adverse neurodevelopment. Continuous Glucose Monitoring (CGM) devices have been used for detection and prevention, but there are challenges in accuracy, access, and cost. Despite this, CGM has aided in understanding the disease and improved trial design.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Sameera Hannah Auckburally, Chris Worth, Maria Salomon-Estebanez, Jacqueline Nicholson, Simon Harper, Paul W. Nutter, Indraneel Banerjee
Summary: In this qualitative study, families' experiences of using continuous glucose monitoring (CGM) in patients with congenital hyperinsulinism (CHI) were explored. The study found that CGM served as an educational tool and motivated behavioral changes, leading to positive experiences and improved management of hypoglycemia. However, there were also negative experiences reported, such as alarms and reliability issues at low glucose levels. Families expected CHI-specific modifications and personalized application of CGM. Incorporating end users' opinions and experiences is crucial for optimizing the use of CGM in glycaemic monitoring of CHI.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Madhini Sivasubramanian, Parizad Avari, Clare Gilbert, Louise Doodson, Kate Morgan, Nick Oliver, Pratik Shah
Summary: This study evaluates the accuracy of continuous glucose monitoring (CGM) and its impact on quality of life in children with hyperinsulinaemic hypoglycaemia (HH). The results show that CGM is feasible and clinically acceptable in children with HH, particularly in detecting hypoglycaemia, and its use leads to significant improvement in quality of life.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Fraydoon Rastinejad
Summary: HNF4α is a crucial nuclear receptor that plays a significant role in the development and functioning of liver and pancreatic islet cells. It regulates vital metabolic processes and is associated with diabetes, metabolic disorders, and cancers. Its structure and functions have been extensively studied, revealing how different domains collaborate to achieve specific functions while forming cohesive higher-order architectures.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Sinead M. McGlacken-Byrne, Jasmina Kallefullah Mohammad, Niamh Conlon, Diliara Gubaeva, Julie Siersbaek, Anders Jorgen Schou, Huseyin Demirbilek, Antonia Dastamani, Jayne A. L. Houghton, Klaus Brusgaard, Maria Melikyan, Henrik Christesen, Sarah E. Flanagan, Nuala P. Murphy, Pratik Shah
Summary: Through the analysis of a cohort of patients with HNF4A/HNF1A mutations presenting with diazoxide-responsive hyperinsulinaemic hypoglycaemia (HH), we have gained a deeper understanding of the natural history and pancreatic and extra-pancreatic phenotypes of this condition.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Anojian Koneshamoorthy, Dilan Seniveratne-Epa, Genevieve Calder, Matthew Sawyer, Thomas W. H. Kay, Stephen Farrell, Thomas Loudovaris, Lina Mariana, Davis McCarthy, Ruqian Lyu, Xin Liu, Peter Thorn, Jason Tong, Lit Kim Chin, Margaret Zacharin, Alison Trainer, Shelby Taylor, Richard J. MacIsaac, Nirupa Sachithanandan, Helen E. Thomas, Balasubramanian Krishnamurthy
Summary: We present a case of an obese 22-year-old man with activating GCK variant who had neonatal hypoglycemia, re-emerging with hypoglycemia later in life. Genetic testing yielded a novel GCK missense class 3 variant that was subsequently found in his mother, sister and nephew and reclassified as a class 4 likely pathogenic variant. This case highlights the variable phenotype of GCK mutations.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Analytical
Ming-Nan Chien, Yu-Jen Chen, Chin-Han Bai, Jung-Tung Huang
Summary: In this research, a continuous blood glucose monitoring system (CGMS) is developed, which includes a microneedle-array blood glucose sensor, a circuit module, and a transmission module placed in a wearable device. The system enables continuous blood glucose sensing and wireless data transmission. Through various experiments and analyses, the feasibility and effectiveness of the system are demonstrated.
Article
Automation & Control Systems
Abhinoy Kumar Singh, Mihailo V. Rebec, Ahmad Haidar
Summary: A continuous glucose monitoring system consists of a glucose sensor and an estimation algorithm, which can monitor blood glucose levels in real-time. The sensor generates electrical current when inserted under the skin, while the algorithm infers glucose levels in the blood. The study proposes a Kalman filter-based estimation algorithm, which provides more accurate results compared to alternative algorithms.
IEEE TRANSACTIONS ON CONTROL SYSTEMS TECHNOLOGY
(2021)
Article
Medical Laboratory Technology
Guido Freckmann, James H. Nichols, Rolf Hinzmann, David C. Klonoff, Yi Ju, Peter Diem, Konstantinos Makris, Robbert J. Slingerland
Summary: People with diabetes need to monitor their glucose levels regularly, and traditional self-monitoring systems are being replaced by minimally invasive continuous glucose monitoring systems. However, these CGM systems face challenges with accuracy and lack of international reference measurement procedures.
CLINICA CHIMICA ACTA
(2021)
Article
Biology
Zsolt Gaal, Zsuzsanna Szucs, Iren Kantor, Andrea Luczay, Peter Toth-Heyn, Orsolya Benn, Eniko Felszeghy, Zsuzsanna Karadi, Laszlo Madar, Istvan Balogh
Summary: MODY is a genetically heterogeneous form of diabetes with about a dozen known causal genes, and treatment should be selected based on the specific gene mutation for each individual patient. The importance of genetic testing in diagnosing MODY and determining the subtype for personalized treatment is highlighted.
Article
Genetics & Heredity
Sarah E. Sheppard, Brett Barrett, Colleen Muraresku, Heather McKnight, Diva D. De Leon, Katherine Lord, Rebecca Ganetzky
Summary: Heterozygous pathogenic variants in HNF4A can result in a range of disorders, including hyperinsulinism and diabetes, with patients potentially exhibiting multiple features simultaneously. Specific pathogenic variants may also lead to the expansion of different clinical phenotypes.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2021)
Review
Pediatrics
Mariangela Martino, Jacopo Sartorelli, Vincenza Gragnaniello, Alberto Burlina
Summary: Congenital hyperinsulinism is a group of diseases characterized by persistent hyperinsulinemic hypoglycemia, which can lead to neurological impairment. New technologies and discoveries in blood glucose monitoring and treatment have the potential to improve neurological outcomes.
FRONTIERS IN PEDIATRICS
(2022)
Article
Nutrition & Dietetics
Souptik Barua, Raven A. Wierzchowska-McNew, Nicolaas E. P. Deutz, Ashutosh Sabharwal
Summary: This study found discordance between plasma glucose measurements made using continuous glucose monitoring (CGM) and fingerstick meter after meals. CGM underestimated the rise in glucose levels and time spent in the normal range, while the fingerstick meter was more accurate. These discordances may have implications for applications such as precision nutrition and early detection of diabetes.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Marlena Gorska, Joanna Kudzin, Anna Borkowska, Agnieszka Szlagatys-Sidorkiewicz, Agnieszka Szadkowska, Malgorzata Mysliwiec, Ewa Toporowska-Kowalska
Summary: Children with severe CNS impairment are at risk of nutritional deficit requiring long-term intervention. Enteral nutrition is commonly implemented through tubes, and the relationship between this nutrition and hyperglycemia is often discussed. This study aimed to assess carbohydrate metabolism in children with severe CNS impairment receiving enteral nutrition delivered via various tubes. Results showed that more than half of the patients were undernourished, and the actual caloric intake was 50 (37.7-68.8) kcal/kg.
Article
Obstetrics & Gynecology
Siobhan Bacon, Jasmin Schmid, Ailbhe McCarthy, Jackie Edwards, Aileen Fleming, Brendan Kinsley, Richard Firth, Bridgette Byrne, Claire Gavin, Maria M. Byrne
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2015)
Article
Endocrinology & Metabolism
S. Bacon, M. P. Kyithar, S. R. Rizvi, E. Donnelly, A. McCarthy, M. Burke, K. Colclough, S. Ellard, M. M. Byrne
Article
Immunology
Rebecca Moore, Hugh Adler, Valerie Jackson, Mairead Lawless, Maria Byrne, Maeve Eogan, John S. Lambert
INTERNATIONAL JOURNAL OF STD & AIDS
(2016)
Article
Genetics & Heredity
Siobhan Bacon, Britta Engelbrecht, Jasmin Schmid, Shona Pfeiffer, Ross Gallagher, Ailbhe McCarthy, Marie Burke, Caoimhin Concannon, Jochen H. M. Prehn, Maria M. Byrne
Meeting Abstract
Medicine, General & Internal
C. J. McCarrick, J. Ioana, S. Bacon, M. Burke, E. O'Sullivan, M. M. Byrne
IRISH JOURNAL OF MEDICAL SCIENCE
(2016)
Meeting Abstract
Medicine, General & Internal
I. A. Ioana, S. Bacon, M. M. Byrne
IRISH JOURNAL OF MEDICAL SCIENCE
(2016)
Meeting Abstract
Medicine, General & Internal
A. Garrahy, E. Noctor, R. Dineen, K. McGurren, M. Byrne, M. O'Grady, C. Costigan, M. Javadpour, A. Agha
IRISH JOURNAL OF MEDICAL SCIENCE
(2016)
Meeting Abstract
Medicine, General & Internal
S. Bacon, B. Engelbrecht, J. Schmid, S. Pfeiffer, C. G. Concannon, A. Mc Carthy, M. Burke, J. H. M. Prehn, M. M. Byrne
IRISH JOURNAL OF MEDICAL SCIENCE
(2016)
Meeting Abstract
Medicine, General & Internal
S. Bacon, M. P. Kyithar, E. M. Condron, N. Vizzard, M. Burke, M. M. Byrne
IRISH JOURNAL OF MEDICAL SCIENCE
(2016)
Meeting Abstract
Endocrinology & Metabolism
S. Bacon, B. Engelbrecht, J. Schmid, S. Pfeiffer, C. G. Concannon, A. McCarthy, M. Burke, J. H. M. Prehn, M. M. Byrne
Meeting Abstract
Endocrinology & Metabolism
M. M. Byrne, J. Schmid, A. McCarthy, J. Edwards, A. Fleming, B. T. Kinsley, R. G. Firth, B. Byrne, C. Gavin, S. Bacon
Meeting Abstract
Medicine, General & Internal
L. Geraghty, C. Davenport, M. Byrne
IRISH JOURNAL OF MEDICAL SCIENCE
(2015)
Meeting Abstract
Medicine, General & Internal
A. Melvin, S. Yogonathan, A. Condren, C. Hannon, M. M. Byrne, M. Hatunic, S. E. McQuaid
IRISH JOURNAL OF MEDICAL SCIENCE
(2014)
Article
Cell Biology
S. Pfeiffer, L. Halang, H. Dussmann, M. M. Byrne, J. H. M. Prehn
CELL DEATH DISCOVERY
(2015)