Regulation of hepatocyte identity and quiescence

Cellular Homeostasis and Repair in the Mammalian Liver

(2015) Ben Z. Stanger   Annual Review of Physiology

Hippo Pathway Regulation of Gastrointestinal Tissues

(2015) Fa-Xing Yu et al.   Annual Review of Physiology

Bile acid signaling and liver regeneration

(2015) Mingjie Fan et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Resetting the transcription factor network reverses terminal chronic hepatic failure

(2015) Taichiro Nishikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease

(2015) Géraldine Gentric et al.   JOURNAL OF CLINICAL INVESTIGATION

Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy

(2015) Randy J. Chandler et al.   JOURNAL OF CLINICAL INVESTIGATION

NAFLD: A multisystem disease

(2015) Christopher D. Byrne et al.   JOURNAL OF HEPATOLOGY

Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration

(2014) James L. Grijalva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Expression of glypican 3 enriches hepatocellular carcinoma development-related genes and associates with carcinogenesis in cirrhotic livers

(2014) Xiyong Liu et al.   CARCINOGENESIS

Hippo Pathway Activity Influences Liver Cell Fate

(2014) Dean Yimlamai et al.   CELL

Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes

(2014) Branden D. Tarlow et al.   Cell Stem Cell

MBSJ MCC Young Scientist Award 2012 Liver regeneration: a unique and flexible reaction depending on the type of injury

(2014) Atsushi Suzuki   GENES TO CELLS

Novel strategies for liver therapy using stem cells

(2014) Tamir Rashid et al.   GUT

Hepatocellular carcinoma: clinical frontiers and perspectives

(2014) Jordi Bruix et al.   GUT

Deletion of serine/arginine-rich splicing factor 3 in hepatocytes predisposes to hepatocellular carcinoma in mice

(2014) Supriya Sen et al.   HEPATOLOGY

Deciphering liver zonation: New insights into the β-catenin, Tcf4, and HNF4α triad

(2014) Carmen Berasain et al.   HEPATOLOGY

Beta-catenin signaling in murine liver zonation and regeneration: A Wnt-Wnt situation!

(2014) Jing Yang et al.   HEPATOLOGY

Reduced nucleic ZHX2 involves in oncogenic activation of glypican 3 in human hepatocellular carcinoma

(2014) Fang Luan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

YAP activation is an early event and a potential therapeutic target in liver cancer development

(2014) Andrea Perra et al.   JOURNAL OF HEPATOLOGY

A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease

(2014) Taichiro Nishikawa et al.   JOURNAL OF HEPATOLOGY

p53 in liver pathologies—taking the good with the bad

(2014) Meital Charni et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mouse liver repopulation with hepatocytes generated from human fibroblasts

(2014) Saiyong Zhu et al.   NATURE

Liver zonation: Novel aspects of its regulation and its impact on homeostasis

(2014) Rolf Gebhardt   WORLD JOURNAL OF GASTROENTEROLOGY

Evidence against a Stem Cell Origin of New Hepatocytes in a Common Mouse Model of Chronic Liver Injury

(2014) Johanna R. Schaub et al.   Cell Reports

Hippo Signaling Influences HNF4A and FOXA2 Enhancer Switching during Hepatocyte Differentiation

(2014) Olivia Alder et al.   Cell Reports

TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation

(2014) Daniil Alpern et al.   eLife

Elucidating the Metabolic Regulation of Liver Regeneration

(2013) Jiansheng Huang et al.   AMERICAN JOURNAL OF PATHOLOGY

Polyploidization in Liver Tissue

(2013) Géraldine Gentric et al.   AMERICAN JOURNAL OF PATHOLOGY

The road to regenerative liver therapies: The triumphs, trials and tribulations

(2013) Ravali Raju et al.   BIOTECHNOLOGY ADVANCES

Mitogenic Insulin Receptor-A Is Overexpressed in Human Hepatocellular Carcinoma due to EGFR-Mediated Dysregulation of RNA Splicing Factors

(2013) Hamza Chettouh et al.   CANCER RESEARCH

CCAAT/enhancer binding protein-mediated regulation of TGF  receptor 2 expression determines the hepatoblast fate decision

(2013) K. Takayama et al.   DEVELOPMENT

Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma

(2013) Jorge Filmus et al.   FEBS Journal

Role of the Microenvironment in the Pathogenesis and Treatment of Hepatocellular Carcinoma

(2013) Virginia Hernandez–Gea et al.   GASTROENTEROLOGY

Links Between Hepatic Fibrosis, Ductular Reaction, and Progenitor Cell Expansion

(2013) Michael J. Williams et al.   GASTROENTEROLOGY

Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice

(2013) Iker Uriarte et al.   GUT

Hepatocyte nuclear factor-4α reverses malignancy of hepatocellular carcinoma through regulating miR-134 in the DLK1-DIO3 region

(2013) Chuan Yin et al.   HEPATOLOGY

Hepatocyte nuclear factor 4 alpha deletion promotes diethylnitrosamine-induced hepatocellular carcinoma in rodents

(2013) Chad Walesky et al.   HEPATOLOGY

T-cell factor 4 and β-catenin chromatin occupancies pattern zonal liver metabolism in mice

(2013) Angélique Gougelet et al.   HEPATOLOGY

Differentiation of progenitors in the liver: a matter of local choice

(2013) Luke Boulter et al.   JOURNAL OF CLINICAL INVESTIGATION

Underlying potential: cellular and molecular determinants of adult liver repair

(2013) Anna Mae Diehl et al.   JOURNAL OF CLINICAL INVESTIGATION

Progress in microRNA delivery

(2013) Yu Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Regression effect of hepatocyte nuclear factor 4α on liver cirrhosis in rats

(2013) Ting Ting Fan et al.   Journal of Digestive Diseases

The role of microRNAs in hepatocarcinogenesis: current knowledge and future prospects

(2013) Motoyuki Otsuka et al.   JOURNAL OF GASTROENTEROLOGY

The burden of liver disease in Europe: A review of available epidemiological data

(2013) Martin Blachier et al.   JOURNAL OF HEPATOLOGY

Recombinant AAV as a Platform for Translating the Therapeutic Potential of RNA Interference

(2013) Florie Borel et al.   MOLECULAR THERAPY

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis

(2013) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

Adeno-associated virus (AAV) vectors in gene therapy: immune challenges and strategies to circumvent them

(2013) Sangeetha Hareendran et al.   REVIEWS IN MEDICAL VIROLOGY

Aneuploidy, polyploidy and ploidy reversal in the liver

(2013) Andrew W. Duncan   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function

(2013) Supriya Sen et al.   Nature Communications

Hepatocyte-specific deletion of hepatocyte nuclear factor-4α in adult mice results in increased hepatocyte proliferation

(2012) Chad Walesky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Cyclin D1 inhibits hepatic lipogenesis via repression of carbohydrate response element binding protein and hepatocyte nuclear factor 4α

(2012) Eric A. Hanse et al.   CELL CYCLE

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

(2012) Y. Liu-Chittenden et al.   GENES & DEVELOPMENT

Prospective validation of an immunohistochemical panel (glypican 3, heat shock protein 70 and glutamine synthetase) in liver biopsies for diagnosis of very early hepatocellular carcinoma

(2012) Silvia Tremosini et al.   GUT

Suppression of Hepatocyte Proliferation by Hepatocyte Nuclear Factor 4α in Adult Mice

(2012) Jessica A. Bonzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liver regeneration

(2012) Nelson Fausto et al.   JOURNAL OF HEPATOLOGY

S-adenosylmethionine (SAMe) therapy in liver disease: A review of current evidence and clinical utility

(2012) Quentin M. Anstee et al.   JOURNAL OF HEPATOLOGY

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Nuclear receptors in regenerating liver and hepatocellular carcinoma

(2012) Michele Vacca et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Genetic signatures shared in embryonic liver development and liver cancer define prognostically relevant subgroups in HCC

(2012) Diana Becker et al.   Molecular Cancer

S-adenosylmethionine in Liver Health, Injury, and Cancer

(2012) Shelly C. Lu et al.   PHYSIOLOGICAL REVIEWS

Molecular mechanisms of liver and bile duct development

(2012) Yiwei Zong et al.   Wiley Interdisciplinary Reviews-Developmental Biology

The Expression of Embryonic Liver Development Genes in Hepatitis C Induced Cirrhosis and Hepatocellular Carcinoma

(2012) Martha Behnke et al.   Cancers

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

An HNF4α-miRNA Inflammatory Feedback Circuit Regulates Hepatocellular Oncogenesis

(2011) Maria Hatziapostolou et al.   CELL

An epistatic mini-circuitry between the transcription factors Snail and HNF4α controls liver stem cell and hepatocyte features exhorting opposite regulation on stemness-inhibiting microRNAs

(2011) F Garibaldi et al.   CELL DEATH AND DIFFERENTIATION

AAV vectors transduce hepatocytes in vivo as efficiently in cirrhotic as in healthy rat livers

(2011) L Sobrevals et al.   GENE THERAPY

Connective tissue growth factor autocriny in human hepatocellular carcinoma: Oncogenic role and regulation by epidermal growth factor receptor/yes-associated protein-mediated activation

(2011) Raquel Urtasun et al.   HEPATOLOGY

Recombinant adenovirus carrying the hepatocyte nuclear factor-1alpha gene inhibits hepatocellular carcinoma xenograft growth in mice

(2011) Xin Zeng et al.   HEPATOLOGY

The stable repression of mesenchymal program is required for hepatocyte identity: A novel role for hepatocyte nuclear factor 4α

(2011) Laura Santangelo et al.   HEPATOLOGY

Gankyrin-mediated dedifferentiation facilitates the tumorigenicity of rat hepatocytes and hepatoma cells

(2011) Wen Sun et al.   HEPATOLOGY

Lack of Abcc3 expression impairs bile-acid induced liver growth and delays hepatic regeneration after partial hepatectomy in mice

(2011) Maite G. Fernández-Barrena et al.   JOURNAL OF HEPATOLOGY

Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors

(2011) Pengyu Huang et al.   NATURE

Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors

(2011) Sayaka Sekiya et al.   NATURE

Chromatin "Prepattern" and Histone Modifiers in a Fate Choice for Liver and Pancreas

(2011) C.-R. Xu et al.   SCIENCE

Gene therapy of liver diseases: A 2011 perspective

(2011) Gloria Gonzalez-Aseguinolaza et al.   Clinics and Research in Hepatology and Gastroenterology

Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development

(2010) J Avruch et al.   BRITISH JOURNAL OF CANCER

Hepatocyte Nuclear Factor 4  Suppresses the Development of Hepatocellular Carcinoma

(2010) B.-F. Ning et al.   CANCER RESEARCH

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

(2010) Nailing Zhang et al.   DEVELOPMENTAL CELL

Organogenesis and Development of the Liver

(2010) Karim Si-Tayeb et al.   DEVELOPMENTAL CELL

Beta-catenin signaling in hepatic development and progenitors: Which way does the WNT blow?

(2010) Abigale G. Lade et al.   DEVELOPMENTAL DYNAMICS

Regulation of liver regeneration by growth factors and cytokines

(2010) Friederike Böhm et al.   EMBO Molecular Medicine

Liver Regeneration in Surgical Animal Models – A Historical Perspective and Clinical Implications

(2010) K.E. Mortensen et al.   EUROPEAN SURGICAL RESEARCH

Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver

(2010) S. Benhamouche et al.   GENES & DEVELOPMENT

Long distance calling for liver regeneration: Identification of neuroendocrine signalling pathways activated after partial hepatectomy

(2010) Matías A. Avila   JOURNAL OF HEPATOLOGY

Immediate neuroendocrine signaling after partial hepatectomy through acute portal hyperpressure and cholestasis

(2010) Isabelle Doignon et al.   JOURNAL OF HEPATOLOGY

Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

(2010) Kenichiro Furuyama et al.   NATURE GENETICS

Evolving challenges in hepatic fibrosis

(2010) Scott L. Friedman   Nature Reviews Gastroenterology & Hepatology

The Fox Genes in the Liver: From Organogenesis to Functional Integration

(2010) John Le lay et al.   PHYSIOLOGICAL REVIEWS

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

(2010) H. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impairment of pre-mRNA splicing in liver disease: Mechanisms and consequences

(2010) Carmen Berasain   WORLD JOURNAL OF GASTROENTEROLOGY

Liver Regeneration after Partial Hepatectomy

(2009) George K. Michalopoulos   AMERICAN JOURNAL OF PATHOLOGY

Wilms' Tumor 1 Gene Expression in Hepatocellular Carcinoma Promotes Cell Dedifferentiation and Resistance to Chemotherapy

(2009) Maria J. Perugorria et al.   CANCER RESEARCH

Mechanisms of Liver Development: Concepts for Understanding Liver Disorders and Design of Novel Therapies

(2009) Frédéric P. Lemaigre   GASTROENTEROLOGY

Convergence of Wnt Signaling on the HNF4α-Driven Transcription in Controlling Liver Zonation

(2009) Marta Colletti et al.   GASTROENTEROLOGY

Hepatocyte nuclear factor 4  attenuates hepatic fibrosis in rats

(2009) H.-Y. Yue et al.   GUT

p21 is required for dextrose-mediated inhibition of mouse liver regeneration

(2009) Alexander Weymann et al.   HEPATOLOGY

Integrated approach for the identification of human hepatocyte nuclear factor 4α target genes using protein binding microarrays

(2009) Eugene Bolotin et al.   HEPATOLOGY

Transcription dynamics in a physiological process: β-Catenin signaling directs liver metabolic zonation

(2009) Cyril Torre et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Foxa1 and Foxa2 regulate bile duct development in mice

(2009) Zhaoyu Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatocyte Nuclear Factor 4  Coordinates a Transcription Factor Network Regulating Hepatic Fatty Acid Metabolism

(2009) C. P. Martinez-Jimenez et al.   MOLECULAR AND CELLULAR BIOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Crucial role of vHNF1 in vertebrate hepatic specification

(2008) L. Lokmane et al.   DEVELOPMENT

Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression

(2008) A. Suzuki et al.   DEVELOPMENT

Wnt9a secreted from the walls of hepatic sinusoids is essential for morphogenesis, proliferation, and glycogen accumulation of chick hepatic epithelium

(2008) Ken Matsumoto et al.   DEVELOPMENTAL BIOLOGY

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

Tbx3 promotes liver bud expansion during mouse development by suppression of cholangiocyte differentiation

(2008) Timo H.-W. Lüdtke et al.   HEPATOLOGY

Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4α gene

(2008) Chuan Yin et al.   HEPATOLOGY

β-Catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development

(2008) Xinping Tan et al.   HEPATOLOGY

Dominant and Redundant Functions of TFIID Involved in the Regulation of Hepatic Genes

(2008) Antonis Tatarakis et al.   MOLECULAR CELL

Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress

(2008) Irina M Bochkis et al.   NATURE MEDICINE

Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma

(2008) Yujin Hoshida et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nuclear Receptor Hepatocyte Nuclear Factor 4α1 Competes with Oncoprotein c-Myc for Control of the p21/WAF1 Promoter

(2007) Wendy W. Hwang-Verslues et al.   MOLECULAR ENDOCRINOLOGY