Article
Oncology
Qianhui Xu, Hao Xu, Rongshan Deng, Nanjun Li, Ruiqi Mu, Zhixuan Qi, Yunuo Shen, Zijie Wang, Jingchao Wen, Jiaxin Zhao, Di Weng, Wen Huang
Summary: In this study, a total of 3294 AS events associated with the survival of HCC patients were identified. Based on splicing subtypes, eight AS prognostic signatures with robust predictive accuracy were constructed. Additionally, a quantitative prognostic nomogram was developed and validated for prognostic prediction.
CANCER CELL INTERNATIONAL
(2021)
Review
Oncology
Jose J. G. Marin, Maria Reviejo, Meraris Soto, Elisa Lozano, Maitane Asensio, Sara Ortiz-Rivero, Carmen Berasain, Matias A. Avila, Elisa Herraez
Summary: This article discusses the impact of alternative splicing on liver carcinogenesis and the development of malignant characteristics of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). Understanding these impacts is crucial for developing novel therapeutic approaches that can manipulate the phenotype of cancer cells.
Article
Gastroenterology & Hepatology
Ambria S. Moten, Alexander M. Fagenson, Henry A. Pitt, Kwan N. Lau
Summary: Analysis of data on patients diagnosed with hepatocellular carcinoma between 2012 and 2016 revealed persistent racial disparities in the treatment and outcomes of the disease. While Asians were less likely to undergo transplant, they showed better survival rates after undergoing resection or ablation.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Shanshan Yu, Luya Cai, Chuan Liu, Ruihong Gu, Lingyi Cai, Leying Zhuo
Summary: This study analyzed the impact of prognostic AS events on immune-related perspectives in HCC using transcriptional data from the TCGA database. The results showed that high immune/stromal scores were associated with longer survival probability in HCC patients. Differentially expressed AS events (DEASs) related to stromal/immune scores were enriched in pathways related to HCC tumorigenesis and the immune microenvironment, with a final prognostic signature containing 16 DEASs showing strong predictive ability. Gene set variation analysis suggested that activation of carcinogenic pathways and immune-related pathways in the high-risk group may lead to poor prognosis.
MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Xu-Xiao Chen, Bao-Hua Zhang, Yan-Cen Lu, Zi-Qiang Li, Cong-Yan Chen, Yu-Chen Yang, Yong-Jun Chen, Di Ma
Summary: This study established a robust 16-gene AS signature for predicting tumor relapse in stage I-III HCC, which is significantly associated with the immune status of the HCC microenvironment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Mengfei Sheng, Yuanyuan Zhang, Yaoyun Wang, Weiyi Liu, Xingyu Wang, Tiaoying Ke, Pingyang Liu, Sihan Wang, Wei Shao
Summary: Alternative splicing plays a critical role in gene expression by generating diverse transcript isoforms, which can affect protein function and regulation. Aberrant alternative splicing is an important factor in cancer development and impacts various activities of cancer cells.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Christopher Montemagno, Jerome Durivault, Cecile Gastaldi, Maeva Dufies, Valerie Vial, Xingkang He, Damien Ambrosetti, Anna Kamenskaya, Sylvie Negrier, Jean-Christophe Bernhard, Delphine Borchiellini, Yihai Cao, Gilles Pages
Summary: The efficacy of anti-angiogenic treatment in metastatic clear cell renal cell carcinoma varies among patients. This study identifies novel splice variants of VEGF that are less efficiently inhibited by anti-VEGF/VEGFR targeting and explores their potential role as therapeutic targets.
MOLECULAR ONCOLOGY
(2023)
Article
Oncology
Dingan Luo, Deze Zhao, Mao Zhang, Chuan Hu, Haoran Li, Shun Zhang, Xiaowu Chen, Lakshmi Huttad, Bailiang Li, Cheng Jin, Changwei Lin, Bing Han
Summary: Alternative splicing events serve as novel biomarkers for tumor tumorigenesis and progression. In this study, differentially expressed alternative splicing events between hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (ICC) tissues and their normal tissues were identified, showing distinct immune features and clinical prognosis between the two types of cancer. This research provides valuable insights for the treatment of HCC and ICC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Maria Papatsirou, Panagiotis G. Adamopoulos, Pinelopi Artemaki, Vasiliki P. Georganti, Andreas Scorilas, Dido Vassilacopoulou, Christos K. Kontos
Summary: This study identified new splice variants of the DDC gene containing novel exons in hepatocellular and lung cancer cell lines using NGS technology and PCR. Seven new DDC exons were discovered, and the structure of ten new DDC transcripts was determined, with three potentially encoding previously unknown protein isoforms. Future research should focus on understanding their role in cellular physiology and cancer pathobiology.
Article
Oncology
Han Zhuo, Shuying Miao, Zhenquan Jin, Deming Zhu, Zhenggang Xu, Dongwei Sun, Jie Ji, Zhongming Tan
Summary: This study indicates that LGR4 promotes cell proliferation, migration, and invasion in HCC, which can be reduced by metformin through alternative splicing.
JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Saranya Chidambaranathan Reghupaty, Sadia Kanwal, Rachel G. Mendoza, Eva Davis, Haiwen Li, Zhao Lai, Mikhail G. Dozmorov, Milton Omar Faison, Rafat Ali Siddiqui, Devanand Sarkar
Summary: Hepatocellular carcinoma (HCC) is a common primary liver cancer influenced by chronic liver inflammation and race/ethnicity. Analysis of RNA-sequencing data revealed the activation of an inflammatory pathway in HCC tumors of African-American/Black patients. Ginger extract (GE), known for its anti-inflammatory properties, showed potential efficacy in inhibiting HCC cell growth, particularly in cells from African-American/Black patients. These findings suggest that a holistic diet containing ginger may benefit African-American/Black HCC patients.
Review
Gastroenterology & Hepatology
Bipul Gnyawali, Antoinette Pusateri, Ashley Nickerson, Sajid Jalil, Khalid Mumtaz
Summary: Chronic Hepatitis B is a globally prevalent disease that poses a significant healthcare burden, especially in low-resource regions where access to diagnosis, vaccination, screening, and treatment is limited. Mitigating the impact of the disease includes increasing screening in high-risk groups, improving health literacy in vulnerable populations, and developing robust vaccination programs in underserved areas.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Cell Biology
Xi Chen, Minfeng Zhang, Nan Li, Rui Pu, Ting Wu, Yibo Ding, Peng Cai, Hongwei Zhang, Jun Zhao, Jianhua Yin, Guangwen Cao
Summary: The study identified HBV preS variants G40C and C147T as serological biomarkers for HCC prognosis, with a prognostic model consisting of serological alpha-fetoprotein and G40C achieving the best performance in predicting postoperative prognosis.
Article
Oncology
Sylvie Muhimpundu, Rebecca Baqiyyah N. Conway, Shaneda Warren Andersen, Loren Lipworth, Mark D. Steinwandel, William J. Blot, Xiao-Ou Shu, Staci L. Sudenga
Summary: Liver cancer incidence is higher among African Americans compared to White Americans in the US, but the determinants of racial disparities in liver cancer incidence are unclear. This study found racial differences in both incidence rates and risk factors associated with hepatocellular carcinoma among White and African Americans.
Review
Immunology
Christine C. Hsu, Harish Gopalakrishna, Maria Mironova, Mei-Hsuan Lee, Chien-Jen Chen, Hwai- Yang, Manfred Wiese, Kyong-Mi Chang, Elizabeth C. Wright, Tomilowo Abijo, Jordan J. Feld, David E. Kaplan
Summary: In a hepatitis C virus (HCV)-controlled human infection model (CHIM), researchers assessed the risk of hepatocellular carcinoma (HCC) after viral clearance in noncirrhosis patients with sustained virological response (SVR) to HCV treatment. The overall HCC rate in noncirrhosis SVR patients was 0.33 per 100 patient-years. The data suggests that the risk of HCC in the HCV CHIM is very low or negligible.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medical Laboratory Technology
Sasan Setoodeh, Li Liu, Sarag A. Boukhar, Amit G. Singal, Maria Westerhoff, Akbar K. Waljee, Tasneem Ahmed, Purva Gopal
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2019)
Article
Cell Biology
Priya Handa, Sunil Thomas, Vicki Morgan-Stevenson, Bryan D. Maliken, Eric Gochanour, Sarag Boukhar, Matthew M. Yeh, Kris V. Kowdley
JOURNAL OF LEUKOCYTE BIOLOGY
(2019)
Article
Surgery
Ravishankar Pillenahalli Maheshwarappa, Yusuf Menda, Michael M. Graham, Sarag A. Boukhar, Gideon K. D. Zamba, Isaac Samuel
Article
Medicine, General & Internal
Matthew W. McGee, Sarag A. Boukhar, Varun Monga, Ronald Weigel, Sneha D. Phadke
JOURNAL OF MEDICAL CASE REPORTS
(2019)
Article
Gastroenterology & Hepatology
Alyssa Y. Choi, Florencia Jalikis, Maria Westerhoff, Sarag Boukhar, Elinor Pulcini, Chris Damman, Lei Yu
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2018)
Review
Pathology
Sarag Aboujafar Boukhar, Ricky Kaneshiro, Alan Schiller, Keith Terada, Pamela Tauchi-Nishi