PI3Kβ is selectively required for growth factor-stimulated macropinocytosis

A Single Discrete Rab5 Binding Site in PI3Kβ is Required for Tumor Cell Invasion

(2019) Samantha D Heitz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer

(2019) Cindy Hodakoski et al.   Cancers

PI3Kβ links integrin activation and PI(3,4)P2 production during invadopodial maturation

(2019) Zahra Erami et al.   MOLECULAR BIOLOGY OF THE CELL

The Canonical Wnt Pathway Drives Macropinocytosis in Cancer

(2018) Gil Redelman-Sidi et al.   CANCER RESEARCH

Differential ability of proinflammatory and anti-inflammatory macrophages to perform macropinocytosis

(2018) Dar’ya S. Redka et al.   MOLECULAR BIOLOGY OF THE CELL

PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells

(2018) Seong M. Kim et al.   Cancer Discovery

A high-avidity biosensor reveals plasma membrane PI(3,4)P2 is predominantly a class I PI3K signaling product

(2018) Brady D. Goulden et al.   JOURNAL OF CELL BIOLOGY

Dorsal ruffles enhance activation of Akt by growth factors

(2018) Sei Yoshida et al.   JOURNAL OF CELL SCIENCE

Macropinocytosis: New Insights Into Its Underappreciated Role in Innate Immune Cell Surveillance

(2018) Johnathan Canton   Frontiers in Immunology

Critical role for PI3-kinase in regulating the use of proteins as an amino acid source

(2017) Wilhelm Palm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging evidence of signalling roles for PI(3,4)P2 in Class I and II PI3K-regulated pathways

(2016) P. T. Hawkins et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

GPCR Signaling Mediates Tumor Metastasis via PI3K 

(2016) B. D. Khalil et al.   CANCER RESEARCH

Uses and abuses of macropinocytosis

(2016) Gareth Bloomfield et al.   JOURNAL OF CELL SCIENCE

CXCL12-induced macropinocytosis modulates two distinct pathways to activate mTORC1 in macrophages

(2016) Regina Pacitto et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells

(2016) Daniel M. Houslay et al.   Science Signaling

Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages

(2016) Johnathan Canton et al.   Nature Communications

A plasma membrane template for macropinocytic cups

(2016) Douwe M Veltman et al.   eLife

Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells

(2016) Daniel M. Houslay et al.   Science Signaling

Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin

(2015) Anthony Leyme et al.   JOURNAL OF CELL BIOLOGY

Growth factor signaling to mTORC1 by amino acid–laden macropinosomes

(2015) Sei Yoshida et al.   JOURNAL OF CELL BIOLOGY

A PI3K p110β–Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis

(2015) Haluk Yuzugullu et al.   Nature Communications

Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling

(2015) Nicolas Aznar et al.   eLife

Macropinocytosis: a pathway to protozoan infection

(2015) Tecia M. U. de Carvalho et al.   Frontiers in Physiology

Regulation of Macropinocytosis by Diacylglycerol Kinase ζ

(2015) Ryan Ard et al.   PLoS One

Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis

(2014) M. Maekawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms

(2013) Ralph Fritsch et al.   CELL

Two distinct functions for PI3-kinases in macropinocytosis

(2013) O. Hoeller et al.   JOURNAL OF CELL SCIENCE

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Role of Phospholipids in Endocytosis, Phagocytosis, and Macropinocytosis

(2013) Michal Bohdanowicz et al.   PHYSIOLOGICAL REVIEWS

G Protein-Coupled Receptor-Mediated Activation of p110  by G   Is Required for Cellular Transformation and Invasiveness

(2012) H. A. Dbouk et al.   Science Signaling

Functional Characterization of an Isoform-Selective Inhibitor of PI3K-p110β as a Potential Anticancer Agent

(2012) Jing Ni et al.   Cancer Discovery

A growth factor signaling cascade confined to circular ruffles in macrophages

(2012) T. P. Welliver et al.   Biology Open

Macropinocytosis: an endocytic pathway for internalising large gulps

(2011) Jet Phey Lim et al.   IMMUNOLOGY AND CELL BIOLOGY

SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain

(2011) Junya Hasegawa et al.   JOURNAL OF CELL BIOLOGY

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

(2010) Mirkka Koivusalo et al.   JOURNAL OF CELL BIOLOGY

Sequential signaling in plasma-membrane domains during macropinosome formation in macrophages

(2009) S. Yoshida et al.   JOURNAL OF CELL SCIENCE

GIV is a nonreceptor GEF for G i with a unique motif that regulates Akt signaling

(2009) M. Garcia-Marcos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling and Cross-talk by C5a and UDP in Macrophages Selectively Use PLCβ3 to Regulate Intracellular Free Calcium

(2008) Tamara I. A. Roach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

(2008) Shidong Jia et al.   NATURE

Shaping cups into phagosomes and macropinosomes

(2008) Joel A. Swanson   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The p110  isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110 

(2008) J. Guillermet-Guibert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTEN-deficient cancers depend on PIK3CB

(2008) S. Wee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoinositide 3-Kinase p110  Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development

(2008) E. Ciraolo et al.   Science Signaling