Role of Phospholipids in Endocytosis, Phagocytosis, and Macropinocytosis

Yersinia Entry into Host Cells Requires Rab5-Dependent Dephosphorylation of PI(4,5)P2 and Membrane Scission

(2012) Helen Sarantis et al.   Cell Host & Microbe

An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice

(2012) Kathryn M. Kinross et al.   JOURNAL OF CLINICAL INVESTIGATION

Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase

(2012) Marko Jović et al.   MOLECULAR BIOLOGY OF THE CELL

Mammalian phospholipase D physiological and pathological roles

(2011) X. Peng et al.   Acta Physiologica

Mechanisms of Membrane Curvature Sensing

(2011) Bruno Antonny   Annual Review of Biochemistry

STIM Proteins and the Endoplasmic Reticulum-Plasma Membrane Junctions

(2011) Silvia Carrasco et al.   Annual Review of Biochemistry

Bis (monoacylglycero) phosphate interfacial properties and lipolysis by pancreatic lipase-related protein 2, an enzyme present in THP-1 human monocytes

(2011) Michel Record et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Osh Proteins Regulate Phosphoinositide Metabolism at ER-Plasma Membrane Contact Sites

(2011) Christopher J. Stefan et al.   CELL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention

(2011) Edward A. Dennis et al.   CHEMICAL REVIEWS

Regulation and Functions of Diacylglycerol Kinases

(2011) Yulia V. Shulga et al.   CHEMICAL REVIEWS

The Inositol 5-Phosphatase dOCRL Controls PI(4,5)P2 Homeostasis and Is Necessary for Cytokinesis

(2011) Khaled Ben El Kadhi et al.   CURRENT BIOLOGY

Septins

(2011) Mathew P. Estey et al.   CURRENT BIOLOGY

Lipid transfer and signaling at organelle contact sites: the tip of the iceberg

(2011) Alexandre Toulmay et al.   CURRENT OPINION IN CELL BIOLOGY

Clathrin-independent endocytosis: mechanisms and function

(2011) Kirsten Sandvig et al.   CURRENT OPINION IN CELL BIOLOGY

Synaptojanin 1-Mediated PI(4,5)P2 Hydrolysis Is Modulated by Membrane Curvature and Facilitates Membrane Fission

(2011) Belle Chang-Ileto et al.   DEVELOPMENTAL CELL

A Highly Dynamic ER-Derived Phosphatidylinositol-Synthesizing Organelle Supplies Phosphoinositides to Cellular Membranes

(2011) Yeun Ju Kim et al.   DEVELOPMENTAL CELL

The ESCRT Pathway

(2011) William M. Henne et al.   DEVELOPMENTAL CELL

Membrane surface charge dictates the structure and function of the epithelial Na+/H+exchanger

(2011) Robert Todd Alexander et al.   EMBO JOURNAL

Complementary Functions of the Flippase ATP8B1 and the Floppase ABCB4 in Maintaining Canalicular Membrane Integrity

(2011) Annemiek Groen et al.   GASTROENTEROLOGY

High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine

(2011) Gregory D. Fairn et al.   JOURNAL OF CELL BIOLOGY

Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers

(2011) Maud de Saint-Jean et al.   JOURNAL OF CELL BIOLOGY

PLD1 rather than PLD2 regulates phorbol-ester-, adhesion-dependent and Fc -receptor-stimulated ROS production in neutrophils

(2011) L. J. Norton et al.   JOURNAL OF CELL SCIENCE

Phosphatidylinositol-(4,5)-bisphosphate regulates clathrin-coated pit initiation, stabilization, and size

(2011) Costin N. Antonescu et al.   MOLECULAR BIOLOGY OF THE CELL

Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling

(2011) Michal Bohdanowicz et al.   MOLECULAR BIOLOGY OF THE CELL

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Phosphatidylserine is polarized and required for proper Cdc42 localization and for development of cell polarity

(2011) Gregory D. Fairn et al.   NATURE CELL BIOLOGY

Actin dynamics counteract membrane tension during clathrin-mediated endocytosis

(2011) Steeve Boulant et al.   NATURE CELL BIOLOGY

Sorting nexins provide diversity for retromer-dependent trafficking events

(2011) Peter J. Cullen et al.   NATURE CELL BIOLOGY

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

(2011) Harvey T. McMahon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk

(2011) E. Zampese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of glycerophospholipid homeostasis in mammalian cells

(2011) Martin Hermansson et al.   PROGRESS IN LIPID RESEARCH

Structural remodeling, trafficking and functions of glycosylphosphatidylinositol-anchored proteins

(2011) Yusuke Maeda et al.   PROGRESS IN LIPID RESEARCH

Hotspots Organize Clathrin-Mediated Endocytosis by Efficient Recruitment and Retention of Nucleating Resources

(2011) Daniel Nunez et al.   TRAFFIC

Dynamic Transbilayer Lipid Asymmetry

(2011) G. van Meer   Cold Spring Harbor Perspectives in Biology

A High Precision Survey of the Molecular Dynamics of Mammalian Clathrin-Mediated Endocytosis

(2011) Marcus J. Taylor et al.   PLOS BIOLOGY

Lipids and Cholesterol as Regulators of Traffic in the Endomembrane System

(2010) Jennifer Lippincott-Schwartz et al.   Annual Review of Biophysics

The Distribution and Function of Phosphatidylserine in Cellular Membranes

(2010) Peter A. Leventis et al.   Annual Review of Biophysics

LPA Receptors: Subtypes and Biological Actions

(2010) Ji Woong Choi et al.   Annual Review of Pharmacology and Toxicology

Biochemical and cellular functions of P4ATPases

(2010) Lieke M. van der Velden et al.   BIOCHEMICAL JOURNAL

External Lipid PI3P Mediates Entry of Eukaryotic Pathogen Effectors into Plant and Animal Host Cells

(2010) Shiv D. Kale et al.   CELL

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

(2010) Dale W. Hailey et al.   CELL

Molecules, mechanisms, and cellular roles of clathrin-independent endocytosis

(2010) Mark T Howes et al.   CURRENT OPINION IN CELL BIOLOGY

I-BAR domain proteins: linking actin and plasma membrane dynamics

(2010) Hongxia Zhao et al.   CURRENT OPINION IN CELL BIOLOGY

Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella

(2010) Markus C Kerr et al.   EMBO JOURNAL

Where do they come from? Insights into autophagosome formation

(2010) Maho Hamasaki et al.   FEBS LETTERS

P4 ATPases - The physiological relevance of lipid flipping transporters

(2010) Coen C. Paulusma et al.   FEBS LETTERS

Functions of phospholipid flippases

(2010) K. Tanaka et al.   JOURNAL OF BIOCHEMISTRY

Stress-induced Synthesis of Phosphatidylinositol 3-Phosphate in Mycobacteria

(2010) Yasu S. Morita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class I and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes

(2010) Michal Bohdanowicz et al.   JOURNAL OF CELL BIOLOGY

Dynamic macrophage “probing” is required for the efficient capture of phagocytic targets

(2010) Ronald S. Flannagan et al.   JOURNAL OF CELL BIOLOGY

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

(2010) Mirkka Koivusalo et al.   JOURNAL OF CELL BIOLOGY

The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics

(2010) Fubito Nakatsu et al.   JOURNAL OF CELL BIOLOGY

Type I Phosphatidylinositol Phosphate Kinase Beta Regulates Focal Adhesion Disassembly by Promoting  1 Integrin Endocytosis

(2010) W.-T. Chao et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphatidic Acid Plays a Regulatory Role in Clathrin-mediated Endocytosis

(2010) Costin N. Antonescu et al.   MOLECULAR BIOLOGY OF THE CELL

Membranes in Balance: Mechanisms of Sphingolipid Homeostasis

(2010) David K. Breslow et al.   MOLECULAR CELL

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

Plasma membrane contributes to the formation of pre-autophagosomal structures

(2010) Brinda Ravikumar et al.   NATURE CELL BIOLOGY

Revitalizing membrane rafts: new tools and insights

(2010) Kai Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Non-vesicular lipid transport by lipid-transfer proteins and beyond

(2010) Sima Lev   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of the Actin Cytoskeleton-Plasma Membrane Interplay by Phosphoinositides

(2010) Juha Saarikangas et al.   PHYSIOLOGICAL REVIEWS

The SNX-PX-BAR Family in Macropinocytosis: The Regulation of Macropinosome Formation by SNX-PX-BAR Proteins

(2010) Jack T. H. Wang et al.   PLoS One

Diacylglycerol kinase   mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI

(2010) F. Chianale et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1

(2010) Laura E. Swan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

(2010) S. Miller et al.   SCIENCE

Retromer Is Required for Apoptotic Cell Clearance by Phagocytic Receptor Recycling

(2010) D. Chen et al.   SCIENCE

Phosphatidic Acid Is a pH Biosensor That Links Membrane Biogenesis to Metabolism

(2010) B. P. Young et al.   SCIENCE

FCHo Proteins Are Nucleators of Clathrin-Mediated Endocytosis

(2010) W. M. Henne et al.   SCIENCE

PLC regulation: emerging pictures for molecular mechanisms

(2010) Tom D. Bunney et al.   TRENDS IN BIOCHEMICAL SCIENCES

Exploring the caves: cavins, caveolins and caveolae

(2010) Carsten G. Hansen et al.   TRENDS IN CELL BIOLOGY

Coordination of Golgi functions by phosphatidylinositol 4-kinases

(2010) Todd R. Graham et al.   TRENDS IN CELL BIOLOGY

Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS

(2009) Clement Y. Chow et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease

(2009) Lisa M. Ooms et al.   BIOCHEMICAL JOURNAL

Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function

(2009) Stephen K. Dove et al.   BIOCHEMICAL JOURNAL

P4 ATPases - Lipid flippases and their role in disease

(2009) Dineke E. Folmer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism

(2009) Yuxin Mao et al.   EMBO JOURNAL

CtBP1/BARS is an activator of phospholipase D1 necessary for agonist-induced macropinocytosis

(2009) Yuki Haga et al.   EMBO JOURNAL

Lysosomal degradation of membrane lipids

(2009) Thomas Kolter et al.   FEBS LETTERS

Phosphatidylserine decarboxylases, key enzymes of lipid metabolism

(2009) Irmgard Schuiki et al.   IUBMB LIFE

Essential and unique roles of PIP5K-γ and -α in Fcγ receptor-mediated phagocytosis

(2009) Yuntao S. Mao et al.   JOURNAL OF CELL BIOLOGY

Steric and not structure-specific factors dictate the endocytic mechanism of glycosylphosphatidylinositol-anchored proteins

(2009) Pinkesh Bhagatji et al.   JOURNAL OF CELL BIOLOGY

An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis

(2009) Gregory D. Fairn et al.   JOURNAL OF CELL BIOLOGY

Contribution of phosphatidylserine to membrane surface charge and protein targeting during phagosome maturation

(2009) Tony Yeung et al.   JOURNAL OF CELL BIOLOGY

Phospholipase C–mediated hydrolysis of PIP2 releases ERM proteins from lymphocyte membrane

(2009) Jian-Jiang Hao et al.   JOURNAL OF CELL BIOLOGY

Diacylglycerol Kinase ζ Regulates Actin Cytoskeleton Reorganization through Dissociation of Rac1 from RhoGDI

(2009) Hanan Abramovici et al.   MOLECULAR BIOLOGY OF THE CELL

Basolateral Internalization of GPI-anchored Proteins Occurs via a Clathrin-independent Flotillin-dependent Pathway in Polarized Hepatic Cells

(2009) Tounsia Aït-Slimane et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

(2009) Mitsuko Hayashi-Nishino et al.   NATURE CELL BIOLOGY

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

(2009) Ronald S. Flannagan et al.   NATURE REVIEWS MICROBIOLOGY

Sensors and regulators of intracellular pH

(2009) Joseph R. Casey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reconstitution of phospholipid translocase activity with purified Drs2p, a type-IV P-type ATPase from budding yeast

(2009) X. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A distinct pool of phosphatidylinositol 4,5-bisphosphate in caveolae revealed by a nanoscale labeling technique

(2009) A. Fujita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amino acid-containing membrane lipids in bacteria

(2009) Otto Geiger et al.   PROGRESS IN LIPID RESEARCH

Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis

(2009) A. Nishikimi et al.   SCIENCE

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

Defining Macropinocytosis

(2009) Markus C. Kerr et al.   TRAFFIC

The Sec14 superfamily and mechanisms for crosstalk between lipid metabolism and lipid signaling

(2009) Vytas A. Bankaitis et al.   TRENDS IN BIOCHEMICAL SCIENCES

MAM: more than just a housekeeper

(2009) Teruo Hayashi et al.   TRENDS IN CELL BIOLOGY

The Mechanochemistry of Endocytosis

(2009) Jian Liu et al.   PLOS BIOLOGY

PTEN and the PI3-Kinase Pathway in Cancer

(2008) Nader Chalhoub et al.   Annual Review of Pathology-Mechanisms of Disease

Lipid Mediators in Health and Disease: Enzymes and Receptors as Therapeutic Targets for the Regulation of Immunity and Inflammation

(2008) Takao Shimizu   Annual Review of Pharmacology and Toxicology

The regulation and function of Class III PI3Ks: novel roles for Vps34

(2008) Jonathan M. Backer   BIOCHEMICAL JOURNAL

Two pathways for lysophosphatidic acid production

(2008) J AOKI   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Principles of lysosomal membrane degradation

(2008) Heike Schulze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Electrostatic Contribution to the Surface Pressure of Charged Monolayers Containing Polyphosphoinositides

(2008) I. Levental et al.   BIOPHYSICAL JOURNAL

GTPase Cycle of Dynamin Is Coupled to Membrane Squeeze and Release, Leading to Spontaneous Fission

(2008) Pavel V. Bashkirov et al.   CELL

Real-Time Visualization of Dynamin-Catalyzed Membrane Fission and Vesicle Release

(2008) Thomas J. Pucadyil et al.   CELL

TheLegionella pneumophilaphosphatidylinositol-4 phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuole

(2008) Curdin Ragaz et al.   CELLULAR MICROBIOLOGY

The GTPase-Activating Protein GRAF1 Regulates the CLIC/GEEC Endocytic Pathway

(2008) Richard Lundmark et al.   CURRENT BIOLOGY

Defining the Importance of Phosphatidylserine Synthase-1 (PSS1)

(2008) Devi Arikketh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysobisphosphatidic Acid Controls Endosomal Cholesterol Levels

(2008) Julien Chevallier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor

(2008) N. Abe et al.   JOURNAL OF CELL SCIENCE

The multiple roles of PtdIns(4)P - not just the precursor of PtdIns(4,5)P2

(2008) G. D'Angelo et al.   JOURNAL OF CELL SCIENCE

Recent progress on acyl CoA: lysophospholipid acyltransferase research

(2008) Hideo Shindou et al.   JOURNAL OF LIPID RESEARCH

Physiological consequences of disruption of mammalian phospholipid biosynthetic genes

(2008) Dennis E. Vance et al.   JOURNAL OF LIPID RESEARCH

Thematic Review Series: Glycerolipids.Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids

(2008) Jean E. Vance   JOURNAL OF LIPID RESEARCH

Membrane phospholipid synthesis and endoplasmic reticulum function

(2008) Paolo Fagone et al.   JOURNAL OF LIPID RESEARCH

The ability of Listeria monocytogenes PI-PLC to facilitate escape from the macrophage phagosome is dependent on host PKCβ

(2008) Mathilde A. Poussin et al.   MICROBIAL PATHOGENESIS

In Vitro Budding of Intralumenal Vesicles into Late Endosomes Is Regulated by Alix and Tsg101

(2008) Thomas Falguières et al.   MOLECULAR BIOLOGY OF THE CELL

Phospholipase D Activity Regulates Integrin-mediated Cell Spreading and Migration by Inducing GTP-Rac Translocation to the Plasma Membrane

(2008) Young Chan Chae et al.   MOLECULAR BIOLOGY OF THE CELL

Assembly of a Fab1 Phosphoinositide Kinase Signaling Complex Requires the Fig4 Phosphoinositide Phosphatase

(2008) Roberto J. Botelho et al.   MOLECULAR BIOLOGY OF THE CELL

Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles

(2008) Cheryl L. Birmingham et al.   NATURE

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

(2008) Hongwu Zheng et al.   NATURE

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

Membrane recognition by phospholipid-binding domains

(2008) Mark A. Lemmon   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

From cells to organs: building polarized tissue

(2008) David M. Bryant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Shaping cups into phagosomes and macropinosomes

(2008) Joel A. Swanson   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization

(2008) T. Yeung et al.   SCIENCE

PtdIns5P regulation through evolution: roles in membrane trafficking?

(2008) Odile Lecompte et al.   TRENDS IN BIOCHEMICAL SCIENCES