Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer

Fenofibrate prevents skeletal muscle loss in mice with lung cancer

(2018) Marcus D. Goncalves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical role for PI3-kinase in regulating the use of proteins as an amino acid source

(2017) Wilhelm Palm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamic Pyruvate Transaminase GPT2 Promotes Tumorigenesis of Breast Cancer Cells by Activating Sonic Hedgehog Signaling

(2017) Yuan Cao et al.   Theranostics

Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells

(2016) Jonathan L. Coloff et al.   Cell Metabolism

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

(2016) Shawn M Davidson et al.   NATURE MEDICINE

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

(2016) J. R. Mayers et al.   SCIENCE

Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages

(2016) Johnathan Canton et al.   Nature Communications

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

(2016) Yujun Hao et al.   Nature Communications

Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells

(2016) Bradley Smith et al.   Cell Reports

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level

(2015) Kun Qian et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Cancer’s Fuel Choice: New Flavors for a Picky Eater

(2015) Gina M. DeNicola et al.   MOLECULAR CELL

Cancer Cells Hijack Gluconeogenic Enzymes to Fuel Cell Growth

(2015) Eduardo Balsa-Martinez et al.   MOLECULAR CELL

PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth

(2015) Emily D. Montal et al.   MOLECULAR CELL

Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth

(2015) Emma E. Vincent et al.   MOLECULAR CELL

Dysregulated metabolism contributes to oncogenesis

(2015) Matthew D. Hirschey et al.   SEMINARS IN CANCER BIOLOGY

Extracellular ATP is internalized by macropinocytosis and induces intracellular ATP increase and drug resistance in cancer cells

(2014) Yanrong Qian et al.   CANCER LETTERS

Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain

(2014) J. Chen et al.   CANCER RESEARCH

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport

(2014) Chendong Yang et al.   MOLECULAR CELL

Fructose-1,6-bisphosphatase opposes renal carcinoma progression

(2014) Bo Li et al.   NATURE

Determining the macropinocytic index of cells through a quantitative image-based assay

(2014) Cosimo Commisso et al.   Nature Protocols

PCK2 activation mediates an adaptive response to glucose depletion in lung cancer

(2014) K Leithner et al.   ONCOGENE

Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1 

(2014) B. Faubert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship

(2012) Julian R. Molina et al.   MAYO CLINIC PROCEEDINGS

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Coupling of Glucose Deprivation with Impaired Histone H2B Monoubiquitination in Tumors

(2012) Yasuyo Urasaki et al.   PLoS One

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

(2011) N. Stransky et al.   SCIENCE

Cancer Metabolism: Is Glutamine Sweeter than Glucose?

(2010) Weiqin Lu et al.   CANCER CELL

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

(2010) Mirkka Koivusalo et al.   JOURNAL OF CELL BIOLOGY

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

Metabolic Profiling of Human Lung Cancer Tissue by1H High Resolution Magic Angle Spinning (HRMAS) NMR Spectroscopy

(2009) Cláudia M. Rocha et al.   JOURNAL OF PROTEOME RESEARCH

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE