Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH

In Vivo Application of Proton-Electron Double-Resonance Imaging

(2018) Shun Kishimoto et al.   ANTIOXIDANTS & REDOX SIGNALING

Flip-angle based ratiometric approach for pulsed CEST-MRI pH imaging

(2018) Francesca Arena et al.   JOURNAL OF MAGNETIC RESONANCE

Development of a Series of Practical Fluorescent Chemical Tools To Measure pH Values in Living Samples

(2018) Shodai Takahashi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical exchange-sensitive spin-lock (CESL) MRI of glucose and analogs in brain tumors

(2018) Tao Jin et al.   MAGNETIC RESONANCE IN MEDICINE

Preliminary Results that Assess Metformin Treatment in a Preclinical Model of Pancreatic Cancer Using Simultaneous [18F]FDG PET and acidoCEST MRI

(2018) Joshua M. Goldenberg et al.   MOLECULAR IMAGING AND BIOLOGY

Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

(2018) Shen-Han Lee et al.   BRITISH JOURNAL OF CANCER

Metabolic studies of tumor cells using [1-13C] pyruvate hyperpolarized by means of PHIP-Side Arm Hydrogenation.

(2018) Eleonora Cavallari et al.   CHEMPHYSCHEM

The Monocarboxylate transporter inhibitor Quercetin induces intracellular acidification in a mouse model of Glioblastoma Multiforme: in-vivo detection using magnetic resonance imaging

(2018) Mohammed Albatany et al.   INVESTIGATIONAL NEW DRUGS

CEST-MRI for glioma pH quantification in mouse model: Validation by immunohistochemistry

(2018) Giuseppe Ferrauto et al.   NMR IN BIOMEDICINE

In Vivo Extracellular pH Mapping of Tumors Using Electron Paramagnetic Resonance

(2018) Denis A. Komarov et al.   ANALYTICAL CHEMISTRY

Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications

(2017) Dario Livio Longo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In vivo evaluation of tumour acidosis for assessing the early metabolic response and onset of resistance to dichloroacetate by using magnetic resonance pH imaging

(2017) Annasofia Anemone et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Intracellular pH measured by 31 P-MR-spectroscopy might predict site of progression in recurrent glioblastoma under antiangiogenic therapy

(2017) Katharina J. Wenger et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Dichloroacetate induced intracellular acidification in glioblastoma: in vivo detection using AACID-CEST MRI at 9.4 Tesla

(2017) Mohammed Albatany et al.   JOURNAL OF NEURO-ONCOLOGY

pH-sensitive amide proton transfer effect dominates the magnetization transfer asymmetry contrast during acute ischemia-quantification of multipool contribution to in vivo CEST MRI

(2017) Yin Wu et al.   MAGNETIC RESONANCE IN MEDICINE

Spin-lock imaging of exogenous exchange-based contrast agents to assess tissue pH

(2017) Zhongliang Zu et al.   MAGNETIC RESONANCE IN MEDICINE

Noninvasive evaluation of renal pH homeostasis after ischemia reperfusion injury by CEST-MRI

(2017) Dario Livio Longo et al.   NMR IN BIOMEDICINE

Therapeutic implications of tumor interstitial acidification

(2017) Iryna Kolosenko et al.   SEMINARS IN CANCER BIOLOGY

Value of pH regulators in the diagnosis, prognosis and treatment of cancer

(2017) Sara Granja et al.   SEMINARS IN CANCER BIOLOGY

Applications of pHLIP Technology for Cancer Imaging and Therapy

(2017) Linden C. Wyatt et al.   TRENDS IN BIOTECHNOLOGY

Imaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid

(2017) Stephan Düwel et al.   Nature Communications

In vivo quantitative imaging of tumor pH by nanosonophore assisted multispectral photoacoustic imaging

(2017) Janggun Jo et al.   Nature Communications

Semiconducting Oligomer Nanoparticles as an Activatable Photoacoustic Probe with Amplified Brightness for In Vivo Imaging of pH

(2016) Qingqing Miao et al.   ADVANCED MATERIALS

PET Imaging of Extracellular pH in Tumors with 64Cu- and 18F-Labeled pHLIP Peptides: A Structure–Activity Optimization Study

(2016) Dustin Wayne Demoin et al.   BIOCONJUGATE CHEMISTRY

Albumin-NIR dye self-assembled nanoparticles for photoacoustic pH imaging and pH-responsive photothermal therapy effective for large tumors

(2016) Qian Chen et al.   BIOMATERIALS

In Vivo Imaging of Tumor Metabolism and Acidosis by Combining PET and MRI-CEST pH Imaging

(2016) Dario L. Longo et al.   CANCER RESEARCH

Developing imidazoles as CEST MRI pH sensors

(2016) Xing Yang et al.   Contrast Media & Molecular Imaging

MRI-CEST assessment of tumour perfusion using X-ray iodinated agents: comparison with a conventional Gd-based agent

(2016) Annasofia Anemone et al.   EUROPEAN RADIOLOGY

In Vitro and In Vivo Assessment of Nonionic Iodinated Radiographic Molecules as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Tumor Perfusion Agents

(2016) Dario Livio Longo et al.   INVESTIGATIVE RADIOLOGY

Topiramate induces acute intracellular acidification in glioblastoma

(2016) Kamini Marathe et al.   JOURNAL OF NEURO-ONCOLOGY

Clinical Translation of Tumor Acidosis Measurements with AcidoCEST MRI

(2016) Kyle M. Jones et al.   MOLECULAR IMAGING AND BIOLOGY

Contrast agents for molecular photoacoustic imaging

(2016) Judith Weber et al.   NATURE METHODS

Imaging the intratumoral-peritumoral extracellular pH gradient of gliomas

(2016) Daniel Coman et al.   NMR IN BIOMEDICINE

Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy

(2016) Dario L. Longo et al.   Advanced Healthcare Materials

Potential Clinical Roles for Metabolic Imaging with Hyperpolarized [1-13C]Pyruvate

(2016) Eva M. Serrao et al.   Frontiers in Oncology

A Self-Assembled Albumin-Based Nanoprobe for In Vivo Ratiometric Photoacoustic pH Imaging

(2015) Qian Chen et al.   ADVANCED MATERIALS

A pH-Responsive MRI Agent that Can Be Activated Beyond the Tissue Magnetization Transfer Window

(2015) Xiaojing Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Caged [18F]FDG Glycosylamines for Imaging Acidic Tumor Microenvironments Using Positron Emission Tomography

(2015) Robert R. Flavell et al.   BIOCONJUGATE CHEMISTRY

A comparison of iopromide and iopamidol, two acidoCEST MRI contrast media that measure tumor extracellular pH

(2015) Brianna F. Moon et al.   Contrast Media & Molecular Imaging

MRICEST at 1T with large µeff Ln3+ complexes T m3+ -HPDO3A: An efficient MRI pH reporter

(2015) Giaime Rancan et al.   MAGNETIC RESONANCE IN MEDICINE

pH imaging of mouse kidneys in vivo using a frequency-dependent paraCEST agent

(2015) Yunkou Wu et al.   MAGNETIC RESONANCE IN MEDICINE

Evaluations of Tumor Acidosis Within In Vivo Tumor Models Using Parametric Maps Generated with AcidoCEST MRI

(2015) Liu Qi Chen et al.   MOLECULAR IMAGING AND BIOLOGY

Imaging chemical exchange saturation transfer (CEST) effects following tumor-selective acidification using lonidamine

(2015) Nevin McVicar et al.   NMR IN BIOMEDICINE

ParaHydrogen Induced Polarization of 13C carboxylate resonance in acetate and pyruvate

(2015) Francesca Reineri et al.   Nature Communications

Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging

(2015) George W. J. Harston et al.   BRAIN

Extracellular acidity, a “reappreciated” trait of tumor environment driving malignancy: perspectives in diagnosis and therapy

(2014) Silvia Peppicelli et al.   CANCER AND METASTASIS REVIEWS

Light In and Sound Out: Emerging Translational Strategies for Photoacoustic Imaging

(2014) S. Zackrisson et al.   CANCER RESEARCH

Lanthanide ion (III) complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaminophosphonate for dual biosensing of pH with chemical exchange saturation transfer (CEST) and biosensor imaging of redundant deviation in shifts (BIRDS)

(2014) Yuegao Huang et al.   Contrast Media & Molecular Imaging

Electron paramagnetic resonance: a powerful tool to support magnetic resonance imaging research

(2014) Pierre Danhier et al.   Contrast Media & Molecular Imaging

Evaluating tumor metastatic potential by imaging intratumoral acidosisviapH-activatable near-infrared fluorescent probe

(2014) Lu Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Quantitative Tissue Ph Measurement during Cerebral Ischemia Using Amine and Amide Concentration-Independent Detection (AACID) with MRI

(2014) Nevin McVicar et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A General MRI-CEST Ratiometric Approach for pH Imaging: Demonstration of in Vivo pH Mapping with Iobitridol

(2014) Dario L. Longo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functional MRI Using Spin Lock Editing Preparation Pulses

(2014) Swati Rane et al.   MAGNETIC RESONANCE IMAGING

Pilot study of Iopamidol-based quantitative pH imaging on a clinical 3T MR scanner

(2014) Anja Müller-Lutz et al.   MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE

Quantification of iopamidol multi-site chemical exchange properties for ratiometric chemical exchange saturation transfer (CEST) imaging of pH

(2014) Phillip Zhe Sun et al.   PHYSICS IN MEDICINE AND BIOLOGY

In Vivo Proton–Electron Double-Resonance Imaging of Extracellular Tumor pH Using an Advanced Nitroxide Probe

(2013) Alexandre Samouilov et al.   ANALYTICAL CHEMISTRY

Multi-Chromatic pH-Activatable19F-MRI Nanoprobes with Binary ON/OFF pH Transitions and Chemical-Shift Barcodes

(2013) Xiaonan Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acidic extracellular microenvironment and cancer

(2013) Yasumasa Kato et al.   Cancer Cell International

Quantitative In Vivo Characterization of Intracellular and Extracellular pH Profiles in Heterogeneous Tumors: A Novel Method Enabling Multiparametric pH Analysis

(2013) N. W. Lutz et al.   CANCER RESEARCH

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

(2013) V. Estrella et al.   CANCER RESEARCH

Optical Image-Guided Cancer Surgery: Challenges and Limitations

(2013) S. Keereweer et al.   CLINICAL CANCER RESEARCH

The importance of water exchange rates in the design of responsive agents for MRI

(2013) A. Dean Sherry et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Evaluations of extracellular pH within in vivo tumors using acidoCEST MRI

(2013) Liu Qi Chen et al.   MAGNETIC RESONANCE IN MEDICINE

In vivo maps of extracellular pH in murine melanoma by CEST-MRI

(2013) D Delli Castelli et al.   MAGNETIC RESONANCE IN MEDICINE

A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals

(2013) Yiguang Wang et al.   NATURE MATERIALS

Comparison of three reference methods for the measurement of intracellular pH using31P MRS in healthy volunteers and patients with lymphoma

(2013) Mihaela Rata et al.   NMR IN BIOMEDICINE

Nuts and bolts of chemical exchange saturation transfer MRI

(2013) Guanshu Liu et al.   NMR IN BIOMEDICINE

Chemical exchange saturation transfer (CEST) and MRZ-spectroscopyin vivo: a review of theoretical approaches and methods

(2013) Moritz Zaiss et al.   PHYSICS IN MEDICINE AND BIOLOGY

Real-Time Noninvasive Monitoring of In Vivo Inflammatory Responses using a pH Ratiometric Fluorescence Imaging Probe

(2013) Yi-Ting Tsai et al.   Advanced Healthcare Materials

Dual-Function pH and Oxygen Phosphonated Trityl Probe

(2012) Andrey A. Bobko et al.   ANALYTICAL CHEMISTRY

Relaxivity Enhancement in Macromolecular and Nanosized GdIII-Based MRI Contrast Agents

(2012) Mauro Botta et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Relaxometric Investigations and MRI Evaluation of a Liposome-Loaded pH-Responsive Gadolinium(III) Complex

(2012) E. Gianolio et al.   INORGANIC CHEMISTRY

Error analysis of ratiometric imaging of extracellular pH in a window chamber model

(2012) Yuxiang Lin et al.   JOURNAL OF BIOMEDICAL OPTICS

CEST: From basic principles to applications, challenges and opportunities

(2012) Elena Vinogradov et al.   JOURNAL OF MAGNETIC RESONANCE

6-Trifluoromethylpyridoxine: Novel 19F NMR pH Indicator for in Vivo Detection

(2012) Jian-Xin Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Imaging the pH evolution of an acute kidney injury model by means of iopamidol, a MRI-CEST pH-responsive contrast agent

(2012) Dario Livio Longo et al.   MAGNETIC RESONANCE IN MEDICINE

Laser optoacoustic tomography: Towards new technology for biomedical diagnostics

(2012) Richard Su et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT

New frontiers and developing applications in 19F NMR

(2012) Jian-Xin Yu et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs

(2012) L. V. Wang et al.   SCIENCE

YbIII-HPDO3A: A Dual pH- and Temperature-Responsive CEST Agent

(2011) Daniela Delli Castelli et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reduction of metastasis using a non-volatile buffer

(2011) Arig Ibrahim Hashim et al.   CLINICAL & EXPERIMENTAL METASTASIS

Association between pH-Weighted Endogenous Amide Proton Chemical Exchange Saturation Transfer MRI and Tissue Lactic Acidosis during Acute Ischemic Stroke

(2011) Phillip Zhe Sun et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Simulation and optimization of pulsed radio frequency irradiation scheme for chemical exchange saturation transfer (CEST) MRI-demonstration of pH-weighted pulsed-amide proton CEST MRI in an animal model of acute cerebral ischemia

(2011) Phillip Zhe Sun et al.   MAGNETIC RESONANCE IN MEDICINE

In vivo monitoring of pH, redox status, and glutathione using L-band EPR for assessment of therapeutic effectiveness in solid tumors

(2011) Andrey A. Bobko et al.   MAGNETIC RESONANCE IN MEDICINE

Exchange-mediated contrast agents for spin-lock imaging

(2011) Jared G. Cobb et al.   MAGNETIC RESONANCE IN MEDICINE

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

A lanthanide complex with dual biosensing properties: CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts) with europium DOTA-tetraglycinate

(2011) Daniel Coman et al.   NMR IN BIOMEDICINE

Imaging the extracellular pH of tumors by MRI after injection of a single cocktail ofT1andT2contrast agents

(2011) Gary V. Martinez et al.   NMR IN BIOMEDICINE

CEST and PARACEST MR contrast agents

(2010) Ileana Hancu et al.   ACTA RADIOLOGICA

Molecular Imaging by Means of Multispectral Optoacoustic Tomography (MSOT)

(2010) Vasilis Ntziachristos et al.   CHEMICAL REVIEWS

Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?

(2010) Ioanna Papandreou et al.   INTERNATIONAL JOURNAL OF CANCER

Spin-locking versus chemical exchange saturation transfer MRI for investigating chemical exchange process between water and labile metabolite protons

(2010) Tao Jin et al.   MAGNETIC RESONANCE IN MEDICINE

Iopamidol as a responsive MRI-chemical exchange saturation transfer contrast agent for pH mapping of kidneys: In vivo studies in mice at 7 T

(2010) Dario Livio Longo et al.   MAGNETIC RESONANCE IN MEDICINE

Early Experience of Translating pH-Weighted MRI to Image Human Subjects at 3 Tesla

(2010) P. Z. Sun et al.   STROKE

Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases

(2009) I. F. Robey et al.   CANCER RESEARCH

A Novel Technology for the Imaging of Acidic Prostate Tumors by Positron Emission Tomography

(2009) A. L. Vavere et al.   CANCER RESEARCH

Poly-β-cyclodextrin based platform for pH mapping via a ratiometric 19F/1H MRI method

(2009) Eliana Gianolio et al.   CHEMICAL COMMUNICATIONS

Primer on gadolinium chemistry

(2009) A. Dean Sherry et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

DNP-Hyperpolarized 13C Magnetic Resonance Metabolic Imaging for Cancer Applications

(2008) S. J. Nelson et al.   APPLIED MAGNETIC RESONANCE

Pulsed EPR imaging of nitroxides in mice

(2008) Fuminori Hyodo et al.   JOURNAL OF MAGNETIC RESONANCE

Imaging pH using the chemical exchange saturation transfer (CEST) MRI: Correction of concomitant RF irradiation effects to quantify CEST MRI for chemical exchange rate and pH

(2008) Phillip Zhe Sun et al.   MAGNETIC RESONANCE IN MEDICINE

Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate

(2008) Ferdia A. Gallagher et al.   NATURE