Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs – an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research

Tumor hypoxia and metabolism – Towards novel anticancer approaches

(2013) Johanna Chiche et al.   ANNALES D ENDOCRINOLOGIE

Regulation of the Na+/H+ Exchanger (NHE1) in Breast Cancer Metastasis

(2013) S. R. Amith et al.   CANCER RESEARCH

Ion Channels and Transporters in Cancer: Pathophysiology, Regulation, and Clinical Potential

(2013) S. F. Pedersen et al.   CANCER RESEARCH

Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite?

(2013) Stephen Yiu Chuen Choi et al.   JOURNAL OF PATHOLOGY

SLC9/NHE gene family, a plasma membrane and organellar family of Na+/H+ exchangers

(2013) Mark Donowitz et al.   MOLECULAR ASPECTS OF MEDICINE

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Elucidation of How Cancer Cells Avoid Acidosis through Comparative Transcriptomic Data Analysis

(2013) Kun Xu et al.   PLoS One

Na+/H+exchanger 1 inhibition contributes to K562 leukaemic cell differentiation

(2012) Weina Jin et al.   CELL BIOLOGY INTERNATIONAL

An Inhibitor of Na+/H+Exchanger (NHE), Ethyl-Isopropyl Amiloride (EIPA), Diminishes Proliferation of MKN28 Human Gastric Cancer Cells by Decreasing the Cytosolic Cl-Concentration via DIDS-Sensitive Pathways

(2012) Shigekuni Hosogi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Is the Multifunctional Na+/H+ Exchanger Isoform 1 a Potential Therapeutic Target in Cancer?

(2012) C. Stock et al.   CURRENT MEDICINAL CHEMISTRY

NHE-1: A Promising Target for Novel Anti-cancer Therapeutics

(2012) Ser Yue Loo et al.   CURRENT PHARMACEUTICAL DESIGN

Physiology, Pharmacology and Pathophysiology of the pH Regulatory Transport Proteins NHE1 and NBCn1: Similarities, Differences, and Implications for Cancer Therapy

(2012) E. Boedtkjer et al.   CURRENT PHARMACEUTICAL DESIGN

pH regulators in invadosomal functioning: Proton delivery for matrix tasting

(2012) Lucie Brisson et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Potential Role of Sodium-Proton Exchangers in the Low Concentration Arsenic Trioxide-Increased Intracellular pH and Cell Proliferation

(2012) Carmen Aravena et al.   PLoS One

Bicarbonate and dichloroacetate: Evaluating pH altering therapies in a mouse model for metastatic breast cancer

(2011) Ian F Robey et al.   BMC CANCER

The Na+/H+ exchanger NHE1, but not the Na+, cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2

(2011) Gitte Lauritzen et al.   CANCER LETTERS

Evolution of Tumor Invasiveness: The Adaptive Tumor Microenvironment Landscape Model

(2011) H.-O. Lee et al.   CANCER RESEARCH

Na+/H+ exchanger regulatory factor 1 expression levels in blood and tissue predict breast tumour clinical behaviour

(2011) Antonia Bellizzi et al.   HISTOPATHOLOGY

Lansoprazole as a rescue agent in chemoresistant tumors: a phase I/II study in companion animals with spontaneously occurring tumors

(2011) Enrico P Spugnini et al.   Journal of Translational Medicine

Inhibition of K562 leukemia angiogenesis and growth by selective Na+/H+ exchanger inhibitor cariporide through down-regulation of pro-angiogenesis factor VEGF

(2011) Wei Gao et al.   LEUKEMIA RESEARCH

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Hypoxia-Induced Invadopodia Formation Involves Activation of NHE-1 by the p90 Ribosomal S6 Kinase (p90RSK)

(2011) Fabrice Lucien et al.   PLoS One

Teaching New Dogs Old Tricks: Membrane Biophysical Properties in Drug Delivery and Resistance

(2011) Nina Milosavljevic et al.   Recent Patents on Anti-Cancer Drug Discovery

NHE1 promotes invadopodial ECM proteolysis through acidification of the peri-invadopodial space

(2010) Giovanni Busco et al.   FASEB JOURNAL

pH control mechanisms of tumor survival and growth

(2010) Scott K. Parks et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Proton dynamics in cancer

(2010) Veronica Huber et al.   Journal of Translational Medicine

Suppression of NHE1 by small interfering RNA inhibits HIF-1α-induced angiogenesis in vitro via modulation of calpain activity

(2010) Xian-Gang Mo et al.   MICROVASCULAR RESEARCH

Intra-tumoural extra-cellular pH: a useful parameter of response to chemotherapy in syngeneic tumour lines

(2009) D Lindner et al.   BRITISH JOURNAL OF CANCER

Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases

(2009) I. F. Robey et al.   CANCER RESEARCH

Toward a mechanical control of drug delivery. On the relationship between Lipinski’s 2nd rule and cytosolic pH changes in doxorubicin resistance levels in cancer cells: a comparison to published data

(2009) Cyril Rauch   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

A change of strategy in the war on cancer

(2009) Robert A. Gatenby   NATURE

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

(2008) J. Chiche et al.   CANCER RESEARCH

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

Protons extruded by NHE1: Digestive or glue?

(2008) C STOCK et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate

(2008) Ferdia A. Gallagher et al.   NATURE