Tumor pH and metastasis: a malignant process beyond hypoxia

Acidic pH e regulates cytoskeletal dynamics through conformational integrin β1 activation and promotes membrane protrusion

(2018) Shun Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Kraken Wakes: induced EMT as a driver of tumour aggression and poor outcome

(2018) Andrew D. Redfern et al.   CLINICAL & EXPERIMENTAL METASTASIS

Hypoxic Signalling in Tumour Stroma

(2018) Anu Laitala et al.   Frontiers in Oncology

Acidic extracellular environment affects miRNA expression in tumors in vitro and in vivo

(2018) Anne Riemann et al.   INTERNATIONAL JOURNAL OF CANCER

The Different Routes to Metastasis via Hypoxia-Regulated Programs

(2018) Ana Rita Nobre et al.   TRENDS IN CELL BIOLOGY

Expression of proton‐sensing G‐protein‐coupled receptors in selected skin tumors

(2018) Anaïs Nassios et al.   EXPERIMENTAL DERMATOLOGY

Metabolic reprogramming and epithelial-to-mesenchymal transition in cancer

(2017) Marco Sciacovelli et al.   FEBS Journal

MicroRNAs Associated with Von Hippel–Lindau Pathway in Renal Cell Carcinoma: A Comprehensive Review

(2017) Lisa-Maria Schanza et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A comparison of exogenous and endogenous CESTMRI methods for evaluating in vivo pH

(2017) Leila R. Lindeman et al.   MAGNETIC RESONANCE IN MEDICINE

Evidence that activation of ASIC1a by acidosis increases osteoclast migration and adhesion by modulating integrin/Pyk2/Src signaling pathway

(2017) X. Li et al.   OSTEOPOROSIS INTERNATIONAL

Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis

(2017) Peiwen Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-215 suppresses proliferation and migration of non-small cell lung cancer cells

(2017) Xiaopan Cai et al.   Oncology Letters

TRPM5 mediates acidic extracellular pH signaling and TRPM5 inhibition reduces spontaneous metastasis in mouse B16-BL6 melanoma cells

(2017) Toyonobu Maeda et al.   Oncotarget

Tris-base buffer: a promising new inhibitor for cancer progression and metastasis

(2017) Arig Ibrahim-Hashim et al.   Cancer Medicine

Tumor Acidosis and Hypoxia Differently Modulate the Inflammatory Program: Measurements In Vitro and In Vivo

(2017) Anne Riemann et al.   NEOPLASIA

Extracellular protonation modulates cell-cell interaction mechanics and tissue invasion in human melanoma cells

(2017) Verena Hofschröer et al.   Scientific Reports

The hypoxic tumor microenvironment: A driving force for breast cancer progression

(2016) Gregg L. Semenza   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The mechanism between epithelial mesenchymal transition in breast cancer and hypoxia microenvironment

(2016) Tong Gao et al.   BIOMEDICINE & PHARMACOTHERAPY

Acidosis Acts through HSP90 in a PHD/VHL-Independent Manner to Promote HIF Function and Stem Cell Maintenance in Glioma

(2016) Alina Filatova et al.   CANCER RESEARCH

Epithelial–mesenchymal transition (EMT) and metastasis: yes, no, maybe?

(2016) Maren Diepenbruck et al.   CURRENT OPINION IN CELL BIOLOGY

Acidic microenvironments induce lymphangiogenesis and IL-8 production via TRPV1 activation in human lymphatic endothelial cells

(2016) Masako Nakanishi et al.   EXPERIMENTAL CELL RESEARCH

MicroRNA-183 functions as the tumor suppressor via inhibiting cellular invasion and metastasis by targeting MMP-9 in cervical cancer

(2016) Dongmei Fan et al.   GYNECOLOGIC ONCOLOGY

Implications of Hypoxia in Breast Cancer Metastasis to Bone

(2016) Daniele Gilkes   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling

(2016) Sergiy M. Nadtochiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The tumour hypoxia induced non-coding transcriptome

(2016) Hani Choudhry et al.   MOLECULAR ASPECTS OF MEDICINE

Acidic extracellular pH promotes prostate cancer bone metastasis by enhancing PC-3 stem cell characteristics, cell invasiveness and VEGF-induced vasculogenesis of BM-EPCs

(2016) Sheng Huang et al.   ONCOLOGY REPORTS

Hypoxic control of metastasis

(2016) E. B. Rankin et al.   SCIENCE

Cancer: fundamentals behind pH targeting and the double-edged approach

(2016) Tomas Koltai   OncoTargets and Therapy

Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells

(2016) A. Spiegel et al.   Cancer Discovery

miRNA Deregulation in Cancer Cells and the Tumor Microenvironment

(2016) R. Rupaimoole et al.   Cancer Discovery

A nonrandomized cohort and a randomized study of local control of large hepatocarcinoma by targeting intratumoral lactic acidosis

(2016) Ming Chao et al.   eLife

ERK-mediated NF-κB activation through ASIC1 in response to acidosis

(2016) B Chen et al.   Oncogenesis

The Proton-Sensing G-Protein Coupled Receptor GPR4 Promotes Angiogenesis in Head and Neck Cancer

(2016) Zhibin Jing et al.   PLoS One

Ion channels and transporters in metastasis

(2015) Christian Stock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Acidic environment activates inflammatory programs in fibroblasts via a cAMP–MAPK pathway

(2015) A. Riemann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

miR-183 induces cell proliferation, migration, and invasion by regulating PDCD4 expression in the SW1990 pancreatic cancer cell line

(2015) Ying-Ying Lu et al.   BIOMEDICINE & PHARMACOTHERAPY

Extracellular acidity strengthens mesenchymal stem cells to promote melanoma progression

(2015) Silvia Peppicelli et al.   CELL CYCLE

Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway

(2015) Valéry L. Payen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Epigenetic Regulation of Epithelial-Mesenchymal Transition by Hypoxia in Cancer: Targets and Therapy

(2015) Jian Wang et al.   CURRENT PHARMACEUTICAL DESIGN

GPR4 decreases B16F10 melanoma cell spreading and regulates focal adhesion dynamics through the G13/Rho signaling pathway

(2015) Calvin R. Justus et al.   EXPERIMENTAL CELL RESEARCH

The Na+/HCO3−Co-Transporter SLC4A4 Plays a Role in Growth and Migration of Colon and Breast Cancer Cells

(2015) Scott K. Parks et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression

(2015) Xin Ye et al.   TRENDS IN CELL BIOLOGY

Involvement of acid-sensing ion channel 1α in hepatic carcinoma cell migration and invasion

(2015) Cheng Jin et al.   TUMOR BIOLOGY

Cathepsin B Mediates the pH-Dependent Proinvasive Activity of Tumor-Shed Microvesicles

(2015) Ilaria Giusti et al.   NEOPLASIA

Acidic preconditioning improves the proangiogenic responses of endothelial colony forming cells

(2014) Hebe A. Mena et al.   ANGIOGENESIS

E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition

(2014) Augustine Chen et al.   BMC CANCER

The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis

(2014) Un-Ho Jin et al.   BMC CANCER

Extracellular acidity, a “reappreciated” trait of tumor environment driving malignancy: perspectives in diagnosis and therapy

(2014) Silvia Peppicelli et al.   CANCER AND METASTASIS REVIEWS

Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy

(2014) Stefano Fais et al.   CANCER AND METASTASIS REVIEWS

Contribution of acidic melanoma cells undergoing epithelial-to-mesenchymal transition to aggressiveness of non-acidic melanoma cells

(2014) Silvia Peppicelli et al.   CLINICAL & EXPERIMENTAL METASTASIS

Molecular Pathways: Linking Tumor Microenvironment to Epithelial-Mesenchymal Transition in Metastasis

(2014) H.-Y. Jung et al.   CLINICAL CANCER RESEARCH

Evaluating tumor metastatic potential by imaging intratumoral acidosisviapH-activatable near-infrared fluorescent probe

(2014) Lu Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Multiple functions of hypoxia-regulated miR-210 in cancer

(2014) Qin Qin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Acidic priming enhances metastatic potential of cancer cells

(2014) Anne Riemann et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Ion channels and transporters in tumour cell migration and invasion

(2014) A. Schwab et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

miR-203 Suppresses the Proliferation and Migration and Promotes the Apoptosis of Lung Cancer Cells by Targeting SRC

(2014) Nan Wang et al.   PLoS One

Platelets, Selectins, and the Control of Tumor Metastasis

(2014) Lucy A. Coupland et al.   SEMINARS IN ONCOLOGY

The Microenvironment of Cervical Carcinoma Xenografts: Associations with Lymph Node Metastasis and Its Assessment by DCE-MRI

(2014) Christine Ellingsen et al.   Translational Oncology

miR-203 inhibits tumor cell migration and invasion via caveolin-1 in pancreatic cancer cells

(2014) LIFENG MIAO et al.   Oncology Letters

Acidic extracellular microenvironment and cancer

(2013) Yasumasa Kato et al.   Cancer Cell International

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

(2013) V. Estrella et al.   CANCER RESEARCH

miR-192, miR-194 and miR-215: a convergent microRNA network suppressing tumor progression in renal cell carcinoma

(2013) H.W.Z. Khella et al.   CARCINOGENESIS

Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells

(2013) Dhivya R. Sudhan et al.   CLINICAL & EXPERIMENTAL METASTASIS

Acidic pH via NF-κB favours VEGF-C expression in human melanoma cells

(2013) Silvia Peppicelli et al.   CLINICAL & EXPERIMENTAL METASTASIS

Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decade

(2013) Jennifer Vandooren et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

MicroRNA-183 suppresses retinoblastoma cell growth, invasion and migration by targeting LRP6

(2013) Jianwen Wang et al.   FEBS Journal

Extracellular matrix composition and interstitial pH modulate NHE1-mediated melanoma cell motility

(2013) ANNE-KRISTIN VAHLE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Signaling between Transforming Growth Factor β (TGF-β) and Transcription Factor SNAI2 Represses Expression of MicroRNA miR-203 to Promote Epithelial-Mesenchymal Transition and Tumor Metastasis

(2013) Xiangming Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor and its microenvironment: A synergistic interplay

(2013) Veronica Catalano et al.   SEMINARS IN CANCER BIOLOGY

Carbonic anhydrase IX

(2013) Eliska Svastova et al.   Cell Adhesion & Migration

The effect of carbonic anhydrase IX on focal contacts during cell spreading and migration

(2013) Lucia Csaderova et al.   Frontiers in Physiology

Acidic tumor microenvironment and pH-sensing G protein-coupled receptors

(2013) Calvin R. Justus et al.   Frontiers in Physiology

pH sensing and regulation in cancer

(2013) Mehdi Damaghi et al.   Frontiers in Physiology

Additive Influence of Extracellular pH, Oxygen Tension, and Pressure on Invasiveness and Survival of Human Osteosarcoma Cells

(2013) Takao Matsubara et al.   Frontiers in Oncology

Extracellular Acidification Activates cAMP Responsive Element Binding Protein via Na+/H+ Exchanger Isoform 1–Mediated Ca 2+ Oscillation in Central Nervous System Pericytes

(2012) Kuniyuki Nakamura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Extracellular acidosis accelerates bone resorption by enhancing osteoclast survival, adhesion, and migration

(2012) Heejin Ahn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Voltage-gated sodium channels and metastatic disease

(2012) William J. Brackenbury   Channels

Multiple Biological Activities of Lactic Acid in Cancer: Influences on Tumor Growth,Angiogenesis and Metastasis

(2012) Suveera Dhup et al.   CURRENT PHARMACEUTICAL DESIGN

Acidosis-induced V-ATPase trafficking in salivary ducts is initiated by cAMP/PKA/CREB pathway via regulation of Rab11b expression

(2012) Oliver Oehlke et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Na+/H+-exchanger (NHE1) generates pH nanodomains at focal adhesions

(2012) Florian Timo Ludwig et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hypochlorite-induced oxidative stress elevates the capability of HDL in promoting breast cancer metastasis

(2012) Bing Pan et al.   Journal of Translational Medicine

Redox regulation of cancer cell migration and invasion

(2012) Lalchhandami Tochhawng et al.   MITOCHONDRION

Role of Ion Channels and Transporters in Cell Migration

(2012) Albrecht Schwab et al.   PHYSIOLOGICAL REVIEWS

The regulation of cell-cell adhesion during epithelial-mesenchymal transition, motility and tumor progression

(2012) Grégoire F. Le Bras et al.   Cell Adhesion & Migration

Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor

(2011) Lorenza Wyder et al.   ANGIOGENESIS

Inhibition of tumor cell migration and metastasis by the proton-sensing GPR4 receptor

(2011) Reid D. Castellone et al.   CANCER LETTERS

Functional Interaction between Responses to Lactic Acidosis and Hypoxia Regulates Genomic Transcriptional Outputs

(2011) X. Tang et al.   CANCER RESEARCH

Hypoxia Predicts Aggressive Growth and Spontaneous Metastasis Formation from Orthotopically Grown Primary Xenografts of Human Pancreatic Cancer

(2011) Q. Chang et al.   CANCER RESEARCH

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Reduction of metastasis using a non-volatile buffer

(2011) Arig Ibrahim Hashim et al.   CLINICAL & EXPERIMENTAL METASTASIS

Elevated CO2Levels Cause Mitochondrial Dysfunction and Impair Cell Proliferation

(2011) Christine U. Vohwinkel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Initial steps of metastasis: Cell invasion and endothelial transmigration

(2011) Franziska van Zijl et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Acidic Environment Leads to ROS-Induced MAPK Signaling in Cancer Cells

(2011) Anne Riemann et al.   PLoS One

Intracellular pH gradients in migrating cells

(2010) Christine Martin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

NOX4-dependent ROS production by stromal mammary cells modulates epithelial MCF-7 cell migration

(2010) N Tobar et al.   BRITISH JOURNAL OF CANCER

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Acidic stress facilitates tyrosine phosphorylation of HLJ1 to associate with actin cytoskeleton in lung cancer cells

(2010) Ching-Hsien Chen et al.   EXPERIMENTAL CELL RESEARCH

Transcriptional control of melanoma metastasis: The importance of the tumor microenvironment

(2010) Russell R. Braeuer et al.   SEMINARS IN CANCER BIOLOGY

Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases

(2009) I. F. Robey et al.   CANCER RESEARCH

The Potential Role of Systemic Buffers in Reducing Intratumoral Extracellular pH and Acid-Mediated Invasion

(2009) A. S. Silva et al.   CANCER RESEARCH

Role of HIF-1α in proton-mediated CXCR4 down-regulation in endothelial cells

(2009) Roberta Melchionna et al.   CARDIOVASCULAR RESEARCH

The role of hypoxia and acidosis in promoting metastasis and resistance to chemotherapy

(2009) Katie DeClerck   Frontiers in Bioscience-Landmark

Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation

(2009) Xin Huang et al.   MOLECULAR CELL

Normoxic induction of cerebral HIF-1α by acetazolamide in rats: Role of acidosis

(2009) Jiajun Xu et al.   NEUROSCIENCE LETTERS

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species

(2008) Wen-Sheng Wu et al.   CANCER AND METASTASIS REVIEWS

An acidic extracellular pH induces Src kinase-dependent loss of β-catenin from the adherens junction

(2008) Kuo-Hsin Chen et al.   CANCER LETTERS

The tumor microenvironment and metastatic disease

(2008) Sarah Jane Lunt et al.   CLINICAL & EXPERIMENTAL METASTASIS

Acid treatment of melanoma cells selects for invasive phenotypes

(2008) Raymond E. Moellering et al.   CLINICAL & EXPERIMENTAL METASTASIS

Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1)in vitroandin vivoby increasing the activity of the p-glycoproteinviaactivation of p38

(2008) Christoph Sauvant et al.   INTERNATIONAL JOURNAL OF CANCER

Acidic pH stimulates the production of the angiogenic CXC chemokine, CXCL8 (interleukin‐8), in human adult mesenchymal stem cells via the extracellular signal‐regulated kinase, p38 mitogen‐activated protein kinase, and NF‐κB pathways

(2008) David S. Bischoff et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Molecular Basis of Metastasis

(2008) Anne C. Chiang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling

(2008) J. Srivastava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA