The Link of the Prion Protein with Ca2+ Metabolism and ROS Production, and the Possible Implication in Aβ Toxicity

Amyloid β Oligomers Increase ER-Mitochondria Ca2+ Cross Talk in Young Hippocampal Neurons and Exacerbate Aging-Induced Intracellular Ca2+ Remodeling

(2019) Maria Calvo-Rodriguez et al.   Frontiers in Cellular Neuroscience

STIM1 phosphorylation at Y316 modulates its interaction with SARAF and the activation of SOCE and ICRAC

(2019) Esther Lopez et al.   JOURNAL OF CELL SCIENCE

Selective recruitment of different Ca2+-dependent transcription factors by STIM1-Orai1 channel clusters

(2019) Yu-Ping Lin et al.   Nature Communications

Prions, prionoids and protein misfolding disorders

(2018) Claudia Scheckel et al.   NATURE REVIEWS GENETICS

The Prion Protein Regulates Synaptic Transmission by Controlling the Expression of Proteins Key to Synaptic Vesicle Recycling and Exocytosis

(2018) Caterina Peggion et al.   MOLECULAR NEUROBIOLOGY

Toxic Protein Spread in Neurodegeneration: Reality versus Fantasy

(2018) Eleanna Kara et al.   TRENDS IN MOLECULAR MEDICINE

The prion protein regulates glutamate-mediated Ca2+entry and mitochondrial Ca2+accumulation in neurons

(2017) Agnese De Mario et al.   JOURNAL OF CELL SCIENCE

Amyloid β-42 induces neuronal apoptosis by targeting mitochondria

(2017) Xiao-Jian Han et al.   Molecular Medicine Reports

α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B

(2017) Diana G Ferreira et al.   NATURE NEUROSCIENCE

Generation and validation of novel adeno-associated viral vectors for the analysis of Ca2+ homeostasis in motor neurons

(2017) Rosa Pia Norante et al.   Scientific Reports

Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity

(2017) Despoina Goniotaki et al.   PLoS Pathogens

The Biological Function of the Prion Protein: A Cell Surface Scaffold of Signaling Modules

(2017) Rafael Linden   Frontiers in Molecular Neuroscience

α-Synuclein Amyloids Hijack Prion Protein to Gain Cell Entry, Facilitate Cell-to-Cell Spreading and Block Prion Replication

(2017) Suzana Aulić et al.   Scientific Reports

Generation and usage of aequorin lentiviral vectors for Ca2+ measurement in sub-cellular compartments of hard-to-transfect cells

(2016) Dmitry Lim et al.   CELL CALCIUM

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

(2016) Shanmugam Manoharan et al.   Oxidative Medicine and Cellular Longevity

Extensive phosphorylation of AMPA receptors in neurons

(2016) Graham H. Diering et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Biology of Prions and Prionoids: A Status Report

(2016) Adriano Aguzzi et al.   TRENDS IN CELL BIOLOGY

Amyloid β oligomers elicit mitochondrial transport defects and fragmentation in a time-dependent and pathway-specific manner

(2016) Yanfang Rui et al.   Molecular Brain

Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight

(2015) Aashiq Hussain Bhat et al.   BIOMEDICINE & PHARMACOTHERAPY

Generation and functions of second messengers microdomains

(2015) Riccardo Filadi et al.   CELL CALCIUM

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

(2015) Paolo Bernardi et al.   PHYSIOLOGICAL REVIEWS

Involvement of Intracellular and Mitochondrial Aβ in the Ameliorative Effects of Huperzine A against Oligomeric Aβ42-Induced Injury in Primary Rat Neurons

(2015) Yun Lei et al.   PLoS One

The prion protein constitutively controls neuronal store-operated Ca2+ entry through Fyn kinase

(2015) Agnese De Mario et al.   Frontiers in Cellular Neuroscience

Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?

(2015) Jan Lewerenz et al.   Frontiers in Neuroscience

PrPC signalling in neurons: From basics to clinical challenges

(2014) Théo Z. Hirsch et al.   BIOCHIMIE

STIM1 Controls Neuronal Ca2+ Signaling, mGluR1-Dependent Synaptic Transmission, and Cerebellar Motor Behavior

(2014) Jana Hartmann et al.   NEURON

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Store-Operated Calcium Entry Promotes the Degradation of the Transcription Factor Sp4 in Resting Neurons

(2014) J. Lalonde et al.   Science Signaling

mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo

(2014) Neng-Wei Hu et al.   Nature Communications

Molecular pharmacology of store-operated CRAC channels

(2013) Amit Jairaman et al.   Channels

Cytotoxicity of Intracellular A 42 Amyloid Oligomers Involves Ca2+ Release from the Endoplasmic Reticulum by Stimulated Production of Inositol Trisphosphate

(2013) A. Demuro et al.   JOURNAL OF NEUROSCIENCE

Overcoming barriers and thresholds -- signaling of oligomeric Abeta through the prion protein to Fyn

(2013) Hansen Wang et al.   Molecular Neurodegeneration

Amyloid-β induced signaling by cellular prion protein and Fyn kinase in Alzheimer disease

(2013) Ji Won Um et al.   Prion

ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion

(2013) R. S. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenic prions deviate PrPC signaling in neuronal cells and impair A-beta clearance

(2013) E Pradines et al.   Cell Death & Disease

Biochemistry of Amyloid  -Protein and Amyloid Deposits in Alzheimer Disease

(2013) C. L. Masters et al.   Cold Spring Harbor Perspectives in Medicine

Alzheimer's disease-associated peptide Aβ42 mobilizes ER Ca2+ via InsP3R-dependent and -independent mechanisms

(2013) Laura E. Jensen et al.   Frontiers in Molecular Neuroscience

What is the pathological significance of tau oligomers?

(2012) Catherine M. Cowan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Targeting NOX enzymes in the central nervous system: therapeutic opportunities

(2012) Silvia Sorce et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

STIM1 tyrosine-phosphorylation is required for STIM1-Orai1 association in human platelets

(2012) Esther Lopez et al.   CELLULAR SIGNALLING

The Complex PrPc-Fyn Couples Human Oligomeric A  with Pathological Tau Changes in Alzheimer's Disease

(2012) M. Larson et al.   JOURNAL OF NEUROSCIENCE

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

STIM proteins: dynamic calcium signal transducers

(2012) Jonathan Soboloff et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A  neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors

(2012) H. You et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Possible role for Ca2+ in the pathophysiology of the prion protein?

(2011) Caterina Peggion et al.   BIOFACTORS

Is PrP the road to ruin?

(2011) Kelly A Barton et al.   EMBO JOURNAL

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

(2011) Ulrike K Resenberger et al.   EMBO JOURNAL

Cross talk between mitochondria and NADPH oxidases

(2011) Sergey Dikalov   FREE RADICAL BIOLOGY AND MEDICINE

Cellular prion protein is implicated in the regulation of local Ca2+ movements in cerebellar granule neurons

(2011) Cristian Lazzari et al.   JOURNAL OF NEUROCHEMISTRY

Calcium Signaling and Amyloid Toxicity in Alzheimer Disease

(2010) Angelo Demuro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tyrosine phosphorylation modulates store-operated calcium entry in cultured rat epididymal basal cells

(2010) Wu-Lin Zuo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

(2010) D. A. Gimbel et al.   JOURNAL OF NEUROSCIENCE

The prion protein as a receptor for amyloid-β

(2010) Helmut W. Kessels et al.   NATURE

Is indeed the prion protein a Harlequin servant of "many" masters?

(2010) M. Catia Sorgato et al.   Prion

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Reaction-Diffusion Model of ROS-Induced ROS Release in a Mitochondrial Network

(2010) Lufang Zhou et al.   PLoS Computational Biology

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

STIM2 Regulates Capacitive Ca2+ Entry in Neurons and Plays a Key Role in Hypoxic Neuronal Cell Death

(2009) A. Berna-Erro et al.   Science Signaling

From cell protection to death: May Ca2+ signals explain the chameleonic attributes of the mammalian prion protein?

(2008) M. Catia Sorgato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CREB-dependent gene regulation by prion protein: Impact on MMP-9 and β-dystroglycan

(2008) Elodie Pradines et al.   CELLULAR SIGNALLING

Prion protein attenuates excitotoxicity by inhibiting NMDA receptors

(2008) Houman Khosravani et al.   JOURNAL OF CELL BIOLOGY

Complex I specific increase in superoxide formation and respiration rate by PrP-null mouse brain mitochondria

(2008) Andrew W. J. Paterson et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Soluble Beta-Amyloid Leads to Mitochondrial Defects in Amyloid Precursor Protein and Tau Transgenic Mice

(2008) Anne Eckert et al.   Neurodegenerative Diseases

Linking Calcium to Aβ and Alzheimer's Disease

(2008) Kim N. Green et al.   NEURON

Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease

(2008) M. D. White et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES