A  neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

(2011) Ulrike K Resenberger et al.   EMBO JOURNAL

Unification of the Copper(I) Binding Affinities of the Metallo-chaperones Atx1, Atox1, and Related Proteins

(2011) Zhiguang Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's Disease Brain-Derived Amyloid- -Mediated Inhibition of LTP In Vivo Is Prevented by Immunotargeting Cellular Prion Protein

(2011) A. E. Barry et al.   JOURNAL OF NEUROSCIENCE

Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

(2011) Darragh B. Freir et al.   Nature Communications

Cellular copper distribution: a mechanistic systems biology approach

(2010) Lucia Banci et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Prion protein and Aβ-related synaptic toxicity impairment

(2010) Anna Maria Calella et al.   EMBO Molecular Medicine

Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin γ1 chain

(2010) Flavio H. Beraldo et al.   FASEB JOURNAL

Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

(2010) D. A. Gimbel et al.   JOURNAL OF NEUROSCIENCE

The prion protein as a receptor for amyloid-β

(2010) Helmut W. Kessels et al.   NATURE

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Protein aggregation diseases: pathogenicity and therapeutic perspectives

(2010) Adriano Aguzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copper(II) Binding to Amyloid-β Fibrils of Alzheimer’s Disease Reveals a Picomolar Affinity: Stoichiometry and Coordination Geometry Are Independent of Aβ Oligomeric Form

(2009) Claire J. Sarell et al.   BIOCHEMISTRY

β-Amyloid Impairs AMPA Receptor Trafficking and Function by Reducing Ca2+/Calmodulin-dependent Protein Kinase II Synaptic Distribution

(2009) Zhenglin Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper in the brain and Alzheimer’s disease

(2009) Ya Hui Hung et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

The interaction of biological and noxious transition metals with the zinc probes FluoZin-3 and Newport Green

(2008) Jinfu Zhao et al.   ANALYTICAL BIOCHEMISTRY

The Prion's Elusive Reason for Being

(2008) Adriano Aguzzi et al.   Annual Review of Neuroscience

Prion protein attenuates excitotoxicity by inhibiting NMDA receptors

(2008) Houman Khosravani et al.   JOURNAL OF CELL BIOLOGY

Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship

(2008) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

NMDA receptors in clinical neurology: excitatory times ahead

(2008) Lorraine V Kalia et al.   LANCET NEUROLOGY

Candidate anti-Aβ fluorene compounds selected from analogs of amyloid imaging agents

(2008) Hyun-Seok Hong et al.   NEUROBIOLOGY OF AGING

Allosteric modulation of NMDA receptor via elevation of brain glycine and d-serine: The therapeutic potentials for schizophrenia

(2008) Charles R. Yang et al.   PHARMACOLOGY & THERAPEUTICS

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

(2003) Craig S. Atwood et al.   JOURNAL OF NEUROCHEMISTRY