Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity

Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions

(2017) Amulya Nidhi Shrivastava et al.   NEURON

Regulation of Amyloid β Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex

(2016) Flavio H. Beraldo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Synaptopodin in Membrane Protein Diffusion in the Dendritic Spine Neck

(2016) Lili Wang et al.   PLoS One

Differential Toxicity of Antibodies to the Prion Protein

(2016) Regina R. Reimann et al.   PLoS Pathogens

Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer’s disease

(2015) Laura T. Haas et al.   BRAIN

Metabotropic glutamate receptor 5 as drug target for Fragile X syndrome

(2015) Sebastian H Scharf et al.   CURRENT OPINION IN PHARMACOLOGY

 -synuclein assemblies sequester neuronal  3-Na+/K+-ATPase and impair Na+ gradient

(2015) A. N. Shrivastava et al.   EMBO JOURNAL

Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models

(2015) Mikhail A. Kostylev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2

(2015) A. Aguilar-Valles et al.   JOURNAL OF NEUROSCIENCE

Prion Infections and Anti-PrP Antibodies Trigger Converging Neurotoxic Pathways

(2015) Uli S. Herrmann et al.   PLoS Pathogens

A Genome Wide Association Study Links Glutamate Receptor Pathway to Sporadic Creutzfeldt-Jakob Disease Risk

(2015) Pascual Sanchez-Juan et al.   PLoS One

Therapeutic Molecules and Endogenous Ligands Regulate the Interaction between Brain Cellular Prion Protein (PrPC) and Metabotropic Glutamate Receptor 5 (mGluR5)

(2014) Laura T. Haas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hijacking PrPc-dependent signal transduction: when prions impair Aβ clearance

(2014) Julia Hernandez-Rapp et al.   Frontiers in Aging Neuroscience

The Role of the NADPH Oxidase NOX2 in Prion Pathogenesis

(2014) Silvia Sorce et al.   PLoS Pathogens

Chronic Metabotropic Glutamate Receptor 5 Inhibition Corrects Local Alterations of Brain Activity and Improves Cognitive Performance in Fragile X Mice

(2013) Aubin Michalon et al.   BIOLOGICAL PSYCHIATRY

β-amyloid and ATP-induced diffusional trapping of astrocyte and neuronal metabotropic glutamate type-5 receptors

(2013) Amulya Nidhi Shrivastava et al.   GLIA

Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease

(2013) Valeriy G. Ostapchenko et al.   JOURNAL OF NEUROCHEMISTRY

The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein

(2013) Tiziana Sonati et al.   NATURE

Knocking down metabotropic glutamate receptor 1 improves survival and disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis

(2013) Marco Milanese et al.   NEUROBIOLOGY OF DISEASE

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

(2013) Ji Won Um et al.   NEURON

Fragile X syndrome: a preclinical review on metabotropic glutamate receptor 5 (mGluR5) antagonists and drug development

(2013) Andreea S. Pop et al.   PSYCHOPHARMACOLOGY

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

(2013) J. A. Moreno et al.   Science Translational Medicine

Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic?

(2012) Filippo Caraci et al.   NEUROCHEMISTRY INTERNATIONAL

Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC α2δ-1 Subunit

(2012) Assunta Senatore et al.   NEURON

Prion Pathogenesis Is Faithfully Reproduced in Cerebellar Organotypic Slice Cultures

(2012) Jeppe Falsig et al.   PLoS Pathogens

Postsynaptic Receptors for Amyloid-β Oligomers as Mediators of Neuronal Damage in Alzheimer’s Disease

(2012) Margarita C. Dinamarca et al.   Frontiers in Physiology

Possible role for Ca2+ in the pathophysiology of the prion protein?

(2011) Caterina Peggion et al.   BIOFACTORS

Differential Binding of Calmodulin to Group I Metabotropic Glutamate Receptors Regulates Receptor Trafficking and Signaling

(2011) K. Y. Choi et al.   JOURNAL OF NEUROSCIENCE

Ablation of Cellular Prion Protein Does Not Ameliorate Abnormal Neural Network Activity or Cognitive Dysfunction in the J20 Line of Human Amyloid Precursor Protein Transgenic Mice

(2011) M. Cisse et al.   JOURNAL OF NEUROSCIENCE

AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome

(2011) Josien Levenga et al.   NEUROBIOLOGY OF DISEASE

Differential distribution of group I metabotropic glutamate receptors in developing human cortex

(2010) Karin Boer et al.   BRAIN RESEARCH

Prion protein and Aβ-related synaptic toxicity impairment

(2010) Anna Maria Calella et al.   EMBO Molecular Medicine

Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin γ1 chain

(2010) Flavio H. Beraldo et al.   FASEB JOURNAL

Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain–dependent manner

(2010) Jan Kranich et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The prion protein as a receptor for amyloid-β

(2010) Helmut W. Kessels et al.   NATURE

Axonal prion protein is required for peripheral myelin maintenance

(2010) Juliane Bremer et al.   NATURE NEUROSCIENCE

Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5

(2010) Marianne Renner et al.   NEURON

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-β peptide

(2009) Christopher S. Casley et al.   BRAIN RESEARCH

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Tests to assess motor phenotype in mice: a user's guide

(2009) Simon P. Brooks et al.   NATURE REVIEWS NEUROSCIENCE

A role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome

(2009) Gul Dolen et al.   NEUROSCIENCE RESEARCH

Prion protein attenuates excitotoxicity by inhibiting NMDA receptors

(2008) Houman Khosravani et al.   JOURNAL OF CELL BIOLOGY

Metabotropic Glutamate Receptors in Glial Cells

(2008) Simona D’Antoni et al.   NEUROCHEMICAL RESEARCH

The POM Monoclonals: A Comprehensive Set of Antibodies to Non-Overlapping Prion Protein Epitopes

(2008) Magdalini Polymenidou et al.   PLoS One

Neuroprotective effects of the selective type 1 metabotropic glutamate receptor antagonist YM-202074 in rat stroke models

(2007) Atsuyuki Kohara et al.   BRAIN RESEARCH