Glioblastoma, a Brief Review of History, Molecular Genetics, Animal Models and Novel Therapeutic Strategies

Mouse Models to Interrogate the Implications of the Differentiation Status In the Ontogeny of Gliomas

(2015) Diana Marcela Muñoz et al.   Oncotarget

Glioblastoma Stem-like Cell Lines with Either Maintenance or Loss of High-Level EGFR Amplification, Generated via Modulation of Ligand Concentration

(2012) A. Schulte et al.   CLINICAL CANCER RESEARCH

High-Resolution In-Vivo Analysis of Normal Brain Response to Cranial Irradiation

(2012) Kelly Burrell et al.   PLoS One

Glioma cells showing IDH1 mutation cannot be propagated in standard cell culture conditions

(2011) S Piaskowski et al.   BRITISH JOURNAL OF CANCER

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

MMP-9 induces CD44 cleavage and CD44 mediated cell migration in glioblastoma xenograft cells

(2011) Chandramu Chetty et al.   CELLULAR SIGNALLING

Alkylpurine–DNA–N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients

(2011) Sameer Agnihotri et al.   JOURNAL OF CLINICAL INVESTIGATION

A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas

(2011) Sameer Agnihotri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

A new alternative mechanism in glioblastoma vascularization: tubular vasculogenic mimicry

(2010) S. El Hallani et al.   BRAIN

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

(2010) Houtan Noushmehr et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Suberoylanilide hydroxamic acid limits migration and invasion of glioma cells in two and three dimensional culture

(2010) Zhihua An et al.   CANCER LETTERS

RHAMM is differentially expressed in the cell cycle and downregulated by the tumor suppressor p53

(2010) Sindy Sohr et al.   CELL CYCLE

Glioma stem cell signaling: therapeutic opportunities and challenges

(2010) Jörg Dietrich et al.   Expert Review of Anticancer Therapy

Change in Pattern of Relapse After Antiangiogenic Therapy in High-Grade Glioma

(2010) Ashwatha Narayana et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice

(2010) Mitomu Kioi et al.   JOURNAL OF CLINICAL INVESTIGATION

Phase II Study of Cediranib, an Oral Pan–Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Recurrent Glioblastoma

(2010) Tracy T. Batchelor et al.   JOURNAL OF CLINICAL ONCOLOGY

Updated Response Assessment Criteria for High-Grade Gliomas: Response Assessment in Neuro-Oncology Working Group

(2010) Patrick Y. Wen et al.   JOURNAL OF CLINICAL ONCOLOGY

Erratum: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2010) Lenny Dang et al.   NATURE

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Glioblastoma stem-like cells give rise to tumour endothelium

(2010) Rong Wang et al.   NATURE

Metabolic Modulation of Glioblastoma with Dichloroacetate

(2010) E. D. Michelakis et al.   Science Translational Medicine

IDH1 Mutations Are Early Events in the Development of Astrocytomas and Oligodendrogliomas

(2009) Takuya Watanabe et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of endothelial progenitors and other bone marrow-derived cells in the development of the tumor vasculature

(2009) G-One Ahn et al.   ANGIOGENESIS

Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Model

(2009) Sheila Alcantara Llaguno et al.   CANCER CELL

Inducible site-specific recombination in neural stem/progenitor cells

(2009) Jian Chen et al.   GENESIS

Radiosensitizing Effects of Temozolomide Observed in vivo only in a Subset of O6-Methylguanine-DNA Methyltransferase Methylated Glioblastoma Multiforme Xenografts

(2009) Brett L. Carlson et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Time Trends in Brain Tumor Incidence Rates in Denmark, Finland, Norway, and Sweden, 1974-2003

(2009) I. Deltour et al.   JNCI-Journal of the National Cancer Institute

Biology of glioma cancer stem cells

(2009) Deric M. Park et al.   MOLECULES AND CELLS

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Development of a novel mouse glioma model using lentiviral vectors

(2009) Tomotoshi Marumoto et al.   NATURE MEDICINE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1 

(2009) S. Zhao et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Brain cancer propagating cells: biology, genetics and targeted therapies

(2009) Costas G. Hadjipanayis et al.   TRENDS IN MOLECULAR MEDICINE

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

(2008) Rose Du et al.   CANCER CELL

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Yes and PI3K Bind CD95 to Signal Invasion of Glioblastoma

(2008) Susanne Kleber et al.   CANCER CELL

Growth-Inhibitory and Tumor- Suppressive Functions of p53 Depend on Its Repression of CD44 Expression

(2008) Samuel Godar et al.   CELL

Brain Tumor Stem Cells: Bringing Order to the Chaos of Brain Cancer

(2008) Peter B. Dirks   JOURNAL OF CLINICAL ONCOLOGY

Phase II Trial of Single-Agent Bevacizumab Followed by Bevacizumab Plus Irinotecan at Tumor Progression in Recurrent Glioblastoma

(2008) Teri N. Kreisl et al.   JOURNAL OF CLINICAL ONCOLOGY

Incorporation of endothelial progenitor cells into the neovasculature of malignant glioma xenograft

(2008) Hua-rong Zhang et al.   JOURNAL OF NEURO-ONCOLOGY

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Glioma Stem Cells: A Midterm Exam

(2008) Charles D. Stiles et al.   NEURON

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Methyl jasmonate binds to and detaches mitochondria-bound hexokinase

(2008) N Goldin et al.   ONCOGENE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells

(2008) Lionel M. L. Chow et al.   TRANSGENIC RESEARCH

Brain Tumour Stem Cells: Implications for Cancer Therapy and Regenerative Medicine

(2008) Manuel Sanchez-Martin   Current Stem Cell Research & Therapy