MEIS transcription factors in development and disease

Exploring targets of TET2-mediated methylation reprogramming as potential discriminators of prostate cancer progression

(2019) Shivani Kamdar et al.   Clinical Epigenetics

Hypermethylated and downregulated MEIS2 are involved in stemness properties and oxaliplatin-based chemotherapy resistance of colorectal cancer

(2019) Xiaojie Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

‘Building a perfect body’: control of vertebrate organogenesis by PBX-dependent regulatory networks

(2019) Licia Selleri et al.   GENES & DEVELOPMENT

MEIS2 gene is responsible for intellectual disability, cardiac defects and a distinct facial phenotype

(2019) Annarita Giliberti et al.   European Journal of Medical Genetics

Polypyrimidine tract binding protein 1 promotes lymphatic metastasis and proliferation of bladder cancer via alternative splicing of MEIS2 and PKM

(2019) Ruihui Xie et al.   CANCER LETTERS

The human HOXA9 protein uses paralog-specific residues of the homeodomain to interact with TALE-class cofactors

(2019) Amélie Dard et al.   Scientific Reports

Tumorigenic and Antiproliferative Properties of the TALE-Transcription Factors MEIS2D and MEIS2A in Neuroblastoma

(2018) Anja Groß et al.   CANCER RESEARCH

MEIS1 and MEIS2 Expression and Prostate Cancer Progression: A Role For HOXB13 Binding Partners in Metastatic Disease

(2018) Raj R. Bhanvadia et al.   CLINICAL CANCER RESEARCH

Meis1 Coordinates Cerebellar Granule Cell Development by Regulating Pax6 Transcription, BMP Signaling and Atoh1 Degradation

(2018) Tomoo Owa et al.   JOURNAL OF NEUROSCIENCE

The homeodomain transcription factor MEIS1 triggers chemokine expression and is involved in CD8+ T-lymphocyte infiltration in early stage ovarian cancer

(2018) Athanasios Karapetsas et al.   MOLECULAR CARCINOGENESIS

MEIS-1 level in unresectable hepatocellular carcinoma can predict the post-treatment outcomes of radiofrequency ablation

(2018) Hui Xie et al.   Oncotarget

Human HOX Proteins Use Diverse and Context-Dependent Motifs to Interact with TALE Class Cofactors

(2018) Amélie Dard et al.   Cell Reports

TALE factors use two distinct functional modes to control an essential zebrafish gene expression program

(2018) Franck Ladam et al.   eLife

Arginine Methylation Regulates MEIS2 Nuclear Localization to Promote Neuronal Differentiation of Adult SVZ Progenitors

(2018) Jasmine Kolb et al.   Stem Cell Reports

De novo missense variants in MEIS2 recapitulate the microdeletion phenotype of cardiac and palate abnormalities, developmental delay, intellectual disability and dysmorphic features

(2018) Ganka Douglas et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Variant PRC1 competes with retinoic acid-related signals to repress Meis2 in distal forelimb bud

(2018) Nayuta Yakushiji-Kaminatsui et al.   DEVELOPMENT

Common ancestry of heterodimerizing TALE homeobox transcription factors across Metazoa and Archaeplastida

(2018) Sunjoo Joo et al.   BMC BIOLOGY

Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1

(2018) Lehang Lin et al.   NUCLEIC ACIDS RESEARCH

HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer

(2018) Dorhyun Johng et al.   PROSTATE

MEIS homeodomain proteins facilitate PARP1/ARTD1-mediated eviction of histone H1

(2017) Ann-Christin Hau et al.   JOURNAL OF CELL BIOLOGY

Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis

(2017) Barbara Schormair et al.   LANCET NEUROLOGY

A Constitutive Intrinsic Inflammatory Signaling Circuit Composed of miR-196b, Meis2, PPP3CC, and p65 Drives Prostate Cancer Castration Resistance

(2017) Ji-Hak Jeong et al.   MOLECULAR CELL

Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits

(2017) Anke R Hammerschlag et al.   NATURE GENETICS

Myeloid ecotropic viral integration site 1 inhibits cell proliferation, invasion or migration in human gastric cancer

(2017) Fei Song et al.   Oncotarget

Nuclear receptors connect progenitor transcription factors to cell cycle control

(2017) Marta Neto et al.   Scientific Reports

Deregulation of the HOXA9/MEIS1 axis in acute leukemia

(2016) Cailin T. Collins et al.   CURRENT OPINION IN HEMATOLOGY

Pbx1 is required for adult subventricular zone neurogenesis

(2016) Britta Moyo Grebbin et al.   DEVELOPMENT

De novo MEIS2 mutation causes syndromic developmental delay with persistent gastro-esophageal reflux

(2016) Atsushi Fujita et al.   JOURNAL OF HUMAN GENETICS

The TALE homeodomain transcription factor MEIS1 activates the pro-metastatic melanoma cell adhesion moleculeMcamto promote migration of pancreatic cancer cells

(2016) Johannes von Burstin et al.   MOLECULAR CARCINOGENESIS

Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits

(2016) Jacqueline M Lane et al.   NATURE GENETICS

Special AT-rich sequence-binding protein 2 acts as a negative regulator of stemness in colorectal cancer cells

(2016) Ying Li et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The Gene Regulatory Network of Lens Induction Is Wired through Meis-Dependent Shadow Enhancers of Pax6

(2016) Barbora Antosova et al.   PLoS Genetics

Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death

(2016) Fabrice Bouilloux et al.   eLife

An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors

(2016) Ami V. Patel et al.   EBioMedicine

MEIS2involvement in cardiac development, cleft palate, and intellectual disability

(2015) Jacoba J. Louw et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Meis2 is essential for cranial and cardiac neural crest development

(2015) Ondrej Machon et al.   BMC DEVELOPMENTAL BIOLOGY

Retinoic acid signaling and neuronal differentiation

(2015) Amanda Janesick et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restrictingMeis2expression

(2015) Nayuta Yakushiji-Kaminatsui et al.   DEVELOPMENT

Meis1 coordinates a network of genes implicated in eye development and microphthalmia

(2015) S. Marcos et al.   DEVELOPMENT

Hoxa2 Selectively Enhances Meis Binding to Change a Branchial Arch Ground State

(2015) Shilu Amin et al.   DEVELOPMENTAL CELL

miR-134 Modulates the Proliferation of Human Cardiomyocyte Progenitor Cells by Targeting Meis2

(2015) Ya-Han Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigenetic therapy restores normal hematopoiesis in a zebrafish model of NUP98–HOXA9-induced myeloid disease

(2015) A P Deveau et al.   LEUKEMIA

Meis3 is required for neural crest invasion of the gut during zebrafish enteric nervous system development

(2015) Rosa A. Uribe et al.   MOLECULAR BIOLOGY OF THE CELL

DNA-dependent formation of transcription factor pairs alters their binding specificity

(2015) Arttu Jolma et al.   NATURE

Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets

(2015) C T Collins et al.   ONCOGENE

DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia

(2015) H J Ferreira et al.   ONCOGENE

Eye Selector Logic for a Coordinated Cell Cycle Exit

(2015) Carla S. Lopes et al.   PLoS Genetics

Genome-wide methylation and transcriptome analysis in penile carcinoma: uncovering new molecular markers

(2015) Hellen Kuasne et al.   Clinical Epigenetics

Elucidating the Mechanism of Regulation of Transforming Growth Factor β Type II Receptor Expression in Human Lung Cancer Cell Lines

(2015) Sunil K. Halder et al.   NEOPLASIA

Haploinsufficiency ofMEIS2is associated with orofacial clefting and learning disability

(2014) Stefan Johansson et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Diffusible signals and epigenetic timing cooperate in late proximo-distal limb patterning

(2014) A. Rosello-Diez et al.   DEVELOPMENT

TALE Factors Poise Promoters for Activation by Hox Proteins

(2014) Seong-Kyu Choe et al.   DEVELOPMENTAL CELL

Polycomb Potentiates Meis2 Activation in Midbrain by Mediating Interaction of the Promoter with a Tissue-Specific Enhancer

(2014) Takashi Kondo et al.   DEVELOPMENTAL CELL

MEIS1 functions as a potential AR negative regulator

(2014) Liang Cui et al.   EXPERIMENTAL CELL RESEARCH

Restless Legs Syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon

(2014) D. Spieler et al.   GENOME RESEARCH

MiR-144 regulates hematopoiesis and vascular development by targeting meis1 during zebrafish development

(2014) Zhenhong Su et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

(2014) Eric S. Fischer et al.   NATURE

Homeodomain Transcription Factor Meis1 Is a Critical Regulator of Adult Bone Marrow Hematopoiesis

(2014) Reina Ariki et al.   PLoS One

Meis1 Regulates Epidermal Stem Cells and Is Required for Skin Tumorigenesis

(2014) Kazuhiro Okumura et al.   PLoS One

Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis

(2014) L. Dardaei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MEIS2 is essential for neuroblastoma cell survival and proliferation by transcriptional control of M-phase progression

(2014) Y Zha et al.   Cell Death & Disease

Meis2 is a Pax6 co-factor in neurogenesis and dopaminergic periglomerular fate specification in the adult olfactory bulb

(2013) Z. Agoston et al.   DEVELOPMENT

Hox regulation of transcription: More complex(es)

(2013) Franck Ladam et al.   DEVELOPMENTAL DYNAMICS

TALE transcription factors during early development of the vertebrate brain and eye

(2013) Dorothea Schulte et al.   DEVELOPMENTAL DYNAMICS

A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis

(2013) Vida Senkus Melvin et al.   DEVELOPMENTAL DYNAMICS

Meis1 regulates postnatal cardiomyocyte cell cycle arrest

(2013) Ahmed I. Mahmoud et al.   NATURE

Analysis of the DNA-Binding Profile and Function of TALE Homeoproteins Reveals Their Specialization and Specific Interactions with Hox Genes/Proteins

(2013) Dmitry Penkov et al.   Cell Reports

Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells

(2012) F. Kocabas et al.   BLOOD

Genetic and physical interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development

(2012) Zsuzsa Agoston et al.   BMC DEVELOPMENTAL BIOLOGY

Deregulation of a Hox Protein Regulatory Network Spanning Prostate Cancer Initiation and Progression

(2012) J. L. Chen et al.   CLINICAL CANCER RESEARCH

A hindbrain-repressive Wnt3a/Meis3/Tsh1 circuit promotes neuronal differentiation and coordinates tissue maturation

(2012) Y. M. Elkouby et al.   DEVELOPMENT

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(2012) Andrea Hoffmann et al.   MOLECULAR MEDICINE

Germline Mutations inHOXB13and Prostate-Cancer Risk

(2012) Charles M. Ewing et al.   NEW ENGLAND JOURNAL OF MEDICINE

The application and biology of immunomodulatory drugs (IMiDs) in cancer

(2012) Beiqing Pan et al.   PHARMACOLOGY & THERAPEUTICS

Hox and Pbx Factors Control Retinoic Acid Synthesis during Hindbrain Segmentation

(2011) Antonio Vitobello et al.   DEVELOPMENTAL CELL

Distinct and redundant expression and transcriptional diversity of MEIS gene paralogs during chicken development

(2011) Luis Óscar Sánchez-Guardado et al.   DEVELOPMENTAL DYNAMICS

MicroRNA-9 Regulates Neurogenesis in Mouse Telencephalon by Targeting Multiple Transcription Factors

(2011) M. Shibata et al.   JOURNAL OF NEUROSCIENCE

Cooperative Transcriptional Activation by Klf4, Meis2, and Pbx1

(2011) G. A. Bjerke et al.   MOLECULAR AND CELLULAR BIOLOGY

A Conserved Tissue-Specific Homeodomain-Less Isoform of MEIS1 Is Downregulated in Colorectal Cancer

(2011) Richard C. Crist et al.   PLoS One

Selection of distinct Hox-Extradenticle interaction modes fine-tunes Hox protein activity

(2011) M. Saadaoui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA methylation biomarkers for lung cancer

(2011) Tibor A. Rauch et al.   TUMOR BIOLOGY

Further evidence for the possible role ofMEIS2in the development of cleft palate and cardiac septum

(2010) Moira A. Crowley et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The Hox cofactors Meis1 and Pbx act upstream of gata1 to regulate primitive hematopoiesis

(2010) Laura M. Pillay et al.   DEVELOPMENTAL BIOLOGY

Expression analysis of TALE family transcription factors during avian development

(2010) Sarah E. Coy et al.   DEVELOPMENTAL DYNAMICS

Loss of adenomatous polyposis coli (apc) results in an expanded ciliary marginal zone in the zebrafish eye

(2010) W. Zac Stephens et al.   DEVELOPMENTAL DYNAMICS

An autoinhibitory effect of the homothorax domain of Meis2

(2010) Cathy Hyman-Walsh et al.   FEBS Journal

The role of meis1 in primitive and definitive hematopoiesis during zebrafish development

(2010) A. Cvejic et al.   HAEMATOLOGICA

Prep1 (pKnox1)-deficiency leads to spontaneous tumor development in mice and accelerates EμMyc lymphomagenesis: A tumor suppressor role for Prep1

(2010) E. Longobardi et al.   Molecular Oncology

Transcriptional role of cyclin D1 in development revealed by a genetic–proteomic screen

(2010) Frédéric Bienvenu et al.   NATURE

Genome-wide association study of PR interval

(2010) Arne Pfeufer et al.   NATURE GENETICS

Meis1 specifies positional information in the retina and tectum to organize the zebrafish visual system

(2010) Timothy Erickson et al.   Neural Development

Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1

(2010) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-204 is required for lens and retinal development via Meis2 targeting

(2010) I. Conte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a Primary Target of Thalidomide Teratogenicity

(2010) T. Ito et al.   SCIENCE

Meis2 competes with the Groucho co-repressor Tle4 for binding to Otx2 and specifies tectal fate without induction of a secondary midbrain-hindbrain boundary organizer

(2009) Z. Agoston et al.   DEVELOPMENT

hth maintains the pool of eye progenitors and its downregulation by Dpp and Hh couples retinal fate acquisition with cell cycle exit

(2009) Carla S. Lopes et al.   DEVELOPMENTAL BIOLOGY

Meis Cofactors Control HDAC and CBP Accessibility at Hox-Regulated Promoters during Zebrafish Embryogenesis

(2009) Seong-Kyu Choe et al.   DEVELOPMENTAL CELL

Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma

(2009) M. Berdasco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TMEM25, REPS2 and Meis 1: Favourable Prognostic and Predictive Biomarkers for Breast Cancer

(2009) P. Doolan et al.   TUMOR BIOLOGY

MicroRNA 155 modulates megakaryopoiesis at progenitor and precursor level by targeting Ets-1 and Meis1 transcription factors

(2008) Paolo Romania et al.   BRITISH JOURNAL OF HAEMATOLOGY

Pbx/Meis Deficiencies Demonstrate Multigenetic Origins of Congenital Heart Disease

(2008) Kryn Stankunas et al.   CIRCULATION RESEARCH

meis1 regulates cyclin D1 and c-myc expression, and controls the proliferation of the multipotent cells in the early developing zebrafish eye

(2008) J. Bessa et al.   DEVELOPMENT

Evidence for an evolutionary conserved role of homothorax/Meis1/2 during vertebrate retina development

(2008) P. Heine et al.   DEVELOPMENT