The Gene Regulatory Network of Lens Induction Is Wired through Meis-Dependent Shadow Enhancers of Pax6

Shadow Enhancers Are Pervasive Features of Developmental Regulatory Networks

(2016) Enrico Cannavò et al.   CURRENT BIOLOGY

Meis2 is essential for cranial and cardiac neural crest development

(2015) Ondrej Machon et al.   BMC DEVELOPMENTAL BIOLOGY

Meis1 coordinates a network of genes implicated in eye development and microphthalmia

(2015) S. Marcos et al.   DEVELOPMENT

Suboptimization of developmental enhancers

(2015) E. K. Farley et al.   SCIENCE

The cellular and molecular mechanisms of vertebrate lens development

(2014) A. Cvekl et al.   DEVELOPMENT

A survey of ancient conserved non-coding elements in the PAX6 locus reveals a landscape of interdigitated cis-regulatory archipelagos

(2014) Shipra Bhatia et al.   DEVELOPMENTAL BIOLOGY

Efficient gene targeting of theRosa26locus in mouse zygotes using TALE nucleases

(2014) Petr Kasparek et al.   FEBS LETTERS

The oncoprotein v-Myb activates transcription of Gremlin 2 during in vitro differentiation of the chicken neural crest to melanoblasts

(2014) Michaela Starostová et al.   GENE

Disruption of Autoregulatory Feedback by a Mutation in a Remote, Ultraconserved PAX6 Enhancer Causes Aniridia

(2013) Shipra Bhatia et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates

(2013) E. Longobardi et al.   DEVELOPMENTAL DYNAMICS

Analysis of the DNA-Binding Profile and Function of TALE Homeoproteins Reveals Their Specialization and Specific Interactions with Hox Genes/Proteins

(2013) Dmitry Penkov et al.   Cell Reports

Sequencing of Pax6 Loci from the Elephant Shark Reveals a Family of Pax6 Genes in Vertebrate Genomes, Forged by Ancient Duplications and Divergences

(2013) Vydianathan Ravi et al.   PLoS Genetics

Precision of Hunchback Expression in the Drosophila Embryo

(2012) Michael W. Perry et al.   CURRENT BIOLOGY

Segregation of eye and antenna fates maintained by mutual antagonism in Drosophila

(2012) C.-W. Wang et al.   DEVELOPMENT

The functional role of the Meis/Prep-binding elements in Pax6 locus during pancreas and eye development

(2012) Christian Carbe et al.   DEVELOPMENTAL BIOLOGY

SOX2 hypomorphism disrupts development of the prechordal floor and optic cup

(2012) Lee Langer et al.   MECHANISMS OF DEVELOPMENT

Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6

(2011) D. Matsushima et al.   DEVELOPMENT

Deletion of a remote enhancer near ATOH7 disrupts retinal neurogenesis, causing NCRNA disease

(2011) Noor M Ghiasvand et al.   NATURE NEUROSCIENCE

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

(2011) Tomas Cermak et al.   NUCLEIC ACIDS RESEARCH

The lens: a classical model of embryonic induction providing new insights into cell determination in early development

(2011) L. Gunhaga   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Shadow Enhancers Foster Robustness of Drosophila Gastrulation

(2010) Michael W. Perry et al.   CURRENT BIOLOGY

Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity

(2010) S. Rowan et al.   GENES & DEVELOPMENT

Reduced expression of Pax6 in lens and cornea of mutant mice leads to failure of chamber angle development and juvenile glaucoma

(2010) M. Kroeber et al.   HUMAN MOLECULAR GENETICS

Phenotypic robustness conferred by apparently redundant transcriptional enhancers

(2010) Nicolás Frankel et al.   NATURE

Emerging properties of animal gene regulatory networks

(2010) Eric H. Davidson   NATURE

Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis

(2009) A. N. Smith et al.   DEVELOPMENT

Pax6 is essential for lens fiber cell differentiation

(2009) O. Shaham et al.   DEVELOPMENT

Zebrafish enhancer detection (ZED) vector: A new tool to facilitate transgenesis and the functional analysis ofcis-regulatory regions in zebrafish

(2009) José Bessa et al.   DEVELOPMENTAL DYNAMICS

Evo-Devo and an Expanding Evolutionary Synthesis: A Genetic Theory of Morphological Evolution

(2008) Sean B. Carroll   CELL

Properties of developmental gene regulatory networks

(2008) E. H. Davidson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shadow Enhancers as a Source of Evolutionary Novelty

(2008) J.-W. Hong et al.   SCIENCE