Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets

Three-dimensional genome architecture: players and mechanisms

(2015) Ana Pombo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia

(2015) Gabriela Brumatti et al.   Oncotarget

TALE Factors Poise Promoters for Activation by Hox Proteins

(2014) Seong-Kyu Choe et al.   DEVELOPMENTAL CELL

The methyltransferase G9a regulates HoxA9-dependent transcription in AML

(2014) B. Lehnertz et al.   GENES & DEVELOPMENT

Insulin-like growth factor 1 is a direct HOXA9 target important for hematopoietic transformation

(2014) J Steger et al.   LEUKEMIA

C/EBPα is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis

(2014) Cailin Collins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p15Ink4b Functions in determining hematopoietic cell fates: Implications for its role as a tumor suppressor

(2013) Linda Wolff et al.   BLOOD CELLS MOLECULES AND DISEASES

The long non-coding RNA HOTAIR indicates a poor prognosis and promotes metastasis in non-small cell lung cancer

(2013) Xiang-hua Liu et al.   BMC CANCER

Long non-coding RNA HOTAIR is an independent prognostic marker of metastasis in estrogen receptor-positive primary breast cancer

(2013) Kristina P. Sørensen et al.   BREAST CANCER RESEARCH AND TREATMENT

Long non-coding RNAs: A new frontier in the study of human diseases

(2013) Xuefei Shi et al.   CANCER LETTERS

HOTAIR, a prognostic factor in esophageal squamous cell carcinoma, inhibits WIF-1 expression and activates Wnt pathway

(2013) Xiao-Song Ge et al.   CANCER SCIENCE

Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates

(2013) E. Longobardi et al.   DEVELOPMENTAL DYNAMICS

Tracking context-specific transcription factors regulating hox activity

(2013) Samir Merabet et al.   DEVELOPMENTAL DYNAMICS

Hox regulation of transcription: More complex(es)

(2013) Franck Ladam et al.   DEVELOPMENTAL DYNAMICS

Non-transcriptional interactions of Hox proteins: Inventory, facts, and future directions

(2013) René Rezsohazy   DEVELOPMENTAL DYNAMICS

Hoxa9 collaborates with E2A-PBX1 in mouse B cell leukemia in association with Flt3 activation and decrease of B cell gene expression

(2013) Mona Hassawi et al.   DEVELOPMENTAL DYNAMICS

“Self-regulation,” a new facet ofHoxgenes' function

(2013) Rushikesh Sheth et al.   DEVELOPMENTAL DYNAMICS

Cell-type specificcis-regulatory networks

(2013) Maria Polychronidou et al.   FLY

Hoxc Gene Collinear Expression and Epigenetic Modifications Established during Embryogenesis Are Maintained until after Birth

(2013) Hyehyun Min et al.   International Journal of Biological Sciences

Bromodomain-PHD finger protein 1 is critical for leukemogenesis associated with MOZ–TIF2 fusion

(2013) Haruko Shima et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations

(2013) Daichi Inoue et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction of long intergenic non-coding RNA HOTAIR in lung cancer cells by type I collagen

(2013) Yan Zhuang et al.   Journal of Hematology & Oncology

Epigenetic dysregulation of leukaemic HOX code inMLL-rearranged leukaemia mouse model

(2013) Ray Kit Ng et al.   JOURNAL OF PATHOLOGY

NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern

(2013) J D E de Rooij et al.   LEUKEMIA

Multiple mechanisms deregulate EZH2 and histone H3 lysine 27 epigenetic changes in myeloid malignancies

(2013) S N Khan et al.   LEUKEMIA

The fusion partner specifies the oncogenic potential of NUP98 fusion proteins

(2013) Jesslyn Saw et al.   LEUKEMIA RESEARCH

HOTAIR, a cell cycle–associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma

(2013) Jun-Xia Zhang et al.   NEURO-ONCOLOGY

HOX-mediated LMO2 expression in embryonic mesoderm is recapitulated in acute leukaemias

(2013) F J Calero-Nieto et al.   ONCOGENE

Hoxa9 Transduction Induces Hematopoietic Stem and Progenitor Cell Activity through Direct Down-Regulation of Geminin Protein

(2013) Yoshinori Ohno et al.   PLoS One

Contribution of Distinct Homeodomain DNA Binding Specificities to Drosophila Embryonic Mesodermal Cell-Specific Gene Expression Programs

(2013) Brian W. Busser et al.   PLoS One

The Homeodomain Transcription Factor Hoxa2 Interacts with and Promotes the Proteasomal Degradation of the E3 Ubiquitin Protein Ligase RCHY1

(2013) Isabelle Bergiers et al.   PLoS One

Analysis of the DNA-Binding Profile and Function of TALE Homeoproteins Reveals Their Specialization and Specific Interactions with Hox Genes/Proteins

(2013) Dmitry Penkov et al.   Cell Reports

Antagonism Versus Cooperativity with TALE Cofactors at the Base of the Functional Diversification of Hox Protein Function

(2013) María Luisa Rivas et al.   PLoS Genetics

Distinct Molecular Strategies for Hox-Mediated Limb Suppression in Drosophila: From Cooperativity to Dispensability/Antagonism in TALE Partnership

(2013) Nagraj Sambrani et al.   PLoS Genetics

Quantitative multiplex quantum dot in-situ hybridisation based gene expression profiling in tissue microarrays identifies prognostic genes in acute myeloid leukaemia

(2012) Eleni Tholouli et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML

(2012) Z. Li et al.   BLOOD

Beyond Hox: the role of ParaHox genes in normal and malignant hematopoiesis

(2012) V. P. S. Rawat et al.   BLOOD

PBX3 is an important cofactor of HOXA9 in leukemogenesis

(2012) Z. Li et al.   BLOOD

The homeodomain region controls the phenotype of HOX-induced murine leukemia

(2012) C. Breitinger et al.   BLOOD

Protein interactions of the transcription factor Hoxa1

(2012) Barbara Lambert et al.   BMC DEVELOPMENTAL BIOLOGY

Selective treatment of mixed-lineage leukemia leukemic stem cells through targeting glycogen synthase kinase 3 and the canonical Wnt/β-catenin pathway

(2012) Tsz K. Fung et al.   CURRENT OPINION IN HEMATOLOGY

Regulatory role for a conserved motif adjacent to the homeodomain of Hox10 proteins

(2012) I. Guerreiro et al.   DEVELOPMENT

Dimer formation via the homeodomain is required for function and specificity of Sex combs reduced in Drosophila

(2012) Dimitrios K. Papadopoulos et al.   DEVELOPMENTAL BIOLOGY

Hox transcription factors influence motoneuron identity through the integrated actions of both homeodomain and non-homeodomain regions

(2012) Mala Misra et al.   DEVELOPMENTAL DYNAMICS

Thecis-regulatory code of Hox function inDrosophila

(2012) Sebastian Sorge et al.   EMBO JOURNAL

Gene expression profiling and candidate gene resequencing identifies pathways and mutations important for malignant transformation caused by leukemogenic fusion genes

(2012) Rachel L. Novak et al.   EXPERIMENTAL HEMATOLOGY

HOX genes regulate Rac1 activity in hematopoietic cells through control of Vav2 expression

(2012) C Breitinger et al.   LEUKEMIA

Polycomb-group proteins in hematopoietic stem cell regulation and hematopoietic neoplasms

(2012) V Radulović et al.   LEUKEMIA

The role of HOX genes in normal hematopoiesis and acute leukemia

(2012) R A Alharbi et al.   LEUKEMIA

HOXA9 Methylation by PRMT5 Is Essential for Endothelial Cell Expression of Leukocyte Adhesion Molecules

(2012) S. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Scmh1 Has E3 Ubiquitin Ligase Activity for Geminin and Histone H2A and Regulates Geminin Stability Directly or Indirectly via Transcriptional Repression of Hoxa9 and Hoxb4

(2012) S. Yasunaga et al.   MOLECULAR AND CELLULAR BIOLOGY

Upregulation of the long non-coding rna hotair promotes esophageal squamous cell carcinoma metastasis and poor prognosis

(2012) Fang-Jun Chen et al.   MOLECULAR CARCINOGENESIS

ADP Ribosylation by PARP-1 Suppresses HOXB7 Transcriptional Activity

(2012) Xinyan Wu et al.   PLoS One

Structural basis for homeodomain recognition by the cell-cycle regulator Geminin

(2012) B. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct regulation of c-myb gene expression by HoxA9, Meis1 and Pbx proteins in normal hematopoietic progenitors and transformed myeloid cells

(2012) E Dassé et al.   Blood Cancer Journal

The Structure of the Nuclear Pore Complex

(2011) André Hoelz et al.   Annual Review of Biochemistry

The Pathogenesis of Mixed-Lineage Leukemia

(2011) Andrew G. Muntean et al.   Annual Review of Pathology-Mechanisms of Disease

Identification and characterization of Hoxa9 binding sites in hematopoietic cells

(2011) Y. Huang et al.   BLOOD

NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights

(2011) S. M. Gough et al.   BLOOD

NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern

(2011) I. H. I. M. Hollink et al.   BLOOD

Long Noncoding RNA HOTAIR Regulates Polycomb-Dependent Chromatin Modification and Is Associated with Poor Prognosis in Colorectal Cancers

(2011) R. Kogo et al.   CANCER RESEARCH

Cofactor Binding Evokes Latent Differences in DNA Binding Specificity between Hox Proteins

(2011) Matthew Slattery et al.   CELL

Polycomb-Dependent Regulatory Contacts between Distant Hox Loci in Drosophila

(2011) Frédéric Bantignies et al.   CELL

Functional Crosstalk between Bmi1 and MLL/Hoxa9 Axis in Establishment of Normal Hematopoietic and Leukemic Stem Cells

(2011) Lan-Lan Smith et al.   Cell Stem Cell

The histone deacetylase inhibitor entinostat (SNDX-275) induces apoptosis in Hodgkin lymphoma cells and synergizes with Bcl-2 family inhibitors

(2011) Ádám Jóna et al.   EXPERIMENTAL HEMATOLOGY

A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

(2011) Kevin C. Wang et al.   NATURE

Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice

(2011) George S Vassiliou et al.   NATURE GENETICS

Genome-Wide Analysis of the Binding of the Hox Protein Ultrabithorax and the Hox Cofactor Homothorax in Drosophila

(2011) Siew Woh Choo et al.   PLoS One

Genome-Wide Tissue-Specific Occupancy of the Hox Protein Ultrabithorax and Hox Cofactor Homothorax in Drosophila

(2011) Matthew Slattery et al.   PLoS One

Evolution of a derived protein–protein interaction between HoxA11 and Foxo1a in mammals caused by changes in intramolecular regulation

(2011) Kathryn J. Brayer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variable motif utilization in homeotic selector (Hox)-cofactor complex formation controls specificity

(2011) K. M. Lelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions among Polycomb Domains Are Guided by Chromosome Architecture

(2011) Bas Tolhuis et al.   PLoS Genetics

DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia

(2010) Maria E. Figueroa et al.   CANCER CELL

GSK-3 Promotes Conditional Association of CREB and Its Coactivators with MEIS1 to Facilitate HOX-Mediated Transcription and Oncogenesis

(2010) Zhong Wang et al.   CANCER CELL

Acute myeloid leukemia with mutated NPM1: diagnosis, prognosis and therapeutic perspectives

(2010) Brunangelo Falini et al.   CURRENT OPINION IN ONCOLOGY

Connecting the transcription site to the nuclear pore: a multi-tether process that regulates gene expression

(2010) G. Dieppois et al.   JOURNAL OF CELL SCIENCE

Hoxa9 Regulates Flt3 in Lymphohematopoietic Progenitors

(2010) K. Gwin et al.   JOURNAL OF IMMUNOLOGY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

New insights to the MLL recombinome of acute leukemias

(2009) C Meyer et al.   LEUKEMIA

Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications

(2009) B Falini et al.   LEUKEMIA

The SWI/SNF complex and cancer

(2009) D Reisman et al.   ONCOGENE

HOXA9 is required for survival in human MLL-rearranged acute leukemias

(2008) J. Faber et al.   BLOOD

Modulation of murine embryonic stem cell-derived CD41+c-kit+ hematopoietic progenitors by ectopic expression of Cdx genes

(2008) S. L. McKinney-Freeman et al.   BLOOD

Variation in Homeodomain DNA Binding Revealed by High-Resolution Analysis of Sequence Preferences

(2008) Michael F. Berger et al.   CELL

Analysis of Homeodomain Specificities Allows the Family-wide Prediction of Preferred Recognition Sites

(2008) Marcus B. Noyes et al.   CELL

Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation

(2008) M. E. Dinger et al.   GENOME RESEARCH

Nucleophosmin Interacts with HEXIM1 and Regulates RNA Polymerase II Transcription

(2008) Meera Gurumurthy et al.   JOURNAL OF MOLECULAR BIOLOGY

HOX expression patterns identify a common signature for favorable AML

(2008) M Andreeff et al.   LEUKEMIA

HoxA9 induces insulin-like growth factor-1 receptor expression in B-lineage acute lymphoblastic leukemia

(2008) J T Whelan et al.   LEUKEMIA

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy

(2008) Zhong Wang et al.   NATURE

Cdx gene deficiency compromises embryonic hematopoiesis in the mouse

(2008) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA