Article
Oncology
Adam B. Weiner, Farzana A. Faisal, Elai Davicioni, R. Jeffrey Karnes, Donald J. Vander Griend, Tamara L. Lotan, Edward M. Schaeffer
Summary: Prostate cancer tumors with increased expression of HOXB13 and low expression of its binding partner MEIS1/2 show a higher propensity for metastasis following radical prostatectomy. The tumors with this expression pattern also exhibit heightened sensitivity to androgen suppression, which may contribute to worse outcomes.
EUROPEAN UROLOGY ONCOLOGY
(2021)
Article
Oncology
Radhika A. Patel, Erolcan Sayar, Ilsa Coleman, Martine P. Roudier, Brian Hanratty, Jin-Yih Low, Neha Jaiswal, Azra Ajkunic, Ruth Dumpit, Caner Ercan, Nina Salama, Valerie P. O'Brien, William B. Isaacs, Jonathan Epstein, Angelo M. De Marzo, Bruce J. Trock, Jun Luo, W. Nathaniel Brennen, Maria Tretiakova, Funda Vakar-Lopez, Lawrence D. True, David W. Goodrich, Eva Corey, Colm Morrissey, Peter S. Nelson, Paula J. Hurley, Roman Gulati, Michael C. Haffner
Summary: This study investigated the expression pattern of HOXB13 in prostate development and cancer progression. HOXB13 was found to be more highly expressed in localized prostate cancers and retained in advanced metastatic prostate cancers. The expression of HOXB13 was reduced in tumors with evidence of lineage plasticity, but most androgen receptor-negative castration-resistant prostate cancers and neuroendocrine prostate cancers still had detectable levels of HOXB13. HOXB13 showed greater sensitivity in detecting advanced metastatic prostate cancers compared to the commonly used marker NKX3.1. HOXB13 immunohistochemistry had high sensitivity and specificity for confirming the prostatic origin of tumors in clinical samples.
JOURNAL OF PATHOLOGY
(2023)
Article
Genetics & Heredity
Xiaodong Lu, Ka-wing Fong, Fang Wang, Galina Gritsina, Sylvan C. Baca, Jacob E. Berchuck, Jenny Ross, Eva Corey, Navdeep Chandel, William J. Catalona, Ximing Yang, Matthew L. Freedman, Jonathan C. Zhao, Jindan Yu, Lourdes T. Brea, Sandor Spisak, CoIm Morrissey
Summary: The study reveals that HOXB13 suppresses lipogenic transcriptional program in prostate cancer through HDAC3 recruitment, which inhibits tumor metastasis. Loss or mutation of HOXB13 leads to lipid accumulation in PCa cells, promoting cell motility and tumor metastasis. This study provides important insights into the roles of HOXB13 in prostate cancer progression and metastasis.
Article
Biochemistry & Molecular Biology
Shaojie Zhao, Bing Zhang, Hua Yuan, Yongxiang Yin, Suwan Qi, Wenjuan Li, Xiadi Wu, Feng Yaling
Summary: The study found that the N6-methyladenosine RNA methylation regulator IGF2BP2 and its target genes MEIS2 and GATA6 were highly expressed in ovarian endometriosis. IGF2BP2 promoted the proliferation, migration, and invasion of ectopic endometrial stromal cells by stabilizing the mRNA of MEIS2 and GATA6. Based on IGF2BP2, five molecules were developed that could be used to treat ovarian endometriosis.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Review
Oncology
Andrew Hartley, Imran Ahmad
Summary: PPAR gamma plays an important role in prostate cancer progression and its splice variants may have different effects. While it is a potential target for therapy, the clinical use of drugs targeting PPAR gamma is limited by their associated side effects.
BRITISH JOURNAL OF CANCER
(2023)
Review
Cell Biology
Martina Bedeschi, Noemi Marino, Elena Cavassi, Filippo Piccinini, Anna Tesei
Summary: Prostate cancer is a common cancer in European males and androgen deprivation therapy is the standard treatment. However, resistance to this therapy has led to cancer progression and long-term side effects. Studies have shown that cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment (TME) and targeting them could be a potential therapeutic approach to overcome therapy resistance in prostate cancer.
Article
Oncology
Juening Kang, Federico La Manna, Francesco Bonollo, Natalie Sampson, Ian L. Alberts, Clemens Mingels, Ali Afshar-Oromieh, George N. Thalmann, Sofia Karkampouna
Summary: During the progression of prostate cancer, particularly in bone metastases, the tumor microenvironment (TME) undergoes changes that support tumor spread and colonization at distant sites. This article discusses the profile of advanced metastatic prostate cancer and genetic alterations. It also explores the role of the TME, particularly the extracellular matrix and fibroblast cells, in different stages of metastatic spread and bone metastasis. Evidence of premetastatic niche formation, stromal similarities between primary prostate cancer and bone metastasis, and the contribution of the TME to androgen deprivation therapy resistance are presented. The article also provides an overview of transgenic mouse models for studying bone metastasis and current diagnostic and therapeutic strategies.
Article
Oncology
Mohammed Alshalalfa, Hatem Abou-Ouf, Elai Davicioni, R. Jeffrey Karnes, Reda Alhajj, Tarek A. Bismar
Summary: The study found that ISL1 is highly correlated with MEIS genes in prostate cancer, and its downregulation is associated with cancer progression, aggressive primary tumors, and metastatic outcomes. The expression of ISL1 and MEIS genes is significantly related to metastasis-free survival and lethal disease, and their downregulation in CRPC and hormone naive metastatic tumors but upregulation in neuroendocrine tumors suggest their potential as targets for therapy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Gloria Cecilia Galvan, Everardo Macias, Sergio Sanders, Adela Ramirez-Torres, Shannon Stock, Sungyong You, Celine E. Riera, Patrick Tamukong, Stephanie A. Smith-Warner, Jeanine M. Genkinger, Daniel J. Luthringer, Michael R. Freeman, Stephen J. Freedland
Summary: Although low-carbohydrate diets have been shown to slow the growth of prostate cancer, improving carbohydrate quality alone may not have the same effect.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Oncology
Sungun Bang, Dongju Won, Saeam Shin, Kang Su Cho, Jae Won Park, Jongsoo Lee, Young Deuk Choi, Suwan Kang, Seung-Tae Lee, Jong Rak Choi, Hyunho Han
Summary: In our study, we discovered genetic mutations in the DNA of cancer cells obtained from the blood of metastatic prostate cancer patients. These mutations were more common in patients with aggressive and progressing cancer that did not respond to conventional treatment. Compared to the traditional method of measuring prostate-specific antigen (PSA) levels, these genetic mutations were more sensitive in detecting prostate cancer progression. This suggests that a simple blood test could be used to track genetic mutations, identify aggressive cancer subtypes, monitor disease progression, and improve the management of advanced prostate cancer.
Article
Biochemistry & Molecular Biology
Karina A. Miller, Seamus Degan, Yanqing Wang, Joseph Cohen, Sheng Yu Ku, David W. Goodrich, Irwin H. Gelman
Summary: PTEN loss is a common mutation in prostate cancer, driving disease progression through AKT activation. Different transgenic prostate cancer models with Akt activation and Rb loss exhibit different metastatic outcomes. PTEN deficiency is correlated with increased dependence on p110 beta and AKT2 for metastatic growth or motility, and downregulation of the metastasis suppressor SMAD4. On the other hand, PTEN expression is associated with greater dependence on p110 alpha and AKT1.
Article
Oncology
Valeria Manuelli, Fidelma Cahill, Harriet Wylie, Cheryl Gillett, Isabel Correa, Susanne Heck, Alex Rimmer, Anna Haire, Mieke Van Hemelrijck, Sarah Rudman, Claire M. Wells
Summary: This study found that prostate cancer cells have the ability to spontaneously form invadopodia and degrade extracellular matrix, leading to invasion and metastasis in vivo. Circulating tumor cells from patients also exhibited similar characteristics, supporting the role of invadopodia activity in prostate cancer progression.
Review
Biochemistry & Molecular Biology
Ryan Cronin, Greg N. Brooke, Filippo Prischi
Summary: Prostate cancer is the second most commonly occurring cancer in men, with standard treatments including androgen-deprivation therapy and AR signaling inhibitors. However, the development of therapy resistance can occur. The p90 ribosomal S6 kinase (RSK) family is a potential novel target for treatment, exhibiting roles in transcription and translation regulation.
Article
Oncology
Kathleen Ruchalski, Hyun J. Kim, Michael Douek, Steven Raman, Maitraya Patel, Victor Sai, Antonio Gutierrez, Benjamin Levine, Cheryce Fischer, Martin Allen-Auerbach, Pawan Gupta, Heidi Coy, Bianca Villegas, Matthew Brown, Jonathan Goldin
Summary: This retrospective cohort study evaluated the disease progression in patients with castration resistant metastatic prostate cancer (mCRPC) and found that patients with pre-treatment visceral metastases were more likely to experience disease progression in the bones while on systemic therapy.
Article
Biochemistry & Molecular Biology
Katarina Vlajic, Hannah Pennington Kluger, Wenjun Bie, Bradley J. Merrill, Larisa Nonn, Andre Kajdacsy-Balla, Angela L. Tyner
Summary: The example illustrates the role of tuft cells in prostate cancer, which are activated early in cancer development and increase in number with disease progression. Tuft cells contribute to the prostate cancer microenvironment and may promote the development of more advanced disease.
Article
Food Science & Technology
Shashank Gaur, Emely C. Lopez, Ankur Ojha, Juan E. Andrade
JOURNAL OF FOOD SCIENCE
(2018)
Article
Pathology
Wenjun Kang, Sabah Kadri, Rutika Puranik, Michelle N. Wurst, Sushant A. Patil, Ibro Mujacic, Sonia Benhamed, Nifang Niu, Chao Jie Zhen, Bekim Ameti, Bradley C. Long, Filipo Galbo, David Montes, Crystal Iracheta, Venessa L. Gamboa, Daisy Lopez, Michael Yourshaw, Carolyn A. Lawrence, Dara L. Aisner, Carrie Fitzpatrick, Megan E. McNerney, Y. Lynn Wang, Jorge Andrade, Samuel L. Volchenboum, Larissa Furtado, Lauren L. Ritterhouse, Jeremy P. Segal
JOURNAL OF MOLECULAR DIAGNOSTICS
(2018)
Review
Public, Environmental & Occupational Health
S. A. Darfour-Oduro, J. E. Andrade, D. S. Grigsby-Toussaint
JOURNAL OF PUBLIC HEALTH
(2019)
Article
Parasitology
Shashank Gaur, Theresa B. Kuhlenschmidt, Mark S. Kuhlenschmidt, Juan E. Andrade
PARASITOLOGY INTERNATIONAL
(2018)
Article
Biochemistry & Molecular Biology
Shiyuan Hong, Junfen Xu, Yan Li, Jorge Andrade, Paul Hoover, Paul J. Kaminski, Laimonis A. Laimins
Article
Food Science & Technology
Peter Goldsmith, Juan Andrade, Margaret Cornelius, Mawuli Asigbee, Philip Atim, Courtney Tamimie
FOOD AND NUTRITION BULLETIN
(2019)
Article
Nutrition & Dietetics
Anna W. Waller, Marco Toc, Dylan J. Rigsby, Marcela Gaytan-Martinez, Juan E. Andrade
Article
Nutrition & Dietetics
Anna W. Waller, Astrid Dominguez-Uscanga, Emely Lopez Barrera, Juan E. Andrade, Jeanette M. Andrade
Review
Nutrition & Dietetics
Anna W. Waller, Juan E. Andrade, Luis A. Mejia
Article
Medicine, Research & Experimental
Kate Poropatich, Donye Dominguez, Wen-Ching Chan, Jorge Andrade, Yuanyuan Zha, Brian Wray, Jason Miska, Lei Qin, Lisa Cole, Sydney Coates, Urjeet Patel, Sandeep Samant, Bin Zhang
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Biochemistry & Molecular Biology
Abdelnaby Khalyfa, Shobhan Gaddameedhi, Elena Crooks, Chunling Zhang, Yan Li, Zhuanhong Qiao, Wojciech Trzepizur, Steve A. Kay, Jorge Andrade, Brieann C. Satterfield, Devon A. Hansen, Leila Kheirandish-Gozal, Hans P. A. Van Dongen, David Gozal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Plant Sciences
Laura Helena Caicedo-Lopez, Ramon Gerardo Guevara-Gonzalez, Juan E. Andrade, Adolfo Esquivel-Delgado, Andres Esteban Perez-Matzumoto, Irineo Torres-Pacheco, Luis Miguel Contreras-Medina
Summary: Specific vibration frequencies can enhance plant fitness performance and mimic plant signals, affecting plant responses. Categorizing different vibration signals as Acoustic Emission Patterns (AEP) to simulate low, medium, and high hydric stress conditions on plants.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Genetics & Heredity
Dustin J. Wcisel, Alex Dornburg, Sean C. McConnell, Kyle M. Hernandez, Jorge Andrade, Jill L. O. de Jong, Gary W. Litman, Jeffrey A. Yoder
Summary: Multiple novel immunoglobulin-like transcripts (NILTs) have been identified in salmon, trout, and carp, but a definitive framework of NILT diversity is still lacking. In this study, the researchers identified five NILT loci in the Atlantic salmon genome, defined 86 NILT Ig domains in zebrafish chromosome 1, and described 41 NILT Ig domains in an alternative haplotype for the same genomic region. They found an unprecedented diversity of Ig domain sequences and combinations for NILTs within a single species. The results suggest that this gene family likely plays multiple roles in host immunity.
Article
Nanoscience & Nanotechnology
Julian H. Reed, Andrew E. Gonsalves, Jessica K. Roman, Junho Oh, Hyeongyun Cha, Catherine E. Dana, Marco Toc, Sungmin Hong, Jacob B. Hoffman, Juan E. Andrade, Kyoo D. Jo, Marianne Alleyne, Nenad Miljkovic, Donald M. Cropek
ACS APPLIED BIO MATERIALS
(2019)
Article
Food Science & Technology
Shashank Gaur, Anna W. Waller, Juan E. Andrade