‘Building a perfect body’: control of vertebrate organogenesis by PBX-dependent regulatory networks

Regulatory integration of Hox factor activity with T-box factors in limb development

(2018) Deepak Jain et al.   DEVELOPMENT

Face morphogenesis is promoted by Pbx-dependent EMT via regulation of Snail1 during frontonasal prominence fusion

(2018) Marta Losa et al.   DEVELOPMENT

Coupling the roles of Hox genes to regulatory networks patterning cranial neural crest

(2018) Hugo J. Parker et al.   DEVELOPMENTAL BIOLOGY

Pbx loss in cranial neural crest, unlike in epithelium, results in cleft palate only and a broader midface

(2018) Ian C. Welsh et al.   JOURNAL OF ANATOMY

Shaping Gene Expression by Landscaping Chromatin Architecture: Lessons from a Master

(2018) Vittorio Sartorelli et al.   MOLECULAR CELL

Genetic determinants and epigenetic effects of pioneer-factor occupancy

(2018) Julie Donaghey et al.   NATURE GENETICS

Human HOX Proteins Use Diverse and Context-Dependent Motifs to Interact with TALE Class Cofactors

(2018) Amélie Dard et al.   Cell Reports

TALE factors use two distinct functional modes to control an essential zebrafish gene expression program

(2018) Franck Ladam et al.   eLife

Making lineage decisions with biological noise: Lessons from the early mouse embryo

(2018) Claire S. Simon et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Enhancer redundancy provides phenotypic robustness in mammalian development

(2018) Marco Osterwalder et al.   NATURE

Incomplete penetrance for isolated congenital asplenia in humans with mutations in translated and untranslated RPSA exons

(2018) Alexandre Bolze et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional testing of a human PBX3 variant in zebrafish reveals a potential modifier role in congenital heart defects

(2018) Gist H. Farr et al.   Disease Models & Mechanisms

Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock

(2017) Jacqueline Deschamps et al.   GENES & DEVELOPMENT

HOXA1 and TALE proteins display cross-regulatory interactions and form a combinatorial binding code on HOXA1 targets

(2017) Bony De Kumar et al.   GENOME RESEARCH

De novo, deleterious sequence variants that alter the transcriptional activity of the homeoprotein PBX1 are associated with intellectual disability and pleiotropic developmental defects

(2017) Anne Slavotinek et al.   HUMAN MOLECULAR GENETICS

MEIS homeodomain proteins facilitate PARP1/ARTD1-mediated eviction of histone H1

(2017) Ann-Christin Hau et al.   JOURNAL OF CELL BIOLOGY

PBX transcription factors drive pulmonary vascular adaptation to birth

(2017) David J. McCulley et al.   JOURNAL OF CLINICAL INVESTIGATION

Toward Microsurgical Correction of Cleft Lip Ex Utero through Restoration of Craniofacial Developmental Programs

(2017) Xue Dong et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration

(2017) J. Manuel Hernández-Hernández et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Long Journey of Pontine Nuclei Neurons: From Rhombic Lip to Cortico-Ponto-Cerebellar Circuitry

(2017) Claudius F. Kratochwil et al.   Frontiers in Neural Circuits

Targeting HOX/PBX dimers in cancer

(2017) Richard Morgan et al.   Oncotarget

Genome-Wide Binding of Posterior HOXA/D Transcription Factors Reveals Subgrouping and Association with CTCF

(2017) Ivana Jerković et al.   PLoS Genetics

The Human Cell Atlas

(2017) Aviv Regev et al.   eLife

Segmental arithmetic: summing up the Hox gene regulatory network for hindbrain development in chordates

(2017) Hugo J. Parker et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Ovarian Cancer Chemoresistance Relies on the Stem Cell Reprogramming Factor PBX1

(2016) Jin-Gyoung Jung et al.   CANCER RESEARCH

Transcriptome Encyclopedia of Early Human Development

(2016) Anna Sahakyan et al.   CELL

The Molecular and Cellular Choreography of Appendage Regeneration

(2016) Elly M. Tanaka   CELL

Ever-Changing Landscapes: Transcriptional Enhancers in Development and Evolution

(2016) Hannah K. Long et al.   CELL

Pbx1 is required for adult subventricular zone neurogenesis

(2016) Britta Moyo Grebbin et al.   DEVELOPMENT

A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease

(2016) J Carlos Villaescusa et al.   EMBO JOURNAL

A role for HOX13 proteins in the regulatory switch between TADs at theHoxDlocus

(2016) Leonardo Beccari et al.   GENES & DEVELOPMENT

The second decade of 3C technologies: detailed insights into nuclear organization

(2016) Annette Denker et al.   GENES & DEVELOPMENT

Spleen hypoplasia leads to abnormal stress hematopoiesis in mice with loss of Pbx homeoproteins in splenic mesenchyme

(2016) Rediet Zewdu et al.   JOURNAL OF ANATOMY

Parallel Pbx -Dependent Pathways Govern the Coalescence and Fate of Motor Columns

(2016) Olivia Hanley et al.   NEURON

Transposon mutagenesis identifies genes and cellular processes driving epithelial-mesenchymal transition in hepatocellular carcinoma

(2016) Takahiro Kodama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Light-sheet imaging of mammalian development

(2016) Gustavo de Medeiros et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A toolbox to explore the mechanics of living embryonic tissues

(2016) Otger Campàs   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

To Be Specific or Not: The Critical Relationship Between Hox And TALE Proteins

(2016) Samir Merabet et al.   TRENDS IN GENETICS

Distal Limb Patterning Requires Modulation of cis -Regulatory Activities by HOX13

(2016) Rushikesh Sheth et al.   Cell Reports

Meis2 is essential for cranial and cardiac neural crest development

(2015) Ondrej Machon et al.   BMC DEVELOPMENTAL BIOLOGY

Enhancer Divergence and cis-Regulatory Evolution in the Human and Chimp Neural Crest

(2015) Sara L. Prescott et al.   CELL

Low Affinity Binding Site Clusters Confer Hox Specificity and Regulatory Robustness

(2015) Justin Crocker et al.   CELL

Homeodomain proteins: an update

(2015) Thomas R. Bürglin et al.   CHROMOSOMA

Pbx1-dependent control of VMC differentiation kinetics underlies gross renal vascular patterning

(2015) Romulo Hurtado et al.   DEVELOPMENT

Hoxa2 Selectively Enhances Meis Binding to Change a Branchial Arch Ground State

(2015) Shilu Amin et al.   DEVELOPMENTAL CELL

Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons

(2015) Olga Golonzhka et al.   NEURON

Single cells get together: High-resolution approaches to study the dynamics of early mouse development

(2015) Néstor Saiz et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

De Novo Inference of Systems-Level Mechanistic Models of Development from Live-Imaging-Based Phenotype Analysis

(2014) Zhuo Du et al.   CELL

The analysis, roles and regulation of quiescence in hematopoietic stem cells

(2014) A. Nakamura-Ishizu et al.   DEVELOPMENT

TALE Factors Poise Promoters for Activation by Hox Proteins

(2014) Seong-Kyu Choe et al.   DEVELOPMENTAL CELL

Contrasting roles for MyoD in organizing myogenic promoter structures during embryonic skeletal muscle development

(2014) Ok Hyun Cho et al.   DEVELOPMENTAL DYNAMICS

Pioneer transcription factors in cell reprogramming

(2014) Makiko Iwafuchi-Doi et al.   GENES & DEVELOPMENT

Pbx1 activates Fgf10 in the mesenchyme of developing lungs

(2014) Wei Li et al.   GENESIS

Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs

(2014) Javier Lopez-Rios et al.   NATURE

A comparative encyclopedia of DNA elements in the mouse genome

(2014) Feng Yue et al.   NATURE

Evolution of transcription factor binding in metazoans — mechanisms and functional implications

(2014) Diego Villar et al.   NATURE REVIEWS GENETICS

Signalling dynamics in vertebrate segmentation

(2014) Alexis Hubaud et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transcription factor PREP1 induces EMT and metastasis by controlling the TGF- -SMAD3 pathway in non-small cell lung adenocarcinoma

(2014) M. Risolino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Convergent evolution of complex regulatory landscapes and pleiotropy at Hox loci

(2014) N. Lonfat et al.   SCIENCE

Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution

(2014) J. Vierstra et al.   SCIENCE

Genetic dissection of ventral folding morphogenesis in mouse: embryonic visceral endoderm-supplied BMP2 positions head and heart

(2013) Svetlana Gavrilov et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Human pluripotent stem cells: an emerging model in developmental biology

(2013) Z. Zhu et al.   DEVELOPMENT

pbx is required for pole and eye regeneration in planarians

(2013) C.-C. G. Chen et al.   DEVELOPMENT

PBX/extradenticle is required to re-establish axial structures and polarity during planarian regeneration

(2013) R. A. Blassberg et al.   DEVELOPMENT

Gene Regulatory Networks Governing Pancreas Development

(2013) H. Efsun Arda et al.   DEVELOPMENTAL CELL

Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates

(2013) E. Longobardi et al.   DEVELOPMENTAL DYNAMICS

Hox regulation of transcription: More complex(es)

(2013) Franck Ladam et al.   DEVELOPMENTAL DYNAMICS

Glimpse into Hox and tale regulation of cell differentiation and reprogramming

(2013) Nuria Cerdá-Esteban et al.   DEVELOPMENTAL DYNAMICS

TALE transcription factors during early development of the vertebrate brain and eye

(2013) Dorothea Schulte et al.   DEVELOPMENTAL DYNAMICS

Pbx1 restrains myeloid maturation while preserving lymphoid potential in hematopoietic progenitors

(2013) F. Ficara et al.   JOURNAL OF CELL SCIENCE

Ribosomal Protein SA Haploinsufficiency in Humans with Isolated Congenital Asplenia

(2013) A. Bolze et al.   SCIENCE

Connections of the superior colliculus to shoulder muscles of the rat: a dual tracing study

(2013) J. M. Rubelowski et al.   Frontiers in Neuroanatomy

Analysis of the DNA-Binding Profile and Function of TALE Homeoproteins Reveals Their Specialization and Specific Interactions with Hox Genes/Proteins

(2013) Dmitry Penkov et al.   Cell Reports

Pbx and Prdm1a transcription factors differentially regulate subsets of the fast skeletal muscle program in zebrafish

(2013) Z. Yao et al.   Biology Open

Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation

(2012) M. Cai et al.   BLOOD

Beyond Hox: the role of ParaHox genes in normal and malignant hematopoiesis

(2012) V. P. S. Rawat et al.   BLOOD

Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module

(2012) Matthew Koss et al.   DEVELOPMENTAL CELL

Extradenticle and Homothorax Control Adult Muscle Fiber Identity in Drosophila

(2012) Anton L. Bryantsev et al.   DEVELOPMENTAL CELL

Non-synonymous variants in pre-B cell leukemia homeobox (PBX) genes are associated with congenital heart defects

(2012) Cammon B. Arrington et al.   European Journal of Medical Genetics

Transcription factors: from enhancer binding to developmental control

(2012) François Spitz et al.   NATURE REVIEWS GENETICS

Congenital diaphragmatic hernia candidate genes derived from embryonic transcriptomes

(2012) M. K. Russell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Origin of blood cells and HSC production in the embryo

(2012) Guilherme Costa et al.   TRENDS IN IMMUNOLOGY

Limb Regeneration: A New Development?

(2011) Eugen Nacu et al.   Annual Review of Cell and Developmental Biology

Cofactor Binding Evokes Latent Differences in DNA Binding Specificity between Hox Proteins

(2011) Matthew Slattery et al.   CELL

Maintaining embryonic stem cell pluripotency with Wnt signaling

(2011) S. Y. Sokol   DEVELOPMENT

Hox and Pbx Factors Control Retinoic Acid Synthesis during Hindbrain Segmentation

(2011) Antonio Vitobello et al.   DEVELOPMENTAL CELL

A Conserved Pbx-Wnt-p63-Irf6 Regulatory Module Controls Face Morphogenesis by Promoting Epithelial Apoptosis

(2011) Elisabetta Ferretti et al.   DEVELOPMENTAL CELL

Control of pelvic girdle development by genes of the Pbx family and Emx2

(2011) Terence D. Capellini et al.   DEVELOPMENTAL DYNAMICS

Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth

(2011) Terence D. Capellini et al.   DEVELOPMENTAL DYNAMICS

Pax6 regulates craniofacial form through its control of an essential cephalic ectodermal patterning center

(2011) Claudia Compagnucci et al.   GENESIS

Cooperative Transcriptional Activation by Klf4, Meis2, and Pbx1

(2011) G. A. Bjerke et al.   MOLECULAR AND CELLULAR BIOLOGY

Cleft lip and palate: understanding genetic and environmental influences

(2011) Michael J. Dixon et al.   NATURE REVIEWS GENETICS

Selection of distinct Hox-Extradenticle interaction modes fine-tunes Hox protein activity

(2011) M. Saadaoui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translating cell polarity into tissue elongation

(2011) Athea Vichas et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PBX1: A Novel Stage-Specific Regulator of Adipocyte Development

(2011) Miguel C. Monteiro et al.   STEM CELLS

PBX1 Genomic Pioneer Function Drives ERα Signaling Underlying Progression in Breast Cancer

(2011) Luca Magnani et al.   PLoS Genetics

The temporal dynamics of vertebrate limb development, teratogenesis and evolution

(2010) Rolf Zeller   CURRENT OPINION IN GENETICS & DEVELOPMENT

Scapula development is governed by genetic interactions of Pbx1 with its family members and with Emx2 via their cooperative control of Alx1

(2010) T. D. Capellini et al.   DEVELOPMENT

The Hox cofactors Meis1 and Pbx act upstream of gata1 to regulate primitive hematopoiesis

(2010) Laura M. Pillay et al.   DEVELOPMENTAL BIOLOGY

Prep1 Controls Insulin Glucoregulatory Function in Liver by Transcriptional Targeting of SHP1 Tyrosine Phosphatase

(2010) F. Oriente et al.   DIABETES

FGF signalling as a mediator of lineage transitions-Evidence from embryonic stem cell differentiation

(2010) Santiago Nahuel Villegas et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pbx1 Represses Osteoblastogenesis by Blocking Hoxa10-Mediated Recruitment of Chromatin Remodeling Factors

(2010) J. A. R. Gordon et al.   MOLECULAR AND CELLULAR BIOLOGY

Hematopoietic stem cell: self-renewal versus differentiation

(2010) Jun Seita et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

The TALE Class Homeobox Gene Smed-prep Defines the Anterior Compartment for Head Regeneration

(2010) Daniel A. Felix et al.   PLoS Genetics

Hox Genes and Segmentation of the Hindbrain and Axial Skeleton

(2009) Tara Alexander et al.   Annual Review of Cell and Developmental Biology

Rostral and caudal pharyngeal arches share a common neural crest ground pattern

(2009) M. Minoux et al.   DEVELOPMENT

Pbx acts with Hand2 in early myocardial differentiation

(2009) Lisa Maves et al.   DEVELOPMENTAL BIOLOGY

Meis Cofactors Control HDAC and CBP Accessibility at Hox-Regulated Promoters during Zebrafish Embryogenesis

(2009) Seong-Kyu Choe et al.   DEVELOPMENTAL CELL

PBX1 is dispensable for neural commitment of RA-treated murine ES cells

(2009) Anne S. Jürgens et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

The association of PBX1 polymorphisms with overweight/obesity and metabolic alterations in the Korean population

(2009) Ju Yeon Ban et al.   Nutrition Research and Practice

KLF4 and PBX1 Directly RegulateNANOGExpression in Human Embryonic Stem Cells

(2009) Ken Kwok-Keung Chan et al.   STEM CELLS

Evaluating the association of common PBX1variants with type 2 diabetes

(2008) Konsta Duesing et al.   BMC Medical Genetics

Evo-Devo and an Expanding Evolutionary Synthesis: A Genetic Theory of Morphological Evolution

(2008) Sean B. Carroll   CELL

Pbx1 Regulates Self-Renewal of Long-Term Hematopoietic Stem Cells by Maintaining Their Quiescence

(2008) Francesca Ficara et al.   Cell Stem Cell

Pbx/Meis Deficiencies Demonstrate Multigenetic Origins of Congenital Heart Disease

(2008) Kryn Stankunas et al.   CIRCULATION RESEARCH

Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract

(2008) C.-P. Chang et al.   DEVELOPMENT

Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome

(2008) Terence D. Capellini et al.   DEVELOPMENTAL BIOLOGY