DNA G‐Quadruplexes (G4s) Modulate Epigenetic (Re)Programming and Chromatin Remodeling

Promise of G-Quadruplex Structure Binding Ligands as Epigenetic Modifiers with Anti-Cancer Effects

(2019) Antara Sengupta et al.   MOLECULES

HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types

(2018) Anne Zirkel et al.   MOLECULAR CELL

G-quadruplex binding ability of TLS/FUS depends on the β-spiral structure of the RGG domain

(2018) Ryota Yagi et al.   NUCLEIC ACIDS RESEARCH

Global profiling of protein–DNA and protein–nucleosome binding affinities using quantitative mass spectrometry

(2018) Matthew M. Makowski et al.   Nature Communications

HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation?

(2018) Jussara Amato et al.   CHEMICAL COMMUNICATIONS

Mechanisms for stalled replication fork stabilization: new targets for synthetic lethality strategies in cancer treatments

(2018) Hongwei Liao et al.   EMBO REPORTS

DNA G-quadruplex structures mold the DNA methylome

(2018) Shi-Qing Mao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A tough row to hoe: when replication forks encounter DNA damage

(2018) Darshil R. Patel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Chromatin Stability as a Target for Cancer Treatment

(2018) Katerina V. Gurova   BIOESSAYS

BRD4 and Cancer: going beyond transcriptional regulation

(2018) Benedetta Donati et al.   Molecular Cancer

Molecular Processes Connecting DNA Methylation Patterns with DNA Methyltransferases and Histone Modifications in Mammalian Genomes

(2018) Albert Jeltsch et al.   Genes

Non-duplex G-Quadruplex Structures Emerge as Mediators of Epigenetic Modifications

(2018) Ananda Kishore Mukherjee et al.   TRENDS IN GENETICS

The Effects of Replication Stress on S Phase Histone Management and Epigenetic Memory

(2017) Saša Šviković et al.   JOURNAL OF MOLECULAR BIOLOGY

RNA G-Quadruplexes in Biology: Principles and Molecular Mechanisms

(2017) Marta M. Fay et al.   JOURNAL OF MOLECULAR BIOLOGY

Local epigenetic reprogramming induced by G-quadruplex ligands

(2017) Guillaume Guilbaud et al.   Nature Chemistry

The interplay of epigenetic marks during stem cell differentiation and development

(2017) Yaser Atlasi et al.   NATURE REVIEWS GENETICS

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

(2017) Arnab Ray Chaudhuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential

(2017) Robert Hänsel-Hertsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA

(2017) Xueyin Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HMGN1 and 2 remodel core and linker histone tail domains within chromatin

(2017) Kevin J. Murphy et al.   NUCLEIC ACIDS RESEARCH

The effects of DNA supercoiling on G-quadruplex formation

(2017) Doreen A.T. Sekibo et al.   NUCLEIC ACIDS RESEARCH

Structural Analysis of G-Quadruplex Formation at the Human MEST Promoter

(2017) Aaron J. Stevens et al.   PLoS One

Epigenetic plasticity and the hallmarks of cancer

(2017) William A. Flavahan et al.   SCIENCE

The cancer epigenome: Concepts, challenges, and therapeutic opportunities

(2017) Mark A. Dawson   SCIENCE

PARP1 orchestrates epigenetic events setting up chromatin domains

(2017) Fabio Ciccarone et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Links between DNA methylation and nucleosome occupancy in the human genome

(2017) Clayton K. Collings et al.   Epigenetics & Chromatin

Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA

(2017) Xueyin Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Machine learning model for sequence-driven DNA G-quadruplex formation

(2017) Aleksandr B. Sahakyan et al.   Scientific Reports

PRC2 and SWI/SNF Chromatin Remodeling Complexes in Health and Disease

(2016) Cigall Kadoch et al.   BIOCHEMISTRY

Functional interplay between histone H1 and HMG proteins in chromatin

(2016) Yuri V. Postnikov et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Bromodomain inhibitors and cancer therapy: From structures to applications

(2016) Montserrat Pérez-Salvia et al.   Epigenetics

DNA G-quadruplexes show strong interaction with DNA methyltransferasesin vitro

(2016) Simone L. Cree et al.   FEBS LETTERS

PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells

(2016) Davide Schiavone et al.   MOLECULAR CELL

The Aging Epigenome

(2016) Lauren N. Booth et al.   MOLECULAR CELL

G-quadruplex structures mark human regulatory chromatin

(2016) Robert Hänsel-Hertsch et al.   NATURE GENETICS

G-quadruplex recognition and remodeling by the FANCJ helicase

(2016) Colin G. Wu et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes and helicases

(2016) Oscar Mendoza et al.   NUCLEIC ACIDS RESEARCH

QuadBase2: web server for multiplexed guanine quadruplex mining and visualization

(2016) Parashar Dhapola et al.   NUCLEIC ACIDS RESEARCH

Re-evaluation of G-quadruplex propensity with G4Hunter

(2016) Amina Bedrat et al.   NUCLEIC ACIDS RESEARCH

G-Quadruplexes in DNA Replication: A Problem or a Necessity?

(2016) Anne-Laure Valton et al.   TRENDS IN GENETICS

Increased global transcription activity as a mechanism of replication stress in cancer

(2016) Panagiotis Kotsantis et al.   Nature Communications

G4IPDB: A database for G-quadruplex structure forming nucleic acid interacting proteins

(2016) Subodh Kumar Mishra et al.   Scientific Reports

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

(2016) Ludovica Morera et al.   Clinical Epigenetics

G-Quadruplex DNA- and RNA-Specific-Binding Proteins Engineered from the RGG Domain of TLS/FUS

(2015) Kentaro Takahama et al.   ACS Chemical Biology

Structure and function insights into the NuRD chromatin remodeling complex

(2015) Morgan P. Torchy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Identification of novel interactors of human telomeric G-quadruplex DNA

(2015) Bruno Pagano et al.   CHEMICAL COMMUNICATIONS

Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation

(2015) Erin Witalison et al.   CURRENT DRUG TARGETS

High-throughput sequencing of DNA G-quadruplex structures in the human genome

(2015) Vicki S Chambers et al.   NATURE BIOTECHNOLOGY

Exploiting replicative stress to treat cancer

(2015) Matthias Dobbelstein et al.   NATURE REVIEWS DRUG DISCOVERY

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Guanine-vacancy–bearing G-quadruplexes responsive to guanine derivatives

(2015) Xin-min Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone H4 acetylation required for chromatin decompaction during DNA replication

(2015) Kun Ruan et al.   Scientific Reports

Nucleotide Pool Depletion Induces G-Quadruplex-Dependent Perturbation of Gene Expression

(2015) Charikleia Papadopoulou et al.   Cell Reports

Replication of Structured DNA and its implication in epigenetic stability

(2015) Valentina Cea et al.   Frontiers in Genetics

Existence and consequences of G-quadruplex structures in DNA

(2014) Pierre Murat et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

FANCJ promotes DNA synthesis through G-quadruplex structures

(2014) P. Castillo Bosch et al.   EMBO JOURNAL

Determinants of G quadruplex-induced epigenetic instability in REV1-deficient cells

(2014) D. Schiavone et al.   EMBO JOURNAL

Reconfiguration of nucleosome-depleted regions at distal regulatory elements accompanies DNA methylation of enhancers and insulators in cancer

(2014) Phillippa C. Taberlay et al.   GENOME RESEARCH

ATRX promotes gene expression by facilitating transcriptional elongation through guanine-rich coding regions

(2014) Michael A. Levy et al.   HUMAN MOLECULAR GENETICS

DNA and RNA Quadruplex-Binding Proteins

(2014) Václav Brázda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ATRX Dysfunction Induces Replication Defects in Primary Mouse Cells

(2014) David Clynes et al.   PLoS One

Automodification switches PARP-1 function from chromatin architectural protein to histone chaperone

(2014) U. M. Muthurajan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of epigenetic memory

(2014) Agustina D’Urso et al.   TRENDS IN GENETICS

Bcl2 Induces DNA Replication Stress by Inhibiting Ribonucleotide Reductase

(2013) M. Xie et al.   CANCER RESEARCH

ATRX and the replication of structured DNA

(2013) David Clynes et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Non-coding RNAs as direct and indirect modulators of epigenetic regulation

(2013) Veronica J Peschansky et al.   Epigenetics

Specific Binding of Modified RGG Domain in TLS/FUS to G-Quadruplex RNA: Tyrosines in RGG Domain Recognize 2′-OH of the Riboses of Loops in G-Quadruplex

(2013) Kentaro Takahama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bulges in G-Quadruplexes: Broadening the Definition of G-Quadruplex-Forming Sequences

(2013) Vineeth Thachappilly Mukundan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sites of Acetylation on Newly Synthesized Histone H4 Are Required for Chromatin Assembly and DNA Damage Response Signaling

(2013) Zhongqi Ge et al.   MOLECULAR AND CELLULAR BIOLOGY

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Human Rev1 polymerase disrupts G-quadruplex DNA

(2013) S. Eddy et al.   NUCLEIC ACIDS RESEARCH

Histone chaperone FACT action during transcription through chromatin by RNA polymerase II

(2013) F.-K. Hsieh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Balancing chromatin remodeling and histone modifications in transcription

(2013) Emily Petty et al.   TRENDS IN GENETICS

The G4 Genome

(2013) Nancy Maizels et al.   PLoS Genetics

Stabilization of G-quadruplex DNA by C-5-methyl-cytosine in bcl-2 promoter: Implications for epigenetic regulation

(2012) Jing Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ATRX

(2012) Kajan Ratnakumar et al.   Epigenetics

Genome-Wide Chromatin Remodeling Identified at GC-Rich Long Nucleosome-Free Regions

(2012) Karin Schwarzbauer et al.   PLoS One

Epigenetic Regulation by Long Noncoding RNAs

(2012) J. T. Lee   SCIENCE

The chromatin-binding protein HMGN3 stimulates histone acetylation and transcription across theGlyt1gene

(2011) Gráinne Barkess et al.   BIOCHEMICAL JOURNAL

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

DNA secondary structures and epigenetic determinants of cancer genome evolution

(2011) Subhajyoti De et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA

(2011) Peter Sarkies et al.   NUCLEIC ACIDS RESEARCH

ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner

(2010) Martin J. Law et al.   CELL

Epigenetic Instability due to Defective Replication of Structured DNA

(2010) Peter Sarkies et al.   MOLECULAR CELL

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

(2010) Johanna C. Scheuermann et al.   NATURE

Identification and Characterization of Nucleolin as a c-mycG-quadruplex-binding Protein

(2009) Verónica González et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HMGB1: The jack-of-all-trades protein is a master DNA repair mechanic

(2009) Sabine S. Lange et al.   MOLECULAR CARCINOGENESIS

Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential

(2009) Jay E. Johnson et al.   NUCLEIC ACIDS RESEARCH

First Evidence of a Functional Interaction between DNA Quadruplexes and Poly(ADP-ribose) Polymerase-1

(2008) V. A. Soldatenkov et al.   ACS Chemical Biology

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts

(2008) Timothy B. C. London et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Double Bromodomain Proteins Brd2 and Brd3 Couple Histone Acetylation to Transcription

(2008) Gary LeRoy et al.   MOLECULAR CELL

High mobility group protein B1 enhances DNA repair and chromatin modification after DNA damage

(2008) S. S. Lange et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA