Control of p97 function by cofactor binding

Altered cofactor regulation with disease-associated p97/VCP mutations

(2015) Xiaoyi Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy

(2014) Raymond J Deshaies   BMC BIOLOGY

A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair

(2014) Julian Stingele et al.   CELL

Evaluating p97 Inhibitor Analogues for Their Domain Selectivity and Potency against the p97-p47 Complex

(2014) Chen-Jie Fang et al.   ChemMedChem

Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN

(2014) Tsuyoshi Takiuchi et al.   GENES TO CELLS

Structural Basis for Ovarian Tumor Domain-containing Protein 1 (OTU1) Binding to p97/Valosin-containing Protein (VCP)

(2014) Su Jin Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The p97-FAF1 Protein Complex Reveals a Common Mode of p97 Adaptor Binding

(2014) Caroline A. Ewens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pro178and Pro183of Selenoprotein S Are Essential Residues for Interaction with p97(VCP) during Endoplasmic Reticulum-associated Degradation

(2014) Jea Hwang Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis

(2014) H. Meyer et al.   JOURNAL OF CELL SCIENCE

Specific Inhibition of p97/VCP ATPase and Kinetic Analysis Demonstrate Interaction between D1 and D2 ATPase Domains

(2014) Tsui-Fen Chou et al.   JOURNAL OF MOLECULAR BIOLOGY

Binding of OTULIN to the PUB Domain of HOIP Controls NF-κB Signaling

(2014) Veronique Schaeffer et al.   MOLECULAR CELL

Molecular Basis and Regulation of OTULIN-LUBAC Interaction

(2014) Paul R. Elliott et al.   MOLECULAR CELL

Inter-ring rotations of AAA ATPase p97 revealed by electron cryomicroscopy

(2014) H. O. Yeung et al.   Open Biology

Signal-peptide-mediated translocation is regulated by a p97–AIRAPL complex

(2013) Tal Glinka et al.   BIOCHEMICAL JOURNAL

Structural and mechanistic insights into the arginine/lysine-rich peptide motifs that interact with P97/VCP

(2013) Shuai Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A unique IBMPFD-related P97/VCP mutation with differential binding pattern and subcellular localization

(2013) Yalcin Erzurumlu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants

(2013) Wai Kwan Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NEDD8 Ultimate Buster-1 Long (NUB1L) Protein Promotes Transfer of NEDD8 to Proteasome for Degradation through the P97UFD1/NPL4Complex

(2013) Shuai Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Derlin2 Protein Facilitates HRD1-mediated Retro-translocation of Sonic Hedgehog at the Endoplasmic Reticulum

(2013) Chih-Hsiang Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complex of Fas-associated Factor 1 (FAF1) with Valosin-containing Protein (VCP)-Npl4-Ufd1 and Polyubiquitinated Proteins Promotes Endoplasmic Reticulum-associated Degradation (ERAD)

(2013) Jae-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Transient Binding and Release of Substrate Protein during the Allosteric Cycle of the p97 Nanomachine

(2013) Sam Tonddast-Navaei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bipartite determinants mediate an evolutionarily conserved interaction between Cdc48 and the 20Speptidase

(2013) Dominik Barthelme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Speed Atomic Force Microscopic Observation of ATP-Dependent Rotation of the AAA+ Chaperone p97

(2013) Kentaro Noi et al.   STRUCTURE

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

The Role of the N-Domain in the ATPase Activity of the Mammalian AAA ATPase p97/VCP

(2012) Hajime Niwa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and functional deviations in disease-associated p97 mutants

(2012) Wai Kwan Tang et al.   JOURNAL OF STRUCTURAL BIOLOGY

Ubiquitin-Dependent Intramembrane Rhomboid Protease Promotes ERAD of Membrane Proteins

(2012) Lina Fleig et al.   MOLECULAR CELL

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

(2012) Hemmo Meyer et al.   NATURE CELL BIOLOGY

DVC1 (C1orf124) is a DNA damage–targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

(2012) Anna Mosbech et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATP Binding to p97/VCP D1 Domain Regulates Selective Recruitment of Adaptors to Its Proximal N-Domain

(2012) Wei Sheng Chia et al.   PLoS One

Dynamic flexibility of the ATPase p97 is important for its interprotomer motion transmission

(2012) C. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interprotomer motion-transmission mechanism for the hexameric AAA ATPase p97

(2012) G. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopy

(2012) C. Bebeacua et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growing sphere of influence: Cdc48/p97 orchestrates ubiquitin-dependent extraction from chromatin

(2012) Nico P. Dantuma et al.   TRENDS IN CELL BIOLOGY

AAA+ Proteases: ATP-Fueled Machines of Protein Destruction

(2011) Robert T. Sauer et al.   Annual Review of Biochemistry

Crystal structure of human FAF1 UBX domain reveals a novel FcisP touch-turn motif in p97/VCP-binding region

(2011) Wonchull Kang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Recent advances in p97/VCP/Cdc48 cellular functions

(2011) Kunitoshi Yamanaka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of p97 in the ubiquitin–proteasome system by the UBX protein-family

(2011) Patrik Kloppsteck et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Ubiquitin Regulatory X (UBX) Domain-containing Protein TUG Regulates the p97 ATPase and Resides at the Endoplasmic Reticulum-Golgi Intermediate Compartment

(2011) Charisse M. Orme et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Positive Cooperativity of the p97 AAA ATPase Is Critical for Essential Functions

(2011) Shingo Nishikori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The General Definition of the p97/Valosin-containing Protein (VCP)-interacting Motif (VIM) Delineates a New Family of p97 Cofactors

(2011) Christopher Stapf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structural and Functional Basis of the p97/Valosin-containing Protein (VCP)-interacting Motif (VIM)

(2011) Petra Hänzelmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Valosin-containing protein and neurofibromin interact to regulate dendritic spine density

(2011) Hsiao-Fang Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

The Multiple Faces of Valosin-Containing Protein-Associated Diseases: Inclusion Body Myopathy with Paget’s Disease of Bone, Frontotemporal Dementia, and Amyotrophic Lateral Sclerosis

(2011) Angèle Nalbandian et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Cellular Functions of Ufd2 and Ufd3 in Proteasomal Protein Degradation Depend on Cdc48 Binding

(2011) S. Bohm et al.   MOLECULAR AND CELLULAR BIOLOGY

Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations

(2011) Danilo Ritz et al.   NATURE CELL BIOLOGY

Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum

(2011) Ethan J Greenblatt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SVIP Induces Localization of p97/VCP to the Plasma and Lysosomal Membranes and Regulates Autophagy

(2011) Yang Wang et al.   PLoS One

Crystal structure of FAF1 UBX domain in complex with p97/VCP N domain reveals a conformational change in the conserved FcisP touch-turn motif of UBX domain

(2011) Kyoung Hoon Kim et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Hierarchical Binding of Cofactors to the AAA ATPase p97

(2011) Petra Hänzelmann et al.   STRUCTURE

Cdc48: a power machine in protein degradation

(2011) Alexandra Stolz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ubiquitin: Same Molecule, Different Degradation Pathways

(2010) Michael J. Clague et al.   CELL

A novel ATP-dependent conformation in p97 N–D1 fragment revealed by crystal structures of disease-related mutants

(2010) Wai Kwan Tang et al.   EMBO JOURNAL

Imbalances in p97 co-factor interactions in human proteinopathy

(2010) Vanesa Fernández-Sáiz et al.   EMBO REPORTS

A Stress-Responsive System for Mitochondrial Protein Degradation

(2010) Jin-Mi Heo et al.   MOLECULAR CELL

UBXD1 binds p97 through two independent binding sites

(2009) Maximilian Kern et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Evolutionary divergence of valosin-containing protein/cell division cycle protein 48 binding interactions among endoplasmic reticulum-associated degradation proteins

(2009) Giacomo Morreale et al.   FEBS Journal

COP9 Signalosome Interacts ATP-dependently with p97/Valosin-containing Protein (VCP) and Controls the Ubiquitination Status of Proteins Bound to p97/VCP

(2009) Sevil Cayli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Function of the PLAA/Ufd3-p97/Cdc48 Complex

(2009) Liyan Qiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

(2009) Jeong-Sun Ju et al.   JOURNAL OF CELL BIOLOGY

Hereditary Inclusion Body Myopathy-Linked p97/VCP Mutations in the NH2 Domain and the D1 Ring Modulate p97/VCP ATPase Activity and D2 Ring Conformation

(2009) D. Halawani et al.   MOLECULAR AND CELLULAR BIOLOGY

The Otubain YOD1 Is a Deubiquitinating Enzyme that Associates with p97 to Facilitate Protein Dislocation from the ER

(2009) Robert Ernst et al.   MOLECULAR CELL

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An Armadillo motif in Ufd3 interacts with Cdc48 and is involved in ubiquitin homeostasis and protein degradation

(2009) G. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tyrosine phosphorylation of ATPase p97 regulates its activity during ERAD

(2008) Guangtao Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Insights into adaptor binding to the AAA protein p97

(2008) Heidi O. Yeung et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

UBXD7 Binds Multiple Ubiquitin Ligases and Implicates p97 in HIF1α Turnover

(2008) Gabriela Alexandru et al.   CELL

UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97

(2008) C. Schuberth et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ubxd1 is a novel co-factor of the human p97 ATPase

(2008) Louise Madsen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Analysis of Nucleotide Binding to P97 Reveals the Properties of a Tandem AAA Hexameric ATPase

(2008) Louise C. Briggs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans

(2008) C. Yun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved Structures of Full-Length p97, an AAA ATPase: Implications for Mechanisms of Nucleotide-Dependent Conformational Change

(2008) Jason M. Davies et al.   STRUCTURE