Article
Multidisciplinary Sciences
Anthony Martin, Gertrude Ecklu-Mensah, Connie W. Y. Ha, Gustaf Hendrick, Donald K. Layman, Jack Gilbert, Suzanne Devkota
Summary: Dietary protein restriction triggers the hepatic FGF21 adaptive metabolic pathway, which is influenced by the gut microbiome and can be regulated by dietary fiber supplementation. In the absence of gut microbiome, FGF21 loses sensitivity to protein restriction.
NATURE COMMUNICATIONS
(2021)
Article
Food Science & Technology
Yuhui Yang, Jing Qian, Bowen Li, Manman Lu, Guowei Le, Yanli Xie
Summary: The study found that methionine restriction can improve metabolic dysfunction by reducing lipid accumulation, oxidative stress, and inflammation in the spleen. The mechanism may involve the activation of the autophagy pathway.
Review
Nutrition & Dietetics
Hannah Lail, Angela M. Mabb, Marise B. Parent, Filipe Pinheiro, Desiree Wanders
Summary: Dietary restriction of methionine has been shown to have unique metabolic protection and cognitive benefits, protecting against impairments in learning and memory induced by obesity, age, and Alzheimer's disease in animal models. These benefits are likely mediated by various mechanisms, including increases in fibroblast growth factor 21, alterations in methionine metabolism pathways, reductions in neuroinflammation and central oxidative stress, and potential changes in the gut microbiome, mitochondrial function, and synaptic plasticity.
Article
Oncology
Lauren C. Morehead, Sarita Garg, Katherine F. Wallis, Camila C. Simoes, Eric R. Siegel, Alan J. Tackett, Isabelle R. Miousse
Summary: The study found that restricting methionine in the diet increased the expression of MHC-I and PD-L1 in colorectal cancer cells, as well as the expression of STING and interferon. This led to a better response to immune checkpoint inhibitors in a mouse model of colorectal cancer.
Article
Agriculture, Multidisciplinary
Yuhui Yang, Manman Lu, Yuncong Xu, Jing Qian, Guowei Le, Yanli Xie
Summary: High-methionine diets can impair learning and memory function, induce neurodegeneration similar to dementia, and increase the risk of Alzheimer's disease. On the other hand, low-methionine diets can improve learning and memory function. The changes in intestinal microbiota may be the underlying mechanism for these opposite effects.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Yuhui Yang, Manman Lu, Jing Qian, Yuncong Xu, Bowen Li, Guowei Le, Yanli Xie
Summary: This study investigates the effects of a methionine-restricted diet (MRD) on fat browning and hepatic lipid accumulation in mice fed with a high-choline diet (HCD) and their potential mechanisms. The results show that MRD reduces body weight and fat mass, increases heat production and locomotor activity, reduces lipid levels in the liver and plasma, promotes fat browning and catabolism, and inhibits fat anabolism. Furthermore, MRD enhances antioxidant defenses, reduces inflammatory cytokine levels, improves thyroid function, and promotes the synthesis and action of thyroid hormones. These findings suggest that MRD promotes fat browning and attenuates hepatic lipid accumulation in HCD mice through improvements in thyroid function.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Yuhui Yang, Manman Lu, Jing Qian, Yuncong Xu, Bowen Li, Guowei Le, Yanli Xie
Summary: This study aimed to investigate the effects of methionine-restricted diet (MRD) on fat browning and hepatic lipid accumulation in mice fed with a high-choline diet (HCD) and their possible mechanisms. The results showed that MRD reduced body weight and fat mass, increased heat production and locomotor activity, decreased hepatic and plasma lipid levels, promoted fat browning, and inhibited fat anabolism in the liver and adipose tissue. Additionally, MRD enhanced antioxidant defenses and improved thyroid function, resulting in the attenuation of hepatic lipid accumulation in HCD mice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Manman Lu, Yuhui Yang, Yuncong Xu, Xiaoyue Wang, Bo Li, Guowei Le, Yanli Xie
Summary: Dietary methionine restriction (MR) can reduce plasma trimethylamine-N-oxide (TMAO) levels by manipulating gut microbiota in mice. MR decreases the ability of gut microbiota to produce trimethylamine (TMA), reduces TMA levels and expression of choline TMA-lyase (CutC) in the intestine, and increases the abundance of SCFA-producing bacteria.
Article
Food Science & Technology
Clemence Rives, Celine Marie Pauline Martin, Lauris Evariste, Arnaud Polizzi, Marine Huillet, Frederic Lasserre, Valerie Alquier-Bacquie, Prunelle Perrier, Jelskey Gomez, Yannick Lippi, Claire Naylies, Thierry Levade, Frederique Sabourdy, Herve Remignon, Pierre Fafournoux, Benoit Chassaing, Nicolas Loiseau, Herve Guillou, Sandrine Ellero-Simatos, Laurence Gamet-Payrastre, Anne Fougerat
Summary: This study found that dietary intake of free amino acids can prevent the unhealthy metabolic outcomes of a Western diet in male mice. Replacing casein with a free amino acid mixture that mimics its composition prevents weight gain in both male and female mice. Free amino acids in the diet can prevent liver damage and associated changes in liver gene expression only in males. These results indicate that dietary intake of free amino acids can prevent the negative metabolic effects of a Western diet in a sex-specific manner, possibly involving the gut microbiota.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Agriculture, Multidisciplinary
Chuanxing Feng, Yuge Jiang, Guoqing Wu, Yonghui Shi, Yueting Ge, Bowen Li, Xiangrong Cheng, Xue Tang, Jianjin Zhu, Guowei Le
Summary: Methionine restriction improves glucose metabolism by promoting insulin secretion and enhancing glucose uptake and utilization in skeletal muscle. The key regulator H19 plays a crucial role in these processes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Marina Souza Matos, Bettina Platt, Mirela Delibegovic
Summary: With advancements in medical treatments, public health, improved housing, and dietary choices, there has been a significant increase in the aging population in developed countries, leading to a rise in chronic diseases among the elderly. Non-pharmacological dietary interventions such as energetic restriction and methionine restriction have shown promising outcomes in preventing and treating aging-related disorders.
PROCEEDINGS OF THE NUTRITION SOCIETY
(2021)
Article
Food Science & Technology
Yuhui Yang, Manman Lu, Yuncong Xu, Jing Qian, Guowei Le, Yanli Xie
Summary: This study investigated the effects of different dietary methionine levels on hepatic lipid accumulation in mice and found that high dietary methionine intake can promote liver lipid accumulation, inhibit lipid and glycolysis metabolism, and increase oxidative stress and inflammation in the liver. Methionine restriction can reverse these adverse effects.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Endocrinology & Metabolism
Han Fang, Kirsten P. Stone, Laura A. Forney, Desiree Wanders, Thomas W. Gettys
Summary: FGF21 is a potent metabolic regulator that is influenced by dietary protein, specifically methionine restriction, leading to effects on energy balance, adipose tissue remodeling, and insulin sensitivity. Liver functions as a sentinel to detect changes in dietary amino acid composition and mobilizes FGF21 as a key element of the homeostatic response. Therapeutic diets could be developed to increase FGF21 levels through nutritional modulation for sustained biological effects.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Yinghui Wu, Hao Li, Yueyue Miao, Jian Peng, Hongkui Wei
Summary: The study aimed to investigate the impact of methionine restriction on sperm quality in aging mice and found that methionine restriction could alleviate the decline in sperm quality, which may be related to changes in methionine metabolism and inhibition of sperm DNA and RNA methylation.
Article
Nutrition & Dietetics
William O. Jonsson, Nicholas S. Margolies, Emily T. Mirek, Qian Zhang, Melissa A. Linden, Cristal M. Hill, Christopher Link, Nazmin Bithi, Brian Zalma, Jordan L. Levy, Ashley P. Pettit, Joshua W. Miller, Christopher Hine, Christopher D. Morrison, Thomas W. Gettys, Benjamin F. Miller, Karyn L. Hamilton, Ronald C. Wek, Tracy G. Anthony
Summary: The study investigated the role of ATF4 as a converging point in the integrated stress response during dietary sulfur amino acid restriction (SAAR). The results showed that ATF4 is essential for the sustained production of endogenous hydrogen sulfide and also plays a role in inducing hepatokine fibroblast growth factor 21. Additionally, biological sex was found to be a determinant of the response to dietary SAAR independent of ATF4 status.
JOURNAL OF NUTRITION
(2021)