Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagy

UniProt: the universal protein knowledgebase

(2018) The UniProt Consortium   NUCLEIC ACIDS RESEARCH

Integrating genome-wide association study and expression quantitative trait locus study identifies multiple genes and gene sets associated with schizophrenia

(2018) Yan Zhao et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans

(2017) Thomas Wilhelm et al.   GENES & DEVELOPMENT

Distinct roles for motor neuron autophagy early and late in the SOD1G93Amouse model of ALS

(2017) Noam D. Rudnick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paraquat-and Rotenone-Induced Models of Parkinson's Disease

(2017) R. Nisticò et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

An updated review of Parkinson's disease genetics and clinicopathological correlations

(2016) M. Ferreira et al.   ACTA NEUROLOGICA SCANDINAVICA

Simultaneous determination of 8 neurotransmitters and their metabolite levels in rat brain using liquid chromatography in tandem with mass spectrometry: Application to the murine Nrf2 model of depression

(2016) Aneta Wojnicz et al.   CLINICA CHIMICA ACTA

Imputation of DNA Methylation Levels in the Brain Implicates a Risk Factor for Parkinsons Disease

(2016) K. Rawlik et al.   GENETICS

Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression

(2016) Anthony A. Grace   NATURE REVIEWS NEUROSCIENCE

Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

(2016) Patrick P. Michel et al.   NEURON

Transcriptional and epigenetic regulation of autophagy in aging

(2015) Louis R Lapierre et al.   Autophagy

Nicotinamide N-methyltransferase increases complex I activity in SH-SY5Y cells via sirtuin 3

(2015) Karolina Y. Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification and Characterization of Cancer Stem Cells from Head and Neck Squamous Cell Carcinoma Cell Lines

(2015) Valentina Pozzi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Association of Nicotinamide-N-Methyltransferase Gene rs694539 Variant with Epilepsy

(2015) Gensay Sazci et al.   MOLECULAR NEUROBIOLOGY

Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization

(2015) Shangyu Hong et al.   NATURE MEDICINE

Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci

(2015) Eilis Hannon et al.   NATURE NEUROSCIENCE

Methionine is a signal of amino acid sufficiency that inhibits autophagy through the methylation of PP2A

(2014) Sunil Laxman et al.   Autophagy

Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy

(2014) Shintaro Kira et al.   Autophagy

Posttranslational modification of autophagy-related proteins in macroautophagy

(2014) Yangchun Xie et al.   Autophagy

Female Specific Association between NNMT Gene and Schizophrenia in a Han Chinese population

(2014) Guo-xia Wang et al.   International Journal of Medical Sciences

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

(2014) Daniel Kraus et al.   NATURE

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression

(2013) Ju-Xian Song et al.   Autophagy

Methionine Inhibits Autophagy and Promotes Growth by Inducing the SAM-Responsive Methylation of PP2A

(2013) Benjamin M. Sutter et al.   CELL

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

Association of nicotinamide-N-methyltransferase (NNMT) gene rs694539 variant with bipolar disorder

(2013) Ali Sazci et al.   GENE

Neuroprotective Effects of Nicotinamide N -Methyltransferase and its Metabolite 1-Methylnicotinamide

(2013) Zeinab H. Milani et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans

(2013) Julia Bornhorst et al.   Metallomics

Autophagy has a key role in the pathophysiology of schizophrenia

(2013) A Merenlender-Wagner et al.   MOLECULAR PSYCHIATRY

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

(2013) Kathrin Schmeisser et al.   Nature Chemical Biology

NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink

(2013) Olesya A Ulanovskaya et al.   Nature Chemical Biology

Nicotinamide N-methyltransferase expression in SH-SY5Y neuroblastoma and N27 mesencephalic neurones induces changes in cell morphology via ephrin-B2 and Akt signalling

(2013) M G Thomas et al.   Cell Death & Disease

A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans

(2013) Huanhu Zhu et al.   eLife

Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease

(2012) M. F. Keller et al.   HUMAN MOLECULAR GENETICS

Dopamine Signaling Is Essential for Precise Rates of Locomotion by C. elegans

(2012) Daniel T. Omura et al.   PLoS One

Inhibition of autophagy by 3-methyladenine protects 1321N1 astrocytoma cells against pyocyanin- and 1-hydroxyphenazine-induced toxicity

(2011) Amelia J. McFarland et al.   ARCHIVES OF TOXICOLOGY

The expression of nicotinamideN-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors

(2011) Richard B. Parsons et al.   BIOCHEMICAL JOURNAL

Structural Basis of Substrate Recognition in Human NicotinamideN-Methyltransferase

(2011) Yi Peng et al.   BIOCHEMISTRY

Rotenone and Paraquat Linked to Parkinson’s Disease: Human Exposure Study Supports Years of Animal Studies

(2011) Angela Spivey   ENVIRONMENTAL HEALTH PERSPECTIVES

Nicotinamide-N-methyltransferase (NNMT) in schizophrenia: genetic association and decreased frontal cortex mRNA levels

(2011) Anna Bromberg et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Enhanced Autophagy from Chronic Toxicity of Iron and Mutant A53T α-Synuclein

(2011) Katherine C. M. Chew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Hexachlorocyclohexane levels in serum and risk of Parkinson's disease

(2011) Jason R. Richardson et al.   NEUROTOXICOLOGY

Web-Based Genome-Wide Association Study Identifies Two Novel Loci and a Substantial Genetic Component for Parkinson's Disease

(2011) Chuong B. Do et al.   PLoS Genetics

Protein phosphatase 2A cooperates with the autophagy-related kinase UNC-51 to regulate axon guidance in Caenorhabditis elegans

(2010) K. i. Ogura et al.   DEVELOPMENT

The heritability of risk and age at onset of Parkinson's disease after accounting for known genetic risk factors

(2010) Taye H Hamza et al.   JOURNAL OF HUMAN GENETICS

Enhancement of Odor Avoidance Regulated by Dopamine Signaling in Caenorhabditis elegans

(2010) K. D. Kimura et al.   JOURNAL OF NEUROSCIENCE

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Automated High-Content Live Animal Drug Screening Using C. elegans Expressing the Aggregation Prone Serpin α1-antitrypsin Z

(2010) Sager J. Gosai et al.   PLoS One

Age at onset and cognition in schizophrenia: meta-analysis

(2009) T. K. Rajji et al.   BRITISH JOURNAL OF PSYCHIATRY

Schizophrenia: A Concise Overview of Incidence, Prevalence, and Mortality

(2008) J. McGrath et al.   EPIDEMIOLOGIC REVIEWS

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE