Role of the COP9 Signalosome (CSN) in Cardiovascular Diseases

CSN5 inhibition triggers inflammatory signaling and Rho/ROCK-dependent loss of endothelial integrity

(2019) Jisca Majolée et al.   Scientific Reports

Smooth muscle cell fate and plasticity in atherosclerosis

(2018) Sima Allahverdian et al.   CARDIOVASCULAR RESEARCH

NEDD8 — its role in the regulation of Cullin-RING ligases

(2018) Claus Schwechheimer   CURRENT OPINION IN PLANT BIOLOGY

Mif-deficiency favors an atheroprotective autoantibody phenotype in atherosclerosis

(2018) Corinna Schmitz et al.   FASEB JOURNAL

Cytokine MIF Enhances Blood-Brain Barrier Permeability: Impact for Therapy in Ischemic Stroke

(2018) Yu-Chuan Liu et al.   Scientific Reports

Roles of Perivascular Adipose Tissue in the Pathogenesis of Atherosclerosis

(2018) Kimie Tanaka et al.   Frontiers in Physiology

COP9 signalosome subunit 6 mediates PDGF -induced pulmonary arterial smooth muscle cells proliferation

(2018) Yanting Zhu et al.   EXPERIMENTAL CELL RESEARCH

Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase

(2017) Daniel C Scott et al.   Nature Chemical Biology

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo

(2017) Yaw Asare et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Murine Myocardial Transcriptome Analysis Reveals a Critical Role of COPS8 in the Gene Expression of Cullin-RING Ligase Substrate Receptors and Redox and Vesicle Trafficking Pathways

(2017) Ammara Abdullah et al.   Frontiers in Physiology

The Arabidopsis Cop9 signalosome subunit 4 (CSN4) is involved in adventitious root formation

(2017) Daniel Ioan Pacurar et al.   Scientific Reports

Apolipoprotein A-1 binding protein promotes macrophage cholesterol efflux by facilitating apolipoprotein A-1 binding to ABCA1 and preventing ABCA1 degradation

(2016) Min Zhang et al.   ATHEROSCLEROSIS

Adaptive Response of T and B Cells in Atherosclerosis

(2016) Daniel F.J. Ketelhuth et al.   CIRCULATION RESEARCH

Integrins and integrin-related proteins in cardiac fibrosis

(2016) Chao Chen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Targeted inhibition of the COP9 signalosome for treatment of cancer

(2016) Anita Schlierf et al.   Nature Communications

Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle

(2016) Ruzbeh Mosadeghi et al.   eLife

Overexpression of COP9 signalosome subunits, CSN7A and CSN7B, exerts different effects on adipogenic differentiation

(2016) Xiaohua Huang et al.   FEBS Open Bio

Cellular Cholesterol Accumulation Facilitates Ubiquitination and Lysosomal Degradation of Cell Surface-Resident ABCA1

(2015) T. Mizuno et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pevonedistat (MLN4924), a First-in-Class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukaemia and myelodysplastic syndromes: a phase 1 study

(2015) Ronan T. Swords et al.   BRITISH JOURNAL OF HAEMATOLOGY

Regulation of Signal Transduction by Reactive Oxygen Species in the Cardiovascular System

(2015) D. I. Brown et al.   CIRCULATION RESEARCH

COP9 Signalosome Controls the Degradation of Cytosolic Misfolded Proteins and Protects Against Cardiac ProteotoxicityNovelty and Significance

(2015) Huabo Su et al.   CIRCULATION RESEARCH

Phase I Study of the Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (TAK-924/MLN4924) in Patients with Advanced Solid Tumors

(2015) J. Sarantopoulos et al.   CLINICAL CANCER RESEARCH

Diversity of COP9 signalosome structures and functional consequences

(2015) Dawadschargal Dubiel et al.   FEBS LETTERS

Endothelial Hypoxia-Inducible Factor-1α Promotes Atherosclerosis and Monocyte Recruitment by Upregulating MicroRNA-19a

(2015) Shamima Akhtar et al.   HYPERTENSION

Recent insights into the cellular biology of atherosclerosis

(2015) Ira Tabas et al.   JOURNAL OF CELL BIOLOGY

Inhibition of ABCA1 protein degradation promotes HDL cholesterol efflux capacity and RCT and reduces atherosclerosis in mice

(2015) LinZhang Huang et al.   JOURNAL OF LIPID RESEARCH

Protein neddylation: beyond cullin–RING ligases

(2015) Radoslav I. Enchev et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of Plaque Formation and Rupture

(2014) Jacob Fog Bentzon et al.   CIRCULATION RESEARCH

Activation of AMPK inhibits pulmonary arterial smooth muscle cells proliferation

(2014) Yuanyuan Wu et al.   EXPERIMENTAL LUNG RESEARCH

Baicalin Inhibits Hypoxia-Induced Pulmonary Artery Smooth Muscle Cell Proliferation via the AKT/HIF-1α/p27-Associated Pathway

(2014) Lin Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cardiovascular remodelling in coronary artery disease and heart failure

(2014) Gerd Heusch et al.   LANCET

Corralling a protein-degradation regulator

(2014) Raymond J. Deshaies   NATURE

Crystal structure of the human COP9 signalosome

(2014) Gondichatnahalli M. Lingaraju et al.   NATURE

The inflammatory response in myocardial injury, repair and remodelling

(2014) Nikolaos G. Frangogiannis   Nature Reviews Cardiology

Structure of the Rpn11–Rpn8 dimer reveals mechanisms of substrate deubiquitination during proteasomal degradation

(2014) Evan J Worden et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Endothelin-1 Overexpression Exacerbates Atherosclerosis and Induces Aortic Aneurysms in Apolipoprotein E Knockout Mice

(2013) Melissa W. Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Impaired Assembly and Post-translational Regulation of 26S Proteasome in Human End-Stage Heart Failure

(2013) Sharlene M. Day et al.   Circulation-Heart Failure

The COP9 Signalosome Is Required for Autophagy, Proteasome-Mediated Proteolysis, and Cardiomyocyte Survival in Adult Mice

(2013) Huabo Su et al.   Circulation-Heart Failure

Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes

(2013) Oliver Soehnlein et al.   EMBO Molecular Medicine

COP9 Signalosome Subunit Csn8 Is Involved in Maintaining Proper Duration of the G1Phase

(2013) Cheng Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelin Receptor Signaling: New Insight Into Its Regulatory Mechanisms

(2013) Takahiro Horinouchi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Deletion of macrophage migration inhibitory factor worsens stroke outcome in female mice

(2013) L. Christine Turtzo et al.   NEUROBIOLOGY OF DISEASE

Endothelial CSN5 impairs NF-κB activation and monocyte adhesion to endothelial cells and is highly expressed in human atherosclerotic lesions

(2013) Yaw Asare et al.   THROMBOSIS AND HAEMOSTASIS

Hypoxia in murine atherosclerotic plaques and its adverse effects on macrophages

(2013) Saj Parathath et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Inflammation in Atherosclerosis

(2012) Peter Libby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sex, stroke, and inflammation: The potential for estrogen-mediated immunoprotection in stroke

(2012) Rodney M. Ritzel et al.   HORMONES AND BEHAVIOR

Inhibition of Neddylation Represses Lipopolysaccharide-induced Proinflammatory Cytokine Production in Macrophage Cells

(2012) Fang-Mei Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Central Role for Endothelial Human Deneddylase-1/SENP8 in Fine-Tuning the Vascular Inflammatory Response

(2012) S. F. Ehrentraut et al.   JOURNAL OF IMMUNOLOGY

Hypoxic preconditioning induces stroke tolerance in mice via a cascading HIF, sphingosine kinase, and CCL2 signaling pathway

(2012) Bradley K. Wacker et al.   JOURNAL OF NEUROCHEMISTRY

Structural Basis for a Reciprocal Regulation between SCF and CSN

(2012) Radoslav I. Enchev et al.   Cell Reports

The COP9 signalosome, cullin 3 and Keap1 supercomplex regulates CHOP stability and adipogenesis

(2012) X. Huang et al.   Biology Open

Desmin-related cardiomyopathy: an unfolding story

(2011) Patrick M. McLendon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hematopoietic progenitor migration to the adult thymus

(2011) Daniel A. Zlotoff et al.   Annals of the New York Academy of Sciences

Epigenetic Control of Smooth Muscle Cell Differentiation and Phenotypic Switching in Vascular Development and Disease

(2011) Matthew R. Alexander et al.   Annual Review of Physiology

Proteasomal Inhibition Promotes ATP-Binding Cassette Transporter A1 (ABCA1) and ABCG1 Expression and Cholesterol Efflux From Macrophages In Vitro and In Vivo

(2011) Masatsune Ogura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Calpain-mediated ABCA1 degradation: Post-translational regulation of ABCA1 for HDL biogenesis

(2011) Shinji Yokoyama et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling

(2011) R. A. McDonald et al.   CARDIOVASCULAR RESEARCH

The Molecular Basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting, and Activation

(2011) Eric S. Fischer et al.   CELL

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Roles of COP9 signalosome in cancer

(2011) Mong-Hong Lee et al.   CELL CYCLE

COP9 Signalosome Regulates Autophagosome Maturation

(2011) Huabo Su et al.   CIRCULATION

Extramedullary Hematopoiesis Generates Ly-6C high Monocytes That Infiltrate Atherosclerotic Lesions

(2011) Clinton S. Robbins et al.   CIRCULATION

Hypoxia Is Present in Murine Atherosclerotic Plaques and Has Multiple Adverse Effects on Macrophage Lipid Metabolism

(2011) Sajesh Parathath et al.   CIRCULATION RESEARCH

Perivascular adipose tissue: more than just structural support

(2011) Theodora Szasz et al.   CLINICAL SCIENCE

Activator protein-1 (AP-1) signalling in human atherosclerosis: results of a systematic evaluation and intervention study

(2011) C. Arnoud Meijer et al.   CLINICAL SCIENCE

The ubiquitin–proteasome system in cardiomyopathies

(2011) Saskia Schlossarek et al.   CURRENT OPINION IN CARDIOLOGY

Structural regulation of cullin-RING ubiquitin ligase complexes

(2011) David M Duda et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Chemokines: established and novel targets in atherosclerosis

(2011) Rory R. Koenen et al.   EMBO Molecular Medicine

Relationship between location and size of myocardial infarction and their reciprocal influences on post-infarction left ventricular remodelling

(2011) P. G. Masci et al.   EUROPEAN HEART JOURNAL

The immune system in atherosclerosis

(2011) Göran K Hansson et al.   NATURE IMMUNOLOGY

Atherosclerosis: current pathogenesis and therapeutic options

(2011) Christian Weber et al.   NATURE MEDICINE

Adaptive immunity in atherosclerosis: mechanisms and future therapeutic targets

(2011) Charlotte Lahoute et al.   Nature Reviews Cardiology

COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σ

(2011) H H Choi et al.   ONCOGENE

Left Ventricular Remodeling in Heart Failure

(2011) Marvin A. Konstam et al.   JACC-Cardiovascular Imaging

Control of NF-κB activation by the COP9 signalosome

(2010) Katrin Schweitzer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF- B-dependent lymphoma

(2010) M. A. Milhollen et al.   BLOOD

Sent to Destroy

(2010) Monte S. Willis et al.   CIRCULATION RESEARCH

Perturbation of Cullin Deneddylation via Conditional Csn8 Ablation Impairs the Ubiquitin–Proteasome System and Causes Cardiomyocyte Necrosis and Dilated Cardiomyopathy in Mice

(2010) Huabo Su et al.   CIRCULATION RESEARCH

Adaptive T cell immune responses and atherogenesis

(2010) Soraya Taleb et al.   CURRENT OPINION IN PHARMACOLOGY

Structural assembly of cullin-RING ubiquitin ligase complexes

(2010) Erik S Zimmerman et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Hypoxia-inducible Factor α Subunit Stabilization by NEDD8 Conjugation Is Reactive Oxygen Species-dependent

(2010) Ji-Hye Ryu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage Migration Inhibitory Factor Promotes Cell Death and Aggravates Neurologic Deficits after Experimental Stroke

(2010) Ana R Inácio et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study

(2010) Martin J O'Donnell et al.   LANCET

Hypoxia: an alarm signal during intestinal inflammation

(2010) Sean P. Colgan et al.   Nature Reviews Gastroenterology & Hepatology

The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBP  for degradation

(2010) M. T. Bengoechea-Alonso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune and Inflammatory Mechanisms of Atherosclerosis

(2009) Elena Galkina et al.   Annual Review of Immunology

The COP9 signalosome controls ubiquitinylation of ABCA1

(2009) Yuya Azuma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Jab1 regulates levels of endothelin type A and B receptors by promoting ubiquitination and degradation

(2009) Arata Nishimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of ERK/MAPK in endothelin receptor signaling in human aortic smooth muscle cells

(2009) Qing-wen Chen et al.   BMC CELL BIOLOGY

Revisiting the COP9 signalosome as a transcriptional regulator

(2009) Daniel A Chamovitz   EMBO REPORTS

Mechanisms of macrophage migration inhibitory factor (MIF)-dependent tumor microenvironmental adaptation

(2009) Beatriz E. Rendon et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Mammalian COP9 signalosome

(2009) Jun-ya Kato et al.   GENES TO CELLS

Crosstalk between the NF-κB activating IKK-complex and the CSN signalosome

(2009) Lukas Orel et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Obesity, inflammation, and atherosclerosis

(2009) Viviane Z. Rocha et al.   Nature Reviews Cardiology

PPAR-γ AF-2 Domain Functions as a Component of a Ubiquitin-dependent Degradation Signal

(2009) Gail E. Kilroy et al.   Obesity

Symmetrical Modularity of the COP9 Signalosome Complex Suggests its Multifunctionality

(2009) Michal Sharon et al.   STRUCTURE

Chemokines in Atherosclerosis

(2008) Alma Zernecke et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The ubiquitin–proteasome system in cardiac dysfunction

(2008) Giulia Mearini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment

(2008) G. Stoll et al.   BLOOD

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Subunit 3 of the COP9 Signalosome Is Poised to Facilitate Communication between the Extracellular Matrix and the Nucleus through the Muscle-Specific β1D Integrin

(2008) Chris Hunter et al.   CELL COMMUNICATION AND ADHESION

Endothelial Cell-Specific NF-κB Inhibition Protects Mice from Atherosclerosis

(2008) Ralph Gareus et al.   Cell Metabolism

Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6C hi and Ly6C lo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

(2008) Christophe Combadière et al.   CIRCULATION

CDK Inhibitors: Cell Cycle Regulators and Beyond

(2008) Arnaud Besson et al.   DEVELOPMENTAL CELL

The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription

(2008) Huabo Su et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Targeted inactivation of the COP9 signalosome impairs multiple stagesof T cell development

(2008) Martina Panattoni et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypoxia, Hypoxia-Inducible Transcription Factor, and Macrophages in Human Atherosclerotic Plaques Are Correlated With Intraplaque Angiogenesis

(2008) Judith C. Sluimer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

(2008) Yusuke Sato et al.   NATURE

The COP9 signalosome: more than a protease

(2008) N WEI et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of Cullin RING Ligases

(2007) Sara K. Hotton et al.   Annual Review of Plant Biology

JAB1 accelerates mitochondrial apoptosis by interaction with proapoptotic BclGs

(2007) Xiangjun Liu et al.   CELLULAR SIGNALLING

Roles for CSN5 in control of p53/MDM2 activities

(2007) Xiao-Chun Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY