Immunogenic Cell Death and Immunotherapy of Multiple Myeloma

Proteasome inhibitors for the treatment of multiple myeloma

(2018) Emilia Scalzulli et al.   EXPERT OPINION ON PHARMACOTHERAPY

At the crossway of ER-stress and proinflammatory responses

(2018) Marisa Reverendo et al.   FEBS Journal

Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications

(2018) Aitor Almanza et al.   FEBS Journal

Relevance of the chaperone-like protein calreticulin for the biological behavior and clinical outcome of cancer

(2018) Jitka Fucikova et al.   IMMUNOLOGY LETTERS

Immunogenic Apoptosis as a Novel Tool for Anticancer Vaccine Development

(2018) Barbara Montico et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Critical Interactions between Immunogenic Cancer Cell Death, Oncolytic Viruses, and the Immune System Define the Rational Design of Combination Immunotherapies

(2018) Jacob P. van Vloten et al.   JOURNAL OF IMMUNOLOGY

Necroptosis: a regulated inflammatory mode of cell death

(2018) Yogesh K. Dhuriya et al.   Journal of Neuroinflammation

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combining chemotherapy with PD-1 blockade in NSCLC

(2018) Matthen Mathew et al.   PHARMACOLOGY & THERAPEUTICS

Significance of calreticulin as a prognostic factor in endometrial cancer

(2018) Qin Xu et al.   Oncology Letters

Expansion of allogeneic NK cells with efficient antibody-dependent cell cytotoxicity against multiple tumors

(2018) Diego Sanchez-Martinez et al.   Theranostics

Regulation of Cytokine Production by the Unfolded Protein Response; Implications for Infection and Autoimmunity

(2018) Judith A. Smith   Frontiers in Immunology

IMiDs through loss of Ikaros and Aiolos primes myeloma cells for daratumumab mediated killing by upregulation of CD38

(2018) Pasquale L. Fedele et al.   BLOOD

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Drug resistance in multiple myeloma

(2018) Pawel Robak et al.   CANCER TREATMENT REVIEWS

Role of Proteasome Inhibitors in Relapsed and/or Refractory Multiple Myeloma

(2018) Xavier Leleu et al.   Clinical Lymphoma Myeloma & Leukemia

Targeting B Cell Maturation Antigen (BCMA) in Multiple Myeloma: Potential Uses of BCMA-Based Immunotherapy

(2018) Shih-Feng Cho et al.   Frontiers in Immunology

CD38 Antibodies in Multiple Myeloma: Mechanisms of Action and Modes of Resistance

(2018) Niels W.C.J. van de Donk et al.   Frontiers in Immunology

Checkpoint Inhibition in Myeloma: Opportunities and Challenges

(2018) Federica Costa et al.   Frontiers in Immunology

Translating the anti-myeloma activity of Natural Killer cells into clinical application

(2018) Cinzia Fionda et al.   CANCER TREATMENT REVIEWS

The challenges of checkpoint inhibition in the treatment of multiple myeloma

(2018) Barry Paul et al.   CELLULAR IMMUNOLOGY

Immunotherapy: A Novel Era of Promising Treatments for Multiple Myeloma

(2018) Maria Castella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting B-cell maturation antigen with GSK2857916 antibody–drug conjugate in relapsed or refractory multiple myeloma (BMA117159): a dose escalation and expansion phase 1 trial

(2018) Suzanne Trudel et al.   LANCET ONCOLOGY

Is immunotherapy here to stay in multiple myeloma?

(2017) Paula Rodríguez-Otero et al.   HAEMATOLOGICA

Suppression of T cells by myeloid-derived suppressor cells in cancer

(2017) Jieying Chen et al.   HUMAN IMMUNOLOGY

Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses

(2017) Abhishek D. Garg et al.   IMMUNOLOGICAL REVIEWS

Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors

(2017) Raffaella Iurlaro et al.   MOLECULAR AND CELLULAR BIOLOGY

The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling

(2017) Alexander R. van Vliet et al.   MOLECULAR CELL

Proteasome inhibitors in cancer therapy

(2017) Elisabet E. Manasanch et al.   Nature Reviews Clinical Oncology

Role of Immunotherapy in Targeting the Bone Marrow Microenvironment in Multiple Myeloma: An Evolving Therapeutic Strategy

(2017) Clement Chung   PHARMACOTHERAPY

Human DKK1 and human HSP70 fusion DNA vaccine induces an effective anti-tumor efficacy in murine multiple myeloma

(2017) Ting-Ting Liu et al.   Oncotarget

Bone marrow micro-environment is a crucial player for myelomagenesis and disease progression

(2017) Patrizia Mondello et al.   Oncotarget

Is immunotherapy here to stay in multiple myeloma?

(2017) Paula Rodríguez-Otero et al.   HAEMATOLOGICA

Calreticulin Release at an Early Stage of Death Modulates the Clearance by Macrophages of Apoptotic Cells

(2017) Rim Osman et al.   Frontiers in Immunology

Severe, but not mild heat-shock treatment induces immunogenic cell death in cancer cells

(2017) Irena Adkins et al.   OncoImmunology

Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics

(2017) Abhishek D. Garg et al.   OncoImmunology

Unfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancer

(2017) Juan R. Cubillos-Ruiz et al.   Journal for ImmunoTherapy of Cancer

Endoplasmic Reticulum Stress, Unfolded Protein Response, and Cancer Cell Fate

(2017) Marco Corazzari et al.   Frontiers in Oncology

When under pressure, get closer: PERKing up membrane contact sites during ER stress

(2016) Alexander R. van Vliet et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

MDSCs in cancer: Conceiving new prognostic and therapeutic targets

(2016) Francesco De Sanctis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Calreticulin exposure by malignant blasts correlates with robust anticancer immunity and improved clinical outcome in AML patients

(2016) J. Fucikova et al.   BLOOD

Myeloid-derived suppressor cells: The green light for myeloma immune escape

(2016) Ehsan Malek et al.   BLOOD REVIEWS

Inhibition of autophagy with chloroquine potentiates carfilzomib-induced apoptosis in myeloma cells in vitro and in vivo

(2016) Vidal Jarauta et al.   CANCER LETTERS

Repression of Mcl-1 and disruption of the Mcl-1/Bak interaction in myeloma cells couple ER stress to mitochondrial apoptosis

(2016) Patricia Gomez-Bougie et al.   CANCER LETTERS

Calreticulin Expression in Human Non–Small Cell Lung Cancers Correlates with Increased Accumulation of Antitumor Immune Cells and Favorable Prognosis

(2016) Jitka Fucikova et al.   CANCER RESEARCH

Immune responses in multiple myeloma: role of the natural immune surveillance and potential of immunotherapies

(2016) Camille Guillerey et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The T Cell in Myeloma

(2016) Douglas Joshua et al.   Clinical Lymphoma Myeloma & Leukemia

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

(2016) Christina Pfirschke et al.   IMMUNITY

Nivolumab in Patients With Relapsed or Refractory Hematologic Malignancy: Preliminary Results of a Phase Ib Study

(2016) Alexander M. Lesokhin et al.   JOURNAL OF CLINICAL ONCOLOGY

The C-Terminal Acidic Region of Calreticulin Mediates Phosphatidylserine Binding and Apoptotic Cell Phagocytosis

(2016) Sanjeeva Joseph Wijeyesakere et al.   JOURNAL OF IMMUNOLOGY

Daratumumab monotherapy in patients with treatment-refractory multiple myeloma (SIRIUS): an open-label, randomised, phase 2 trial

(2016) Sagar Lonial et al.   LANCET

Oxidative stress and proteasome inhibitors in multiple myeloma

(2016) Brittany C. Lipchick et al.   PHARMACOLOGICAL RESEARCH

Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell–driven rejection of high-grade glioma

(2016) Abhishek D. Garg et al.   Science Translational Medicine

Granulocyte-like myeloid derived suppressor cells (G-MDSC) are increased in multiple myeloma and are driven by dysfunctional mesenchymal stem cells (MSC)

(2016) Cesarina Giallongo et al.   Oncotarget

Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity

(2016) Tania Løve Aaes et al.   Cell Reports

Exploiting the Immunogenic Potential of Cancer Cells for Improved Dendritic Cell Vaccines

(2016) Lien Vandenberk et al.   Frontiers in Immunology

Calreticulin expression: Interaction with the immune infiltrate and impact on survival in patients with ovarian and non-small cell lung cancer

(2016) Gautier Stoll et al.   OncoImmunology

Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy

(2016) Heng Yang et al.   OncoImmunology

Multiple Mechanisms of Unfolded Protein Response–Induced Cell Death

(2015) Nobuhiko Hiramatsu et al.   AMERICAN JOURNAL OF PATHOLOGY

Induction of Immunogenic Cell Death by Chemotherapeutic Platinum Complexes

(2015) Daniel Yuan Qiang Wong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Concurrent MEK and autophagy inhibition is required to restore cell death associated danger-signalling in Vemurafenib-resistant melanoma cells

(2015) S. Martin et al.   BIOCHEMICAL PHARMACOLOGY

Dendritic cells accumulate in the bone marrow of myeloma patients where they protect tumor plasma cells from CD8+ T-cell killing

(2015) P. Leone et al.   BLOOD

Antitumor Immunity Triggered by Melphalan Is Potentiated by Melanoma Cell Surface-Associated Calreticulin

(2015) A. M. Dudek-Peri  et al.   CANCER RESEARCH

Lenalidomide Enhances Immune Checkpoint Blockade-Induced Immune Response in Multiple Myeloma

(2015) G. Gorgun et al.   CLINICAL CANCER RESEARCH

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Immunogenic cell death

(2015) Abhishek D. Garg et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure induce strong immune responses and display therapeutic effects both in murine TC-1 and TRAMP-C2 tumors when combined with docetaxel chemotherapy

(2015) ROMANA MIKYŠKOVÁ et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Prospective molecular monitoring of minimal residual disease after non-myeloablative allografting in newly diagnosed multiple myeloma

(2015) M Ladetto et al.   LEUKEMIA

PD-L1/PD-1 presence in the tumor microenvironment and activity of PD-1 blockade in multiple myeloma

(2015) B Paiva et al.   LEUKEMIA

Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components

(2015) Tien-Jen Lin et al.   Molecular Cancer

NY-ESO-1–specific TCR–engineered T cells mediate sustained antigen-specific antitumor effects in myeloma

(2015) Aaron P Rapoport et al.   NATURE MEDICINE

Live to die another way: modes of programmed cell death and the signals emanating from dying cells

(2015) Yaron Fuchs et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Elotuzumab Therapy for Relapsed or Refractory Multiple Myeloma

(2015) Sagar Lonial et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma

(2015) Henk M. Lokhorst et al.   NEW ENGLAND JOURNAL OF MEDICINE

RIPK1 and NF- B signaling in dying cells determines cross-priming of CD8+ T cells

(2015) N. Yatim et al.   SCIENCE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions

(2015) Kohsuke Kanekura et al.   Science Signaling

Adoptive transfer of activated marrow-infiltrating lymphocytes induces measurable antitumor immunity in the bone marrow in multiple myeloma

(2015) Kimberly A. Noonan et al.   Science Translational Medicine

Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

(2015) David L. Porter et al.   Science Translational Medicine

The PERKs of damage-associated molecular patterns mediating cancer immunogenicity: From sensor to the plasma membrane and beyond

(2015) A.R. van Vliet et al.   SEMINARS IN CANCER BIOLOGY

Immunomodulatory molecule PD-L1 is expressed on malignant plasma cells and myeloma-propagating pre-plasma cells in the bone marrow of multiple myeloma patients

(2015) S Yousef et al.   Blood Cancer Journal

IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions

(2015) Kohsuke Kanekura et al.   Science Signaling

Combinatorial Strategies for the Induction of Immunogenic Cell Death

(2015) Lucillia Bezu et al.   Frontiers in Immunology

Mechanisms of Translocation of ER Chaperones to the Cell Surface and Immunomodulatory Roles in Cancer and Autoimmunity

(2015) Valerie R. Wiersma et al.   Frontiers in Oncology

Elevated endoplasmic reticulum stress reinforced immunosuppression in the tumor microenvironment via myeloid-derived suppressor cells

(2015) Bo-Ra Lee et al.   Oncotarget

Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells

(2014) J. Wang et al.   BLOOD

FOXP3 and CTLA4 overexpression in multiple myeloma bone marrow as a sign of accumulation of CD4+ T regulatory cells

(2014) Walter Moises Tobias Braga et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Gemcitabine-treated pancreatic cancer cell medium induces the specific CTL antitumor activity by stimulating the maturation of dendritic cells

(2014) Qingshan Pei et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant

(2014) Rebecca Saenz et al.   Journal of Translational Medicine

Clinical use of dendritic cells for cancer therapy

(2014) Sébastien Anguille et al.   LANCET ONCOLOGY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Clinical Efficacy of Tumor Antigen-Pulsed DC Treatment for High-Grade Glioma Patients: Evidence from a Meta-Analysis

(2014) Jun-Xia Cao et al.   PLoS One

Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 Complex

(2014) Nicole C. McKnight et al.   PLoS Genetics

Physical modalities inducing immunogenic tumor cell death for cancer immunotherapy

(2014) Irena Adkins et al.   OncoImmunology

Screening of novel immunogenic cell death inducers within the NCI Mechanistic Diversity Set

(2014) Abdul Qader Sukkurwala et al.   OncoImmunology

ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death

(2013) Abhishek D. Garg et al.   Autophagy

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma

(2013) G. P. Linette et al.   BLOOD

Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity

(2013) C. Atkins et al.   CANCER RESEARCH

Danger signalling during cancer cell death: origins, plasticity and regulation

(2013) A D Garg et al.   CELL DEATH AND DIFFERENTIATION

Molecular mechanisms of ATP secretion during immunogenic cell death

(2013) I Martins et al.   CELL DEATH AND DIFFERENTIATION

Vaccination with Dendritic Cell/Tumor Fusions following Autologous Stem Cell Transplant Induces Immunologic and Clinical Responses in Multiple Myeloma Patients

(2013) J. Rosenblatt et al.   CLINICAL CANCER RESEARCH

Crosstalk between ER stress and immunogenic cell death

(2013) Oliver Kepp et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Enhanced cross-priming of naive CD8+T cells by dendritic cells treated by the IMiDs®immunomodulatory compounds lenalidomide and pomalidomide

(2013) Jake Y. Henry et al.   IMMUNOLOGY

Overexpression of Calreticulin Contributes to the Development and Progression of Pancreatic Cancer

(2013) Weiwei Sheng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development

(2013) Jeffrey M. Axten et al.   ACS Medicinal Chemistry Letters

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Spatiotemporal autophagic degradation of oxidatively damaged organelles after photodynamic stress is amplified by mitochondrial reactive oxygen species

(2012) Noemi Rubio et al.   Autophagy

Maturation of autophagosomes and endosomes: A key role for Rab7

(2012) Juha M.T. Hyttinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Blockade of XBP1 splicing by inhibition of IRE1  is a promising therapeutic option in multiple myeloma

(2012) N. Mimura et al.   BLOOD

Photodynamic therapy-mediated DC immunotherapy is highly effective for the inhibition of established solid tumors

(2012) Nam-Chul Jung et al.   CANCER LETTERS

Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma

(2012) S. Jube et al.   CANCER RESEARCH

Immunogenic Tumor Cell Death Induced by Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma

(2012) Yoshiyuki Suzuki et al.   CANCER RESEARCH

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

PDT-induced HSP70 externalization up-regulates NO production via TLR2 signal pathway in macrophages

(2012) Sheng Song et al.   FEBS LETTERS

Evaluation of anti-inflammatory activity of Typha angustifolia pollen grains extracts in experimental animals

(2012) ArchanaR Juvekar et al.   INDIAN JOURNAL OF PHARMACOLOGY

Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking

(2012) H. J. Kim et al.   JOURNAL OF CELL SCIENCE

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Marrow stromal cells induce B7-H1 expression on myeloma cells, generating aggressive characteristics in multiple myeloma

(2012) H Tamura et al.   LEUKEMIA

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(2012) Huan Yang et al.   MOLECULAR MEDICINE

Cell-Extrinsic Effects of Tumor ER Stress Imprint Myeloid Dendritic Cells and Impair CD8+ T Cell Priming

(2012) Navin R. Mahadevan et al.   PLoS One

Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death

(2012) L. Menger et al.   Science Translational Medicine

The emergence of phox-ER stress induced immunogenic apoptosis

(2012) Abhishek D. Garg et al.   OncoImmunology

The convergence of radiation and immunogenic cell death signaling pathways

(2012) Encouse B. Golden et al.   Frontiers in Oncology

Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin

(2011) Abhishek D. Garg et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Measles virus causes immunogenic cell death in human melanoma

(2011) O G Donnelly et al.   GENE THERAPY

Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1

(2011) S. C. W. Ling et al.   HAEMATOLOGICA

Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics

(2011) Roberto Bravo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Contribution of IL-17–producing γδ T cells to the efficacy of anticancer chemotherapy

(2011) Yuting Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endoplasmic Reticulum Calcium Depletion Impacts Chaperone Secretion, Innate Immunity, and Phagocytic Uptake of Cells

(2011) L. R. Peters et al.   JOURNAL OF IMMUNOLOGY

Tumor-Produced Secreted Form of Binding of Immunoglobulin Protein Elicits Antigen-Specific Tumor Immunity

(2011) Yasuaki Tamura et al.   JOURNAL OF IMMUNOLOGY

Investigations on the C1q–Calreticulin–Phosphatidylserine Interactions Yield New Insights into Apoptotic Cell Recognition

(2011) Helena Païdassi et al.   JOURNAL OF MOLECULAR BIOLOGY

Initial genome sequencing and analysis of multiple myeloma

(2011) Michael A. Chapman et al.   NATURE

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

(2011) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Low dose hypericin-PDT induces complete tumor regression in BALB/c mice bearing CT26 colon carcinoma

(2011) Renata Sanovic et al.   Photodiagnosis and Photodynamic Therapy

Compromising the Unfolded Protein Response Induces Autophagy-Mediated Cell Death in Multiple Myeloma Cells

(2011) Anne-Sophie Michallet et al.   PLoS One

The Role of PKR/eIF2α Signaling Pathway in Prognosis of Non-Small Cell Lung Cancer

(2011) Yong He et al.   PLoS One

Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells

(2011) N. R. Mahadevan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

CD91-dependent programming of T-helper cell responses following heat shock protein immunization

(2011) Sudesh Pawaria et al.   Nature Communications

Adjuvant Immunotherapy with Whole-Cell Lysate Dendritic Cells Vaccine for Glioblastoma Multiforme: A Phase II Clinical Trial

(2011) Der-Yang Cho et al.   World Neurosurgery

CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis

(2010) Sophie C. Cazanave et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

HMGB1 and RAGE in Inflammation and Cancer

(2010) Gary P. Sims et al.   Annual Review of Immunology

Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat

(2010) Diego Rodriguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

XBP1s levels are implicated in the biology and outcome of myeloma mediating different clinical outcomes to thalidomide-based treatments

(2010) T. Bagratuni et al.   BLOOD

Vaccination with dendritic cell/tumor fusion cells results in cellular and humoral antitumor immune responses in patients with multiple myeloma

(2010) J. Rosenblatt et al.   BLOOD

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

(2010) I. Papandreou et al.   BLOOD

Multiple myeloma: biology of the disease

(2010) Anuj Mahindra et al.   BLOOD REVIEWS

Targeting ER stress induced apoptosis and inflammation in cancer

(2010) Tom Verfaillie et al.   CANCER LETTERS

Improved Clinical Outcome in Indolent B-Cell Lymphoma Patients Vaccinated with Autologous Tumor Cells Experiencing Immunogenic Death

(2010) R. Zappasodi et al.   CANCER RESEARCH

Cyclophosphamide Synergizes with Type I Interferons through Systemic Dendritic Cell Reactivation and Induction of Immunogenic Tumor Apoptosis

(2010) G. Schiavoni et al.   CANCER RESEARCH

Bcl-2 proteins regulate ER membrane permeability to luminal proteins during ER stress-induced apoptosis

(2010) X Wang et al.   CELL DEATH AND DIFFERENTIATION

Programmed death-1 upregulation is correlated with dysfunction of tumor-infiltrating CD8+ T lymphocytes in human non-small cell lung cancer

(2010) Yan Zhang et al.   Cellular & Molecular Immunology

Towards effective immunotherapy of myeloma: enhanced elimination of myeloma cells by combination of lenalidomide with the human CD38 monoclonal antibody daratumumab

(2010) M. S. van der Veer et al.   HAEMATOLOGICA

Autophagy pathways activated in response to PDT contribute to cell resistance against ROS damage

(2010) Michael Dewaele et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+T cell dysfunction in melanoma patients

(2010) Julien Fourcade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Mechanism of Release of Calreticulin from Cells During Apoptosis

(2010) Joanna M. Tarr et al.   JOURNAL OF MOLECULAR BIOLOGY

High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation

(2010) Chuan-Yong Mu et al.   MEDICAL ONCOLOGY

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

(2010) Philip W. Kantoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Restoration of the immunogenicity of cisplatin-induced cancer cell death by endoplasmic reticulum stress

(2010) I Martins et al.   ONCOGENE

Dendritic cell vaccination in human melanoma: relationships between clinical effects and vaccine parameters

(2010) Noriaki Nakai et al.   Pigment Cell & Melanoma Research

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

(2010) D. Ren et al.   SCIENCE

Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

(2010) M. P. Chao et al.   Science Translational Medicine

Expression of calreticulin is associated with infiltration of T-cells in stage IIIB colon cancer

(2010) Rui-Qing Peng   WORLD JOURNAL OF GASTROENTEROLOGY

Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum

(2009) Marek Michalak et al.   BIOCHEMICAL JOURNAL

Immunogenic cell death, DAMPs and anticancer therapeutics: An emerging amalgamation

(2009) Abhishek D. Garg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features

(2009) T Vanden Berghe et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL

Regulation of Endoplasmic Reticulum Stress-induced Cell Death by ATF4 in Neuroectodermal Tumor Cells

(2009) Jane L. Armstrong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Immunogenic death of colon cancer cells treated with oxaliplatin

(2009) A Tesniere et al.   ONCOGENE

Identification of Calreticulin as a Prognosis Marker and Angiogenic Regulator in Human Gastric Cancer

(2008) Chiung-Nien Chen et al.   ANNALS OF SURGICAL ONCOLOGY

Cooperation between Apo2L/TRAIL and bortezomib in multiple myeloma apoptosis

(2008) Patricia Balsas et al.   BIOCHEMICAL PHARMACOLOGY

Post-apoptotic tumors are more palatable to dendritic cells and enhance their antigen cross-presentation activity

(2008) Davide Brusa et al.   VACCINE