Review
Oncology
Lin Tang, Rui Zhang, Xiaoyu Zhang, Li Yang
Summary: In the past few decades, there has been significant progress in the clinical application of DC vaccines loaded with personalized neoantigens, showing potential as safe and effective treatment strategies in patients with melanoma and glioblastoma. Despite their stability and safety, there are still various factors limiting the effectiveness of DC vaccines.
FRONTIERS IN ONCOLOGY
(2021)
Review
Microbiology
Sauson Soldozy, Daniel G. Eichberg, Alexis A. Morell, Evan Luther, Victor M. Lu, Dominique M. O. Higgins, Nitesh V. Patel, Ashish H. Shah, Simon J. Hanft, Ricardo J. Komotar, Michael E. Ivan
Summary: The incidence of brain tumors, particularly glioblastoma, is increasing. Current treatments have limited success, highlighting the need for new strategies. Oncolytic virotherapy shows promise as a robust and effective treatment for brain tumors, with ongoing clinical trials for high-grade glioma. The unique properties of the nervous system and heterogeneity of brain tumors make oncolytic viruses a potential solution, with the ability for genetic modification and direct inoculation.
Article
Oncology
Hao Zhang, Zhiyang Chen, Zeyu Wang, Ziyu Dai, Zhengang Hu, Xun Zhang, Min Hu, Zhixiong Liu, Quan Cheng
Summary: APOBEC3B expression level is high in advanced gliomas and other cancer types, correlating with poorer prognosis. It can impact patient survival and is significantly associated with infiltrating immune and stromal cell types in the tumor microenvironment. Additionally, APOBEC3B is involved in tumor mutation and regulation of oncogenic genes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Clinical Neurology
Yu Tung Lo, Hyunkyung Lee, Cher Shui, Nayan Lamba, Rasika Korde, Sharmila Devi, Shreya Chawla, Younjong Nam, Romel Patel, Joanne Doucette, Adomas Bunevicius, Rania A. Mekary
Summary: The meta-analysis found that iMRI improved gross total resection in gliomas, especially for low-grade gliomas. However, there was no demonstrated benefit in terms of progression-free survival (PFS) and overall survival (OS).
WORLD NEUROSURGERY
(2021)
Review
Pharmacology & Pharmacy
Yanan Xu, Haijing Guan, Kefu Yu, Nan Ji, Zhigang Zhao
Summary: This study compared the efficacy and safety of treatments for patients with recurrent high-grade gliomas. The results showed that regorafenib and bevacizumab plus lomustine (90 mg/m(2)) improved overall survival, but had lower objective response rates in these patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Zhile Wang, Fucun Xie, Yijun Wu, Li Wang, Yi Bai, Junyu Long, Xiang Wang
Summary: The study showed a close correlation between high ICI scores and high TMB values, with ICI scores serving as reliable prognostic predictors. The predictive model established demonstrated significant superiority among glioma patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Michele Dal Bo, Maurizio Polano, Tamara Ius, Federica Di Cintio, Alessia Mondello, Ivana Manini, Enrico Pegolo, Daniela Cesselli, Carla Di Loreto, Miran Skrap, Giuseppe Toffoli
Summary: Machine learning was utilized to investigate the contribution of different available data in predicting overall survival of patients with glioma grade 4 (GG4). The study found that radiological parameters, gene mutations, and tumor mutational burden (TMB) played important roles in predicting the survival of GG4 patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Marco Gallus, Darwin Kwok, Senthilnath Lakshmanachetty, Akane Yamamichi, Hideho Okada
Summary: IDH-mutant low-grade gliomas (LGG) are slow-growing glial cell-derived tumors of the central nervous system (CNS) that predominantly manifest in young adults and often show malignant transformation. Despite therapeutic advances in other areas, immunotherapies remain ineffective in treating LGG patients. This review summarizes relevant research findings and discusses challenges and lessons learned from clinical trials, as well as future perspectives on improving immunotherapy for IDH-mutant LGG.
Article
Chemistry, Analytical
Sanghyuk Im, Jonghwan Hyeon, Eunyoung Rha, Janghyeon Lee, Ho-Jin Choi, Yuchae Jung, Tae-Jung Kim
Summary: This study demonstrates how deep learning approaches can be used for automatic classification of diffuse glioma subtypes and grading, improving diagnostic accuracy and showcasing the emerging role of deep learning in pathological diagnosis practice.
Review
Oncology
Lilly W. Tang, Arka N. Mallela, Hansen Deng, Timothy E. Richardson, Shawn L. Hervey-Jumper, Samuel K. McBrayer, Kalil G. Abdullah
Summary: Models for human gliomas are crucial for advancing our understanding of glioma biology and developing effective therapies. However, creating lower-grade glioma (LGG) models has been challenging, resulting in limited research and progress in standard treatment. In order to reliably predict and validate novel treatments, LGG models need to meet specific standards that mimic tumor genetic abnormalities and microenvironment. This review discusses the challenges in model development, evaluates existing LGG models, and proposes future directions for improved disease mechanism exploration and therapeutic development.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Dalia Haydar, Jorge Ibanez-Vega, Giedre Krenciute
Summary: Despite years of research, pediatric CNS tumors remain challenging to treat, with current therapies unable to cure these diseases and associated with serious adverse effects. CAR T-cell therapy shows promise in improving survival rates without the adverse effects of traditional treatments, but faces limitations in targeting brain tumors due to lack of suitable antigens and barriers to cell migration. Research is focused on overcoming these obstacles to enhance the effectiveness of CAR T-cell therapy for pediatric CNS tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Guanglie Li, Xiwei Xu, Jianqi Cui, Fan Zhang, Siyang Wang
Summary: Recurrent high-grade glioma is a refractory disease with poor prognosis. Apatinib combined with temozolomide has been shown to improve efficacy and prolong survival in the treatment of recurrent high-grade gliomas. A meta-analysis of 10 studies involving 357 patients was conducted to further investigate the efficacy and prognosis of this treatment. The results indicated that apatinib combined with temozolomide had a significant overall objective response rate and disease control rate, with better outcomes observed in the dose-dense temozolomide subgroup.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Immunology
Baofeng Guo, Shengnan Zhang, Libo Xu, Jicheng Sun, Wai-Lun Chan, Pengfei Zheng, Jinnan Zhang, Ling Zhang
Summary: In this systematic review and meta-analysis, the efficacy and safety of immunotherapy in high-grade glioma (HGG) were evaluated. The study found that immunotherapy extended the overall survival (OS) and progression-free survival (PFS) of the patients, although adverse events were observed. Dendritic cell (DC) vaccine significantly prolonged the OS of HGG patients, while oncolytic viral therapy (VT) showed survival extension only in a subgroup analysis. Immunopotentiation (IP) did not prolong OS, but further investigation is needed.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Daniel Felix Fleischmann, Rudolph Schoen, Stefanie Corradini, Raphael Bodensohn, Indrawati Hadi, Jan Hofmaier, Robert Forbrig, Niklas Thon, Mario Dorostkar, Claus Belka, Maximilian Niyazi
Summary: Multifocal manifestation of high-grade glioma is a rare and unfavorable disease with unclear pathogenesis and treatment guidelines. This retrospective analysis of 20 cases treated with conventionally fractionated radiation therapy suggests that RT combined with chemotherapy is safe for patients with multifocal high-grade glioma.
RADIATION ONCOLOGY
(2021)
Review
Clinical Neurology
Martin A. Merenzon, Shovan Bhatia, Adam Levy, Tiffany Eatz, Alexis A. Morell, Lekhaj C. Daggubati, Evan Luther, Ashish H. Shah, Ricardo J. Komotar, Michael E. Ivan
Summary: Seizures are common in patients with low-grade brain tumors, and frontal lobe epilepsy has worse seizure outcomes compared to temporal lobe epilepsy. This study conducted a systematic review, reported a case series, and performed a pooled analysis to identify clinical predictors of seizure outcomes in frontal lobe low-grade brain tumors.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)