Obesity-Induced Adipose Tissue Inflammation as a Strong Promotional Factor for Pancreatic Ductal Adenocarcinoma

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The IL-1/IL-1 receptor axis and tumor cell released inflammasome adaptor ASC are key regulators of TSLP secretion by cancer associated fibroblasts in pancreatic cancer

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Statin Use and Risk of Pancreatic Cancer

(2019) Yun Zhang et al.   PANCREAS

Inflammation and Pancreatic Cancer: Focus on Metabolism, Cytokines, and Immunity

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Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development

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Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in KrasG12D mice

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The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation

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Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice

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IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma

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Effects of statins on cancer mortality and progression: A systematic review and meta-analysis of 95 cohorts including 1,111,407 individuals

(2017) Zubing Mei et al.   INTERNATIONAL JOURNAL OF CANCER

Ectopic fat accumulation in the pancreas and its clinical relevance: A systematic review, meta-analysis, and meta-regression

(2017) Ruma G. Singh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

IL6 Receptor Blockade Enhances Chemotherapy Efficacy in Pancreatic Ductal Adenocarcinoma

(2017) Kristen B. Long et al.   MOLECULAR CANCER THERAPEUTICS

Adapting to obesity with adipose tissue inflammation

(2017) Shannon M. Reilly et al.   Nature Reviews Endocrinology

KRAS, YAP, and obesity in pancreatic cancer: A signaling network with multiple loops

(2017) Guido Eibl et al.   SEMINARS IN CANCER BIOLOGY

Exclusive and Combined Use of Statins and Aspirin and the Risk of Pancreatic Cancer: a Case-Control Study

(2017) Livia Archibugi et al.   Scientific Reports

Adiposity and cancer at major anatomical sites: umbrella review of the literature

(2017) Maria Kyrgiou et al.   BMJ-British Medical Journal

Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity

(2017) Brittney R. Coats et al.   Cell Reports

Adiposity and cancer at major anatomical sites: umbrella review of the literature

(2017) Maria Kyrgiou et al.   BMJ-British Medical Journal

Oxidative Stress: A New Target for Pancreatic Cancer Prognosis and Treatment

(2017) Javier Martinez-Useros et al.   Journal of Clinical Medicine

Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice

(2017) Hui-Hua Chang et al.   PLoS One

Body Fat Distribution and the Risk of Incident Metabolic Syndrome: A Longitudinal Cohort Study

(2017) Hyuktae Kwon et al.   Scientific Reports

Obesity, Inflammation, and Cancer

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Metabolic endotoxemia with obesity: Is it real and is it relevant?

(2016) Nabil E. Boutagy et al.   BIOCHIMIE

Prospective analysis of association between statins and pancreatic cancer risk in the Women’s Health Initiative

(2016) Michael S. Simon et al.   CANCER CAUSES & CONTROL

Pancreatic Cancer Risk Associated with Prediagnostic Plasma Levels of Leptin and Leptin Receptor Genetic Polymorphisms

(2016) Ana Babic et al.   CANCER RESEARCH

Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance?

(2016) M. Bluher   CLINICAL SCIENCE

Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study

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Statin Use and Its Impact on Survival in Pancreatic Cancer Patients

(2016) Hee Seung Lee et al.   MEDICINE

Targeting adipose tissue in the treatment of obesity-associated diabetes

(2016) Christine M. Kusminski et al.   NATURE REVIEWS DRUG DISCOVERY

Body Fatness and Cancer — Viewpoint of the IARC Working Group

(2016) Béatrice Lauby-Secretan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reactive Oxygen Species and Targeted Therapy for Pancreatic Cancer

(2016) Lun Zhang et al.   Oxidative Medicine and Cellular Longevity

Robust Early Inflammation of the Peripancreatic Visceral Adipose Tissue During Diet-Induced Obesity in the KrasG12D Model of Pancreatic Cancer

(2016) Kathleen M. Hertzer et al.   PANCREAS

Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy

(2016) J. Incio et al.   Cancer Discovery

Systematic review with network meta-analysis: statins and risk of hepatocellular carcinoma

(2016) Yao-Yao Zhou et al.   Oncotarget

Inhibiting tumor necrosis factor-alpha diminishes desmoplasia and inflammation to overcome chemoresistance in pancreatic ductal adenocarcinoma

(2016) Xianda Zhao et al.   Oncotarget

Silencing CCR2 in Macrophages Alleviates Adipose Tissue Inflammation and the Associated Metabolic Syndrome in Dietary Obese Mice

(2016) Jongkil Kim et al.   Molecular Therapy-Nucleic Acids

Circulating Leptin and Risk of Pancreatic Cancer: A Pooled Analysis From 3 Cohorts

(2015) Rachael Z. Stolzenberg-Solomon et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Impact of Statin Use on Survival in Patients Undergoing Resection for Early-Stage Pancreatic Cancer

(2015) Bechien U Wu et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Statin use and risk of pancreatic cancer: Results from a large, clinic-based case-control study

(2015) Evan J. Walker et al.   CANCER

Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling

(2015) Robert Caesar et al.   Cell Metabolism

Obesity and Fatty Pancreatic Infiltration Are Risk Factors for Pancreatic Precancerous Lesions (PanIN)

(2015) V. Rebours et al.   CLINICAL CANCER RESEARCH

IL1 Receptor Antagonist Inhibits Pancreatic Cancer Growth by Abrogating NF- B Activation

(2015) Z. Zhuang et al.   CLINICAL CANCER RESEARCH

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(2015) Mei-Jyh Chen et al.   INTERNATIONAL JOURNAL OF CANCER

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

(2015) Felix M Wensveen et al.   NATURE IMMUNOLOGY

Modulation of the Leptin Receptor Mediates Tumor Growth and Migration of Pancreatic Cancer Cells

(2015) Alisha M. Mendonsa et al.   PLoS One

The Association of Statin Use after Cancer Diagnosis with Survival in Pancreatic Cancer Patients: A SEER-Medicare Analysis

(2015) Christie Y. Jeon et al.   PLoS One

Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1α signaling

(2015) Bingqing Huang et al.   Oncotarget

Statins and Cancer

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Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

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IL-6 and related cytokines as the critical lynchpins between inflammation and cancer

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Interleukin-6 in inflammatory and malignant diseases of the pancreas

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Serum levels of IL-6 and IL-1β can predict the efficacy of gemcitabine in patients with advanced pancreatic cancer

(2013) S Mitsunaga et al.   BRITISH JOURNAL OF CANCER

High-Fat, High-Calorie Diet Promotes Early Pancreatic Neoplasia in the Conditional KrasG12D Mouse Model

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The Effect of Simvastatin-Ezetimibe Combination Therapy on Adipose Tissue Hormones and Systemic Inflammation in Patients with Isolated Hypercholesterolemia

(2013) Robert Krysiak et al.   Cardiovascular Therapeutics

Mechanisms and Metabolic Implications of Regional Differences among Fat Depots

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Immunological Goings-on in Visceral Adipose Tissue

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Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat, High-Sucrose Diet in Mice

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Molecular Pathways: Adiponectin and Leptin Signaling in Cancer

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Double-Blind, Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1  Antibody, in Patients With Type 2 Diabetes

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The Differential Effects of Statins on the Risk of Developing Pancreatic Cancer: A Case–Control Study in Two Centres in the United Kingdom

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A High-Fat Diet Activates Oncogenic Kras and COX2 to Induce Development of Pancreatic Ductal Adenocarcinoma in Mice

(2013) Bincy Philip et al.   GASTROENTEROLOGY

Randomized Phase III Multi-Institutional Study of TNFerade Biologic With Fluorouracil and Radiotherapy for Locally Advanced Pancreatic Cancer: Final Results

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Prediagnostic Body Mass Index and Pancreatic Cancer Survival

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Activation of the IL-6R/Jak/Stat Pathway is Associated with a Poor Outcome in Resected Pancreatic Ductal Adenocarcinoma

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(2013) Naomi Gronich et al.   Nature Reviews Clinical Oncology

Disrupting Cytokine Signaling in Pancreatic Cancer

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Diet Induced Mild Hypercholesterolemia in Pigs: Local and Systemic Inflammation, Effects on Vascular Injury – Rescue by High-Dose Statin Treatment

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(2012) Fortunata Carbone et al.   BIOCHIMIE

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Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice

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An NF-κB pathway–mediated positive feedback loop amplifies Ras activity to pathological levels in mice

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MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells

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Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression

(2011) Akihisa Fukuda et al.   CANCER CELL

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

(2011) Marina Lesina et al.   CANCER CELL

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(2011) Teresa Auguet et al.   Obesity

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Downregulation of nuclear factor-κB p65 subunit by small interfering RNA synergizes with gemcitabine to inhibit the growth of pancreatic cancer

(2009) Rui Kong et al.   CANCER LETTERS

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(2009) Rainer Hamacher et al.   CYTOKINE

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Statins Are Not Associated With a Reduced Risk of Pancreatic Cancer at the Population Level, When Taken at Low Doses for Managing Hypercholesterolemia: Evidence From a Meta-Analysis of 12 Studies

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Effects of Statins on Adipose Tissue Inflammation

(2008) Manabu Abe et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case–control study

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Anti-Tumor Necrosis Factor Therapy Inhibits Pancreatic Tumor Growth and Metastasis

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Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

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Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

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Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

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