The IL-1/IL-1 receptor axis and tumor cell released inflammasome adaptor ASC are key regulators of TSLP secretion by cancer associated fibroblasts in pancreatic cancer

Thymic Stromal Lymphopoietin Isoforms, Inflammatory Disorders, and Cancer

(2018) Gilda Varricchi et al.   Frontiers in Immunology

NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma

(2017) Donnele Daley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tezepelumab in Adults with Uncontrolled Asthma

(2017) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients

(2016) Lucia De Monte et al.   CANCER RESEARCH

Thymic stromal lymphopoietin blocks early stages of breast carcinogenesis

(2016) Shadmehr Demehri et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial

(2016) Timothy M Nywening et al.   LANCET ONCOLOGY

Methylation of ASC/TMS1 promoter is associated with poor prognosis of patients with gastric cancer

(2015) L. Wu et al.   Clinical & Translational Oncology

IL1 Receptor Antagonist Inhibits Pancreatic Cancer Growth by Abrogating NF- B Activation

(2015) Z. Zhuang et al.   CLINICAL CANCER RESEARCH

Dual prognostic significance of tumour-associated macrophages in human pancreatic adenocarcinoma treated or untreated with chemotherapy

(2015) Giuseppe Di Caro et al.   GUT

Dichotomy of short and long thymic stromal lymphopoietin isoforms in inflammatory disorders of the bowel and skin

(2015) Giulia Fornasa et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Pancreatic Cancer, Inflammation, and Microbiome

(2014) Constantinos P. Zambirinis et al.   CANCER JOURNAL

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

ASC deficiency suppresses proliferation and prevents medulloblastoma incidence

(2014) E R W Knight et al.   ONCOGENE

Inflammation, Autophagy, and Obesity: Common Features in the Pathogenesis of Pancreatitis and Pancreatic Cancer

(2013) Ilya Gukovsky et al.   GASTROENTEROLOGY

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

The immune network in pancreatic cancer development and progression

(2013) S M Wörmann et al.   ONCOGENE

Clinical significance of apoptosis-associated speck-like protein containing a caspase recruitment domain in oral squamous cell carcinoma

(2013) Tetsu Shimane et al.   Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Immune infiltrates as predictive markers of survival in pancreatic cancer patients

(2013) Maria Pia Protti et al.   Frontiers in Physiology

KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma

(2012) Jianhua Ling et al.   CANCER CELL

Dual Role of Apoptosis-Associated Speck-Like Protein Containing a CARD (ASC) in Tumorigenesis of Human Melanoma

(2012) Weimin Liu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

M2-Polarized Tumor-Associated Macrophage Infiltration of Regional Lymph Nodes Is Associated With Nodal Lymphangiogenesis and Occult Nodal Involvement in pN0 Pancreatic Cancer

(2012) Hiroshi Kurahara et al.   PANCREAS

Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis

(2012) S. K. Drexler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-talk within the tumor microenvironment mediates Th2-type inflammation in pancreatic cancer

(2012) Maria Pia Protti et al.   OncoImmunology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer

(2011) Lucia De Monte et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cancer-related inflammation: Common themes and therapeutic opportunities

(2011) Frances R. Balkwill et al.   SEMINARS IN CANCER BIOLOGY

Pancreatic Cancer

(2010) Manuel Hidalgo   NEW ENGLAND JOURNAL OF MEDICINE

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Secreted Interleukin-1  Induces a Metastatic Phenotype in Pancreatic Cancer by Sustaining a Constitutive Activation of Nuclear Factor- B

(2009) D. Melisi et al.   MOLECULAR CANCER RESEARCH