Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting
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Title
Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting
Authors
Keywords
Pancreatic cancer, Obesity, Insulin resistance, Diabetes, Adiponectin, Leptin, Gut microbiota, Inflammation
Journal
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Volume 37, Issue 1, Pages -
Publisher
Springer Nature
Online
2018-12-19
DOI
10.1186/s13046-018-0963-4
References
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Note: Only part of the references are listed.- Cancer statistics, 2018
- (2018) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
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- (2018) Vrishketan Sethi et al. GASTROENTEROLOGY
- HALO 202: Randomized Phase II Study of PEGPH20 Plus Nab-Paclitaxel/Gemcitabine Versus Nab-Paclitaxel/Gemcitabine in Patients With Untreated, Metastatic Pancreatic Ductal Adenocarcinoma
- (2018) Sunil R. Hingorani et al. JOURNAL OF CLINICAL ONCOLOGY
- Pancreatic Cancer Following Incident Diabetes in African Americans and Latinos: The Multiethnic Cohort
- (2018) Veronica Wendy Setiawan et al. JNCI-Journal of the National Cancer Institute
- The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression
- (2018) Smruti Pushalkar et al. Cancer Discovery
- Leptin-Notch axis impairs 5-fluorouracil effects on pancreatic cancer
- (2018) Adriana Harbuzariu et al. Oncotarget
- Pancreatic Cancer Following Incident Diabetes in African Americans and Latinos: The Multiethnic Cohort
- (2018) Veronica Wendy Setiawan et al. JNCI-Journal of the National Cancer Institute
- Targeting the Tumor Stroma: the Biology and Clinical Development of Pegylated Recombinant Human Hyaluronidase (PEGPH20)
- (2017) Kit Man Wong et al. Current Oncology Reports
- Engineered Resistant-Starch (ERS) Diet Shapes Colon Microbiota Profile in Parallel with the Retardation of Tumor Growth in In Vitro and In Vivo Pancreatic Cancer Models
- (2017) Concetta Panebianco et al. Nutrients
- Adiponectin receptor agonists inhibit leptin induced pSTAT3 and in vivo pancreatic tumor growth
- (2017) Fanuel Messaggio et al. Oncotarget
- A Combination of MUC5AC and CA19-9 Improves the Diagnosis of Pancreatic Cancer: A Multicenter Study
- (2016) Sukhwinder Kaur et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Insulin promotes proliferation and fibrosing responses in activated pancreatic stellate cells
- (2016) Jiayue Yang et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Hepatocyte growth factor inhibition: a novel therapeutic approach in pancreatic cancer
- (2016) Srinivasa P Pothula et al. BRITISH JOURNAL OF CANCER
- VNN1, a potential biomarker for pancreatic cancer-associated new-onset diabetes, aggravates paraneoplastic islet dysfunction by increasing oxidative stress
- (2016) Muxing Kang et al. CANCER LETTERS
- Role of hyaluronan in pancreatic cancer biology and therapy: Once again in the spotlight
- (2016) Norihiro Sato et al. CANCER SCIENCE
- Molecular Biomarkers of Pancreatic Intraepithelial Neoplasia and Their Implications in Early Diagnosis and Therapeutic Intervention of Pancreatic Cancer
- (2016) Junli Guo et al. International Journal of Biological Sciences
- HGF/Met and FOXM1 form a positive feedback loop and render pancreatic cancer cells resistance to Met inhibition and aggressive phenotypes
- (2016) J Cui et al. ONCOGENE
- Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome
- (2016) Goran Hamid Mohammad et al. PLoS One
- Peroxisome proliferator activated receptors at the crossroad of obesity, diabetes, and pancreatic cancer
- (2016) Simone Polvani WORLD JOURNAL OF GASTROENTEROLOGY
- Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy
- (2016) J. Incio et al. Cancer Discovery
- Adipocytes enhance murine pancreatic cancer growth via a hepatocyte growth factor (HGF)-mediated mechanism
- (2016) Kathryn M. Ziegler et al. International Journal of Surgery
- Leptin-Notch signaling axis is involved in pancreatic cancer progression
- (2016) Adriana Harbuzariu et al. Oncotarget
- Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes
- (2016) Janna A. van Diepen et al. Scientific Reports
- Targeting hyaluronan for the treatment of pancreatic ductal adenocarcinoma
- (2016) Norihiro Sato et al. Acta Pharmaceutica Sinica B
- Combining clinicopathological predictors and molecular biomarkers in the oncogenic K-RAS/Ki67/HIF-1α pathway to predict survival in resectable pancreatic cancer
- (2015) R Qin et al. BRITISH JOURNAL OF CANCER
- PKM2 contributes to cancer metabolism
- (2015) Nicholas Wong et al. CANCER LETTERS
- A novel epigenetic mechanism regulating hyaluronan production in pancreatic cancer cells
- (2015) Shiro Kohi et al. CLINICAL & EXPERIMENTAL METASTASIS
- Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue
- (2015) Gunisha Sagar et al. GUT
- The novel tumor angiogenic factor, adrenomedullin-2, predicts survival in pancreatic adenocarcinoma
- (2015) Lindsay L. Hollander et al. JOURNAL OF SURGICAL RESEARCH
- nab-Paclitaxel Plus Gemcitabine for Metastatic Pancreatic Cancer: Long-Term Survival From a Phase III Trial
- (2015) D. Goldstein et al. JNCI-Journal of the National Cancer Institute
- Tumour exosome integrins determine organotropic metastasis
- (2015) Ayuko Hoshino et al. NATURE
- Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
- (2015) Sonia A. Melo et al. NATURE
- Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
- (2015) Bruno Costa-Silva et al. NATURE CELL BIOLOGY
- Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer
- (2015) Erica J Childs et al. NATURE GENETICS
- Pancreatic polypeptide response to a mixed meal is blunted in pancreatic head cancer associated with diabetes mellitus
- (2015) Phil A. Hart et al. PANCREATOLOGY
- Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality
- (2015) Emily Jane Gallagher et al. PHYSIOLOGICAL REVIEWS
- Molecular detection of pancreatic neoplasia: Current status and future promise
- (2015) Shounak Majumder WORLD JOURNAL OF GASTROENTEROLOGY
- Hyaluronan stimulates pancreatic cancer cell motility
- (2015) Xiao-Bo Cheng et al. Oncotarget
- Receptor for Hyaluronic Acid-Mediated Motility is Associated with Poor Survival in Pancreatic Ductal Adenocarcinoma
- (2015) Xiao-Bo Cheng et al. Journal of Cancer
- Roles of Commensal Microbiota in Pancreas Homeostasis and Pancreatic Pathologies
- (2015) Camila Leal-Lopes et al. Journal of Diabetes Research
- nab-Paclitaxel Plus Gemcitabine for Metastatic Pancreatic Cancer: Long-Term Survival From a Phase III Trial
- (2015) D. Goldstein et al. JNCI-Journal of the National Cancer Institute
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- (2015) Bingqing Huang et al. Oncotarget
- Cancer-Stellate Cell Interactions Perpetuate the Hypoxia-Fibrosis Cycle in Pancreatic Ductal Adenocarcinoma
- (2015) Mert Erkan et al. NEOPLASIA
- Obesity and cancer pathogenesis
- (2014) Nathan A. Berger Annals of the New York Academy of Sciences
- Pancreatic Cancer, Inflammation, and Microbiome
- (2014) Constantinos P. Zambirinis et al. CANCER JOURNAL
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- (2014) He Ren et al. CANCER LETTERS
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- (2014) N. Javeed et al. CLINICAL CANCER RESEARCH
- Adiponectin Inhibits Murine Pancreatic Cancer Growth
- (2014) Motohiko Kato et al. DIGESTIVE DISEASES AND SCIENCES
- Pyruvate kinase M2 and cancer: an updated assessment
- (2014) Mohd Askandar Iqbal et al. FEBS LETTERS
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- (2014) Akiko Matsuda et al. PANCREAS
- Metabolomics Evaluation of Serum Markers for Cachexia and Their Intra-Day Variation in Patients with Advanced Pancreatic Cancer
- (2014) Yutaka Fujiwara et al. PLoS One
- Case-control study of diabetes-related genetic variants and pancreatic cancer risk in Japan
- (2014) Sawako Kuruma WORLD JOURNAL OF GASTROENTEROLOGY
- Novel strategies for managing pancreatic cancer
- (2014) Welley S Loc WORLD JOURNAL OF GASTROENTEROLOGY
- Association of Pancreatic Fatty Infiltration With Pancreatic Ductal Adenocarcinoma
- (2014) Mika Hori et al. Clinical and Translational Gastroenterology
- A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome
- (2013) Kirsten E Peters et al. BMC Medical Genetics
- High-Fat, High-Calorie Diet Promotes Early Pancreatic Neoplasia in the Conditional KrasG12D Mouse Model
- (2013) D. W. Dawson et al. Cancer Prevention Research
- Molecular Pathways: Adiponectin and Leptin Signaling in Cancer
- (2013) M. N. VanSaun CLINICAL CANCER RESEARCH
- Hyaluronan Accumulates With High-Fat Feeding and Contributes to Insulin Resistance
- (2013) L. Kang et al. DIABETES
- Calorie restriction delays the progression of lesions to pancreatic cancer in the LSL-KrasG12D; Pdx-1/Cre mouse model of pancreatic cancer
- (2013) Susan Lanza-Jacoby et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- A systematic review ofGymnema sylvestrein obesity and diabetes management
- (2013) Ramesh Pothuraju et al. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
- Extracellular vesicles: communication, coercion, and conditioning
- (2013) David A. Shifrin et al. MOLECULAR BIOLOGY OF THE CELL
- Extracellular vesicles: biology and emerging therapeutic opportunities
- (2013) Samir EL Andaloussi et al. NATURE REVIEWS DRUG DISCOVERY
- Mucins in pancreatic cancer and its microenvironment
- (2013) Sukhwinder Kaur et al. Nature Reviews Gastroenterology & Hepatology
- Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine
- (2013) Daniel D. Von Hoff et al. NEW ENGLAND JOURNAL OF MEDICINE
- Adipocytes: Impact on tumor growth and potential sites for therapeutic intervention
- (2013) Simona Hefetz-Sela et al. PHARMACOLOGY & THERAPEUTICS
- JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1 -mediated glucose metabolism
- (2013) H.-J. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Diabetes and cancer
- (2013) Dana K. Andersen Current Opinion in Endocrinology Diabetes and Obesity
- Glypican-4 is a new comer of adipokines working as insulin sensitizer
- (2013) Yoshikazu Tamori et al. Journal of Diabetes Investigation
- Risk Factors and Therapeutic Targets in Pancreatic Cancer
- (2013) Sonja Maria Wörmann et al. Frontiers in Oncology
- Early diagnosis of pancreatic cancer: challenges and new developments
- (2012) Sukhwinder Kaur et al. Biomarkers in Medicine
- Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
- (2012) Paolo P. Provenzano et al. CANCER CELL
- Interplay between Smoking-induced Genotoxicity and Altered Signaling in Pancreatic Carcinogenesis
- (2012) N. Momi et al. CARCINOGENESIS
- Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APC Min/+ mice
- (2012) Yinghui Li et al. CARCINOGENESIS
- Adrenomedullin is Up-regulated in Patients With Pancreatic Cancer and Causes Insulin Resistance in β Cells and Mice
- (2012) Gaurav Aggarwal et al. GASTROENTEROLOGY
- Sensing of Commensal Organisms by the Intracellular Sensor NOD1 Mediates Experimental Pancreatitis
- (2012) Yoshihisa Tsuji et al. IMMUNITY
- A Prospective Study of Plasma Adiponectin and Pancreatic Cancer Risk in Five US Cohorts
- (2012) Ying Bao et al. JNCI-Journal of the National Cancer Institute
- Mouse models of pancreatic cancer
- (2012) Marta Herreros-Villanueva WORLD JOURNAL OF GASTROENTEROLOGY
- Cancer stem cells and therapeutic targets: an emerging field for cancer treatment
- (2012) Arokia Priyanka Vaz et al. Drug Delivery and Translational Research
- Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression
- (2011) Akihisa Fukuda et al. CANCER CELL
- Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer
- (2011) Marina Lesina et al. CANCER CELL
- The association of circulating adiponectin levels with pancreatic cancer risk: A study within the prospective EPIC cohort
- (2011) Verena A. Grote et al. INTERNATIONAL JOURNAL OF CANCER
- Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer
- (2011) Lucia De Monte et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Visualization of CD44 and CD133 in Normal Pancreas and Pancreatic Ductal Adenocarcinomas
- (2011) Heike Immervoll et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
- (2011) Weiwei Yang et al. NATURE
- Enterotypes of the human gut microbiome
- (2011) Manimozhiyan Arumugam et al. NATURE
- The clinical significance of pancreatic steatosis
- (2011) Mark M. Smits et al. Nature Reviews Gastroenterology & Hepatology
- FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer
- (2011) Thierry Conroy et al. NEW ENGLAND JOURNAL OF MEDICINE
- Novel Blood Biomarkers of Pancreatic Cancer–Associated Diabetes Mellitus Identified by Peripheral Blood–Based Gene Expression Profiles
- (2010) Hai Huang et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Constitutive Canonical NF-κB Activation Cooperates with Disruption of BLIMP1 in the Pathogenesis of Activated B Cell-like Diffuse Large Cell Lymphoma
- (2010) Dinis Pedro Calado et al. CANCER CELL
- Fructose Induces Transketolase Flux to Promote Pancreatic Cancer Growth
- (2010) H. Liu et al. CANCER RESEARCH
- Silencing of RON Receptor Signaling Promotes Apoptosis and Gemcitabine Sensitivity in Pancreatic Cancers
- (2010) J. Logan-Collins et al. CANCER RESEARCH
- Diabetes Mellitus Type 2 – An Independent Risk Factor for Cancer?
- (2010) V. Grote et al. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
- Hyaluronan in human malignancies
- (2010) R.K. Sironen et al. EXPERIMENTAL CELL RESEARCH
- Adiponectin-induced ERK and Akt Phosphorylation Protects against Pancreatic Beta Cell Apoptosis and Increases Insulin Gene Expression and Secretion
- (2010) Nadeeja Wijesekara et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Exosomes: Extracellular organelles important in intercellular communication
- (2010) Suresh Mathivanan et al. Journal of Proteomics
- Adiponectin Represses Colon Cancer Cell Proliferation via AdipoR1- and -R2-Mediated AMPK Activation
- (2010) A Young Kim et al. MOLECULAR ENDOCRINOLOGY
- Distant metastasis occurs late during the genetic evolution of pancreatic cancer
- (2010) Shinichi Yachida et al. NATURE
- Pancreatic Cancer
- (2010) Manuel Hidalgo NEW ENGLAND JOURNAL OF MEDICINE
- NFKBIADeletion in Glioblastomas
- (2010) Markus Bredel et al. NEW ENGLAND JOURNAL OF MEDICINE
- Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action
- (2009) Vijayalakshmi Varma et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance
- (2009) Lale Ozcan et al. Cell Metabolism
- Pancreatic duct replication is increased with obesity and type 2 diabetes in humans
- (2009) A. E. Butler et al. DIABETOLOGIA
- Antidiabetic Therapies Affect Risk of Pancreatic Cancer
- (2009) Donghui Li et al. GASTROENTEROLOGY
- Signal transduction in pancreatic stellate cells
- (2009) Atsushi Masamune et al. JOURNAL OF GASTROENTEROLOGY
- Identification of a Novel Antibody Associated with Autoimmune Pancreatitis
- (2009) Luca Frulloni et al. NEW ENGLAND JOURNAL OF MEDICINE
- Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility
- (2009) Joshua M. Uronis et al. PLoS One
- The ADMR Receptor Mediates the Effects of Adrenomedullin on Pancreatic Cancer Cells and on Cells of the Tumor Microenvironment
- (2009) Vijaya Ramachandran et al. PLoS One
- Serum leptin, but not adiponectin and receptor for advanced glycation end products, is able to distinguish autoimmune pancreatitis from both chronic pancreatitis and pancreatic neoplasms
- (2009) Raffaele Pezzilli et al. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- Obesity potentiates the growth and dissemination of pancreatic cancer
- (2009) Nicholas J. Zyromski et al. SURGERY
- Pancreatic Stellate Cells and Pancreatic Cancer Cells: An Unholy Alliance
- (2008) A. Vonlaufen et al. CANCER RESEARCH
- Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells
- (2008) A. Vonlaufen et al. CANCER RESEARCH
- Impact of the hyaluronan-rich tumor microenvironment on cancer initiation and progression
- (2008) Naoki Itano et al. CANCER SCIENCE
- Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice
- (2008) P. D. Cani et al. DIABETES
- Mouse vanin-1 is cytoprotective for islet beta cells and regulates the development of type 1 diabetes
- (2008) C. Roisin-Bouffay et al. DIABETOLOGIA
- Recent progress on normal and malignant pancreatic stem/progenitor cell research: therapeutic implications for the treatment of type 1 or 2 diabetes mellitus and aggressive pancreatic cancer
- (2008) M Mimeault et al. GUT
- Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies
- (2008) Andrew G Renehan et al. LANCET
- Obesity, Pancreatitis, and Pancreatic Cancer
- (2008) Andrew A. Gumbs OBESITY SURGERY
- Proliferative effects of insulin analogues on mammary epithelial cells
- (2008) Doris Mayer et al. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
- A central role for hepatocyte growth factor in adipose tissue angiogenesis
- (2007) Lauren N. Bell et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
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