Targeting the Canonical WNT/β-Catenin Pathway in Cancer Treatment Using Non-Steroidal Anti-Inflammatory Drugs

Mitochondrial Retrograde Signalling and Metabolic Alterations in the Tumour Microenvironment

(2019) Dongki Yang et al.   Cells

Complex Systems Biology Approach in Connecting PI3K-Akt and NF-κB Pathways in Prostate Cancer

(2019) Eswar Shankar et al.   Cells

Frizzled Receptors as Potential Therapeutic Targets in Human Cancers

(2018) Chui-Mian Zeng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Thermodynamics in Neurodegenerative Diseases: Interplay Between Canonical WNT/Beta-Catenin Pathway–PPAR Gamma, Energy Metabolism and Circadian Rhythms

(2018) Alexandre Vallée et al.   NEUROMOLECULAR MEDICINE

Opposite Interplay Between the Canonical WNT/β-Catenin Pathway and PPAR Gamma: A Potential Therapeutic Target in Gliomas

(2018) Alexandre Vallée et al.   Neuroscience Bulletin

Crosstalk Between Peroxisome Proliferator-Activated Receptor Gamma and the Canonical WNT/β-Catenin Pathway in Chronic Inflammation and Oxidative Stress During Carcinogenesis

(2018) Alexandre Vallée et al.   Frontiers in Immunology

Hypoxia and IF1 Expression Promote ROS Decrease in Cancer Cells

(2018) Gianluca Sgarbi et al.   Cells

Interplay between the renin-angiotensin system, the canonical WNT/β-catenin pathway and PPARγ in hypertension

(2018) Alexandre Vallée et al.   CURRENT HYPERTENSION REPORTS

PPARγ agonists: potential treatment for autism spectrum disorder by inhibiting the canonical WNT/β-catenin pathway

(2018) Alexandre Vallée et al.   MOLECULAR PSYCHIATRY

Wnt signaling dynamics in head and neck squamous cell cancer tumor-stroma interactions

(2018) Phuong N. Le et al.   MOLECULAR CARCINOGENESIS

The emerging link between cancer, metabolism, and circadian rhythms

(2018) Selma Masri et al.   NATURE MEDICINE

Advances in antitumor effects of NSAIDs

(2018) Zhen Zhang et al.   Cancer Management and Research

Targeting DNA Binding for NF-κB as an Anticancer Approach in Hepatocellular Carcinoma

(2018) Po Chung et al.   Cells

Targeting Wnt-driven cancers: Discovery of novel tankyrase inhibitors

(2017) Martina Ferri et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Celecoxib inhibits osteoblast maturation by suppressing the expression of Wnt target genes

(2017) Akihiro Nagano et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Vasculogenesis and angiogenesis initiation under normoxic conditions through Wnt/β-catenin pathway in gliomas

(2017) Alexandre Vallée et al.   REVIEWS IN THE NEUROSCIENCES

Aberrantly activated Cox-2 and Wnt signaling interact to maintain cancer stem cells in glioblastoma

(2017) Megan Wu et al.   Oncotarget

The β-catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner

(2017) Maria Wiese et al.   Oncotarget

Thermodynamics in Gliomas: Interactions between the Canonical WNT/Beta-Catenin Pathway and PPAR Gamma

(2017) Alexandre Vallée et al.   Frontiers in Physiology

PPARγ Agonist Curcumin Reduces the Amyloid-β-Stimulated Inflammatory Responses in Primary Astrocytes

(2017) Hong-Mei Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

The Anti-Oxidant and Antitumor Properties of Plant Polysaccharides

(2016) Rui Jiao et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Chemopreventive action of non-steroidal anti-inflammatory drugs on the inflammatory pathways in colon cancer

(2016) Preety Ghanghas et al.   BIOMEDICINE & PHARMACOTHERAPY

The epigenetic effects of aspirin: the modification of histone H3 lysine 27 acetylation in the prevention of colon carcinogenesis in azoxymethane- and dextran sulfate sodium-treated CF-1 mice

(2016) Yue Guo et al.   CARCINOGENESIS

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

(2016) Rishi V. Puram et al.   CELL

Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals

(2016) Kyle M. Loh et al.   DEVELOPMENTAL CELL

Constitutive expression of PPARγ inhibits proliferation and migration of gastric cancer cells and down-regulates Wnt/β-Catenin signaling pathway downstream target genes TERT and ENAH

(2016) Fang Guo et al.   GENE

Prolonged inflammatory microenvironment is crucial for pro-neoplastic growth and genome instability: a detailed review

(2016) Kumari Anuja et al.   INFLAMMATION RESEARCH

Macrophages of genetically characterized familial hypercholesterolaemia patients show up-regulation of LDL-receptor-related proteins

(2016) Rafael Escate et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Melatonin synergizes the chemotherapeutic effect of 5-fluorouracil in colon cancer by suppressing PI3K/AKT and NF-κB/iNOS signaling pathways

(2016) Yue Gao et al.   JOURNAL OF PINEAL RESEARCH

Wnt signaling pathway in cardiac fibrosis: New insights and directions

(2016) Hui Tao et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches

(2016) Emenike K. Onyido et al.   Molecular Cancer

Melatonin attenuates TGFβ1-induced epithelial-mesenchymal transition in lung alveolar epithelial cells

(2016) Na Yu et al.   Molecular Medicine Reports

Does Thiazolidinedione therapy exacerbate fluid retention in congestive heart failure?

(2016) Ilia Goltsman et al.   PHARMACOLOGY & THERAPEUTICS

Eliminating Cancer Stem Cells by Targeting Embryonic Signaling Pathways

(2016) Ohad Oren et al.   Stem Cell Reviews and Reports

Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis

(2016) Borja Bandera Merchan et al.   PPAR Research

Eliminating Cancer Stem Cells by Targeting Embryonic Signaling Pathways

(2016) Ohad Oren et al.   Stem Cell Reviews and Reports

Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation

(2016) Bin Ma et al.   Frontiers in Immunology

Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms

(2015) Laura Novellasdemunt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mechanisms regulating glioma invasion

(2015) Ivy Paw et al.   CANCER LETTERS

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

Wnts grasp the WIF domain of Wnt Inhibitory Factor 1 at two distinct binding sites

(2015) Krisztina Kerekes et al.   FEBS LETTERS

Secreted Frizzled-Related Protein 3 (sFRP3) in acute coronary syndromes

(2015) Thor Ueland et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

APC controls asymmetric Wnt/β-catenin signaling and cardiomyocyte proliferation gradient in the heart

(2015) Bo Ye et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways

(2015) Musen Lin et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Melatonin set out to ER stress signaling thwarts epithelial mesenchymal transition and peritoneal dissemination via calpain-mediated C/EBPβand NFκB cleavage

(2015) Sheng-Mao Wu et al.   JOURNAL OF PINEAL RESEARCH

PPARγ suppressed Wnt/β-catenin signaling pathway and its downstream effector SOX9 expression in gastric cancer cells

(2015) Xiyun Ren et al.   MEDICAL ONCOLOGY

Arctigenin Suppress Th17 Cells and Ameliorates Experimental Autoimmune Encephalomyelitis Through AMPK and PPAR-γ/ROR-γt Signaling

(2015) Wen Li et al.   MOLECULAR NEUROBIOLOGY

Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists

(2015) Stéphane Prost et al.   NATURE

Targeting the Wnt pathway in human cancers: Therapeutic targeting with a focus on OMP-54F28

(2015) Phuong N. Le et al.   PHARMACOLOGY & THERAPEUTICS

Thiazolidinediones and Edema: Recent Advances in the Pathogenesis of Thiazolidinediones-Induced Renal Sodium Retention

(2015) Shoko Horita et al.   PPAR Research

Clinico-Pathological Correlation of β-Catenin and Telomere Dysfunction in Head and Neck Squamous Cell Carcinoma Patients

(2015) Swatishree Padhi et al.   Journal of Cancer

Aspirin Prevents Colorectal Cancer by Normalizing EGFR Expression

(2015) Haitao Li et al.   EBioMedicine

Cross-talk between the circadian clock and the cell cycle in cancer

(2014) Matúš Soták et al.   ANNALS OF MEDICINE

β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer

(2014) D Jia et al.   CELL DEATH AND DIFFERENTIATION

Molecular Pathways: Aspirin and Wnt Signaling--A Molecularly Targeted Approach to Cancer Prevention and Treatment

(2014) M. K. Gala et al.   CLINICAL CANCER RESEARCH

β-catenin regulates NF-κB activityviaTNFRSF19 in colorectal cancer cells

(2014) Simon Schön et al.   INTERNATIONAL JOURNAL OF CANCER

Physiology and pharmacology of melatonin in relation to biological rhythms

(2014) Jolanta B. Zawilska et al.   Pharmacological Reports

COX-2 as a target for cancer chemotherapy

(2014) Nilanjan Ghosh et al.   Pharmacological Reports

PPARs Integrate the Mammalian Clock and Energy Metabolism

(2014) Lihong Chen et al.   PPAR Research

Interplay between SOX9, β-catenin and PPARγ activation in colorectal cancer

(2013) Anna Panza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular mechanisms underlying chronic inflammation-associated cancers

(2013) Yongzhong Wu et al.   CANCER LETTERS

NSAIDs Inhibit Tumorigenesis, but How?

(2013) Evrim Gurpinar et al.   CLINICAL CANCER RESEARCH

Systems biology approach to identify alterations in the stem cell reservoir of subcutaneous adipose tissue in a rat model of diabetes: effects on differentiation potential and function

(2013) Raquel Ferrer-Lorente et al.   DIABETOLOGIA

Insulin sensitizers in 2013: new insights for the development of novel therapeutic agents to treat metabolic diseases

(2013) Jerry R Colca et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

T Cell Factor 4 Is a Pro-catabolic and Apoptotic Factor in Human Articular Chondrocytes by Potentiating Nuclear Factor κB Signaling

(2013) Bin Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hmgb1-IL-23-IL-17-IL-6-Stat3 Axis Promotes Tumor Growth in Murine Models of Melanoma

(2013) Qiu Tang et al.   MEDIATORS OF INFLAMMATION

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(2013) Christos Savvidis et al.   MOLECULAR MEDICINE

Natural Products as a Source of Anti-Inflammatory Agents Associated with Inflammatory Bowel Disease

(2013) Trishna Debnath et al.   MOLECULES

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Inhibition of Oxidative Stress-Elicited AKT Activation Facilitates PPARγ Agonist-Mediated Inhibition of Stem Cell Character and Tumor Growth of Liver Cancer Cells

(2013) Lanlan Liu et al.   PLoS One

The role of antioxidants and other agents in alleviating hyperglycemia mediated oxidative stress and injury in liver

(2013) Aparajita Dey et al.   Food & Function

Non-steroid anti-inflammatory drugs, prostaglandins, and cancer

(2013) Viola Allaj et al.   Cell and Bioscience

NSAIDs Modulate Clonal Evolution in Barrett's Esophagus

(2013) Rumen L. Kostadinov et al.   PLoS Genetics

Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer

(2012) K. D. Proffitt et al.   CANCER RESEARCH

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

(2012) Sarah Schwitalla et al.   CELL

Over-expression of circadian clock geneBmal1affects proliferation and the canonical Wnt pathway in NIH-3T3 cells

(2012) Fuwei Lin et al.   CELL BIOCHEMISTRY AND FUNCTION

The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway

(2012) Bingyan Guo et al.   FASEB JOURNAL

Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials

(2012) Peter M Rothwell et al.   LANCET

Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials

(2012) Annemijn M Algra et al.   LANCET ONCOLOGY

Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through promoting the ROS production

(2012) Da-yong Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Circadian Gating of Epithelial-to-Mesenchymal Transition in Breast Cancer Cells Via Melatonin-Regulation of GSK3β

(2012) Lulu Mao et al.   MOLECULAR ENDOCRINOLOGY

Systemic PPARγ Deletion Impairs Circadian Rhythms of Behavior and Metabolism

(2012) Guangrui Yang et al.   PLoS One

The JNK- and AKT/GSK3β- Signaling Pathways Converge to Regulate Puma Induction and Neuronal Apoptosis Induced by Trophic Factor Deprivation

(2012) Kristin K. Ambacher et al.   PLoS One

Thiazolidinediones and Risk of Heart Failure in Patients with or at High Risk of Type 2 Diabetes Mellitus

(2011) Adrian V. Hernandez et al.   American Journal of Cardiovascular Drugs

Inhibition of PDE5 by Sulindac Sulfide Selectively Induces Apoptosis and Attenuates Oncogenic Wnt/ -Catenin-Mediated Transcription in Human Breast Tumor Cells

(2011) H. N. Tinsley et al.   Cancer Prevention Research

Inhibition of Lymphoma Cell Proliferation by Peroxisomal Proliferator-Activated Receptor-γ Ligands via Wnt Signaling Pathway

(2011) Jia-Jun Liu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

New perspectives on APC control of cell fate and proliferation in colorectal cancer

(2011) Reid A. Phelps et al.   CELL CYCLE

Chronic inflammation, the tumor microenvironment and carcinogenesis

(2011) Tamas A. Gonda et al.   CELL CYCLE

The circadian mutation PER2 S662G is linked to cell cycle progression and tumorigenesis

(2011) X Gu et al.   CELL DEATH AND DIFFERENTIATION

Meta-Analysis on the Association Between Nonsteroidal Anti-Inflammatory Drug Use and Lung Cancer Risk

(2011) Jiali Xu et al.   Clinical Lung Cancer

Wnt pathway activation, cell migration, and lipid uptake is regulated by low-density lipoprotein receptor-related protein 5 in human macrophages

(2011) Maria Borrell-Pagès et al.   EUROPEAN HEART JOURNAL

Acetylsalicylic acid-induced oxidative stress, cell cycle arrest, apoptosis and mitochondrial dysfunction in human hepatoma HepG2 cells

(2011) Haider Raza et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The circadian molecular clock creates epidermal stem cell heterogeneity

(2011) Peggy Janich et al.   NATURE

ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence

(2011) U Weyemi et al.   ONCOGENE

Cardiovascular Risk with Non-Steroidal Anti-Inflammatory Drugs: Systematic Review of Population-Based Controlled Observational Studies

(2011) Patricia McGettigan et al.   PLOS MEDICINE

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Diabetes, Insulin Use, and Cancer Risk: Are Observational Studies Part of the Solution-or Part of the Problem?

(2010) J. A. Johnson et al.   DIABETES

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cyclooxygenase-2 expression and recurrence of colorectal adenomas: effect of aspirin chemoprevention

(2010) R. Benamouzig et al.   GUT

β-Catenin overexpression in malignant glioma and its role in proliferation and apoptosis in glioblastma cells

(2010) Xiangrong Liu et al.   MEDICAL ONCOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GSK3 signalling in neural development

(2010) Eun-Mi Hur et al.   NATURE REVIEWS NEUROSCIENCE

Circadian Disruption Accelerates Tumor Growth and Angio/Stromagenesis through a Wnt Signaling Pathway

(2010) Yoshihiro Yasuniwa et al.   PLoS One

Alkylation of the Tumor Suppressor PTEN Activates Akt and β-Catenin Signaling: A Mechanism Linking Inflammation and Oxidative Stress with Cancer

(2010) Tracy M. Covey et al.   PLoS One

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways

(2010) Yves Lecarpentier et al.   PPAR Research

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

(2009) F. Colotta et al.   CARCINOGENESIS

Inflammation and oncogenesis: a vicious connection

(2009) Sergei I Grivennikov et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Aryl Hydrocarbon Receptor Facilitates DNA Strand Breaks and 8-Oxo-2′-deoxyguanosine Formation by the Aldo-Keto Reductase Product Benzo[a]pyrene-7,8-dione

(2009) Jong-Heum Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The tumor-promoting actions of TNF-α involve TNFR1 and IL-17 in ovarian cancer in mice and humans

(2009) Kellie A. Charles et al.   JOURNAL OF CLINICAL INVESTIGATION

The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell–intrinsic fashion and suppresses CNS autoimmunity

(2009) Luisa Klotz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial

(2009) Philip D Home et al.   LANCET

Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement

(2009) Jack Cuzick et al.   LANCET ONCOLOGY

GSK3: a multifaceted kinase in Wnt signaling

(2009) Dianqing Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondrial generation of free radicals and hypoxic signaling

(2009) Robert O. Poyton et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Celecoxib-induced degradation of T-cell factors-1 and -4 in human colon cancer cells

(2008) Fumi Takahashi-Yanaga et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanisms of ROS modulated cell survival during carcinogenesis

(2008) J.S. Clerkin et al.   CANCER LETTERS

Increased Susceptibility of Nrf2 Knockout Mice to Colitis-Associated Colorectal Cancer

(2008) T. O. Khor et al.   Cancer Prevention Research

Vascular PPARγ Controls Circadian Variation in Blood Pressure and Heart Rate through Bmal1

(2008) Ningning Wang et al.   Cell Metabolism

Celecoxib induces p53-PUMA pathway for apoptosis in human colorectal cancer cells

(2008) Huei-Fang Liu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A Randomized Multicenter Study of Optimal Circadian Time of Vinorelbine Combined with Chronomodulated 5‐Fluorouracil in Pretreated Metastatic Breast Cancer Patients: EORTC Trial 05971

(2008) Bruno Coudert et al.   CHRONOBIOLOGY INTERNATIONAL

Cyclooxygenase-2 Inhibition Prevents Migration of Colorectal Cancer Cells to Extracellular Matrix by Down-Regulation of Matrix Metalloproteinase-2 Expression

(2008) Edmund Leung et al.   DISEASES OF THE COLON & RECTUM

ß-Catenin triggers nuclear factor ?B-dependent up-regulation of hepatocyte inducible nitric oxide synthase

(2008) Andrea Bandino et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

 -Catenin Induces  -TrCP-Mediated PER2 Degradation Altering Circadian Clock Gene Expression in Intestinal Mucosa of ApcMin/+ Mice

(2008) X. Yang et al.   JOURNAL OF BIOCHEMISTRY

In vivo equilibrium of proinflammatory IL-17+and regulatory IL-10+Foxp3+RORγt+T cells

(2008) Matthias Lochner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Melatonin decreases TLR3-mediated inflammatory factor expression via inhibition of NF-B activation in respiratory syncytial virus-infected RAW264.7 macrophages

(2008) Sheng-Hai Huang et al.   JOURNAL OF PINEAL RESEARCH

Combination of melatonin and a peroxisome proliferator-activated receptor-γ agonist induces apoptosis in a breast cancer cell line

(2008) Ahmet Korkmaz et al.   JOURNAL OF PINEAL RESEARCH

Inflammation: Gearing the journey to cancer

(2008) J KUNDU et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

NSAIDs Downregulate Bcl-XLand Dissociate BAX and Bcl-XLto Induce Apoptosis in Colon Cancer Cells

(2008) Alexander Bank et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Oxidative stress in ulcerative colitis-associated carcinogenesis

(2008) A. Roessner et al.   PATHOLOGY RESEARCH AND PRACTICE

PPARγand Apoptosis in Cancer

(2008) Heath A. Elrod et al.   PPAR Research