Inhibition of Oxidative Stress-Elicited AKT Activation Facilitates PPARγ Agonist-Mediated Inhibition of Stem Cell Character and Tumor Growth of Liver Cancer Cells

Albumin-Binding and Tumor Vasculature Determine the Antitumor Effect of 15-Deoxy-Δ12,14-Prostaglandin-J2in vivo

(2015) Jai Prakash et al.   NEOPLASIA

Peroxisome Proliferator-Activated Receptor-γ Inhibits Transformed Growth of Non-Small Cell Lung Cancer Cells through Selective Suppression of Snail

(2015) Rashmi Choudhary et al.   NEOPLASIA

PPARgamma inhibits hepatocellular carcinoma metastases in vitro and in mice

(2012) B Shen et al.   BRITISH JOURNAL OF CANCER

PPARγ agonists regulate the expression of stemness and differentiation genes in brain tumour stem cells

(2012) E Pestereva et al.   BRITISH JOURNAL OF CANCER

PPARγ agonists enhance ET-743–induced adipogenic differentiation in a transgenic mouse model of myxoid round cell liposarcoma

(2012) Elizabeth Charytonowicz et al.   JOURNAL OF CLINICAL INVESTIGATION

OV6+ tumor-initiating cells contribute to tumor progression and invasion in human hepatocellular carcinoma

(2012) Wen Yang et al.   JOURNAL OF HEPATOLOGY

Resolving the stem-cell debate

(2012) Richard J. Gilbertson et al.   NATURE

Defining the mode of tumour growth by clonal analysis

(2012) Gregory Driessens et al.   NATURE

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Rosiglitazone and AS601245 Decrease Cell Adhesion and Migration through Modulation of Specific Gene Expression in Human Colon Cancer Cells

(2012) Angelo Cerbone et al.   PLoS One

Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas

(2012) A. G. Schepers et al.   SCIENCE

A peroxisome proliferator-activated receptor ligand MCC-555 imparts anti-proliferative response in pancreatic cancer cells by PPARgamma-independent up-regulation of KLF4

(2012) Kyung-Won Min et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Thiazolidinediones regulate expression of cell cycle proteins in human prostate cancer cells via PPARγ-dependent and PPARγ-independent pathways

(2011) Besstina E. Lyles et al.   CELL CYCLE

CD24+ Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG Regulation

(2011) Terence Kin Wah Lee et al.   Cell Stem Cell

Peroxisome proliferator-activated receptor-γ cross-regulation of signaling events implicated in liver fibrogenesis

(2011) Feng Zhang et al.   CELLULAR SIGNALLING

PPAR gamma, bioactive lipids, and cancer progression

(2011) Gregory et al.   Frontiers in Bioscience-Landmark

CD133+ liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling

(2011) Kwan Ho Tang et al.   HEPATOLOGY

Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice

(2011) Eleni Maniati et al.   JOURNAL OF CLINICAL INVESTIGATION

Transient mTOR Inhibition Facilitates Continuous Growth of Liver Tumors by Modulating the Maintenance of CD133+ Cell Populations

(2011) Zhaojuan Yang et al.   PLoS One

miR-130b Promotes CD133+ Liver Tumor-Initiating Cell Growth and Self-Renewal via Tumor Protein 53-Induced Nuclear Protein 1

(2010) Stephanie Ma et al.   Cell Stem Cell

Epigenetic regulation of cancer stem cell marker CD133 by transforming growth factor-β

(2010) Hanning You et al.   HEPATOLOGY

Inhibitory role of peroxisome proliferator-activated receptor gamma in hepatocarcinogenesis in mice and in vitro

(2010) Jun Yu et al.   HEPATOLOGY

Expression of CD133 confers malignant potential by regulating metalloproteinases in human hepatocellular carcinoma

(2010) Keisuke Kohga et al.   JOURNAL OF HEPATOLOGY

15d-PGJ2 Induces Apoptosis by Reactive Oxygen Species-mediated Inactivation of Akt in Leukemia and Colorectal Cancer Cells and Shows In vivo Antitumor Activity

(2009) S.-W. Shin et al.   CLINICAL CANCER RESEARCH

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

(2009) Edward Owusu-Ansah et al.   NATURE

Phase 2 open-label study of single-agent sorafenib in treating advanced hepatocellular carcinoma in a hepatitis B-endemic Asian population

(2008) Thomas Yau et al.   CANCER

RXR agonists inhibit high-glucose-induced oxidative stress by repressing PKC activity in human endothelial cells

(2008) Dajun Chai et al.   FREE RADICAL BIOLOGY AND MEDICINE

CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-β-induced apoptosis

(2008) Wei Ding et al.   HEPATOLOGY

Liver Cancer Stem Cells

(2008) Stewart Sell et al.   JOURNAL OF CLINICAL ONCOLOGY

The Akt signaling pathway contributes to postconditioning’s protection against stroke; the protection is associated with the MAPK and PKC pathways

(2008) Xuwen Gao et al.   JOURNAL OF NEUROCHEMISTRY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE