Infrared and fluorescence assessment of the hydration status of the tryptophan gate in the influenza A M2 proton channel

Exciton circular dichroism couplet arising from nitrile-derivatized aromatic residues as a structural probe of proteins

(2016) Debopreeti Mukherjee et al.   ANALYTICAL BIOCHEMISTRY

Infrared and Fluorescence Assessment of Protein Dynamics: From Folding to Function

(2016) Bei Ding et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Utility of 5-Cyanotryptophan Fluorescence as a Sensitive Probe of Protein Hydration

(2016) Beatrice N. Markiewicz et al.   JOURNAL OF PHYSICAL CHEMISTRY B

CN stretching vibration of 5-cyanotryptophan as an infrared probe of protein local environment: what determines its frequency?

(2016) Wenkai Zhang et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction

(2015) Jessica L. Thomaston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2D IR spectroscopy reveals the role of water in the binding of channel-blocking drugs to the influenza M2 channel

(2014) Ayanjeet Ghosh et al.   JOURNAL OF CHEMICAL PHYSICS

Proton Release from the Histidine-Tetrad in the M2 Channel of the Influenza A Virus

(2014) Hao Dong et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel

(2014) Yibing Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effect of Cytosolic pH on Inward Currents Reveals Structural Characteristics of the Proton Transport Cycle in the Influenza A Protein M2 in Cell-Free Membrane Patches of Xenopus oocytes

(2014) Mattia L. DiFrancesco et al.   PLoS One

Microscopic insights into the protein-stabilizing effect of trimethylamine N-oxide (TMAO)

(2014) J. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiscale simulation reveals a multifaceted mechanism of proton permeation through the influenza A M2 proton channel

(2014) Ruibin Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

pH-Dependent Conformation, Dynamics, and Aromatic Interaction of the Gating Tryptophan Residue of the Influenza M2 Proton Channel from Solid-State NMR

(2013) Jonathan K. Williams et al.   BIOPHYSICAL JOURNAL

Asp44 Stabilizes the Trp41 Gate of the M2 Proton Channel of Influenza A Virus

(2013) Chunlong Ma et al.   STRUCTURE

Nanosecond dynamics of influenza A/M2TM and an amantadine resistant mutant probed by time-dependent red shifts of a native tryptophan

(2012) Vikas Nanda et al.   CHEMICAL PHYSICS

Fast Dynamics of HP35 for Folded and Urea-Unfolded Conditions

(2012) Jean K. Chung et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Environment Polarity in Proteins Mapped Noninvasively by FTIR Spectroscopy

(2012) Joshua Manor et al.   Journal of Physical Chemistry Letters

Hydrogen-Bonding Partner of the Proton-Conducting Histidine in the Influenza M2 Proton Channel Revealed From 1H Chemical Shifts

(2012) Mei Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Solvatochromic Model Calibrates Nitriles’ Vibrational Frequencies to Electrostatic Fields

(2012) Sayan Bagchi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Theory for the Proton Transport of the Influenza Virus M2 Protein: Extensive Test against Conductance Data

(2011) Huan-Xiang Zhou   BIOPHYSICAL JOURNAL

NMR Detection of pH-Dependent Histidine–Water Proton Exchange Reveals the Conduction Mechanism of a Transmembrane Proton Channel

(2011) Fanghao Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Dynamics Simulation Directed Rational Design of Inhibitors Targeting Drug-Resistant Mutants of Influenza A Virus M2

(2011) Jun Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photoinduced Electron Transfer and Fluorophore Motion as a Probe of the Conformational Dynamics of Membrane Proteins: Application to the Influenza A M2 Proton Channel

(2011) Julie M. G. Rogers et al.   LANGMUIR

Tidal surge in the M2 proton channel, sensed by 2D IR spectroscopy

(2011) A. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational Modeling of the Nitrile Stretching Vibration of 5-Cyanoindole in Water

(2010) Matthias M. Waegele et al.   Journal of Physical Chemistry Letters

Conformational Changes of an Ion Channel Detected Through Water−Protein Interactions Using Solid-State NMR Spectroscopy

(2010) Wenbin Luo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proton Transport through the Influenza A M2 Channel: Three-Dimensional Reference Interaction Site Model Study

(2010) Saree Phongphanphanee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kinetic Analysis of the M2 Proton Conduction of the Influenza Virus

(2010) Rafal M. Pielak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

(2010) Sarah D. Cady et al.   NATURE

Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus

(2010) R. Acharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Flu's Proton Escort

(2010) G. Fiorin et al.   SCIENCE

Insight into the Mechanism of the Influenza A Proton Channel from a Structure in a Lipid Bilayer

(2010) M. Sharma et al.   SCIENCE

Mechanisms of Proton Conduction and Gating in Influenza M2 Proton Channels from Solid-State NMR

(2010) F. Hu et al.   SCIENCE

Structure and Function of the Influenza A M2 Proton Channel

(2009) Sarah D. Cady et al.   BIOCHEMISTRY

Functional Studies and Modeling of Pore-Lining Residue Mutants of the Influenza A Virus M2 Ion Channel

(2009) Victoria Balannik et al.   BIOCHEMISTRY

5-Cyanotryptophan as an infrared probe of local hydration status of proteins

(2009) Matthias M. Waegele et al.   CHEMICAL PHYSICS LETTERS

Applications of 2D IR Spectroscopy to Peptides, Proteins, and Hydrogen-Bond Dynamics†

(2009) Yung Sam Kim et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Substituent Effects on Xenon Binding Affinity and Solution Behavior of Water-Soluble Cryptophanes

(2009) P. Aru Hill et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conformational heterogeneity of the M2 proton channel and a structural model for channel activation

(2009) M. Yi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus

(2009) E. Khurana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel

(2009) C. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of drug inhibition and drug resistance of influenza A M2 channel

(2009) R. M. Pielak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gating Mechanism of the Influenza A M2 Channel Revealed by 1D and 2D IR Spectroscopies

(2009) Joshua Manor et al.   STRUCTURE

Structure of Amantadine-Bound M2 Transmembrane Peptide of Influenza A in Lipid Bilayers from Magic-Angle-Spinning Solid-State NMR: The Role of Ser31 in Amantadine Binding

(2008) Sarah D. Cady et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and mechanism of the M2 proton channel of influenza A virus

(2008) Jason R. Schnell et al.   NATURE

Structural basis for the function and inhibition of an influenza virus proton channel

(2008) Amanda L. Stouffer et al.   NATURE

Water in Nonpolar Confinement: From Nanotubes to Proteins and Beyond

(2007) Jayendran C. Rasaiah et al.   Annual Review of Physical Chemistry

Proton Transport through Influenza A Virus M2 Protein Reconstituted in Vesicles

(2007) J. Craig Moffat et al.   BIOPHYSICAL JOURNAL

Solid-State19F NMR Spectroscopy Reveals That Trp41Participates in the Gating Mechanism of the M2 Proton Channel of Influenza A Virus

(2007) Raiker Witter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY