XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction

Acid activation mechanism of the influenza A M2 proton channel

(2016) Ruibin Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the drug-resistant S31N influenza M2 proton channel

(2016) Jessica L. Thomaston et al.   PROTEIN SCIENCE

Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex

(2016) Artem Y Lyubimov et al.   eLife

High-density grids for efficient data collection from multiple crystals

(2016) Elizabeth L. Baxter et al.   Acta Crystallographica Section D-Structural Biology

Data processing pipeline for serial femtosecond crystallography at SACLA

(2016) Takanori Nakane et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

The Influenza M2 Cytoplasmic Tail Changes the Proton-Exchange Equilibria and the Backbone Conformation of the Transmembrane Histidine Residue to Facilitate Proton Conduction

(2015) Shu Y. Liao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction

(2015) Jessica L. Thomaston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Short Hydrogen Bonds in Histidine Tetrad of Full-Length M2 Proton Channel Reveal Tetrameric Structural Heterogeneity and Functional Mechanism

(2015) Yimin Miao et al.   STRUCTURE

Enabling X-ray free electron laser crystallography for challenging biological systems from a limited number of crystals

(2015) Monarin Uervirojnangkoorn et al.   eLife

Diverse application platform for hard X-ray diffraction in SACLA (DAPHNIS): application to serial protein crystallography using an X-ray free-electron laser

(2015) Kensuke Tono et al.   JOURNAL OF SYNCHROTRON RADIATION

Proton Association Constants of His 37 in the Influenza-A M218–60 Dimer-of-Dimers

(2014) Michael T. Colvin et al.   BIOCHEMISTRY

Preparation of microcrystals in lipidic cubic phase for serial femtosecond crystallography

(2014) Wei Liu et al.   Nature Protocols

Effect of Cytosolic pH on Inward Currents Reveals Structural Characteristics of the Proton Transport Cycle in the Influenza A Protein M2 in Cell-Free Membrane Patches of Xenopus oocytes

(2014) Mattia L. DiFrancesco et al.   PLoS One

Multiscale simulation reveals a multifaceted mechanism of proton permeation through the influenza A M2 proton channel

(2014) Ruibin Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

(2014) Uwe Weierstall et al.   Nature Communications

Cheetah: software for high-throughput reduction and analysis of serial femtosecond X-ray diffraction data

(2014) Anton Barty et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

New Python-based methods for data processing

(2013) Nicholas K. Sauter et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Activation and Proton Transport Mechanism in Influenza A M2 Channel

(2013) Chenyu Wei et al.   BIOPHYSICAL JOURNAL

Influenza Virus A M2 Protein Generates Negative Gaussian Membrane Curvature Necessary for Budding and Scission

(2013) Nathan W. Schmidt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Amphipathic Helix of Influenza A Virus M2 Protein Is Required for Filamentous Bud Formation and Scission of Filamentous and Spherical Particles

(2013) K. L. Roberts et al.   JOURNAL OF VIROLOGY

Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus

(2013) Jun Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breaking the indexing ambiguity in serial crystallography

(2013) Wolfgang Brehm et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Linking Crystallographic Model and Data Quality

(2012) P. A. Karplus et al.   SCIENCE

NMR Detection of pH-Dependent Histidine–Water Proton Exchange Reveals the Conduction Mechanism of a Transmembrane Proton Channel

(2011) Fanghao Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Femtosecond X-ray protein nanocrystallography

(2011) Henry N. Chapman et al.   NATURE

Self-terminating diffraction gates femtosecond X-ray nanocrystallography measurements

(2011) Anton Barty et al.   Nature Photonics

Radiation damage in protein serial femtosecond crystallography using an x-ray free-electron laser

(2011) Lukas Lomb et al.   PHYSICAL REVIEW B

Tidal surge in the M2 proton channel, sensed by 2D IR spectroscopy

(2011) A. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Conformational plasticity of the influenza A M2 transmembrane helix in lipid bilayers under varying pH, drug binding, and membrane thickness

(2010) Fanghao Hu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Influenza Virus M2 Protein Mediates ESCRT-Independent Membrane Scission

(2010) Jeremy S. Rossman et al.   CELL

Multiple Proton Confinement in the M2 Channel from the Influenza A Virus

(2010) Vincenzo Carnevale et al.   Journal of Physical Chemistry C

Kinetic Analysis of the M2 Proton Conduction of the Influenza Virus

(2010) Rafal M. Pielak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

(2010) Sarah D. Cady et al.   NATURE

Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus

(2010) R. Acharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proton and cation transport activity of the M2 proton channel from influenza A virus

(2010) T. Leiding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insight into the Mechanism of the Influenza A Proton Channel from a Structure in a Lipid Bilayer

(2010) M. Sharma et al.   SCIENCE

Mechanisms of Proton Conduction and Gating in Influenza M2 Proton Channels from Solid-State NMR

(2010) F. Hu et al.   SCIENCE

Functional Studies and Modeling of Pore-Lining Residue Mutants of the Influenza A Virus M2 Ion Channel

(2009) Victoria Balannik et al.   BIOCHEMISTRY

Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus

(2009) E. Khurana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel

(2009) C. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Secondary Gate As a Mechanism for Inhibition of the M2 Proton Channel by Amantadine

(2008) Myunggi Yi et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structure and mechanism of the M2 proton channel of influenza A virus

(2008) Jason R. Schnell et al.   NATURE

Structural basis for the function and inhibition of an influenza virus proton channel

(2008) Amanda L. Stouffer et al.   NATURE