Involvement of E3 Ligases and Deubiquitinases in the Control of HIF-α Subunit Abundance

USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization

(2018) Chenming Wu et al.   CELL DEATH AND DIFFERENTIATION

Advances in Hypoxia-Inducible Factor Biology

(2018) Hani Choudhry et al.   Cell Metabolism

Monocyte chemoattractant protein-induced protein 1 targets hypoxia-inducible factor 1α to protect against hepatic ischemia/reperfusion injury

(2018) Peng Sun et al.   HEPATOLOGY

FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1α/CEACAM5 functional axis

(2018) Qingguo Li et al.   International Journal of Biological Sciences

Ubiquitin ligase CHIP functions as an oncogene and activates the AKT signaling pathway in prostate cancer

(2018) Li Cheng et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer

(2018) Omar M. Khan et al.   JOURNAL OF CLINICAL INVESTIGATION

USP28 Deficiency Promotes Breast and Liver Carcinogenesis as well as Tumor Angiogenesis in a HIF-independent Manner

(2018) Kati Richter et al.   MOLECULAR CANCER RESEARCH

USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization

(2018) Shangda Yang et al.   Nature Communications

Clinical Significance of Ubiquitin Specific Protease 7 (USP7) in Predicting Prognosis of Hepatocellular Carcinoma and its Functional Mechanisms

(2018) Xujing Wang et al.   MEDICAL SCIENCE MONITOR

High Expression of Ubiquitin-Specific Protease 8 (USP8) Is Associated with Poor Prognosis in Patients with Cervical Squamous Cell Carcinoma

(2018) Min Yan et al.   MEDICAL SCIENCE MONITOR

Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis

(2018) Dongxue Su et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting the overexpressed USP7 inhibits esophageal squamous cell carcinoma cell growth by inducing NOXA-mediated apoptosis

(2018) Tao Hu et al.   MOLECULAR CARCINOGENESIS

USP28 contributes to the proliferation and metastasis of gastric cancer

(2018) Li-Juan Zhao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

MicroRNA-19a regulates the proliferation, migration and invasion of human gastric cancer cells by targeting CUL5

(2018) Yu Zhu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Deubiquitinating enzyme USP20 is a positive regulator of claspin and suppresses the malignant characteristics of gastric cancer cells

(2017) Chao Wang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

CDK5/FBW7-dependent ubiquitination and degradation of EZH2 inhibits pancreatic cancer cell migration and invasion

(2017) Xin Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expressions of insulin-like growth factor receptor-1 and cezanne-1 in lung adenocarcinoma

(2017) Zhaofei Pang et al.   MEDICAL ONCOLOGY

The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks

(2017) Mircea Ivan et al.   MOLECULAR CELL

TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling

(2017) Bin Wang et al.   NATURE

Deubiquitinase USP9X promotes cell migration, invasion and inhibits apoptosis of human pancreatic cancer

(2017) Li Liu et al.   ONCOLOGY REPORTS

High TRAF6 Expression Is Associated With Esophageal Carcinoma Recurrence and Prompts Cancer Cell Invasion

(2017) Xinyang Liu et al.   ONCOLOGY RESEARCH

TRAF6 expression is associated with poorer prognosis and high recurrence in urothelial bladder cancer

(2017) Hanli Wu et al.   Oncology Letters

USP9X regulates centrosome duplication and promotes breast carcinogenesis

(2017) Xin Li et al.   Nature Communications

Aberrant expression of deubiquitylating enzyme USP9X predicts poor prognosis in gastric cancer

(2017) Xiang Fu et al.   Clinics and Research in Hepatology and Gastroenterology

RACK1 promotes lung cancer cell growth via an MCM7/RACK1/Akt signaling complex

(2017) Liangru Fei et al.   Oncotarget

Deubiquitylation of deubiquitylases

(2017) Saba Haq et al.   Open Biology

UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization

(2017) Ryota Nakashima et al.   Scientific Reports

Hypoxia induces epithelial-mesenchymal transition in colorectal cancer cells through ubiquitin-specific protease 47-mediated stabilization of Snail: A potential role of Sox9

(2017) Bae-Jung Choi et al.   Scientific Reports

CHIP involves in non-small cell lung cancer prognosis through VEGF pathway

(2016) QIAN Tingting et al.   BIOMEDICINE & PHARMACOTHERAPY

MCPIP1 Selectively Destabilizes Transcripts Associated with an Antiapoptotic Gene Expression Program in Breast Cancer Cells That Can Elicit Complete Tumor Regression

(2016) Wenbao Lu et al.   CANCER RESEARCH

Inhibition of RACK1 ameliorates choroidal neovascularization formation in vitro and in vivo

(2016) Xiaojuan Liu et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Difference in CXCR4 expression between sporadic and VHL-related hemangioblastoma

(2016) Roeliene C. Kruizinga et al.   Familial Cancer

Ubiquitin chain diversity at a glance

(2016) Masato Akutsu et al.   JOURNAL OF CELL SCIENCE

MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes

(2016) Syed Arif Abdul Rehman et al.   MOLECULAR CELL

A hypoxia-responsive TRAF6–ATM–H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis

(2016) Abdol-Hossein Rezaeian et al.   NATURE CELL BIOLOGY

Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182

(2016) ERIC J. DEVOR et al.   ONCOLOGY REPORTS

OTUD7B and NIK expression in non-small cell lung cancer: Association with clinicopathological features and prognostic implications

(2016) Boxiang Zhang et al.   PATHOLOGY RESEARCH AND PRACTICE

TRAF6 promotes the invasion and metastasis and predicts a poor prognosis in gastric cancer

(2016) Fei Han et al.   PATHOLOGY RESEARCH AND PRACTICE

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

(2016) Caroline Wigerup et al.   PHARMACOLOGY & THERAPEUTICS

K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression

(2016) Han-Tsang Wu et al.   Nature Communications

TRAF6 regulates melanoma invasion and metastasis through ubiquitination of Basigin

(2016) Zhongling Luo et al.   Oncotarget

USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability

(2016) Min Wu et al.   Oncotarget

USP9X destabilizes pVHL and promotes cell proliferation

(2016) Cong Zhang et al.   Oncotarget

FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1

(2016) Carsten C. Scholz et al.   PLOS BIOLOGY

DUBs, the regulation of cell identity and disease

(2015) Johanna Heideker et al.   BIOCHEMICAL JOURNAL

Cezanne regulates E2F1-dependent HIF2  expression

(2015) S. Moniz et al.   JOURNAL OF CELL SCIENCE

Pheochromocytoma Screening Initiation and Frequency in von Hippel-Lindau Syndrome

(2015) Rachel D. Aufforth et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma

(2015) Jia-hong Wang et al.   Journal of Translational Medicine

Deubiquitinase USP47/UBP64E Regulates β-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling

(2015) Jiandang Shi et al.   MOLECULAR AND CELLULAR BIOLOGY

Deubiquitinase inhibition as a cancer therapeutic strategy

(2015) Padraig D'Arcy et al.   PHARMACOLOGY & THERAPEUTICS

Insights into Cullin-RING E3 Ubiquitin Ligase Recruitment: Structure of the VHL-EloBC-Cul2 Complex

(2015) Henry C. Nguyen et al.   STRUCTURE

The de-ubiquitinase UCHL1 promotes gastric cancer metastasis via the Akt and Erk1/2 pathways

(2015) Yu-yu Gu et al.   TUMOR BIOLOGY

CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) and P53 mutation pattern in sporadic colorectal cancer

(2015) Rania Abdelmaksoud-Dammak et al.   TUMOR BIOLOGY

UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α

(2015) Yoko Goto et al.   Nature Communications

UCHL1 is a biomarker of aggressive multiple myeloma required for disease progression

(2015) Sajjad Hussain et al.   Oncotarget

HIF-1α pathway: role, regulation and intervention for cancer therapy

(2015) Georgina N. Masoud et al.   Acta Pharmaceutica Sinica B

CHIP is a novel tumor suppressor in pancreatic cancer and inhibits tumor growth through targeting EGFR

(2015) Tianxiao Wang et al.   Oncotarget

Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy

(2015) Jianying Guo et al.   Oncotarget

K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy

(2015) Joao Vasco Ferreira et al.   Scientific Reports

SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer

(2014) Guoqiang Li et al.   CANCER CELL

Hypoxia-Induced SUMOylation of E3 Ligase HAF Determines Specific Activation of HIF2 in Clear-Cell Renal Cell Carcinoma

(2014) M. Y. Koh et al.   CANCER RESEARCH

Kelch-like ECT2-interacting protein KLEIP regulates late-stage pulmonary maturation via Hif-2  in mice

(2014) N. Woik et al.   Disease Models & Mechanisms

USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin

(2014) T. M. Durcan et al.   EMBO JOURNAL

Cezanne (OTUD7B) regulates HIF-1  homeostasis in a proteasome-independent manner

(2014) A. Bremm et al.   EMBO REPORTS

The multifaceted von Hippel-Lindau tumour suppressor protein

(2014) Claire M. Robinson et al.   FEBS LETTERS

The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers

(2014) Arindam Paul   Frontiers in Bioscience-Landmark

Mdm2 protein expression is strongly associated with survival in malignant pleural mesothelioma

(2014) Fabian D Mairinger et al.   Future Oncology

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase

(2014) X. Zheng et al.   GENES & DEVELOPMENT

The E3 Ubiquitin Ligase Pellino3 Protects against Obesity-Induced Inflammation and Insulin Resistance

(2014) Shuo Yang et al.   IMMUNITY

MDM2 Regulates Hypoxic Hypoxia-inducible Factor 1α Stability in an E3 Ligase, Proteasome, and PTEN-Phosphatidylinositol 3-Kinase-AKT-dependent Manner

(2014) Shweta Joshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer

(2014) Markus E. Diefenbacher et al.   JOURNAL OF CLINICAL INVESTIGATION

TRAF6 is over-expressed in pancreatic cancer and promotes the tumorigenicity of pancreatic cancer cells

(2014) Yefei Rong et al.   MEDICAL ONCOLOGY

Mutations in the deubiquitinase gene USP8 cause Cushing's disease

(2014) Martin Reincke et al.   NATURE GENETICS

HERC2-USP20 axis regulates DNA damage checkpoint through Claspin

(2014) Jian Yuan et al.   NUCLEIC ACIDS RESEARCH

TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation

(2014) Ivano Amelio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antidicer RNAse activity of monocyte chemotactic protein-induced protein-1 is critical for inducing angiogenesis

(2013) Arpita Roy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Metastatic Lymph Node CHIP Expression is a Potential Prognostic Marker for Resected Esophageal Squamous Cell Carcinoma Patients

(2013) Jing Wen et al.   ANNALS OF SURGICAL ONCOLOGY

STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy

(2013) João Vasco Ferreira et al.   Autophagy

The P-body component USP52/PAN2 is a novel regulator ofHIF1AmRNA stability

(2013) John S. Bett et al.   BIOCHEMICAL JOURNAL

Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: Redox proteomics analysis of human brain

(2013) Fabio Di Domenico et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

(2013) Z. Tian et al.   BLOOD

TRAF6 Upregulates Expression of HIF-1  and Promotes Tumor Angiogenesis

(2013) H. Sun et al.   CANCER RESEARCH

CHIP/Stub1 functions as a tumor suppressor and represses NF- B-mediated signaling in colorectal cancer

(2013) Y. Wang et al.   CARCINOGENESIS

Cezanne Regulates Inflammatory Responses to Hypoxia in Endothelial Cells by Targeting TRAF6 for Deubiquitination

(2013) Le A. Luong et al.   CIRCULATION RESEARCH

USP8 Is a Novel Target for Overcoming Gefitinib Resistance in Lung Cancer

(2013) S. Byun et al.   CLINICAL CANCER RESEARCH

HIF1α deubiquitination by USP8 is essential for ciliogenesis in normoxia

(2013) Albino Troilo et al.   EMBO REPORTS

Downregulation of miR-7 upregulates Cullin 5 (CUL5) to facilitate G1/S transition in human hepatocellular carcinoma cells

(2013) Chaoqun Ma et al.   IUBMB LIFE

Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation

(2013) Maimon E. Hubbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression and clinical significance of SIAH in laryngeal squamous cell carcinoma

(2013) Xue-Kui Liu et al.   MEDICAL ONCOLOGY

Downregulation of PHLPP Expression Contributes to Hypoxia-Induced Resistance to Chemotherapy in Colon Cancer Cells

(2013) Yang-An Wen et al.   MOLECULAR AND CELLULAR BIOLOGY

Forced downregulation of RACK1 inhibits glioma development by suppressing Src/Akt signaling activity

(2013) RENJUN PENG et al.   ONCOLOGY REPORTS

Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover

(2013) C. Geng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

USP28 is a potential prognostic marker for bladder cancer

(2013) Guiying Guo et al.   TUMOR BIOLOGY

Expression of carboxyl terminus of Hsp70-interacting protein (CHIP) indicates poor prognosis in human gallbladder carcinoma

(2013) ZHE LONG LIANG et al.   Oncology Letters

USP10 Antagonizes c-Myc Transcriptional Activation through SIRT6 Stabilization to Suppress Tumor Formation

(2013) Zhenghong Lin et al.   Cell Reports

UCHL1 Is a Putative Tumor Suppressor in Ovarian Cancer Cells and Contributes to Cisplatin Resistance

(2013) Chengmeng Jin et al.   Journal of Cancer

Overexpressions of RACK1 and CD147 Associated with Poor Prognosis in Stage T1 Pulmonary Adenocarcinoma

(2012) Xinwen Zhong et al.   ANNALS OF SURGICAL ONCOLOGY

Proteasome inhibitors in mantle cell lymphoma

(2012) Beata Holkova et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Proteasome inhibitors in multiple myeloma: 10 years later

(2012) P. Moreau et al.   BLOOD

MicroRNA-19a and -19b regulate cervical carcinoma cell proliferation and invasion by targeting CUL5

(2012) Xue-Mei Xu et al.   CANCER LETTERS

RACK1 Suppresses Gastric Tumorigenesis by Stabilizing the β-Catenin Destruction Complex

(2012) Yue–Zhen Deng et al.   GASTROENTEROLOGY

CHIP functions as a novel suppressor of tumour angiogenesis with prognostic significance in human gastric cancer

(2012) Shouyu Wang et al.   GUT

Receptor for activated C kinase 1 promotes hepatocellular carcinoma growth by enhancing mitogen-activated protein kinase kinase 7 activity

(2012) Yuanyuan Guo et al.   HEPATOLOGY

RACK1 Promotes Non-small-cell Lung Cancer Tumorigenicity through Activating Sonic Hedgehog Signaling Pathway

(2012) Shuo Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction with ErbB4 Promotes Hypoxia-inducible Factor-1α Signaling

(2012) Ilkka Paatero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

(2012) Pedro A. Pérez-Mancera et al.   NATURE

Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer

(2012) Sakari Vanharanta et al.   NATURE MEDICINE

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Histone Ubiquitination and Deubiquitination in Transcription, DNA Damage Response, and Cancer

(2012) Jian Cao et al.   Frontiers in Oncology

GSK-3  regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1 

(2011) D. Flugel et al.   BLOOD

A Cullin3-KLHL20 Ubiquitin Ligase-Dependent Pathway Targets PML to Potentiate HIF-1 Signaling and Prostate Cancer Progression

(2011) Wei-Chien Yuan et al.   CANCER CELL

The Hypoxia-Associated Factor Switches Cells from HIF-1 - to HIF-2 -Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion

(2011) M. Y. Koh et al.   CANCER RESEARCH

Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms

(2011) P de Bie et al.   CELL DEATH AND DIFFERENTIATION

USP13 Enzyme Regulates Siah2 Ligase Stability and Activity via Noncatalytic Ubiquitin-binding Domains

(2011) Marzia Scortegagna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin-specific Protease 19 (USP19) Regulates Hypoxia-inducible Factor 1α (HIF-1α) during Hypoxia

(2011) Mikael Altun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia

(2011) Jessica M. Cassavaugh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Nuclear expression of the ubiquitin ligase seven in absentia homolog (SIAH)-1 induces proliferation and migration of liver cancer cells

(2011) Antje Brauckhoff et al.   JOURNAL OF HEPATOLOGY

Hypoxia-Induced Epigenetic Regulation and Silencing of the BRCA1 Promoter

(2011) Y. Lu et al.   MOLECULAR AND CELLULAR BIOLOGY

Deubiquitinases in cancer: new functions and therapeutic options

(2011) J M Fraile et al.   ONCOGENE

Identification of Distinctive Patterns of USP19-Mediated Growth Regulation in Normal and Malignant Cells

(2011) Yu Lu et al.   PLoS One

K11-linked ubiquitin chains as novel regulators of cell division

(2011) Katherine E. Wickliffe et al.   TRENDS IN CELL BIOLOGY

USP10 Regulates p53 Localization and Stability by Deubiquitinating p53

(2010) Jian Yuan et al.   CELL

K33-Linked Polyubiquitination of T Cell Receptor-ζ Regulates Proteolysis-Independent T Cell Signaling

(2010) Haining Huang et al.   IMMUNITY

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

The Chaperone-Dependent Ubiquitin Ligase CHIP Targets HIF-1α for Degradation in the Presence of Methylglyoxal

(2010) Carla Figueira Bento et al.   PLoS One

USP14 inhibits ER-associated degradation via interaction with IRE1α

(2009) Atsushi Nagai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination

(2009) Sirio Dupont et al.   CELL

The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates

(2009) Gerco C Hassink et al.   EMBO REPORTS

RACK1: A superior independent predictor for poor clinical outcome in breast cancer

(2009) Xi-Xi Cao et al.   INTERNATIONAL JOURNAL OF CANCER

SEPT9_v1 Up-regulates Hypoxia-inducible Factor 1 by Preventing Its RACK1-mediated Degradation

(2009) Sharon Amir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α

(2009) Weibo Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin-like Sequence in ASK1 Plays Critical Roles in the Recognition and Stabilization by USP9X and Oxidative Stress-Induced Cell Death

(2009) Hiroaki Nagai et al.   MOLECULAR CELL

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

(2009) Martin Schwickart et al.   NATURE

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alterations of ubiquitin ligases in human cancer and their association with the natural history of the tumor

(2009) S Confalonieri et al.   ONCOGENE

Mechanisms of c-Myc Degradation by Nickel Compounds and Hypoxia

(2009) Qin Li et al.   PLoS One

Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase

(2009) E. S. Ehrlich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inactivation of the CYLD Deubiquitinase by HPV E6 Mediates Hypoxia-Induced NF-κB Activation

(2008) Jiabin An et al.   CANCER CELL

Deubiquitination of CXCR4 by USP14 Is Critical for Both CXCL12-induced CXCR4 Degradation and Chemotaxis but Not ERK Activation

(2008) Marjelo A. Mines et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1 , Leading to Its Oxygen-Independent Degradation

(2008) M. Y. Koh et al.   MOLECULAR AND CELLULAR BIOLOGY

Abundance of aspargynyl-hydroxylase FIH is regulated by Siah-1 under normoxic conditions

(2008) Hiromasa Fukuba et al.   NEUROSCIENCE LETTERS

Rac-1 promotes pulmonary artery smooth muscle cell proliferation by upregulation of plasminogen activator inhibitor-1: Role of NFκB-dependent hypoxia-inducible factor-1α transcription

(2008) Isabel Diebold et al.   THROMBOSIS AND HAEMOSTASIS