The multifaceted von Hippel-Lindau tumour suppressor protein

The Von Hippel-Lindau Protein Suppresses Androgen Receptor Activity

(2014) Jing Wang et al.   MOLECULAR ENDOCRINOLOGY

pVHL acts as a downstream target of E2F1 to suppress E2F1 activity

(2013) Wei Ji et al.   BIOCHEMICAL JOURNAL

Deletions of chromosomes 3p and 14q molecularly subclassify clear cell renal cell carcinoma

(2013) Nils Kroeger et al.   CANCER

DCNL1 Functions as a Substrate Sensor and Activator of Cullin 2-RING Ligase

(2013) P. Heir et al.   MOLECULAR AND CELLULAR BIOLOGY

Comprehensive molecular characterization of clear cell renal cell carcinoma

(2013)   NATURE

5-hydroxymethylcytosine and its potential roles in development and cancer

(2013) Gerd P Pfeifer et al.   Epigenetics & Chromatin

5-Methylcytosine DNA Demethylation: More Than Losing a Methyl Group

(2012) Don-Marc Franchini et al.   Annual Review of Genetics

Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer

(2012) Sakari Vanharanta et al.   NATURE MEDICINE

Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression

(2012) W. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-induced DNA hypermethylation in human pulmonary fibroblasts is associated with Thy-1 promoter methylation and the development of a pro-fibrotic phenotype

(2012) Claire M Robinson et al.   RESPIRATORY RESEARCH

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Expression of Hypoxic Marker CA IX Is Regulated by Site-Specific DNA Methylation and Is Associated with the Histology of Gastric Cancer

(2011) Jun Nakamura et al.   AMERICAN JOURNAL OF PATHOLOGY

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells

(2011) Kian Peng Koh et al.   Cell Stem Cell

Chromatin as an oxygen sensor and active player in the hypoxia response

(2011) Andrew Melvin et al.   CELLULAR SIGNALLING

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

(2011) Ignacio Varela et al.   NATURE

Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia

(2011) Ryan C Russell et al.   NATURE MEDICINE

von Hippel–Lindau protein promotes Skp2 destabilization on DNA damage

(2011) J-S Roe et al.   ONCOGENE

Von Hippel-Lindau (VHL) Inactivation in Sporadic Clear Cell Renal Cancer: Associations with Germline VHL Polymorphisms and Etiologic Risk Factors

(2011) Lee E. Moore et al.   PLoS Genetics

Ischemia dysregulates DNA methyltransferases andp16INK4amethylation in human colorectal cancer cells

(2010) Karolina Skowronski et al.   Epigenetics

Epigenetics: The epicenter of the hypoxic response

(2010) Jenny A. Watson et al.   Epigenetics

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

(2010) Gillian L. Dalgliesh et al.   NATURE

Effects of HIF-1 and HIF2 on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts

(2010) Swethajit Biswas et al.   Journal of Oncology

ZUR FRAGE DER ANGIOMATOSIS RETINae UND IHRER HIRNKOMPLIKATIONEN

(2009) ARVID LINDAU   ACTA OPHTHALMOLOGICA

Suppression of Hypoxia-Inducible Factor 2  Restores p53 Activity via Hdm2 and Reverses Chemoresistance of Renal Carcinoma Cells

(2009) A. M. Roberts et al.   CANCER RESEARCH

Generation of an epigenetic signature by chronic hypoxia in prostate cells

(2009) J. A. Watson et al.   HUMAN MOLECULAR GENETICS

CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma

(2009) Fiona E McRonald et al.   Molecular Cancer

VHL loss causes spindle misorientation and chromosome instability

(2009) Claudio R. Thoma et al.   NATURE CELL BIOLOGY

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

(2009) Gijs van Haaften et al.   NATURE GENETICS

Deciphering von Hippel-Lindau (VHL/Vhl)-Associated Pancreatic Manifestations by Inactivating Vhl in Specific Pancreatic Cell Populations

(2009) H.-C. Jennifer Shen et al.   PLoS One

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

(2009) X. Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α

(2008) Patrick J. Pollard et al.   BIOCHEMICAL JOURNAL

Inadequate Activation of the GTPase RhoA Contributes to the Lack of Fibronectin Matrix Assembly in von Hippel-Lindau Protein-defective Renal Cancer Cells

(2008) Monica Feijóo-Cuaresma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF

(2008) Sophie Beyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SWI/SNF Regulates the Cellular Response to Hypoxia

(2008) Niall S. Kenneth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Renal Epithelial Tight Junctions by the von Hippel-Lindau Tumor Suppressor Gene Involves Occludin and Claudin 1 and Is Independent of E-Cadherin

(2008) Sarah K. Harten et al.   MOLECULAR BIOLOGY OF THE CELL