Balkan endemic nephropathy: an update on its aetiology

Sulfotransferase-1A1-dependent bioactivation of aristolochic acid I andN-hydroxyaristolactam I in human cells

(2016) Keiji Hashimoto et al.   CARCINOGENESIS

Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivo

(2016) Helena Dračínská et al.   TOXICOLOGY

Aristolochic acid exposure in Romania and implications for renal cell carcinoma

(2015) Robert J Turesky et al.   BRITISH JOURNAL OF CANCER

Preventing Aristolochic Acid Nephropathy

(2015) N. Anandagoda et al.   Clinical Journal of the American Society of Nephrology

Balkan nephropathy

(2015) Vladisav Stefanovic et al.   CLINICAL NEPHROLOGY

A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches

(2015) Marie Stiborová et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

New approaches for biomonitoring exposure to the human carcinogen aristolochic acid

(2015) Byeong Hwa Yun et al.   Toxicology Research

The influence of ochratoxin A on DNA adduct formation by the carcinogen aristolochic acid in rats

(2014) Marie Stiborová et al.   ARCHIVES OF TOXICOLOGY

Bioactivation of the human carcinogen aristolochic acid

(2014) Viktoriya S. Sidorenko et al.   CARCINOGENESIS

Determination of Sulfotransferase Forms Involved in the Metabolic Activation of the Genotoxicant 1-Hydroxymethylpyrene Using Bacterially Expressed Enzymes and Genetically Modified Mouse Models

(2014) Carolin Bendadani et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Update on endemic nephropathies

(2014) Annika Wernerson et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Mechanisms of Enzyme-Catalyzed Reduction of Two Carcinogenic Nitro-Aromatics, 3-Nitrobenzanthrone and Aristolochic Acid I: Experimental and Theoretical Approaches

(2014) Marie Stiborová et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Limitations and plausibility of the Pliocene lignite hypothesis in explaining the etiology of Balkan endemic nephropathy

(2014) S. V. M. Maharaj   INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH

The influence of dicoumarol on the bioactivation of the carcinogen aristolochic acid I in rats

(2014) Marie Stiborová et al.   MUTAGENESIS

The effect of aristolochic acid I on expression of NAD(P)H:quinone oxidoreductase in mice and rats—A comparative study

(2014) František Bárta et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Unambiguous Detection of Multiple TP53 Gene Mutations in AAN-Associated Urothelial Cancer in Belgium Using Laser Capture Microdissection

(2014) Selda Aydin et al.   PLoS One

Global and specific histone acetylation pattern in patients with Balkan endemic nephropathy, a worldwide disease

(2014) Gordana Kocic et al.   RENAL FAILURE

Evaluating Weight of Evidence in the Mystery of Balkan Endemic Nephropathy

(2014) Travis Bui-Klimke et al.   RISK ANALYSIS

Variation in genomic landscape of clear cell renal cell carcinoma across Europe

(2014) Ghislaine Scelo et al.   Nature Communications

Modelling mutational landscapes of human cancers in vitro

(2014) Magali Olivier et al.   Scientific Reports

Is Increased Susceptibility to Balkan Endemic Nephropathy in Carriers of Common GSTA1 (*A/*B) Polymorphism Linked with the Catalytic Role of GSTA1 in Ochratoxin A Biotransformation? Serbian Case Control Study and In Silico Analysis

(2014) Zorica Reljic et al.   Toxins

NGS NominatedCELA1,HSPG2, andKCNK5as Candidate Genes for Predisposition to Balkan Endemic Nephropathy

(2014) D. Toncheva et al.   Biomed Research International

Human Formalin-Fixed Paraffin-Embedded Tissues: An Untapped Specimen for Biomonitoring of Carcinogen DNA Adducts by Mass Spectrometry

(2013) Byeong Hwa Yun et al.   ANALYTICAL CHEMISTRY

The Epidemiology, Diagnosis, and Management of Aristolochic Acid Nephropathy

(2013) M. Refik Gökmen et al.   ANNALS OF INTERNAL MEDICINE

Induced Expression of Cytochrome P450 1A and NAD(P)H:Quinone Oxidoreductase Determined at mRNA, Protein, and Enzyme Activity Levels in Rats Exposed to the Carcinogenic Azo Dye 1-Phenylazo-2-naphthol (Sudan I)

(2013) Marie Stiborová et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Enzymes Metabolizing Aristolochic Acid and their Contribution to the Development of Aristolochic Acid Nephropathy and Urothelial Cancer

(2013) Marie Stiborova et al.   CURRENT DRUG METABOLISM

Organic compounds in water extracts of coal: links to Balkan endemic nephropathy

(2013) S. V. M. Maharaj et al.   ENVIRONMENTAL GEOCHEMISTRY AND HEALTH

Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy

(2013) Heinz H. Schmeiser et al.   INTERNATIONAL JOURNAL OF CANCER

Consensus statement on screening, diagnosis, classification and treatment of endemic (Balkan) nephropathy

(2013) B. Jelakovi  et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool

(2013) S. L. Poon et al.   Science Translational Medicine

Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing

(2013) M. L. Hoang et al.   Science Translational Medicine

Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid

(2013) Marie Stiborová et al.   XENOBIOTICA

Whole genome methylation array analysis reveals new aspects in Balkan endemic nephropathy etiology

(2013) Rada Staneva et al.   BMC Nephrology

THE ROLE OF BIOTRANSFORMATION ENZYMES IN THE DEVELOPMENT OF RENAL INJURY AND UROTHELIAL CANCER CAUSED BY ARISTOLOCHIC ACID: URGENT QUESTIONS AND DIFFICULT ANSWERS

(2012) Marie Stiborova et al.   BIOMEDICAL PAPERS-OLOMOUC

Biomonitoring of Aristolactam-DNA Adducts in Human Tissues Using Ultra-Performance Liquid Chromatography/Ion-Trap Mass Spectrometry

(2012) Byeong Hwa Yun et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Aristolochic acid nephropathy: Harbinger of a global iatrogenic disease

(2012) Arthur P. Grollman   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

ACB-PCR measurement of H-ras codon 61 CAA→CTA mutation provides an early indication of aristolochic acid I carcinogenic effect in tumor target tissues

(2012) Yiying Wang et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Evidence of exposure to aristolochic acid in patients with urothelial cancer from a Balkan endemic nephropathy region of Romania

(2012) Heinz H. Schmeiser et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Chinese herbs nephropathy and Balkan endemic nephropathy: toward a single entity, aristolochic acid nephropathy

(2012) Marc E. De Broe   KIDNEY INTERNATIONAL

Aristolochic acid-associated urothelial cancer in Taiwan

(2012) C.-H. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I

(2012) Katerina Levova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Endoplasmic reticulum stress mediates aristolochic acid I-induced apoptosis in human renal proximal tubular epithelial cells

(2012) Shaohua Zhu et al.   TOXICOLOGY IN VITRO

An Update on Direct Genotoxicity as a Molecular Mechanism of Ochratoxin A Carcinogenicity

(2011) Annie Pfohl-Leszkowicz et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Role of P450 1A1 and P450 1A2 in Bioactivation versus Detoxication of the Renal Carcinogen Aristolochic Acid I: Studies inCyp1a1(−/−),Cyp1a2(−/−), andCyp1a1/1a2(−/−)Mice

(2011) Volker M. Arlt et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The human carcinogen aristolochic acid i is activated to form DNA adducts by human NAD(P)H:quinone oxidoreductase without the contribution of acetyltransferases or sulfotransferases

(2011) Marie Stiborová et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

TP53 Mutational signature for aristolochic acid: an environmental carcinogen

(2011) Masaaki Moriya et al.   INTERNATIONAL JOURNAL OF CANCER

Glutathione S-transferases T1 null genotype is associated with susceptibility to aristolochic acid nephropathy

(2011) Bicheng Chen et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid

(2011) Bojan Jelaković et al.   KIDNEY INTERNATIONAL

Aristolochic acid-induced carcinogenesis examined by ACB-PCR quantification of H-Ras and K-Ras mutant fraction

(2011) Y. Wang et al.   MUTAGENESIS

Lack of recognition by global-genome nucleotide excision repair accounts for the high mutagenicity and persistence of aristolactam-DNA adducts

(2011) Victoria S. Sidorenko et al.   NUCLEIC ACIDS RESEARCH

Role of Cytochromes P450 1A1/2 in Detoxication and Activation of Carcinogenic Aristolochic Acid I: Studies with the Hepatic NADPH:Cytochrome P450 Reductase Null (HRN) Mouse Model

(2011) Kateřina Levová et al.   TOXICOLOGICAL SCIENCES

Bioactivation versus Detoxication of the Urothelial Carcinogen Aristolochic Acid I by Human Cytochrome P450 1A1 and 1A2

(2011) Marie Stiborová et al.   TOXICOLOGICAL SCIENCES

Inhibition of Renal NQO1 Activity by Dicoumarol Suppresses Nitroreduction of Aristolochic Acid I and Attenuates its Nephrotoxicity

(2011) Min Chen et al.   TOXICOLOGICAL SCIENCES

Aristolochic acid I induced oxidative DNA damage associated with glutathione depletion and ERK1/2 activation in human cells

(2011) Feng-Yih Yu et al.   TOXICOLOGY IN VITRO

Ochratoxin A and Aristolochic Acid Involvement in Nephropathies and Associated Urothelial Tract Tumours

(2010) Annie Pfohl-Leszkowicz   Arhiv za Higijenu Rada i Toksikologiju-Archives of Industrial Hygiene and Toxicology

Cytochrome P450 1A2 Detoxicates Aristolochic Acid in the Mouse

(2010) T. A. Rosenquist et al.   DRUG METABOLISM AND DISPOSITION

Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model

(2010) Jill E. Kucab et al.   FEBS Journal

Gene expression changes induced by the human carcinogen aristolochic acid I in renal and hepatic tissue of mice

(2010) Volker M. Arlt et al.   INTERNATIONAL JOURNAL OF CANCER

Toxicities of aristolochic acid I and aristololactam I in cultured renal epithelial cells

(2010) Ji Li et al.   TOXICOLOGY IN VITRO

Structures of Covalent Adducts between DNA and Ochratoxin A: A New Factor in Debate about Genotoxicity and Human Risk Assessment

(2009) Peter G. Mantle et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Genetic Polymorphism of the Human Cytochrome P450 2C9 Gene and Its Clinical Significance

(2009) Bo Wang et al.   CURRENT DRUG METABOLISM

Detoxification of aristolochic acid I by O-demethylation: Less nephrotoxicity and genotoxicity of aristolochic acid Ia in rodents

(2009) Shinya Shibutani et al.   INTERNATIONAL JOURNAL OF CANCER

Local uses of Aristolochia species and content of nephrotoxic aristolochic acid 1 and 2—A global assessment based on bibliographic sources

(2009) Michael Heinrich et al.   JOURNAL OF ETHNOPHARMACOLOGY

Fifty Years of Balkan Endemic Nephropathy: Challenges of Study Using Epidemiological Method

(2009) Vladisav Stefanovic et al.   RENAL FAILURE

Balkan Nephropathy: Evolution of Our Knowledge

(2008) Giorgos Bamias et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Metals and kidney markers in adult offspring of endemic nephropathy patients and controls: a two-year follow-up study

(2008) Wilfried Karmaus et al.   Environmental Health

TP53mutation signature supports involvement of aristolochic acid in the aetiology of endemic nephropathy-associated tumours

(2008) Tatiana Nedelko et al.   INTERNATIONAL JOURNAL OF CANCER

Hepatic cytochrome P450s metabolize aristolochic acid and reduce its kidney toxicity

(2008) Y. Xiao et al.   KIDNEY INTERNATIONAL

Biotransformation enzymes in development of renal injury and urothelial cancer caused by aristolochic acid

(2008) M. Stiborová et al.   KIDNEY INTERNATIONAL

Aristolochic acid nephropathy: A worldwide problem

(2008) Frédéric D. Debelle et al.   KIDNEY INTERNATIONAL

Mycotoxins and the kidney: Modes of action for renal tumor formation by ochratoxin A in rodents

(2008) Angela Mally et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Induction of P450 1A by 3-methylcholanthrene protects mice from aristolochic acid-I-induced acute renal injury

(2008) X. Xue et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Upper urothelial carcinoma in Balkan endemic nephropathy and non-endemic regions: A comparative study of pathological features

(2008) Ljubinka Jankovic Velickovic et al.   PATHOLOGY RESEARCH AND PRACTICE

Balkan endemic nephropathy and associated urothelial cancer

(2008) Vladisav Stefanovic et al.   Nature clinical practice. Urology

Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy

(2007) Marie Stiborová et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH