Mechanisms of Enzyme-Catalyzed Reduction of Two Carcinogenic Nitro-Aromatics, 3-Nitrobenzanthrone and Aristolochic Acid I: Experimental and Theoretical Approaches

The influence of dicoumarol on the bioactivation of the carcinogen aristolochic acid I in rats

(2014) Marie Stiborová et al.   MUTAGENESIS

The effect of aristolochic acid I on expression of NAD(P)H:quinone oxidoreductase in mice and rats—A comparative study

(2014) František Bárta et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The Epidemiology, Diagnosis, and Management of Aristolochic Acid Nephropathy

(2013) M. Refik Gökmen et al.   ANNALS OF INTERNAL MEDICINE

Enzymes Metabolizing Aristolochic Acid and their Contribution to the Development of Aristolochic Acid Nephropathy and Urothelial Cancer

(2013) Marie Stiborova et al.   CURRENT DRUG METABOLISM

Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy

(2013) Heinz H. Schmeiser et al.   INTERNATIONAL JOURNAL OF CANCER

Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool

(2013) S. L. Poon et al.   Science Translational Medicine

Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing

(2013) M. L. Hoang et al.   Science Translational Medicine

Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid

(2013) Marie Stiborová et al.   XENOBIOTICA

Biomonitoring of Aristolactam-DNA Adducts in Human Tissues Using Ultra-Performance Liquid Chromatography/Ion-Trap Mass Spectrometry

(2012) Byeong Hwa Yun et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The Diesel Exhaust in Miners Study: A Cohort Mortality Study With Emphasis on Lung Cancer

(2012) Michael D. Attfield et al.   JNCI-Journal of the National Cancer Institute

The Diesel Exhaust in Miners Study: A Nested Case-Control Study of Lung Cancer and Diesel Exhaust

(2012) D. T. Silverman et al.   JNCI-Journal of the National Cancer Institute

Aristolochic acid-associated urothelial cancer in Taiwan

(2012) C.-H. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I

(2012) Katerina Levova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Role of P450 1A1 and P450 1A2 in Bioactivation versus Detoxication of the Renal Carcinogen Aristolochic Acid I: Studies inCyp1a1(−/−),Cyp1a2(−/−), andCyp1a1/1a2(−/−)Mice

(2011) Volker M. Arlt et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The human carcinogen aristolochic acid i is activated to form DNA adducts by human NAD(P)H:quinone oxidoreductase without the contribution of acetyltransferases or sulfotransferases

(2011) Marie Stiborová et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

TP53 Mutational signature for aristolochic acid: an environmental carcinogen

(2011) Masaaki Moriya et al.   INTERNATIONAL JOURNAL OF CANCER

Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid

(2011) Bojan Jelaković et al.   KIDNEY INTERNATIONAL

Theoretical investigations on the formation of nitrobenzanthrone-DNA Adducts

(2011) Volker M. Arlt et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Role of Cytochromes P450 1A1/2 in Detoxication and Activation of Carcinogenic Aristolochic Acid I: Studies with the Hepatic NADPH:Cytochrome P450 Reductase Null (HRN) Mouse Model

(2011) Kateřina Levová et al.   TOXICOLOGICAL SCIENCES

Bioactivation versus Detoxication of the Urothelial Carcinogen Aristolochic Acid I by Human Cytochrome P450 1A1 and 1A2

(2011) Marie Stiborová et al.   TOXICOLOGICAL SCIENCES

Inhibition of Renal NQO1 Activity by Dicoumarol Suppresses Nitroreduction of Aristolochic Acid I and Attenuates its Nephrotoxicity

(2011) Min Chen et al.   TOXICOLOGICAL SCIENCES

Mechanisms of the Different DNA Adduct Forming Potentials of the Urban Air Pollutants 2-Nitrobenzanthrone and Carcinogenic 3-Nitrobenzanthrone

(2010) Marie Stiborová et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Cytochrome P450 1A2 Detoxicates Aristolochic Acid in the Mouse

(2010) T. A. Rosenquist et al.   DRUG METABOLISM AND DISPOSITION

Gene expression changes induced by the human carcinogen aristolochic acid I in renal and hepatic tissue of mice

(2010) Volker M. Arlt et al.   INTERNATIONAL JOURNAL OF CANCER

Identification of a Reduction Product of Aristolochic Acid: Implications for the Metabolic Activation of Carcinogenic Aristolochic Acid

(2010) Horacio A. Priestap et al.   JOURNAL OF NATURAL PRODUCTS

Induction of biotransformation enzymes by the carcinogenic air-pollutant 3-nitrobenzanthrone in liver, kidney and lung, after intra-tracheal instillation in rats

(2010) Jana Mizerovská et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Quantification of 3-Nitrobenzanthrone-DNA Adducts Using Online Column-Switching HPLC-Electrospray Tandem Mass Spectrometry

(2009) Gonçalo Gamboa da Costa et al.   CHEMICAL RESEARCH IN TOXICOLOGY

3-Aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone, induces biotransformation enzymes in rat kidney and lung

(2009) Marie Stiborová et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Generation of a ‘humanized’ hCYP1A1_1A2_Cyp1a1/1a2(−/−)_Ahrd mouse line harboring the poor-affinity aryl hydrocarbon receptor

(2008) Zhanquan Shi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mutagenic potential of nitrenium ions of nitrobenzanthrones: Correlation between theory and experiment

(2008) Jóhannes Reynisson et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Hepatic cytochrome P450s metabolize aristolochic acid and reduce its kidney toxicity

(2008) Y. Xiao et al.   KIDNEY INTERNATIONAL

Biotransformation enzymes in development of renal injury and urothelial cancer caused by aristolochic acid

(2008) M. Stiborová et al.   KIDNEY INTERNATIONAL

Aristolochic acid nephropathy: A worldwide problem

(2008) Frédéric D. Debelle et al.   KIDNEY INTERNATIONAL

The carcinogenic air pollutant 3-nitrobenzanthrone induces GC to TA transversion mutations in human p53 sequences

(2008) J. vom Brocke et al.   MUTAGENESIS

Genotoxicity of 3-nitrobenzanthrone and 3-aminobenzanthrone in Muta™Mouse and lung epithelial cells derived from Muta™Mouse

(2008) Volker M. Arlt et al.   MUTAGENESIS

The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity

(2008) Marie Stiborová et al.   TOXICOLOGY

Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy

(2007) Marie Stiborová et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH