Immune Control by TRAF6-Mediated Pathways of Epithelial Cells in the EIME (Epithelial Immune Microenvironment)

Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A

(2018) Mingchao Wang et al.   IMMUNITY

Keratinocyte-Specific Ablation of RIPK4 Allows Epidermal Cornification but Impairs Skin Barrier Formation

(2018) Corinne Urwyler-Rösselet et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

CARD14 Gain-of-Function Mutation Alone Is Sufficient to Drive IL-23/IL-17–Mediated Psoriasiform Skin Inflammation In Vivo

(2018) Mark Mellett et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

(2018) Tom T.P. Seijkens et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis

(2018) Jing Fang et al.   Cell Reports

RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature

(2018) William R. Swindell et al.   Frontiers in Immunology

BCL10 – Bridging CARDs to Immune Activation

(2018) Torben Gehring et al.   Frontiers in Immunology

RIP4 upregulates CCL20 expression through STAT3 signalling in cultured keratinocytes

(2018) Hyun Cheol Bae et al.   EXPERIMENTAL DERMATOLOGY

Loss-of-function mutations in CARD14 are associated with a severe variant of atopic dermatitis

(2018) Alon Peled et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The laminin binding α3 and α6 integrins cooperate to promote epithelial cell adhesion and growth

(2018) Eugenia M. Yazlovitskaya et al.   MATRIX BIOLOGY

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

(2018) Monika Bambouskova et al.   NATURE

RIP kinases as modulators of inflammation and immunity

(2018) Sudan He et al.   NATURE IMMUNOLOGY

IκBζ is a key transcriptional regulator of IL-36–driven psoriasis-related gene expression in keratinocytes

(2018) Anne Müller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor Necrosis Factor Receptor-Associated Factor Regulation of Nuclear Factor κB and Mitogen-Activated Protein Kinase Pathways

(2018) Jian-Hong Shi et al.   Frontiers in Immunology

Holding All the CARDs: How MALT1 Controls CARMA/CARD-Dependent Signaling

(2018) Mélanie Juilland et al.   Frontiers in Immunology

Structure of TRAF Family: Current Understanding of Receptor Recognition

(2018) Hyun H. Park   Frontiers in Immunology

The CBM-opathies—A Rapidly Expanding Spectrum of Human Inborn Errors of Immunity Caused by Mutations in the CARD11-BCL10-MALT1 Complex

(2018) Henry Y. Lu et al.   Frontiers in Immunology

Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance

(2018) Mounia S. Braza et al.   IMMUNITY

A20 and ABIN1 suppression of a keratinocyte inflammatory program with a shared single cell expression signature in diverse human rashes

(2018) Paymann Harirchian et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis

(2018) Teruki Dainichi et al.   NATURE IMMUNOLOGY

Overview of the IL-1 family in innate inflammation and acquired immunity

(2017) Charles A. Dinarello   IMMUNOLOGICAL REVIEWS

TNF-α–induced protein 3 (TNFAIP3) /A20 acts as a master switch in TNF-α blockade–driven IL-17A expression

(2017) Paulo C.M. Urbano et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cutting Edge: TRAF6 Mediates TLR/IL-1R Signaling–Induced Nontranscriptional Priming of the NLRP3 Inflammasome

(2017) Yue Xing et al.   JOURNAL OF IMMUNOLOGY

Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling

(2017) Sam Strickson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGFβ activates PI3K-AKT signaling via TRAF6

(2017) Jie Song et al.   Oncotarget

Lung epithelial MyD88 drives early pulmonary clearance of Pseudomonas aeruginosa by a flagellin dependent mechanism

(2016) Adam A. Anas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF- B activation

(2016) A. Howes et al.   BIOCHEMICAL JOURNAL

RIPK4 activates an IRF6-mediated proinflammatory cytokine response in keratinocytes

(2016) Mei Qi Kwa et al.   CYTOKINE

The paracaspase MALT1 mediates CARD14‐induced signaling in keratinocytes

(2016) Inna S Afonina et al.   EMBO REPORTS

Antimicrobial Peptide LL37 and MAVS Signaling Drive Interferon-β Production by Epidermal Keratinocytes during Skin Injury

(2016) Ling-juan Zhang et al.   IMMUNITY

Characterization of TNF-α– and IL-17A–Mediated Synergistic Induction of  DEFB4 Gene Expression in Human Keratinocytes through IκBζ

(2016) Claus Johansen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

One SNP at a Time: Moving beyond GWAS in Psoriasis

(2016) Helen Ray-Jones et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

MALT1 Protease Activity Controls the Expression of Inflammatory Genes in Keratinocytes upon Zymosan Stimulation

(2016) Anja Schmitt et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Keratinocytes contribute intrinsically to psoriasis upon loss ofTnip1function

(2016) Sirish K. Ippagunta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The paracaspase MALT1: biological function and potential for therapeutic inhibition

(2015) Maike Jaworski et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

IMQ-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome

(2015) Hanitriniaina Rabeony et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice

(2015) Katerina Vlantis et al.   GUT

Tumor necrosis factor receptor- associated factor 6 (TRAF6) regulation of development, function, and homeostasis of the immune system

(2015) Matthew C. Walsh et al.   IMMUNOLOGICAL REVIEWS

A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4–ERK5 axis

(2015) Ling Wu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ubiquitin in the activation and attenuation of innate antiviral immunity

(2015) Steven M. Heaton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: NF-κB p65 and c-Rel Control Epidermal Development and Immune Homeostasis in the Skin

(2015) Yenkel Grinberg-Bleyer et al.   JOURNAL OF IMMUNOLOGY

Deficiency of MALT1 Paracaspase Activity Results in Unbalanced Regulatory and Effector T and B Cell Responses Leading to Multiorgan Inflammation

(2015) Frédéric Bornancin et al.   JOURNAL OF IMMUNOLOGY

Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

(2015) Qian Zhang et al.   NATURE

C/EBPβ Promotes Immunity to Oral Candidiasis through Regulation of β-Defensins

(2015) Michelle R. Simpson-Abelson et al.   PLoS One

IκBζ is a key driver in the development of psoriasis

(2015) Claus Johansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The scaffold protein RACK1 mediates the RANKL-dependent activation of p38 MAPK in osteoclast precursors

(2015) Jingjing Lin et al.   Science Signaling

Effect of interleukin-17 on receptor-interacting protein 4 expression and keratinocyte proliferation

(2015) KUN JIA et al.   Experimental and Therapeutic Medicine

Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci

(2015) Lam C. Tsoi et al.   Nature Communications

The scaffold protein RACK1 mediates the RANKL-dependent activation of p38 MAPK in osteoclast precursors

(2015) Jingjing Lin et al.   Science Signaling

Akirin2 is critical for inducing inflammatory genes by bridging I B-  and the SWI/SNF complex

(2014) S. Tartey et al.   EMBO JOURNAL

The deubiquitinase activity of A20 is dispensable for NF- B signaling

(2014) A. De et al.   EMBO REPORTS

Protein kinase C-associated kinase regulates NF-κB activation through inducing IKK activation

(2014) SANG-WOO KIM et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

TAK1-ECSIT-TRAF6 Complex Plays a Key Role in the TLR4 Signal to Activate NF-κB

(2014) Sae Mi Wi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Receptor-interacting Protein Kinase 4 and Interferon Regulatory Factor 6 Function as a Signaling Axis to Regulate Keratinocyte Differentiation

(2014) Mei Qi Kwa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Classification of inflammatory skin diseases: A proposal based on the disorders of the three-layered defense systems, barrier, innate immunity and acquired immunity

(2014) Teruki Dainichi et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Double-Stranded RNA Induces an Antiviral Defense Status in Epidermal Keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-Mediated Differential Signaling

(2014) B. N. Kalali et al.   JOURNAL OF IMMUNOLOGY

IL-17 Signaling for mRNA Stabilization Does Not Require TNF Receptor-Associated Factor 6

(2014) J. Hartupee et al.   JOURNAL OF IMMUNOLOGY

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis

(2014) Conor Mc Guire et al.   Journal of Neuroinflammation

A cell-intrinsic role for TLR2–MYD88 in intestinal and breast epithelia and oncogenesis

(2014) Ferenc A. Scheeren et al.   NATURE CELL BIOLOGY

IL-17 Induces an Expanded Range of Downstream Genes in Reconstituted Human Epidermis Model

(2014) Andrea Chiricozzi et al.   PLoS One

TLR-Dependent Human Mucosal Epithelial Cell Responses to Microbial Pathogens

(2014) Ryan McClure et al.   Frontiers in Immunology

The activation and regulation of IL-17 receptor mediated signaling

(2013) Xinyang Song et al.   CYTOKINE

Dendritic Cell Expression of the Signaling Molecule TRAF6 Is Critical for Gut Microbiota-Dependent Immune Tolerance

(2013) Daehee Han et al.   IMMUNITY

An ACT1 Mutation Selectively Abolishes Interleukin-17 Responses in Humans with Chronic Mucocutaneous Candidiasis

(2013) Bertrand Boisson et al.   IMMUNITY

The Three CARMA Sisters: So Different, So Similar: A Portrait of the Three CARMA Proteins and Their Involvement in Human Disorders

(2013) Ivan Scudiero et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cutting Edge: ABIN-1 Protects against Psoriasis by Restricting MyD88 Signals in Dendritic Cells

(2013) J. A. Callahan et al.   JOURNAL OF IMMUNOLOGY

Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation

(2013) Yichuan Xiao et al.   NATURE MEDICINE

The Deubiquitinase A20 Mediates Feedback Inhibition of Interleukin-17 Receptor Signaling

(2013) A. V. Garg et al.   Science Signaling

MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

(2013) Siqi Liu et al.   eLife

Rare and Common Variants in CARD14, Encoding an Epidermal Regulator of NF-kappaB, in Psoriasis

(2012) Catherine T. Jordan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

MicroRNAs in Stress Signaling and Human Disease

(2012) Joshua T. Mendell et al.   CELL

Th17 Cells in Immunity to Candida albicans

(2012) Nydiaris Hernández-Santos et al.   Cell Host & Microbe

Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance

(2012) Wei Jin et al.   Cellular & Molecular Immunology

Pro-Angiogenic Activity of TLRs and NLRs: A Novel Link Between Gut Microbiota and Intestinal Angiogenesis

(2012) Anja Schirbel et al.   GASTROENTEROLOGY

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

Psoriasiform dermatitis is driven by IL-36–mediated DC-keratinocyte crosstalk

(2012) Luigi Tortola et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-1R–MyD88 signaling in keratinocyte transformation and carcinogenesis

(2012) Christophe Cataisson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: TNF Receptor-Associated Factor 4 Restricts IL-17-Mediated Pathology and Signaling Processes

(2012) J. A. Zepp et al.   JOURNAL OF IMMUNOLOGY

TRAF6-Dependent Act1 Phosphorylation by the I B Kinase-Related Kinases Suppresses Interleukin-17-Induced NF- B Activation

(2012) F. Qu et al.   MOLECULAR AND CELLULAR BIOLOGY

Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons

(2012) Jakub Siednienko et al.   NATURE IMMUNOLOGY

The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90

(2012) Chenhui Wang et al.   NATURE IMMUNOLOGY

Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25

(2012) Bo Zhong et al.   NATURE IMMUNOLOGY

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Diverse ubiquitin signaling in NF-κB activation

(2012) Kazuhiro Iwai   TRENDS IN CELL BIOLOGY

Regulation of epithelial immunity by IL-17 family cytokines

(2012) Rajita Pappu et al.   TRENDS IN IMMUNOLOGY

TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?

(2012) Ashish K. Marwaha et al.   Frontiers in Immunology

Mutations in RIPK4 Cause the Autosomal-Recessive Form of Popliteal Pterygium Syndrome

(2011) Ersan Kalay et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The role of TBK1 and IKKϵ in the expression and activation of Pellino 1

(2011) Hilary Smith et al.   BIOCHEMICAL JOURNAL

T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1

(2011) Jens Staal et al.   EMBO JOURNAL

IL-17-induced NF-κB Activation via CIKS/Act1

(2011) Søren Ulrik Sønder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-κB activation and endoplasmic reticulum stress-induced cell death

(2011) Ivan Scudiero et al.   JOURNAL OF CELLULAR PHYSIOLOGY

miR-146ais a significant brake on autoimmunity, myeloproliferation, and cancer in mice

(2011) Mark P. Boldin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lipopolysaccharide Signaling without a Nucleus: Kinase Cascades Stimulate Platelet Shedding of Proinflammatory IL-1 -Rich Microparticles

(2011) G. T. Brown et al.   JOURNAL OF IMMUNOLOGY

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation

(2011) Katarzyna Bulek et al.   NATURE IMMUNOLOGY

Interleukin-36–Receptor Antagonist Deficiency and Generalized Pustular Psoriasis

(2011) Slaheddine Marrakchi et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Antibacterial Lectin RegIII  Promotes the Spatial Segregation of Microbiota and Host in the Intestine

(2011) S. Vaishnava et al.   SCIENCE

Persistent Stimulation with Interleukin-17 Desensitizes Cells Through SCF -TrCP-Mediated Degradation of Act1

(2011) P. Shi et al.   Science Signaling

Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling

(2010) Shu Zhu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Overexpression of LEDGF/DFS70 Induces IL-6 via p38 Activation in HaCaT Cells, Similar to that Seen in the Psoriatic Condition

(2010) Takuya Takeichi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Integrative Responses to IL-17 and TNF-α in Human Keratinocytes Account for Key Inflammatory Pathogenic Circuits in Psoriasis

(2010) Andrea Chiricozzi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2

(2010) Eva Ellinghaus et al.   NATURE GENETICS

Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis

(2010) Ulrike Hüffmeier et al.   NATURE GENETICS

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

(2010) Amy Strange et al.   NATURE GENETICS

The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88

(2010) Bing He et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

RIP4 Regulates Epidermal Differentiation and Cutaneous Inflammation

(2009) Ryan B. Rountree et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production

(2009) Mikyoung Chang et al.   NATURE IMMUNOLOGY

TRAF6 Is Required for Generation of the B-1a B Cell Compartment as well as T Cell-Dependent and -Independent Humoral Immune Responses

(2009) Takashi Kobayashi et al.   PLoS One

Two Mechanistically and Temporally Distinct NF- B Activation Pathways in IL-1 Signaling

(2009) K. Yamazaki et al.   Science Signaling

IL-17 Receptor Signaling Inhibits C/EBP  by Sequential Phosphorylation of the Regulatory 2 Domain

(2009) F. Shen et al.   Science Signaling

Act1, a U-box E3 Ubiquitin Ligase for IL-17 Signaling

(2009) C. Liu et al.   Science Signaling

The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology

(2009) Lars Vereecke et al.   TRENDS IN IMMUNOLOGY

Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling

(2008) Atsushi Matsuzawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Tumor Necrosis Factor Family Receptors RANK and CD40 Cooperatively Establish the Thymic Medullary Microenvironment and Self-Tolerance

(2008) Taishin Akiyama et al.   IMMUNITY

IL-1, IL-18, and IL-33 families of cytokines

(2008) William P. Arend et al.   IMMUNOLOGICAL REVIEWS

Class-specific Regulation of Pro-inflammatory Genes by MyD88 Pathways and IκBζ

(2008) Hisako Kayama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice

(2008) Wei Jin et al.   JOURNAL OF CLINICAL INVESTIGATION

TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β

(2008) Motozo Yamashita et al.   MOLECULAR CELL

The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

(2008) Alessandro Sorrentino et al.   NATURE CELL BIOLOGY

T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

(2008) Beatrice Coornaert et al.   NATURE IMMUNOLOGY

The tumor suppressor activity of IKK  in stratified epithelia is exerted in part via the TGF-  antiproliferative pathway

(2008) B. Marinari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apoptosis Signal-Regulating Kinase 1 in Stress and Immune Response

(2007) Kohsuke Takeda et al.   Annual Review of Pharmacology and Toxicology