The CBM-opathies—A Rapidly Expanding Spectrum of Human Inborn Errors of Immunity Caused by Mutations in the CARD11-BCL10-MALT1 Complex

New biologics for allergic diseases

(2018) Laurie A. Manka et al.   Expert Review of Clinical Immunology

Combined immunodeficiency and atopy caused by a dominant negative mutation in caspase activation and recruitment domain family member 11 (CARD11)

(2018) Harjit Dadi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Primary atopic disorders

(2018) Jonathan J. Lyons et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The importance of functional validation after next-generation sequencing: evaluation of a novel CARD11 variant

(2018) Henry Y. Lu et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Assembly mechanism of the CARMA1–BCL10–MALT1–TRAF6 signalosome

(2018) Liron David et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCR Signaling Abnormalities in Human Th2-Associated Atopic Disease

(2018) Joshua D. Milner   Frontiers in Immunology

Clinical, Immunological, and Molecular Findings in Four Cases of B Cell Expansion With NF-κB and T Cell Anergy Disease for the First Time From India

(2018) Maya Gupta et al.   Frontiers in Immunology

Impaired Control of Epstein–Barr Virus Infection in B-Cell Expansion with NF-κB and T-Cell Anergy Disease

(2018) Swadhinya Arjunaraja et al.   Frontiers in Immunology

BCL10 – Bridging CARDs to Immune Activation

(2018) Torben Gehring et al.   Frontiers in Immunology

Hypomorphic caspase activation and recruitment domain 11 (CARD11) mutations associated with diverse immunologic phenotypes with or without atopic disease

(2018) Batsukh Dorjbal et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human CARD9: A Critical Molecule of Fungal Immune Surveillance

(2018) Rebecca A. Drummond et al.   Frontiers in Immunology

The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition

(2017) Maureen Bardet et al.   IMMUNOLOGY AND CELL BIOLOGY

Combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency

(2017) Taco W. Kuijpers et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity

(2017) Capucine Picard et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Disruption of Thrombocyte and T Lymphocyte Development by a Mutation inARPC1B

(2017) Raz Somech et al.   JOURNAL OF IMMUNOLOGY

CARD14-Mediated Activation of Paracaspase MALT1 in Keratinocytes: Implications for Psoriasis

(2017) Elien Van Nuffel et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Deficiency in Mucosa-associated Lymphoid Tissue Lymphoma Translocation 1

(2017) Fabienne Charbit-Henrion et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Evolving Gene Therapy in Primary Immunodeficiency

(2017) Adrian J. Thrasher et al.   MOLECULAR THERAPY

Germline hypomorphic CARD11 mutations in severe atopic disease

(2017) Chi A Ma et al.   NATURE GENETICS

Monogenic immune disorders and severe atopic disease

(2017) Catherine M Biggs et al.   NATURE GENETICS

Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease

(2017) Walter H. A. Kahr et al.   Nature Communications

Specific Antibody Deficiency: Controversies in Diagnosis and Management

(2017) Elena Perez et al.   Frontiers in Immunology

Intrinsic Plasma Cell Differentiation Defects in B Cell Expansion with NF-κB and T Cell Anergy Patient B Cells

(2017) Swadhinya Arjunaraja et al.   Frontiers in Immunology

Mucosa-associated lymphoid tissue lymphoma translocation 1 as a novel therapeutic target for rheumatoid arthritis

(2017) Chang Hoon Lee et al.   Scientific Reports

Lymphocyte signaling and activation by the CARMA1-BCL10-MALT1 signalosome

(2016) Isabel Meininger et al.   BIOLOGICAL CHEMISTRY

Ubiquitin signaling in immune responses

(2016) Hongbo Hu et al.   CELL RESEARCH

Successful clinical treatment and functional immunological normalization of human MALT1 deficiency following hematopoietic stem cell transplantation

(2016) Jacob Rozmus et al.   CLINICAL IMMUNOLOGY

Constant B cell lymphocytosis since early age in a patient with CARD11 mutation: A 20-year follow-up

(2016) Tuula Outinen et al.   CLINICAL IMMUNOLOGY

Role of the CARMA1/BCL10/MALT1 complex in lymphoid malignancies

(2016) Mélanie Juilland et al.   CURRENT OPINION IN HEMATOLOGY

Intramolecular Interactions and Regulation of Cofactor Binding by the Four Repressive Elements in the Caspase Recruitment Domain-containing Protein 11 (CARD11) Inhibitory Domain

(2016) Rakhi P. Jattani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperative Control of Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling by an Unusual Array of Redundant Repressive Elements

(2016) Rakhi P. Jattani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The paracaspase MALT1 cleaves the LUBAC subunit HOIL1 during antigen receptor signaling

(2016) Tiphaine Douanne et al.   JOURNAL OF CELL SCIENCE

COSMIC: somatic cancer genetics at high-resolution

(2016) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Targeting MALT1 Proteolytic Activity in Immunity, Inflammation and Disease: Good or Bad?

(2016) Annelies Demeyer et al.   TRENDS IN MOLECULAR MEDICINE

MALT1 inhibitors prevent the development of DSS-induced experimental colitis in mice via inhibiting NF-κB and NLRP3 inflammasome activation

(2016) Wen Liu et al.   Oncotarget

Omenn syndrome associated with a functional reversion due to a somatic second-site mutation in CARD11 deficiency

(2015) S. Fuchs et al.   BLOOD

B-cell receptor signaling in the pathogenesis of lymphoid malignancies

(2015) Kamil Bojarczuk et al.   BLOOD CELLS MOLECULES AND DISEASES

Gain-of-function mutations and immunodeficiency

(2015) Swadhinya Arjunaraja et al.   Current Opinion in Allergy and Clinical Immunology

MALT1 - a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression

(2015) Inna S. Afonina et al.   FEBS Journal

MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-κB signaling

(2015) Lynn Elton et al.   FEBS Journal

Mild B-cell lymphocytosis in patients with a CARD11 C49Y mutation

(2015) David Buchbinder et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Combined Immunodeficiency Due to MALT1 Mutations, Treated by Hematopoietic Cell Transplantation

(2015) Divya Punwani et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Deficiency of MALT1 Paracaspase Activity Results in Unbalanced Regulatory and Effector T and B Cell Responses Leading to Multiorgan Inflammation

(2015) Frédéric Bornancin et al.   JOURNAL OF IMMUNOLOGY

Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation

(2015) S. Satpathy et al.   Molecular Systems Biology

Regulation of T cells by mTOR: the known knowns and the known unknowns

(2015) Kristen N. Pollizzi et al.   TRENDS IN IMMUNOLOGY

Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2–MALT1 in MALT lymphoma

(2015) Zilin Nie et al.   Nature Communications

The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling

(2015) Theo Klein et al.   Nature Communications

MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses

(2015) Jong W. Yu et al.   PLoS One

A catalytic-independent role for the LUBAC in NF- B activation upon antigen receptor engagement and in lymphoma cells

(2014) S. M. Dubois et al.   BLOOD

Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity

(2014) Maike Jaworski et al.   EMBO JOURNAL

Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

(2014) Mako Nakaya et al.   IMMUNITY

The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency

(2014) Stuart E. Turvey et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Germline CARD11 Mutation in a Patient with Severe Congenital B Cell Lymphocytosis

(2014) Andrew S. Brohl et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Inherited BCL10 deficiency impairs hematopoietic and nonhematopoietic immunity

(2014) Juan Manuel Torres et al.   JOURNAL OF CLINICAL INVESTIGATION

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation

(2014) Katharina M Jeltsch et al.   NATURE IMMUNOLOGY

MALT1 Auto-Proteolysis Is Essential for NF-κB-Dependent Gene Transcription in Activated Lymphocytes

(2014) Mathijs Baens et al.   PLoS One

T Cell Receptor-Dependent Activation of mTOR Signaling in T Cells Is Mediated by Carma1 and MALT1, But Not Bcl10

(2014) K. S. Hamilton et al.   Science Signaling

Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

(2014) Y. Yang et al.   Cancer Discovery

Uncoupling Malt1 Threshold Function from Paracaspase Activity Results in Destructive Autoimmune Inflammation

(2014) Andreas Gewies et al.   Cell Reports

Malt1-Induced Cleavage of Regnase-1 in CD4+ Helper T Cells Regulates Immune Activation

(2013) Takuya Uehata et al.   CELL

The Role of CARMA1 in T Cells

(2013) Marly I. Roche et al.   CRITICAL REVIEWS IN IMMUNOLOGY

The CBM signalosome: Potential therapeutic target for aggressive lymphoma?

(2013) Chenghua Yang et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Whole-exome sequencing links caspase recruitment domain 11 (CARD11) inactivation to severe combined immunodeficiency

(2013) Johann Greil et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Deficiency of caspase recruitment domain family, member 11 (CARD11), causes profound combined immunodeficiency in human subjects

(2013) Polina Stepensky et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency

(2013) Haifa H. Jabara et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Combined immunodeficiency associated with homozygous MALT1 mutations

(2013) Margaret L. McKinnon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly

(2013) Qi Qiao et al.   MOLECULAR CELL

mTOR and metabolic pathways in T cell quiescence and functional activation

(2013) Kai Yang et al.   SEMINARS IN IMMUNOLOGY

Regulation of nuclear factor-κB in autoimmunity

(2013) Shao-Cong Sun et al.   TRENDS IN IMMUNOLOGY

PSORS2 Is Due to Mutations in CARD14

(2012) Catherine T. Jordan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Rare and Common Variants in CARD14, Encoding an Epidermal Regulator of NF-kappaB, in Psoriasis

(2012) Catherine T. Jordan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Familial Pityriasis Rubra Pilaris Is Caused by Mutations in CARD14

(2012) Dana Fuchs-Telem et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The B-cell receptor signaling pathway as a therapeutic target in CLL

(2012) J. A. Woyach et al.   BLOOD

Identification of a novel mutation in ZAP70 and prenatal diagnosis in a Turkish family with severe combined immunodeficiency disorder

(2012) Ender Karaca et al.   GENE

The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells

(2012) Anne Brüstle et al.   JOURNAL OF CLINICAL INVESTIGATION

Human lymphoma mutations reveal CARD11 as the switch between self-antigen–induced B cell death or proliferation and autoantibody production

(2012) Yogesh S. Jeelall et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP

(2012) Gaetana Lanzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Congenital B cell lymphocytosis explained by novel germlineCARD11mutations

(2012) Andrew L. Snow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chronic Activation of the Kinase IKK  Impairs T Cell Function and Survival

(2012) S. Krishna et al.   JOURNAL OF IMMUNOLOGY

CARMA1 Controls Th2 Cell-Specific Cytokine Expression through Regulating JunB and GATA3 Transcription Factors

(2012) M. Blonska et al.   JOURNAL OF IMMUNOLOGY

A Quantitative Signaling Screen Identifies CARD11 Mutations in the CARD and LATCH Domains That Induce Bcl10 Ubiquitination and Human Lymphoma Cell Survival

(2012) W. Chan et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population

(2012) Tomomitsu Hirota et al.   NATURE GENETICS

T cell receptor/CARMA1/NF- B signaling controls T-helper (Th) 17 differentiation

(2012) L. L. Molinero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From MALT lymphoma to the CBM signalosome

(2011) Shaun Rosebeck et al.   CELL CYCLE

T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1

(2011) Jens Staal et al.   EMBO JOURNAL

Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3–positive regulatory versus TH2 effector cells to cause allergy

(2011) John A. Altin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CARMA1 Is Necessary for Optimal T Cell Responses in a Murine Model of Allergic Asthma

(2011) R. A. Ramadas et al.   JOURNAL OF IMMUNOLOGY

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Long-term effects of neonatal glutamine-enriched nutrition in very-low-birth-weight infants

(2011) Annelies van Zwol et al.   NUTRITION REVIEWS

Malt1-dependent RelB cleavage promotes canonical NF- B activation in lymphocytes and lymphoma cell lines

(2011) S. Hailfinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cleavage of NIK by the API2-MALT1 Fusion Oncoprotein Leads to Noncanonical NF- B Activation

(2011) S. Rosebeck et al.   SCIENCE

Selective C-Rel Activation via Malt1 Controls Anti-Fungal TH-17 Immunity by Dectin-1 and Dectin-2

(2011) Sonja I. Gringhuis et al.   PLoS Pathogens

NF-κB signaling pathways regulated by CARMA family of scaffold proteins

(2010) Marzenna Blonska et al.   CELL RESEARCH

CARMA1 Regulation of Regulatory T Cell Development Involves Modulation of Interleukin-2 Receptor Signaling

(2010) Andrew Joon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

(2010) R. Eric Davis et al.   NATURE

A critical role of TAK1 in B-cell receptor–mediated nuclear factor κB activation

(2009) James Schuman et al.   BLOOD

Differential requirement for CARMA1 in agonist-selected T-cell development

(2009) Benjamin D. Medoff et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CARMA1-mediated NF-κB and JNK activation in lymphocytes

(2009) Marzenna Blonska et al.   IMMUNOLOGICAL REVIEWS

The T-cell-receptor signaling network

(2009) M. Huse   JOURNAL OF CELL SCIENCE

Combined Immunodeficiency Associated withDOCK8Mutations

(2009) Qian Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

NF- B as a Critical Link Between Inflammation and Cancer

(2009) M. Karin   Cold Spring Harbor Perspectives in Biology

Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF- B and MAPK activation to selectively control cytokine production

(2008) O. Gross et al.   BLOOD

Clinical heterogeneity can hamper the diagnosis of patients with ZAP70 deficiency

(2008) Tuba Turul et al.   EUROPEAN JOURNAL OF PEDIATRICS

Mutations of the Wiskott–Aldrich Syndrome Protein affect protein expression and dictate the clinical phenotypes

(2008) Hans D. Ochs   IMMUNOLOGIC RESEARCH

T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

(2008) Beatrice Coornaert et al.   NATURE IMMUNOLOGY

The proteolytic activity of the paracaspase MALT1 is key in T cell activation

(2008) Fabien Rebeaud et al.   NATURE IMMUNOLOGY

NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF- B activation

(2008) C.-J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma

(2008) G. Lenz et al.   SCIENCE