A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4–ERK5 axis

ERK5 Is a Critical Mediator of Inflammation-Driven Cancer

(2015) K. G. Finegan et al.   CANCER RESEARCH

ERKs in Cancer: Friends or Foes?

(2014) Xavier Deschênes-Simard et al.   CANCER RESEARCH

Interleukin-17 Receptor A Signaling in Transformed Enterocytes Promotes Early Colorectal Tumorigenesis

(2014) Kepeng Wang et al.   IMMUNITY

IL-17 Signaling for mRNA Stabilization Does Not Require TNF Receptor-Associated Factor 6

(2014) J. Hartupee et al.   JOURNAL OF IMMUNOLOGY

Structure of the unique SEFIR domain from human interleukin 17 receptor A reveals a composite ligand-binding site containing a conserved α-helix for Act1 binding and IL-17 signaling

(2014) Bing Zhang et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

IL-17 in psoriasis: Implications for therapy and cardiovascular co-morbidities

(2013) Jackelyn B. Golden et al.   CYTOKINE

Keratin 5-Cre-driven excision of nonmuscle myosin IIA in early embryo trophectoderm leads to placenta defects and embryonic lethality

(2013) James Crish et al.   DEVELOPMENTAL BIOLOGY

Inflammation and Hras signaling control epithelial-mesenchymal transition during skin tumor progression

(2013) C. E. Wong et al.   GENES & DEVELOPMENT

The Crystal Structure of Six-transmembrane Epithelial Antigen of the Prostate 4 (Steap4), a Ferri/Cuprireductase, Suggests a Novel Interdomain Flavin-binding Site

(2013) George H. Gauss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An interleukin-17–mediated paracrine network promotes tumor resistance to anti-angiogenic therapy

(2013) Alicia S Chung et al.   NATURE MEDICINE

Role of IL-17A in the development of colitis-associated cancer

(2012) Y. S. Hyun et al.   CARCINOGENESIS

Stamp2 Controls Macrophage Inflammation through Nicotinamide Adenine Dinucleotide Phosphate Homeostasis and Protects against Atherosclerosis

(2012) Henrik ten Freyhaus et al.   Cell Metabolism

ERK5: Structure, regulation and function

(2012) Gopika N. Nithianandarajah-Jones et al.   CELLULAR SIGNALLING

Cutting Edge: TNF Receptor-Associated Factor 4 Restricts IL-17-Mediated Pathology and Signaling Processes

(2012) J. A. Zepp et al.   JOURNAL OF IMMUNOLOGY

STEAP Proteins: From Structure to Applications in Cancer Therapy

(2012) I. M. Gomes et al.   MOLECULAR CANCER RESEARCH

Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

(2012) Sergei I. Grivennikov et al.   NATURE

The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90

(2012) Chenhui Wang et al.   NATURE IMMUNOLOGY

IL-17 Mediated Inflammation Promotes Tumor Growth and Progression in the Skin

(2012) Donggou He et al.   PLoS One

A Protective Role by Interleukin-17F in Colon Tumorigenesis

(2012) Zan Tong et al.   PLoS One

Forced Expression of miR-143 Represses ERK5/c-Myc and p68/p72 Signaling in Concert with miR-145 in Gut Tumors of ApcMin Mice

(2012) Yuji Takaoka et al.   PLoS One

Novel Role of NOX in Supporting Aerobic Glycolysis in Cancer Cells with Mitochondrial Dysfunction and as a Potential Target for Cancer Therapy

(2012) Weiqin Lu et al.   PLOS BIOLOGY

IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma

(2011) Jiankun Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MEK5/ERK5 pathway: The first fifteen years

(2011) Barbara A. Drew et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Th17 cells in cancer: help or hindrance?

(2011) Cailin Moira Wilke et al.   CARCINOGENESIS

Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF)

(2011) Dongxu Sun et al.   NATURE IMMUNOLOGY

The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation

(2011) Katarzyna Bulek et al.   NATURE IMMUNOLOGY

Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity

(2011) A. Puel et al.   SCIENCE

Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein

(2010) Qingkai Yang et al.   CANCER CELL

IL-17 Enhances Tumor Development in Carcinogen-Induced Skin Cancer

(2010) L. Wang et al.   CANCER RESEARCH

Regulation of Hepatic Six Transmembrane Epithelial Antigen of Prostate 4 (STEAP4) Expression by STAT3 and CCAAT/Enhancer-binding Protein α

(2010) Preeti Ramadoss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis

(2010) W.-J. Chae et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of neuronal survival by the extracellular signal-regulated protein kinase 5

(2009) K G Finegan et al.   CELL DEATH AND DIFFERENTIATION

The roles of IL-17A in inflammatory immune responses and host defense against pathogens

(2009) Yoichiro Iwakura et al.   IMMUNOLOGICAL REVIEWS

Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients

(2009) Jing-Ping Zhang et al.   JOURNAL OF HEPATOLOGY

MEKK3 Is Essential for Lymphopenia-Induced T Cell Proliferation and Survival

(2009) X. Wang et al.   JOURNAL OF IMMUNOLOGY

Identification of pharmacological inhibitors of the MEK5/ERK5 pathway

(2008) Revati J. Tatake et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways

(2008) K.E. Nograles et al.   BRITISH JOURNAL OF DERMATOLOGY

A skin microRNA promotes differentiation by repressing ‘stemness’

(2008) Rui Yi et al.   NATURE

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE