Imprinting and Editing of the Human CD4 T Cell Response to Influenza Virus

Memory T Cell Dynamics in the Lung during Influenza Virus Infection

(2019) Angela Pizzolla et al.   JOURNAL OF IMMUNOLOGY

Original Antigenic Sin: How First Exposure Shapes Lifelong Anti–Influenza Virus Immune Responses

(2019) Ali Zhang et al.   JOURNAL OF IMMUNOLOGY

Development of a Universal Influenza Vaccine

(2019) Leonardo D. Estrada et al.   JOURNAL OF IMMUNOLOGY

Overcoming Barriers in the Path to a Universal Influenza Virus Vaccine

(2018) Lynda Coughlan et al.   Cell Host & Microbe

Harnessing immune history to combat influenza viruses

(2018) Jenna J Guthmiller et al.   CURRENT OPINION IN IMMUNOLOGY

Distinct and complementary roles of CD4 T cells in protective immunity to influenza virus

(2018) Andrea J Sant et al.   CURRENT OPINION IN IMMUNOLOGY

The tolerogenic role of IFN-γ

(2018) Primož Rožman et al.   CYTOKINE & GROWTH FACTOR REVIEWS

CD4 T cells in protection from influenza virus: Viral antigen specificity and functional potential

(2018) Andrea J. Sant et al.   IMMUNOLOGICAL REVIEWS

Differential T-cell receptor signals for T helper cell programming

(2018) Penelope A. Morel   IMMUNOLOGY

Updates on Influenza Vaccination in Children

(2018) Angela J.P. Campbell et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Overarching Immunodominance Patterns and Substantial Diversity in Specificity and Functionality in the Circulating Human Influenza A and B Virus–Specific CD4+ T-Cell Repertoire

(2018) Katherine A Richards et al.   JOURNAL OF INFECTIOUS DISEASES

From Original Antigenic Sin to the Universal Influenza Virus Vaccine

(2018) Carole Henry et al.   TRENDS IN IMMUNOLOGY

Estimating the annual attack rate of seasonal influenza among unvaccinated individuals: A systematic review and meta-analysis

(2018) Mitchell P. Somes et al.   VACCINE

Opinion: Making Inactivated and Subunit-Based Vaccines Work

(2018) Brendon Y. Chua et al.   VIRAL IMMUNOLOGY

Past Life and Future Effects—How Heterologous Infections Alter Immunity to Influenza Viruses

(2018) Aisha Souquette et al.   Frontiers in Immunology

Influenza Vaccine Effectiveness in the United States during the 2016–2017 Season

(2018) Brendan Flannery et al.   CLINICAL INFECTIOUS DISEASES

Innovative approaches to track lymph node germinal center responses to evaluate development of broadly neutralizing antibodies in human HIV vaccine trials

(2018) M. Patricia D'Souza et al.   VACCINE

CD4 TRM Cells Following Infection and Immunization: Implications for More Effective Vaccine Design

(2018) Mieszko M. Wilk et al.   Frontiers in Immunology

Broadly protective influenza vaccines: design and production platforms

(2018) Husni Elbahesh et al.   Current Opinion in Virology

Comparison of mucosal lining fluid sampling methods and influenza-specific IgA detection assays for use in human studies of influenza immunity

(2017) Thushan I. de Silva et al.   JOURNAL OF IMMUNOLOGICAL METHODS

The Doctrine of Original Antigenic Sin: Separating Good From Evil

(2017) Arnold S. Monto et al.   JOURNAL OF INFECTIOUS DISEASES

Perspectives from the Society for Pediatric Research: Decreased Effectiveness of the Live Attenuated Influenza Vaccine

(2017) Michelle A Gill et al.   PEDIATRIC RESEARCH

Evaluation of the innate immune responses to influenza and live-attenuated influenza vaccine infection in primary differentiated human nasal epithelial cells

(2017) Adriana Forero et al.   VACCINE

Immune history and influenza virus susceptibility

(2017) Sarah Cobey et al.   Current Opinion in Virology

Cellular immune responses of older adults to four influenza vaccines: Results of a randomized, controlled comparison

(2017) Arun Kumar et al.   Human Vaccines & Immunotherapeutics

Indoleamine 2,3-Dioxygenase and Tolerance: Where Are We Now?

(2017) Andrew L. Mellor et al.   Frontiers in Immunology

Competition within the virus-specific CD4 T-cell pool limits the T follicular helper response after influenza infection

(2016) Matthew R Olson et al.   IMMUNOLOGY AND CELL BIOLOGY

The host immune response in respiratory virus infection: balancing virus clearance and immunopathology

(2016) Amy H. Newton et al.   Seminars in Immunopathology

Low hemagglutinin antigen dose influenza vaccines adjuvanted with AS03 alter the long-term immune responses in BALB/c mice

(2016) Karen K. Yam et al.   Human Vaccines & Immunotherapeutics

Balancing Immune Protection and Immune Pathology by CD8+ T-Cell Responses to Influenza Infection

(2016) Susu Duan et al.   Frontiers in Immunology

New Insights into the Generation of CD4 Memory May Shape Future Vaccine Strategies for Influenza

(2016) Priyadharshini Devarajan et al.   Frontiers in Immunology

The Nicaraguan pediatric influenza cohort study: design, methods, use of technology, and compliance

(2015) Aubree Gordon et al.   BMC INFECTIOUS DISEASES

Regulation of human helper T cell subset differentiation by cytokines

(2015) Nathalie Schmitt et al.   CURRENT OPINION IN IMMUNOLOGY

Determinants of immunodominance for CD4 T cells

(2015) AeRyon Kim et al.   CURRENT OPINION IN IMMUNOLOGY

Epitope specific T-cell responses against influenza A in a healthy population

(2015) Miloje Savic et al.   IMMUNOLOGY

Vaccination and heterologous immunity: educating the immune system

(2015) Anna Gil et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Effect of Influenza A(H5N1) Vaccine Prepandemic Priming on CD4+ T-Cell Responses

(2014) Jennifer L. Nayak et al.   JOURNAL OF INFECTIOUS DISEASES

Immunodominant CD4+ T-Cell Responses to Influenza A Virus in Healthy Individuals Focus on Matrix 1 and Nucleoprotein

(2014) L. Chen et al.   JOURNAL OF VIROLOGY

Cytokine Diversity in the Th1-Dominated Human Anti-Influenza Response Caused by Variable Cytokine Expression by Th1 Cells, and a Minor Population of Uncommitted IL-2+IFNγ- Thpp Cells

(2014) Nan Deng et al.   PLoS One

Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation

(2014) S. Keck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCR signal quantity and quality in CD4+ T cell differentiation

(2014) Noah J. Tubo et al.   TRENDS IN IMMUNOLOGY

Adjuvanted inactivated influenza A(H3N2) vaccines induce stronger immunogenicity in mice and confer higher protection in ferrets than unadjuvanted inactivated vaccines

(2014) Julie Ann et al.   VACCINE

Unbalanced Neonatal CD4+ T-Cell Immunity

(2014) Isabelle Debock et al.   Frontiers in Immunology

The Burden of Influenza B: A Structured Literature Review

(2013) W. Paul Glezen et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

T cell memory to evolutionarily conserved and shared hemagglutinin epitopes of H1N1 viruses: a pilot scale study

(2013) Venkata R Duvvuri et al.   BMC INFECTIOUS DISEASES

The evolving history of influenza viruses and influenza vaccines

(2013) Claude Hannoun   Expert Review of Vaccines

Influenza vaccines: from whole virus preparations to recombinant protein technology

(2013) Victor C Huber   Expert Review of Vaccines

Multipronged CD4+T-cell effector and memory responses cooperate to provide potent immunity against respiratory virus

(2013) Tara M. Strutt et al.   IMMUNOLOGICAL REVIEWS

Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4

(2013) Zamaneh Mikhak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Heterosubtypic Influenza Infection Antagonizes Elicitation of Immunological Reactivity to Hemagglutinin

(2013) J. L. Nayak et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Rapid Boosting of Cross-Reactive Memory CD8 T Cells Broadens the Protective Capacity of the Flumist Vaccine

(2013) B. Slutter et al.   JOURNAL OF IMMUNOLOGY

The Control of the Specificity of CD4 T Cell Responses: Thresholds, Breakpoints, and Ceilings

(2013) Andrea J. Sant et al.   Frontiers in Immunology

The Role of Naive T Cell Precursor Frequency and Recruitment in Dictating Immune Response Magnitude

(2012) M. K. Jenkins et al.   JOURNAL OF IMMUNOLOGY

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

(2012) Tom M Wilkinson et al.   NATURE MEDICINE

Trivalent inactivated influenza vaccines induce broad immunological reactivity to both internal virion components and influenza surface proteins

(2012) Katherine A. Richards et al.   VACCINE

Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4+ T-cell repertoire selection

(2012) David K. Cole et al.   Nature Communications

Effects of Different Adjuvants in the Context of Intramuscular and Intranasal Routes on Humoral and Cellular Immune Responses Induced by Detergent-Split A/H3N2 Influenza Vaccines in Mice

(2011) Mariana Baz et al.   Clinical and Vaccine Immunology

Naturally occurring CD4+ T-cell epitope variants act as altered peptide ligands leading to impaired helper T-cell responses in hepatitis C virus infection

(2011) Matthew F. Cusick et al.   HUMAN IMMUNOLOGY

Return of inactivated whole-virus vaccine for superior efficacy

(2011) Yoichi Furuya   IMMUNOLOGY AND CELL BIOLOGY

Why Do Influenza Virus Subtypes Die Out? A Hypothesis

(2011) P. Palese et al.   mBio

Effect of Influenza Vaccination of Children on Infection Rates in Hutterite Communities

(2010) Mark Loeb et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cutting Edge: CD4 T Cells Generated from Encounter with Seasonal Influenza Viruses and Vaccines Have Broad Protein Specificity and Can Directly Recognize Naturally Generated Epitopes Derived from the Live Pandemic H1N1 Virus

(2010) K. A. Richards et al.   JOURNAL OF IMMUNOLOGY

Influenza Vaccines for the Future

(2010) Linda C. Lambert et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Comparative Approach Linking Molecular Dynamics of Altered Peptide Ligands and MHC with In Vivo Immune Responses

(2010) Bernhard Knapp et al.   PLoS One

Immunogenicity, protective efficacy and mechanism of novel CCS adjuvanted influenza vaccine

(2010) Orli Even-Or et al.   VACCINE

Seasonal influenza and vaccination coverage

(2010) Arnold S. Monto   VACCINE

Analyses of the Specificity of CD4 T Cells During the Primary Immune Response to Influenza Virus Reveals Dramatic MHC-Linked Asymmetries in Reactivity to Individual Viral Proteins

(2010) Jennifer L. Nayak et al.   VIRAL IMMUNOLOGY

A unique unresponsive CD4+ T cell phenotype post TCR antagonism

(2009) Lindsay J. Edwards et al.   CELLULAR IMMUNOLOGY

Genome-wide screening of human T-cell epitopes in influenza A virus reveals a broad spectrum of CD4+ T-cell responses to internal proteins, hemagglutinins, and neuraminidases

(2009) Jenny Aurielle B. Babon et al.   HUMAN IMMUNOLOGY

Understanding the focused CD4 T cell response to antigen and pathogenic organisms

(2009) Jason M. Weaver et al.   IMMUNOLOGIC RESEARCH

Suboptimal engagement of the T-cell receptor by a variety of peptide–MHC ligands triggers T-cell anergy

(2009) Scheherazade Sadegh-Nasseri et al.   IMMUNOLOGY

Infection of HLA-DR1 Transgenic Mice with a Human Isolate of Influenza A Virus (H1N1) Primes a Diverse CD4 T-Cell Repertoire That Includes CD4 T Cells with Heterosubtypic Cross-Reactivity to Avian (H5N1) Influenza Virus

(2009) K. A. Richards et al.   JOURNAL OF VIROLOGY

CD4 T cells: fates, functions, and faults

(2008) J. Zhu et al.   BLOOD

FluBlok, a recombinant hemagglutinin influenza vaccine

(2008) Manon M.J. Cox et al.   Influenza and Other Respiratory Viruses

Immunomic Analysis of the Repertoire of T-Cell Specificities for Influenza A Virus in Humans

(2008) E. Assarsson et al.   JOURNAL OF VIROLOGY