Original Antigenic Sin: How First Exposure Shapes Lifelong Anti–Influenza Virus Immune Responses

Imprinting of Repeated Influenza A/H3 Exposures on Antibody Quantity and Antibody Quality: Implications on Seasonal Vaccine Strain Selection and Vaccine Performance

(2018) Martina Kosikova et al.   CLINICAL INFECTIOUS DISEASES

Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced Susceptibility to Death during the 2009 H1N1 Pandemic

(2018) Alain Gagnon et al.   mBio

Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains

(2017) Seth J. Zost et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of Anti-Influenza Virus Neuraminidase Antibodies in Children, Adults, and the Elderly by ELISA and Enzyme Inhibition: Evidence for Original Antigenic Sin

(2017) Madhusudan Rajendran et al.   mBio

Influenza Virus Hemagglutinin Stalk-Specific Antibodies in Human Serum are a Surrogate Marker for In Vivo Protection in a Serum Transfer Mouse Challenge Model

(2017) Henning Jacobsen et al.   mBio

Immune history and influenza virus susceptibility

(2017) Sarah Cobey et al.   Current Opinion in Virology

Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection

(2016) Carole J. Henry Dunand et al.   Cell Host & Microbe

Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains

(2016) Joshua G. Petrie et al.   JOURNAL OF INFECTIOUS DISEASES

Enhanced Genetic Characterization of Influenza A(H3N2) Viruses and Vaccine Effectiveness by Genetic Group, 2014–2015

(2016) Brendan Flannery et al.   JOURNAL OF INFECTIOUS DISEASES

Potent protection against H5N1 and H7N9 influenza via childhood hemagglutinin imprinting

(2016) Katelyn M. Gostic et al.   SCIENCE

Antibodies with ‘Original Antigenic Sin’ Properties Are Valuable Components of Secondary Immune Responses to Influenza Viruses

(2016) Susanne L. Linderman et al.   PLoS Pathogens

A simple mechanistic explanation for original antigenic sin and its alleviation by adjuvants

(2015) Wilfred Ndifon   Journal of the Royal Society Interface

Measuring the neutralization potency of influenza A virus hemagglutinin stalk/stem-binding antibodies in polyclonal preparations by microneutralization assay

(2015) Wenqian He et al.   METHODS

Masking of antigenic epitopes by antibodies shapes the humoral immune response to influenza

(2015) Veronika I. Zarnitsyna et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Immune history profoundly affects broadly protective B cell responses to influenza

(2015) Sarah F. Andrews et al.   Science Translational Medicine

Is Antigenic Sin Always “Original?” Re-examining the Evidence Regarding Circulation of a Human H1 Influenza Virus Immediately Prior to the 1918 Spanish Flu

(2015) Alain Gagnon et al.   PLoS Pathogens

High-throughput sequencing of natively paired antibody chains provides evidence for original antigenic sin shaping the antibody response to influenza vaccination

(2014) Yann-Chong Tan et al.   CLINICAL IMMUNOLOGY

Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season

(2014) S. L. Linderman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans

(2014) A. H. Ellebedy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody landscapes after influenza virus infection or vaccination

(2014) J. M. Fonville et al.   SCIENCE

Influenza Mortality in the United States, 2009 Pandemic: Burden, Timing and Age Distribution

(2013) Ann M. Nguyen et al.   PLoS One

Age-Specific Mortality During the 1918 Influenza Pandemic: Unravelling the Mystery of High Young Adult Mortality

(2013) Alain Gagnon et al.   PLoS One

Neutralizing Antibodies Against Previously Encountered Influenza Virus Strains Increase over Time: A Longitudinal Analysis

(2013) M. S. Miller et al.   Science Translational Medicine

Global Mortality Estimates for the 2009 Influenza Pandemic from the GLaMOR Project: A Modeling Study

(2013) Lone Simonsen et al.   PLOS MEDICINE

1976 and 2009 H1N1 Influenza Virus Vaccines Boost Anti-Hemagglutinin Stalk Antibodies in Humans

(2012) Matthew S. Miller et al.   JOURNAL OF INFECTIOUS DISEASES

Estimated global mortality associated with the first 12 months of 2009 pandemic influenza A H1N1 virus circulation: a modelling study

(2012) Fatimah S Dawood et al.   LANCET INFECTIOUS DISEASES

Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells

(2012) G.-M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strategies to alleviate original antigenic sin responses to influenza viruses

(2012) J. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for Antigenic Seniority in Influenza A (H3N2) Antibody Responses in Southern China

(2012) Justin Lessler et al.   PLoS Pathogens

Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection

(2011) Jens Wrammert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Age-specific mortality risk from pandemic influenza

(2011) Junling Ma et al.   JOURNAL OF THEORETICAL BIOLOGY

Geography May Explain Adult Mortality from the 1918–20 Influenza Pandemic

(2011) Svenn-Erik Mamelund   Epidemics

Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus

(2010) R. Xu et al.   SCIENCE

Original Antigenic Sin Responses to Influenza Viruses

(2009) J. H. Kim et al.   JOURNAL OF IMMUNOLOGY