Balancing Immune Protection and Immune Pathology by CD8+ T-Cell Responses to Influenza Infection

Inflammatory impact of IFN-γ in CD8+ T cell-mediated lung injury is mediated by both Stat1-dependent and -independent pathways

(2015) Chilakamarti V. Ramana et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

SnapShot: Evolution of Human Influenza A Viruses

(2015) Isabel Wendel et al.   Cell Host & Microbe

Antiviral B cell and T cell immunity in the lungs

(2015) Christopher Chiu et al.   NATURE IMMUNOLOGY

Neutrophil trails guide influenza-specific CD8+ T cells in the airways

(2015) K. Lim et al.   SCIENCE

Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8+ T cells

(2015) Zhongfang Wang et al.   Nature Communications

Diverse Heterologous Primary Infections Radically Alter Immunodominance Hierarchies and Clinical Outcomes Following H7N9 Influenza Challenge in Mice

(2015) Susu Duan et al.   PLoS Pathogens

Memory T Cells Generated by Prior Exposure to Influenza Cross React with the Novel H7N9 Influenza Virus and Confer Protective Heterosubtypic Immunity

(2015) Sean R. McMaster et al.   PLoS One

CD8 T cells utilize TRAIL to control influenza virus infection.

(2014) E. L. Brincks et al.   JOURNAL OF IMMUNOLOGY

CD4+ and CD8+ T Cells Exhibit Differential Requirements for CCR7-Mediated Antigen Transport during Influenza Infection

(2014) A. K. Heer et al.   JOURNAL OF IMMUNOLOGY

A Novel Role for Non-Neutralizing Antibodies against Nucleoprotein in Facilitating Resistance to Influenza Virus

(2014) D. M. Carragher et al.   JOURNAL OF IMMUNOLOGY

Endogenous 4-1BB Ligand Plays a Critical Role in Protection from Influenza-Induced Disease

(2014) G. H. Y. Lin et al.   JOURNAL OF IMMUNOLOGY

Plasmacytoid Dendritic Cells Are Dispensable during Primary Influenza Virus Infection

(2014) A. I. Wolf et al.   JOURNAL OF IMMUNOLOGY

Lymphopenia Associated with Highly Virulent H5N1 Virus Infection Due to Plasmacytoid Dendritic Cell-Mediated Apoptosis of T Cells

(2014) K. Boonnak et al.   JOURNAL OF IMMUNOLOGY

Soluble, but Not Transmembrane, TNF-  Is Required during Influenza Infection To Limit the Magnitude of Immune Responses and the Extent of Immunopathology

(2014) M. P. DeBerge et al.   JOURNAL OF IMMUNOLOGY

CD40 Ligand Preferentially Modulates Immune Response and Enhances Protection against Influenza Virus

(2014) Anwar M. Hashem et al.   JOURNAL OF IMMUNOLOGY

Tissue-Protective Effects of NKG2A in Immune-Mediated Clearance of Virus Infection

(2014) Kenneth H. Ely et al.   PLoS One

Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities

(2014) S. Quinones-Parra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD160-Associated CD8 T-Cell Functional Impairment Is Independent of PD-1 Expression

(2014) Selena Viganò et al.   PLoS Pathogens

Differential Roles of Lung Dendritic Cell Subsets Against Respiratory Virus Infection

(2014) Tae Hoon Kim et al.   Immune Network

T-Cell Immunity to Influenza A Viruses

(2013) Emma J. Grant et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Interferon Regulatory Factor 4 Sustains CD8+ T Cell Expansion and Effector Differentiation

(2013) Shuyu Yao et al.   IMMUNITY

The amazing innate immune response to influenza A virus infection

(2013) Shweta Tripathi et al.   Innate Immunity

Local Blockade of Epithelial PDL-1 in the Airways Enhances T Cell Function and Viral Clearance during Influenza Virus Infection

(2013) Beth McNally et al.   JOURNAL OF VIROLOGY

Highly Pathological Influenza A Virus Infection Is Associated with Augmented Expression of PD-1 by Functionally Compromised Virus-Specific CD8+ T Cells

(2013) J. A. Rutigliano et al.   JOURNAL OF VIROLOGY

Human Cytotoxic T Lymphocytes Directed to Seasonal Influenza A Viruses Cross-React with the Newly Emerging H7N9 Virus

(2013) C. E. van de Sandt et al.   JOURNAL OF VIROLOGY

The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells

(2013) Kevin Man et al.   NATURE IMMUNOLOGY

IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8+ T cell responses to influenza A virus

(2013) Iris K Pang et al.   NATURE IMMUNOLOGY

Cellular immune correlates of protection against symptomatic pandemic influenza

(2013) Saranya Sridhar et al.   NATURE MEDICINE

Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus

(2013) Rongbao Gao et al.   NEW ENGLAND JOURNAL OF MEDICINE

ADAM17-Mediated Processing of TNF-α Expressed by Antiviral Effector CD8+ T Cells Is Required for Severe T-Cell-Mediated Lung Injury

(2013) Matthew P. DeBerge et al.   PLoS One

Cooperativity Between CD8+ T Cells, Non-Neutralizing Antibodies, and Alveolar Macrophages Is Important for Heterosubtypic Influenza Virus Immunity

(2013) Brian J. Laidlaw et al.   PLoS Pathogens

Unlike CD4+ T-cell help, CD28 costimulation is necessary for effective primary CD8+ T-cell influenza-specific immunity

(2012) Shirley G.K. Seah et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Viral acute lower respiratory infections impair CD8+ T cells through PD-1

(2012) John J. Erickson et al.   JOURNAL OF CLINICAL INVESTIGATION

Human T-cells directed to seasonal influenza A virus cross-react with 2009 pandemic influenza A (H1N1) and swine-origin triple-reassortant H3N2 influenza viruses

(2012) M. L. B. Hillaire et al.   JOURNAL OF GENERAL VIROLOGY

Multiple Redundant Effector Mechanisms of CD8+ T Cells Protect against Influenza Infection

(2012) H. Hamada et al.   JOURNAL OF IMMUNOLOGY

Influenza-induced, helper-independent CD8+ T cell responses use CD40 costimulation at the late phase of the primary response

(2012) Shirley G. K. Seah et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interleukin-7, but Not Thymic Stromal Lymphopoietin, Plays a Key Role in the T Cell Response to Influenza A Virus

(2012) Adam W. Plumb et al.   PLoS One

Influenza-Infected Neutrophils within the Infected Lungs Act as Antigen Presenting Cells for Anti-Viral CD8+ T Cells

(2012) Matthew M. Hufford et al.   PLoS One

Invariant NKT Cells: Regulation and Function during Viral Infection

(2012) Jennifer A. Juno et al.   PLoS Pathogens

Induction of Virus-Specific Cytotoxic T Lymphocytes as a Basis for the Development of Broadly Protective Influenza Vaccines

(2011) Marine L. B. Hillaire et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Inflammatory chemokine receptors regulate CD8+T cell contraction and memory generation following infection

(2011) Jacob E. Kohlmeier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Magnitude of the T Cell Response to a Clinically Significant Dose of Influenza Virus Is Regulated by TRAIL

(2011) E. L. Brincks et al.   JOURNAL OF IMMUNOLOGY

Potential Role of Invariant NKT Cells in the Control of Pulmonary Inflammation and CD8+ T Cell Response during Acute Influenza A Virus H3N2 Pneumonia

(2011) C. Paget et al.   JOURNAL OF IMMUNOLOGY

Contributions of Antinucleoprotein IgG to Heterosubtypic Immunity against Influenza Virus

(2011) Mark W. LaMere et al.   JOURNAL OF IMMUNOLOGY

CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs

(2011) Jie Sun et al.   NATURE IMMUNOLOGY

T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses

(2011) S. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-Reactive T Cells Are Involved in Rapid Clearance of 2009 Pandemic H1N1 Influenza Virus in Nonhuman Primates

(2011) Jason T. Weinfurter et al.   PLoS Pathogens

Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection

(2010) Taeg S. Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The route of priming influences the ability of respiratory virus–specific memory CD8+T cells to be activated by residual antigen

(2010) Shiki Takamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection

(2010) Jodi McGill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antiviral CD8+T cell effector activities in situ are regulated by target cell type

(2010) Matthew M. Hufford et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Plasmacytoid Dendritic Cells Enhance Mortality during Lethal Influenza Infections by Eliminating Virus-Specific CD8 T Cells

(2010) R. A. Langlois et al.   JOURNAL OF IMMUNOLOGY

A Role for IL-15 in the Migration of Effector CD8 T Cells to the Lung Airways following Influenza Infection

(2010) K. C. Verbist et al.   JOURNAL OF IMMUNOLOGY

Cytotoxic T Lymphocytes Established by Seasonal Human Influenza Cross-React against 2009 Pandemic H1N1 Influenza Virus

(2010) W. Tu et al.   JOURNAL OF VIROLOGY

Cross-reactive CD8+T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses

(2010) Stephanie Gras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interference with Intraepithelial TNF-α Signaling Inhibits CD8+ T-Cell-Mediated Lung Injury in Influenza Infection

(2010) Anon Srikiatkhachorn et al.   VIRAL IMMUNOLOGY

Interferon-γ: A historical perspective

(2009) Alfons Billiau et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Antigen-specific Treg impair CD8+T-cell priming by blocking early T-cell expansion

(2009) Pascal Chappert et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Selected Toll-like Receptor Ligands and Viruses Promote Helper-Independent Cytotoxic T Cell Priming by Upregulating CD40L on Dendritic Cells

(2009) Susan Johnson et al.   IMMUNITY

CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production

(2009) Victor Peperzak et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Contribution of Lung-Resident T Cell Proliferation to the Overall Magnitude of the Antigen-Specific CD8 T Cell Response in the Lungs following Murine Influenza Virus Infection

(2009) J. McGill et al.   JOURNAL OF IMMUNOLOGY

Tc17, a Unique Subset of CD8 T Cells That Can Protect against Lethal Influenza Challenge

(2009) H. Hamada et al.   JOURNAL OF IMMUNOLOGY

Emergence and pandemic potential of swine-origin H1N1 influenza virus

(2009) Gabriele Neumann et al.   NATURE

Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10

(2009) Jie Sun et al.   NATURE MEDICINE

Respiratory Dendritic Cell Subsets Differ in Their Capacity to Support the Induction of Virus-Specific Cytotoxic CD8+ T Cell Responses

(2009) Taeg S. Kim et al.   PLoS One

TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection

(2009) J. R. Aldridge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infection of mice with a human influenza A/H3N2 virus induces protective immunity against lethal infection with influenza A/H5N1 virus

(2009) J.H.C.M. Kreijtz et al.   VACCINE

The Chemokine Receptor CCR5 Plays a Key Role in the Early Memory CD8+ T Cell Response to Respiratory Virus Infections

(2008) Jacob E. Kohlmeier et al.   IMMUNITY

Clearance of influenza virus from the lung depends on migratory langerin+CD11b−but not plasmacytoid dendritic cells

(2008) Corine H. GeurtsvanKessel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs

(2008) Jodi McGill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cross-Recognition of Avian H5N1 Influenza Virus by Human Cytotoxic T-Lymphocyte Populations Directed to Human Influenza A Virus

(2008) J. H. C. M. Kreijtz et al.   JOURNAL OF VIROLOGY

Differential Response of Respiratory Dendritic Cell Subsets to Influenza Virus Infection

(2008) X. Hao et al.   JOURNAL OF VIROLOGY

Heterosubtypic immunity to influenza A virus: where do we stand?

(2008) Kristie M. Grebe et al.   MICROBES AND INFECTION