Influenza vaccines: from whole virus preparations to recombinant protein technology

Multiple heterologous M2 extracellular domains presented on virus-like particles confer broader and stronger M2 immunity than live influenza A virus infection

(2013) Min-Chul Kim et al.   ANTIVIRAL RESEARCH

A Randomized Trial of Candidate Inactivated Quadrivalent Influenza Vaccine versus Trivalent Influenza Vaccines in Children Aged 3–17 Years

(2013) Joseph B. Domachowske et al.   JOURNAL OF INFECTIOUS DISEASES

Antibody Correlates and Predictors of Immunity to Naturally Occurring Influenza in Humans and the Importance of Antibody to the Neuraminidase

(2013) Robert B. Couch et al.   JOURNAL OF INFECTIOUS DISEASES

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(2013) Teresa Lambe   MOLECULAR MEDICINE

Cell-based vaccines yield only modest advances for seasonal flu

(2013) Cassandra Willyard   NATURE MEDICINE

Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus

(2013) Rongbao Gao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Examination of Influenza Specific T Cell Responses after Influenza Virus Challenge in Individuals Vaccinated with MVA-NP+M1 Vaccine

(2013) Timothy J. Powell et al.   PLoS One

Isolation of a Novel Swine Influenza Virus from Oklahoma in 2011 Which Is Distantly Related to Human Influenza C Viruses

(2013) Ben M. Hause et al.   PLoS Pathogens

Influenza Virus H5 DNA Vaccination Is Immunogenic by Intramuscular and Intradermal Routes in Humans

(2012) J. E. Ledgerwood et al.   Clinical and Vaccine Immunology

Preliminary Assessment of the Efficacy of a T-Cell–Based Influenza Vaccine, MVA-NP+M1, in Humans

(2012) Patrick J. Lillie et al.   CLINICAL INFECTIOUS DISEASES

A Virus-Like Particle That Elicits Cross-Reactive Antibodies to the Conserved Stem of Influenza Virus Hemagglutinin

(2012) A. Schneemann et al.   JOURNAL OF VIROLOGY

Hemagglutinin Stalk-Reactive Antibodies Are Boosted following Sequential Infection with Seasonal and Pandemic H1N1 Influenza Virus in Mice

(2012) F. Krammer et al.   JOURNAL OF VIROLOGY

Design of Escherichia coli-Expressed Stalk Domain Immunogens of H1N1 Hemagglutinin That Protect Mice from Lethal Challenge

(2012) G. Bommakanti et al.   JOURNAL OF VIROLOGY

Estimated global mortality associated with the first 12 months of 2009 pandemic influenza A H1N1 virus circulation: a modelling study

(2012) Fatimah S Dawood et al.   LANCET INFECTIOUS DISEASES

Viral reassortment as an information exchange between viral segments

(2012) B. D. Greenbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A distinct lineage of influenza A virus from bats

(2012) S. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets

(2012) S. Herfst et al.   SCIENCE

Safety and immunogenicity of 2010–2011 H1N12009-containing trivalent inactivated influenza vaccine in children 12–59 months of age previously given AS03-adjuvanted H1N12009 pandemic vaccine: A PHAC/CIHR Influenza Research Network (PCIRN) study

(2012) Joanne M. Langley et al.   VACCINE

WHO recommendations for the viruses to be used in the 2012 Southern Hemisphere Influenza Vaccine: Epidemiology, antigenic and genetic characteristics of influenza A(H1N1)pdm09, A(H3N2) and B influenza viruses collected from February to September 2011

(2012) Alexander I. Klimov et al.   VACCINE

Recombinant protein vaccines produced in insect cells

(2012) Manon M.J. Cox   VACCINE

Randomized comparative study of the serum antihemagglutinin and antineuraminidase antibody responses to six licensed trivalent influenza vaccines

(2012) Robert B. Couch et al.   VACCINE

Development of VAX128, a recombinant hemagglutinin (HA) influenza-flagellin fusion vaccine with improved safety and immune response

(2012) David N. Taylor et al.   VACCINE

Correlates of vaccine protection from influenza and its complications

(2012) Jonathan A. McCullers et al.   Human Vaccines & Immunotherapeutics

The rationale for quadrivalent influenza vaccines

(2012) Christopher S. Ambrose et al.   Human Vaccines & Immunotherapeutics

Contribution of murine innate serum inhibitors toward interference within influenza virus immune assays

(2011) Kevin T. Cwach et al.   Influenza and Other Respiratory Viruses

A fast track influenza virus vaccine produced in insect cells

(2011) Manon M.J. Cox et al.   JOURNAL OF INVERTEBRATE PATHOLOGY

Influenza A viruses: new research developments

(2011) Rafael A. Medina et al.   NATURE REVIEWS MICROBIOLOGY

Gene Constellation of Influenza A Virus Reassortants with High Growth Phenotype Prepared as Seed Candidates for Vaccine Production

(2011) Andrew A. Fulvini et al.   PLoS One

A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses

(2011) D. C. Ekiert et al.   SCIENCE

Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine in a blinded, randomized, placebo-controlled trial of adults in Mexico

(2011) Constantino López-Macías et al.   VACCINE

The development of vaccine viruses against pandemic A(H1N1) influenza

(2011) James S. Robertson et al.   VACCINE

Evaluation of the safety, reactogenicity and immunogenicity of FluBlok® trivalent recombinant baculovirus-expressed hemagglutinin influenza vaccine administered intramuscularly to healthy adults 50–64 years of age☆

(2011) R. Baxter et al.   VACCINE

Protective efficacy of a trivalent recombinant hemagglutinin protein vaccine (FluBlok®) against influenza in healthy adults: A randomized, placebo-controlled trial

(2011) John J. Treanor et al.   VACCINE

Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses

(2011) Taronna R. Maines et al.   VIROLOGY

Validation of the safety of MDCK cells as a substrate for the production of a cell-derived influenza vaccine

(2010) David Onions et al.   BIOLOGICALS

Recipients of Vaccine against the 1976 “Swine Flu” Have Enhanced Neutralization Responses to the 2009 Novel H1N1 Influenza Virus

(2010) Jonathan A. McCullers et al.   CLINICAL INFECTIOUS DISEASES

Universal Vaccine Based on Ectodomain of Matrix Protein 2 of Influenza A: Fc Receptors and Alveolar Macrophages Mediate Protection

(2010) K. El Bakkouri et al.   JOURNAL OF IMMUNOLOGY

Efficacy of Whole‐Cell Killed Bacterial Vaccines in Preventing Pneumonia and Death during the 1918 Influenza Pandemic

(2010) Yu‐Wen Chien et al.   JOURNAL OF INFECTIOUS DISEASES

Bacterial HA1 Vaccine against Pandemic H5N1 Influenza Virus: Evidence of Oligomerization, Hemagglutination, and Cross-Protective Immunity in Ferrets

(2010) S. Khurana et al.   JOURNAL OF VIROLOGY

Preclinical and Clinical Development of Plant-Made Virus-Like Particle Vaccine against Avian H5N1 Influenza

(2010) Nathalie Landry et al.   PLoS One

Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes

(2010) T. T. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge

(2010) G. Bommakanti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reassortment of Pandemic H1N1/2009 Influenza A Virus in Swine

(2010) D. Vijaykrishna et al.   SCIENCE

The 2009–2010 influenza pandemic: effects on pandemic and seasonal vaccine uptake and lessons learned for seasonal vaccination campaigns

(2010) Gregory A. Poland   VACCINE

A clinical study to assess the immunogenicity and safety of a monovalent 2009 influenza A (H1N1) vaccine in an area with low-level epidemics of pandemic influenza

(2010) Hsiang-Chi Kung et al.   VACCINE

The 2009 A (H1N1) influenza virus pandemic: A review

(2010) Marc P. Girard et al.   VACCINE

Biosafety of DNA vaccines: New generation of DNA vectors and current knowledge on the fate of plasmids after injection

(2010) Florence Faurez et al.   VACCINE

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain

(2010) J. Steel et al.   mBio

Association between the 2008–09 Seasonal Influenza Vaccine and Pandemic H1N1 Illness during Spring–Summer 2009: Four Observational Studies from Canada

(2010) Danuta M. Skowronski et al.   PLOS MEDICINE

Protection of Mice against Lethal Challenge with 2009 H1N1 Influenza A Virus by 1918-Like and Classical Swine H1N1 Based Vaccines

(2010) Balaji Manicassamy et al.   PLoS Pathogens

Glycosylation Focuses Sequence Variation in the Influenza A Virus H1 Hemagglutinin Globular Domain

(2010) Suman R. Das et al.   PLoS Pathogens

H5N1 influenza viruses: outbreaks and biological properties

(2009) Gabriele Neumann et al.   CELL RESEARCH

Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments

(2009) Michael Schotsaert et al.   Expert Review of Vaccines

An influenza A H1N1 virus revival – pandemic H1N1/09 virus

(2009) M. Michaelis et al.   INFECTION

PB2 and PA genes control the expression of the temperature-sensitive phenotype of cold-adapted B/USSR/60/69 influenza master donor virus

(2009) I. V. Kiseleva et al.   JOURNAL OF GENERAL VIROLOGY

Triple-Reassortant Swine Influenza A (H1) in Humans in the United States, 2005–2009

(2009) Vivek Shinde et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bacterial Pathogens and Death during the 1918 Influenza Pandemic

(2009) Yu-Wen Chien et al.   NEW ENGLAND JOURNAL OF MEDICINE

Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

A Trivalent Virus-Like Particle Vaccine Elicits Protective Immune Responses against Seasonal Influenza Strains in Mice and Ferrets

(2009) Ted M. Ross et al.   PLoS One

Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air

(2009) N. Van Hoeven et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative immunogenicity of recombinant influenza hemagglutinin (rHA) and trivalent inactivated vaccine (TIV) among persons ≥65 years old

(2009) W.A. Keitel et al.   VACCINE

Evaluation of the safety, reactogenicity and immunogenicity of FluBlok® trivalent recombinant baculovirus-expressed hemagglutinin influenza vaccine administered intramuscularly to healthy children aged 6–59 months

(2009) James C. King et al.   VACCINE

DNA vaccination protects against an influenza challenge in a double-blind randomised placebo-controlled phase 1b clinical trial

(2009) Suzanne Jones et al.   VACCINE

M2e-based universal influenza A vaccine

(2009) Walter Fiers et al.   VACCINE

Cloning and assessment of tumorigenicity and oncogenicity of a Madin–Darby canine kidney (MDCK) cell line for influenza vaccine production

(2009) Jonathan Liu et al.   VACCINE

Epidemiological, antigenic and genetic characteristics of seasonal influenza A(H1N1), A(H3N2) and B influenza viruses: Basis for the WHO recommendation on the composition of influenza vaccines for use in the 2009–2010 Northern Hemisphere season

(2009) Ian G. Barr et al.   VACCINE

Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness

(2008) David M. Morens et al.   JOURNAL OF INFECTIOUS DISEASES

The Influenza Virus M2 Protein Cytoplasmic Tail Interacts with the M1 Protein and Influences Virus Assembly at the Site of Virus Budding

(2008) B. J. Chen et al.   JOURNAL OF VIROLOGY

Timely production of A/Fujian-like influenza vaccine matching the 2003–2004 epidemic strain may have been possible using Madin–Darby canine kidney cells

(2008) Keiichi Makizumi et al.   VACCINE

H5N1 VLP vaccine induced protection in ferrets against lethal challenge with highly pathogenic H5N1 influenza viruses

(2008) Kutubuddin Mahmood et al.   VACCINE

FDA/NIH/WHO public workshop on immune correlates of protection against influenza A viruses in support of pandemic vaccine development, Bethesda, Maryland, US, December 10–11, 2007

(2008) Maryna Eichelberger et al.   VACCINE

The cold adapted and temperature sensitive influenza A/Ann Arbor/6/60 virus, the master donor virus for live attenuated influenza vaccines, has multiple defects in replication at the restrictive temperature

(2008) Winnie Chan et al.   VIROLOGY

Molecular studies of temperature-sensitive replication of the cold-adapted B/Ann Arbor/1/66, the master donor virus for live attenuated influenza FluMist® vaccines

(2008) Zhongying Chen et al.   VIROLOGY