PKM2, function and expression and regulation

Long noncoding RNA H19-derived miR-675 aggravates restenosis by targeting PTEN

(2018) Junyuan Lv et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

rs61991156 in miR-379 is associated with low capability of glycolysis of gastric cancer by enhanced regulation of PKM2

(2018) Na Cao et al.   Cancer Cell International

Organ-Specific MicroRNAs (MIR122, 137, and 206) Contribute to Tissue Characteristics and Carcinogenesis by Regulating Pyruvate Kinase M1/2 (PKM) Expression

(2018) Kohei Taniguchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

lncRNA Ftx promotes aerobic glycolysis and tumor progression through the PPARγ pathway in hepatocellular carcinoma

(2018) Xiao Li et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Advance in Anti-tumor Mechanisms of Shikonin, Alkannin and their Derivatives

(2018) Xu Zhang et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein

(2018) Tsu-Yao Cheng et al.   ONCOGENE

MiR-3662 suppresses hepatocellular carcinoma growth through inhibition of HIF-1α-mediated Warburg effect

(2018) Zhiqiang Chen et al.   Cell Death & Disease

Long noncoding RNA MEG3 suppresses liver cancer cells growth through inhibiting β-catenin by activating PKM2 and inactivating PTEN

(2018) Qidi Zheng et al.   Cell Death & Disease

Pyruvate kinase M2 regulates photoreceptor structure, function, and viability

(2018) Ammaji Rajala et al.   Cell Death & Disease

Coagulation Factor X Regulated by CASC2c Recruited Macrophages and Induced M2 Polarization in Glioblastoma Multiforme

(2018) Yan Zhang et al.   Frontiers in Immunology

Posttranslational Modifications of Pyruvate Kinase M2: Tweaks that Benefit Cancer

(2018) Gopinath Prakasam et al.   Frontiers in Oncology

Prognostic value of lncRNA ROR expression in various cancers: a meta-analysis

(2018) Renfu Lu et al.   BIOSCIENCE REPORTS

Metabolic Plasticity of Tumor Cell Mitochondria

(2018) Giuseppe Cannino et al.   Frontiers in Oncology

Effects of PKM2 on global metabolic changes and prognosis in hepatocellular carcinoma: from gene expression to drug discovery

(2018) Wen-Wen Lv et al.   BMC CANCER

Metabolic reprogramming and epithelial-to-mesenchymal transition in cancer

(2017) Marco Sciacovelli et al.   FEBS Journal

NEK2 Promotes Aerobic Glycolysis in Multiple Myeloma Through Regulating Splicing of Pyruvate Kinase

(2017) Zhimin Gu et al.   Journal of Hematology & Oncology

Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer

(2017) Peter W Stacpoole   JNCI-Journal of the National Cancer Institute

HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

(2017) Qiuran Xu et al.   Molecular Cancer

PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis

(2017) Fabao Liu et al.   NATURE CELL BIOLOGY

O-GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect

(2017) Yang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-340 inhibits invasion and metastasis by downregulating ROCK1 in breast cancer cells

(2017) Niraj Maskey et al.   Oncology Letters

MiR-145 negatively regulates Warburg effect by silencing KLF4 and PTBP1 in bladder cancer cells

(2017) Koichiro Minami et al.   Oncotarget

Metabolic reprogramming of the premalignant colonic mucosa is an early event in carcinogenesis

(2017) Mart Dela Cruz et al.   Oncotarget

IGF-1-mediated PKM2/β-catenin/miR-152 regulatory circuit in breast cancer

(2017) Yi-Yang Wen et al.   Scientific Reports

Transcriptomic Changes in Response to Putrescine Production in Metabolically Engineered Corynebacterium glutamicum

(2017) Zhen Li et al.   Frontiers in Microbiology

Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer

(2017) Peter W Stacpoole   JNCI-Journal of the National Cancer Institute

miR-4417 Targets Tripartite Motif-Containing 35 (TRIM35) and Regulates Pyruvate Kinase Muscle 2 (PKM2) Phosphorylation to Promote Proliferation and Suppress Apoptosis in Hepatocellular Carcinoma Cells

(2017) Lijie Song et al.   MEDICAL SCIENCE MONITOR

Molecular association of glucose-6-phosphate isomerase and pyruvate kinase M2 with glyceraldehyde-3-phosphate dehydrogenase in cancer cells

(2016) Mahua R. Das et al.   BMC CANCER

Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2

(2016) Ji Liang et al.   CELL RESEARCH

LncRNA‐MIF, a c‐Myc‐activated long non‐coding RNA, suppresses glycolysis by promoting Fbxw7‐mediated c‐Myc degradation

(2016) Pengfei Zhang et al.   EMBO REPORTS

PKM2, cancer metabolism, and the road ahead

(2016) Talya L Dayton et al.   EMBO REPORTS

PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells

(2016) Joydeep Mukherjee et al.   INTERNATIONAL JOURNAL OF CANCER

Parkin Regulates the Activity of Pyruvate Kinase M2

(2016) Kun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

One carbon metabolism in pregnancy: Impact on maternal, fetal and neonatal health

(2016) Satish C. Kalhan   MOLECULAR AND CELLULAR ENDOCRINOLOGY

PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

(2016) Ninel Azoitei et al.   Molecular Cancer

PI3 kinase pathway regulated miRNome in glioblastoma: identification of miR-326 as a tumour suppressor miRNA

(2016) Zahid Nawaz et al.   Molecular Cancer

SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions

(2016) Abhishek Bhardwaj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of microRNA-133b sensitizes non-small cell lung cancer cells to irradiation through the inhibition of glycolysis

(2016) GANG LIU et al.   Oncology Letters

PKM2 and cancer: The function of PKM2 beyond glycolysis

(2016) GAOCHAO DONG et al.   Oncology Letters

Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation

(2016) Eoin McDonnell et al.   Cell Reports

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Interaction with Pyruvate Kinase M2 Destabilizes Tristetraprolin by Proteasome Degradation and Regulates Cell Proliferation in Breast Cancer

(2016) Liangqian Huang et al.   Scientific Reports

Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1

(2016) Chang-Liang He et al.   Scientific Reports

Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/β-catenin pathway in colon cancer cells

(2015) Peng Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1α and Bcl-xL in culture

(2015) Tianfu Dong et al.   BIOMEDICINE & PHARMACOTHERAPY

Anti-cancer fatty-acid derivative induces autophagic cell death through modulation of PKM isoform expression profile mediated by bcr-abl in chronic myeloid leukemia

(2015) Haruka Shinohara et al.   CANCER LETTERS

Targeting pyruvate kinase M2 contributes to radiosensitivity of non-small cell lung cancer cells in vitro and in vivo

(2015) Mao-Bin Meng et al.   CANCER LETTERS

PKM2 contributes to cancer metabolism

(2015) Nicholas Wong et al.   CANCER LETTERS

Hepatitis C Virus RNA Functionally Sequesters miR-122

(2015) Joseph M. Luna et al.   CELL

Combined effect of microRNA, nutraceuticals and drug on pancreatic cancer cell lines

(2015) Archana Pandita et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy

(2015) M. C. Caino et al.   CLINICAL CANCER RESEARCH

miR-290/371-Mbd2-Myc circuit regulates glycolytic metabolism to promote pluripotency

(2015) Y. Cao et al.   EMBO JOURNAL

DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer

(2015) Callie R. Merry et al.   HUMAN MOLECULAR GENETICS

Pyruvate kinase M2 at a glance

(2015) W. Yang et al.   JOURNAL OF CELL SCIENCE

Cancer’s Fuel Choice: New Flavors for a Picky Eater

(2015) Gina M. DeNicola et al.   MOLECULAR CELL

Lack of Evidence for PKM2 Protein Kinase Activity

(2015) Aaron M. Hosios et al.   MOLECULAR CELL

Regulatory circuit of PKM2/NF-κB/miR-148a/152-modulated tumor angiogenesis and cancer progression

(2015) Q Xu et al.   ONCOGENE

l-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2

(2015) Daiki Nakatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyruvate kinase: Function, regulation and role in cancer

(2015) William J. Israelsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Contribution of metabolic reprogramming to macrophage plasticity and function

(2015) Karim C. EL Kasmi et al.   SEMINARS IN IMMUNOLOGY

PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation

(2015) Valeria Iansante et al.   Nature Communications

MicroRNA-29B (mir-29b) regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3

(2015) Yue Teng et al.   Oncotarget

Organ-specific PTB1-associated microRNAs determine expression of pyruvate kinase isoforms

(2015) Kohei Taniguchi et al.   Scientific Reports

Structural basis of PKM2 regulation

(2015) Weiwei Yang   Protein & Cell

Isoform Switch of Pyruvate Kinase M1 Indeed Occurs but Not to Pyruvate Kinase M2 in Human Tumorigenesis

(2015) Cheng Zhan et al.   PLoS One

Embryonic MicroRNA-369 Controls Metabolic Splicing Factors and Urges Cellular Reprograming

(2015) Masamitsu Konno et al.   PLoS One

Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells

(2015) Weibo Luo et al.   Oncotarget

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

(2015) Katharina Bluemlein et al.   Oncotarget

Follow the ATP: Tumor Energy Production: A Perspective

(2014) Bryan Oronsky et al.   Anti-Cancer Agents in Medicinal Chemistry

The multifaceted regulation and functions of PKM2 in tumor progression

(2014) Zongwei Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

PKM2 as a biomarker for chemosensitivity to front-line platinum-based chemotherapy in patients with metastatic non-small-cell lung cancer

(2014) C Papadaki et al.   BRITISH JOURNAL OF CANCER

PKM2 depletion induces the compensation of glutaminolysis through β-catenin/c-Myc pathway in tumor cells

(2014) Haili Wu et al.   CELLULAR SIGNALLING

Pyruvate kinase M2 and cancer: an updated assessment

(2014) Mohd Askandar Iqbal et al.   FEBS LETTERS

The Pro-Apoptotic Role of the Regulatory Feedback Loop between miR-124 and PKM1/HNF4α in Colorectal Cancer Cells

(2014) Yan Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pyruvate Kinase M2 in Blood Circulation Facilitates Tumor Growth by Promoting Angiogenesis

(2014) Liangwei Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SAICAR Induces Protein Kinase Activity of PKM2 that Is Necessary for Sustained Proliferative Signaling of Cancer Cells

(2014) Kirstie E. Keller et al.   MOLECULAR CELL

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

TRIM35 Interacts with pyruvate kinase isoform M2 to suppress the Warburg effect and tumorigenicity in hepatocellular carcinoma

(2014) Z Chen et al.   ONCOGENE

How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions?

(2014) H Lincet et al.   ONCOGENE

Oleanolic Acid Suppresses Aerobic Glycolysis in Cancer Cells by Switching Pyruvate Kinase Type M Isoforms

(2014) Jia Liu et al.   PLoS One

HSP40 Interacts with Pyruvate Kinase M2 and Regulates Glycolysis and Cell Proliferation in Tumor Cells

(2014) Liangqian Huang et al.   PLoS One

Control of glioma cell death and differentiation by PKM2–Oct4 interaction

(2014) M Morfouace et al.   Cell Death & Disease

Role of PI3K, mTOR and Akt2 signalling in hepatic tumorigenesis via the control of PKM2 expression

(2013) Ivan Nemazanyy et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Regulation and function of pyruvate kinase M2 in cancer

(2013) Weiwei Yang et al.   CANCER LETTERS

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

(2013) William J. Israelsen et al.   CELL

The Value of Expression of M2-PK and VEGF in Patients with Advanced Gastric Cancer

(2013) Lanning Yin et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Proviral Insertion in Murine Lymphomas 2 (PIM2) Oncogene Phosphorylates Pyruvate Kinase M2 (PKM2) and Promotes Glycolysis in Cancer Cells

(2013) Zhenhai Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Tyrosine Phosphatase 1B Regulates Pyruvate Kinase M2 Tyrosine Phosphorylation

(2013) Ahmed Bettaieb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways

(2013) Yasuhito Onodera et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2

(2013) Mohd Iqbal et al.   Molecular Cancer

Understanding Metabolic Regulation and Its Influence on Cell Physiology

(2013) Christian M. Metallo et al.   MOLECULAR CELL

Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM2 Protein Kinase Activity and Nuclear Localization

(2013) Lei Lv et al.   MOLECULAR CELL

PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells

(2013) Yuhui Jiang et al.   MOLECULAR CELL

Pyruvate Kinase M2 Expression, but Not Pyruvate Kinase Activity, Is Up-Regulated in a Grade-Specific Manner in Human Glioma

(2013) Joydeep Mukherjee et al.   PLoS One

Insulin Promotes Glucose Consumption via Regulation of miR-99a/mTOR/PKM2 Pathway

(2013) Wei Li et al.   PLoS One

JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1 -mediated glucose metabolism

(2013) H.-J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF1α Modulates Cell Fate Reprogramming Through Early Glycolytic Shift and Upregulation of PDK1-3 and PKM2

(2013) Alessandro Prigione et al.   STEM CELLS

Dual roles of PKM2 in cancer metabolism

(2012) S. Wu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

(2012) Weiwei Yang et al.   CELL

Pyruvate Kinase M2: Multiple Faces for Conferring Benefits on Cancer Cells

(2012) M. Tamada et al.   CLINICAL CANCER RESEARCH

Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells

(2012) Benjamin Wiench et al.   Evidence-based Complementary and Alternative Medicine

MicroRNA-206 Regulates Cell Movements during Zebrafish Gastrulation by Targeting prickle1a and Regulating c-Jun N-Terminal Kinase 2 Phosphorylation

(2012) X. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

EGFR-Induced and PKCε Monoubiquitylation-Dependent NF-κB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis

(2012) Weiwei Yang et al.   MOLECULAR CELL

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

(2012) Barbara Chaneton et al.   NATURE

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

(2012) Weiwei Yang et al.   NATURE CELL BIOLOGY

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

(2012) Dimitrios Anastasiou et al.   Nature Chemical Biology

Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins

(2012) Mo Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth

(2012) M. Cortes-Cros et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging roles of PKM2 in cell metabolism and cancer progression

(2012) Weibo Luo et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Overexpression of the M2 isoform of pyruvate kinase is an adverse prognostic factor for signet ring cell gastric cancer

(2012) Jae Yun Lim   WORLD JOURNAL OF GASTROENTEROLOGY

PPARγ contributes to PKM2 and HK2 expression in fatty liver

(2012) Ganna Panasyuk et al.   Nature Communications

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

The Warburg effect in 2012

(2011) Jean-Pierre Bayley et al.   CURRENT OPINION IN ONCOLOGY

Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth

(2011) Lei Lv et al.   MOLECULAR CELL

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

(2011) J Chen et al.   ONCOGENE

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review

(2011) Paolo E. Porporato et al.   Frontiers in Pharmacology

Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis

(2010) Jennifer F Barger et al.   ENDOCRINE-RELATED CANCER

Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells

(2010) Sybille Mazurek   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Dominant Negative Mutations Affect Oligomerization of Human Pyruvate Kinase M2Isozyme and Promote Cellular Growth and Polyploidy

(2010) Vibhor Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells

(2010) B. Kefas et al.   NEURO-ONCOLOGY

Human pyruvate kinase M2: A multifunctional protein

(2010) Vibhor Gupta et al.   PROTEIN SCIENCE

Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply

(2009) Gilles A. Spoden et al.   EXPERIMENTAL CELL RESEARCH

Differential Behavior of Missense Mutations in the Intersubunit Contact Domain of the Human Pyruvate Kinase M2Isozyme

(2009) Kamal Akhtar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SUMO-E3 ligase PIAS3 targets pyruvate kinase M2

(2009) Gilles A. Spoden et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

(2009) Charles J. David et al.   NATURE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

(2009) T. Hitosugi et al.   Science Signaling

The PTEN/PI3K/AKT Signalling Pathway in Cancer, Therapeutic Implications

(2008) Amancio Carnero et al.   CURRENT CANCER DRUG TARGETS

Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein

(2008) Nobukazu Shimada et al.   GENES TO CELLS

Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling

(2008) Thian-Sze Wong et al.   INTERNATIONAL JOURNAL OF CANCER

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE