HSP40 Interacts with Pyruvate Kinase M2 and Regulates Glycolysis and Cell Proliferation in Tumor Cells

DNAJB1 stabilizes MDM2 and contributes to cancer cell proliferation in a p53-dependent manner

(2013) Min Qi et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators

(2013) Chuangxing Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Reciprocal Regulation of Protein Kinase and Pyruvate Kinase Activities of Pyruvate Kinase M2 by Growth Signals

(2013) Xueliang Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual roles of PKM2 in cancer metabolism

(2012) S. Wu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

(2012) Weiwei Yang et al.   CELL

Overexpression of Pyruvate Dehydrogenase Kinase 1 and Lactate Dehydrogenase A in Nerve Cells Confers Resistance to Amyloid β and Other Toxins by Decreasing Mitochondrial Respiration and Reactive Oxygen Species Production

(2012) Jordan T. Newington et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of lipogenesis by cyclin-dependent kinase 8–mediated control of SREBP-1

(2012) Xiaoping Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuronal Hypoxia Induces Hsp40-Mediated Nuclear Import of Type 3 Deiodinase As an Adaptive Mechanism to Reduce Cellular Metabolism

(2012) S. Jo et al.   JOURNAL OF NEUROSCIENCE

EGFR-Induced and PKCε Monoubiquitylation-Dependent NF-κB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis

(2012) Weiwei Yang et al.   MOLECULAR CELL

Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

(2012) Dimitrios Anastasiou et al.   Nature Chemical Biology

SAICAR Stimulates Pyruvate Kinase Isoform M2 and Promotes Cancer Cell Survival in Glucose-Limited Conditions

(2012) K. E. Keller et al.   SCIENCE

Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer

(2012) Barbara Chaneton et al.   TRENDS IN BIOCHEMICAL SCIENCES

DNAJC25 is downregulated in hepatocellular carcinoma and is a novel tumor suppressor gene

(2012) TINGTING LIU et al.   Oncology Letters

Human DNAJ in cancer and stem cells

(2011) Jason N. Sterrenberg et al.   CANCER LETTERS

Vitamin K3 and K5 are inhibitors of tumor pyruvate kinase M2

(2011) Jing Chen et al.   CANCER LETTERS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth

(2011) Lei Lv et al.   MOLECULAR CELL

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

(2010) Lisa S. Pike et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Multi-faceted role of HSP40 in cancer

(2009) Aparna Mitra et al.   CLINICAL & EXPERIMENTAL METASTASIS

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism