PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells

Nuclear translocation of PKM2 modulates astrocyte proliferation via p27 and β-catenin pathway after spinal cord injury

(2015) Jinlong Zhang et al.   CELL CYCLE

Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation

(2015) Sophia Y. Lunt et al.   MOLECULAR CELL

Lack of Evidence for PKM2 Protein Kinase Activity

(2015) Aaron M. Hosios et al.   MOLECULAR CELL

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

(2015) Katharina Bluemlein et al.   Oncotarget

A Feedforward Regulatory Loop between HuR and the Long Noncoding RNA linc-MD1 Controls Early Phases of Myogenesis

(2014) Ivano Legnini et al.   MOLECULAR CELL

SAICAR Induces Protein Kinase Activity of PKM2 that Is Necessary for Sustained Proliferative Signaling of Cancer Cells

(2014) Kirstie E. Keller et al.   MOLECULAR CELL

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

(2013) William J. Israelsen et al.   CELL

Multiple Functions of the RNA-Binding Protein HuR in Cancer Progression, Treatment Responses and Prognosis

(2013) Jun Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells

(2013) Yuhui Jiang et al.   MOLECULAR CELL

Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs

(2013) J.-H. Yoon et al.   NUCLEIC ACIDS RESEARCH

Pyruvate Kinase M2 Expression, but Not Pyruvate Kinase Activity, Is Up-Regulated in a Grade-Specific Manner in Human Glioma

(2013) Joydeep Mukherjee et al.   PLoS One

Novel polysome messages and changes in translational activity appear after induction of adipogenesis in 3T3-L1 cells

(2012) Carolin Fromm-Dornieden et al.   BMC MOLECULAR BIOLOGY

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

(2012) Weiwei Yang et al.   CELL

Translation suppression promotes stress granule formation and cell survival in response to cold shock

(2012) Sarah Hofmann et al.   MOLECULAR BIOLOGY OF THE CELL

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

LincRNA-p21 Suppresses Target mRNA Translation

(2012) Je-Hyun Yoon et al.   MOLECULAR CELL

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

(2012) Dimitrios Anastasiou et al.   Nature Chemical Biology

Phosphorylated HuR shuttles in cycles

(2011) Hyeon Ho Kim et al.   CELL CYCLE

The RNA-Binding Protein HuR Promotes Glioma Growth and Treatment Resistance

(2011) N. Filippova et al.   MOLECULAR CANCER RESEARCH

Integrative Regulatory Mapping Indicates that the RNA-Binding Protein HuR Couples Pre-mRNA Processing and mRNA Stability

(2011) Neelanjan Mukherjee et al.   MOLECULAR CELL

Transcriptome-wide Analysis of Regulatory Interactions of the RNA-Binding Protein HuR

(2011) Svetlana Lebedeva et al.   MOLECULAR CELL

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Modification at HuR(S242) alters HuR localization and proliferative influence

(2010) Hyeon Ho Kim et al.   CELL CYCLE

Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis

(2010) Matthew M Gubin et al.   CELL CYCLE

Gauchos and ochos: a Wee1-Cdk tango regulating mitotic entry

(2010) Greg H Enders   Cell Division

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

(2009) T. Hitosugi et al.   Science Signaling

Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR

(2008) Anke Doller et al.   CELLULAR SIGNALLING

Nuclear HuR accumulation through phosphorylation by Cdk1

(2008) H. H. Kim et al.   GENES & DEVELOPMENT

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE