Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK/ERK activation

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Exendin-4 impairs the autophagic flux to induce apoptosis in pancreatic acinar AR42J cells by down-regulating LAMP-2

(2018) Zhiqiang Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy in cancer: a complex relationship

(2018) Lindsay Wilde et al.   BIOCHEMICAL JOURNAL

Targeting autophagy enhances apatinib-induced apoptosis via endoplasmic reticulum stress for human colorectal cancer

(2018) Xi Cheng et al.   CANCER LETTERS

FOXO1, a Potential Therapeutic Target, Regulates Autophagic Flux, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in Human Cholangiocarcinoma QBC939 Cells

(2018) Wei He et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Compound of Stout Camphor Medicinal Mushroom Taiwanofungus camphoratus (Agaricomycetes) Induces Protective Autophagy in SPCA-1 Cells Through AMPK Inhibition-Independent Blockade of Akt/mTOR Pathway

(2018) Hairui Yang et al.   INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS

Chemical, biochemical, preclinical and clinical studies of Ganoderma lucidum polysaccharide as an approved drug for treating myopathy and other diseases in China

(2018) Pengjiao Zeng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Knockdown of Beclin-1 impairs epithelial-mesenchymal transition of colon cancer cells

(2018) Hong Shen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Till Death Do Us Part: The Marriage of Autophagy and Apoptosis

(2018) Katrina F. Cooper   Oxidative Medicine and Cellular Longevity

Identifying the “Mushroom of Immortality”: Assessing the Ganoderma Species Composition in Commercial Reishi Products

(2018) Andrew L. Loyd et al.   Frontiers in Microbiology

Targeting Autophagy in the Tumor Microenvironment: New Challenges and Opportunities for Regulating Tumor Immunity

(2018) Bassam Janji et al.   Frontiers in Immunology

Life, death and autophagy

(2018) Johnna Doherty et al.   NATURE CELL BIOLOGY

FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis

(2018) Iris Schäffner et al.   NEURON

Autophagy in Cancer: Regulation by Small Molecules

(2018) Allison S. Limpert et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Monitoring and Measuring Autophagy

(2017) Saori R. Yoshii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anticarcinogenic effects of water extract of sporoderm-broken spores of Ganoderma lucidum on colorectal cancer in vitro and in vivo

(2017) Kun Na et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Accumulation of autophagosomes confers cytotoxicity

(2017) Robert W. Button et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired lysosomal activity mediated autophagic flux disruption by graphite carbon nanofibers induce apoptosis in human lung epithelial cells through oxidative stress and energetic impairment

(2017) Sandeep Mittal et al.   Particle and Fibre Toxicology

Effect of inhibiting Beclin-1 expression on autophagy, proliferation and apoptosis in colorectal cancer

(2017) Lin Liu et al.   Oncology Letters

Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice

(2017) L. Masuelli et al.   OncoImmunology

Lysosomal dysfunction and autophagy blockade contribute to IMB-6G-induced apoptosis in pancreatic cancer cells

(2017) Lu Liu et al.   Scientific Reports

Rhus coriaria increases protein ubiquitination, proteasomal degradation and triggers non-canonical Beclin-1-independent autophagy and apoptotic cell death in colon cancer cells

(2017) Khawlah Athamneh et al.   Scientific Reports

Inhibition of autophagy by chloroquine induces apoptosis in primary effusion lymphoma in vitro and in vivo through induction of endoplasmic reticulum stress

(2016) Md. Masud Alam et al.   APOPTOSIS

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Astemizole–Histamine induces Beclin-1-independent autophagy by targeting p53-dependent crosstalk between autophagy and apoptosis

(2016) Rekha Jakhar et al.   CANCER LETTERS

Ganoderma

(2016) Nebojša V. Kladar et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Dual PI-3 kinase/mTOR inhibition impairs autophagy flux and induces cell death independent of apoptosis and necroptosis

(2016) Robert W. Button et al.   Oncotarget

Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway

(2016) Xu Chen et al.   Scientific Reports

mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1

(2016) Claudia Manzoni et al.   Scientific Reports

A novel autophagy-independent, oncosuppressive function of BECN1: Degradation of MCL1

(2015) Mohamed Elgendy et al.   Autophagy

Histone deacetylase inhibitors induce autophagy through FOXO1-dependent pathways

(2015) Jianbin Zhang et al.   Autophagy

Ganoderma lucidum for Cancer Treatment

(2015) Shujie Cheng et al.   INTEGRATIVE CANCER THERAPIES

Live to die another way: modes of programmed cell death and the signals emanating from dying cells

(2015) Yaron Fuchs et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Anti-diabetic effects of Ganoderma lucidum

(2015) Haou-Tzong Ma et al.   PHYTOCHEMISTRY

From 2000years of Ganoderma lucidum to recent developments in nutraceuticals

(2015) Karen S. Bishop et al.   PHYTOCHEMISTRY

Inhibition of autophagy induced by quercetin at a late stage enhances cytotoxic effects on glioma cells

(2015) Yunke Bi et al.   TUMOR BIOLOGY

The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation

(2014) Yuanzhi Lao et al.   Autophagy

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gambogenic Acid Kills Lung Cancer Cells through Aberrant Autophagy

(2014) Wang Mei et al.   PLoS One

Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner

(2014) Mohamed Elgendy et al.   Nature Communications

The axis of MAPK1/3-XBP1u-FOXO1 controls autophagic dynamics in cancer cells

(2013) Ying Zhao et al.   Autophagy

Autophagy inhibition induces enhanced proapoptotic effects of ZD6474 in glioblastoma

(2013) J Shen et al.   BRITISH JOURNAL OF CANCER

Autophagy-Mediated Tumor Promotion

(2013) Jessie Yanxiang Guo et al.   CELL

Probing Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes): A Bitter Mushroom with Amazing Health Benefits

(2013) Priya Batra et al.   INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS

Colorectal cancer

(2013) Hermann Brenner et al.   LANCET

Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

(2013) Andrew M. Hau et al.   PLoS One

Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells

(2012) Jing Zhou et al.   Autophagy

Autophagy-independent enhancing effects of Beclin 1 on cytotoxicity of ovarian cancer cells mediated by proteasome inhibitors

(2012) Chuan Liu et al.   BMC CANCER

The dynamic nature of autophagy in cancer

(2011) A. C. Kimmelman   GENES & DEVELOPMENT

Inhibition of MTOR Disrupts Autophagic Flux in Podocytes

(2011) D. P. Cina et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Regulation of Autophagy by Kinases

(2011) Savitha Sridharan et al.   Cancers

Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway

(2010) Ljubica Vucicevic et al.   Autophagy

Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia

(2010) M I Koukourakis et al.   BRITISH JOURNAL OF CANCER

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN/SkiL expression in ovarian carcinoma cells

(2010) D M Smith et al.   CELL DEATH AND DIFFERENTIATION

AMPK-independent induction of autophagy by cytosolic Ca2+ increase

(2010) Antje Grotemeier et al.   CELLULAR SIGNALLING

Role of autophagy in suppression of inflammation and cancer

(2010) Eileen White et al.   CURRENT OPINION IN CELL BIOLOGY

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

(2010) Ying Zhao et al.   NATURE CELL BIOLOGY

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

(2008) Andrea Williams et al.   Nature Chemical Biology