A scavenging system against internal pathogens promoted by the circulating protein apoptosis inhibitor of macrophage (AIM)

Phagocytosed photoreceptor outer segments activate mTORC1 in the retinal pigment epithelium

(2018) Bo Yu et al.   Science Signaling

Phagocytosed photoreceptor outer segments activate mTORC1 in the retinal pigment epithelium

(2018) Bo Yu et al.   Science Signaling

Damage-Associated Molecular Patterns in Inflammatory Diseases

(2018) Jong Seong Roh et al.   Immune Network

The IgM pentamer is an asymmetric pentagon with an open groove that binds the AIM protein

(2018) Emiri Hiramoto et al.   Science Advances

Activation of apoptosis inhibitor of macrophage is a sensitive diagnostic marker for NASH-associated hepatocellular carcinoma

(2017) Noriyuki Koyama et al.   JOURNAL OF GASTROENTEROLOGY

MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1

(2017) Takashi Shichita et al.   NATURE MEDICINE

Apoptosis inhibitor of macrophage ameliorates fungus-induced peritoneal injury model in mice

(2017) Takako Tomita et al.   Scientific Reports

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease and cancer

(2016) R B Birge et al.   CELL DEATH AND DIFFERENTIATION

Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction

(2016) Michio Nakaya et al.   JOURNAL OF CLINICAL INVESTIGATION

Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice

(2016) Satoko Arai et al.   NATURE MEDICINE

Impact of feline AIM on the susceptibility of cats to renal disease

(2016) Ryoichi Sugisawa et al.   Scientific Reports

KIM-1-/TIM-1-mediated phagocytosis links ATG5-/ULK1-dependent clearance of apoptotic cells to antigen presentation

(2015) C. R. Brooks et al.   EMBO JOURNAL

Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells

(2015) Jianpeng Sheng et al.   IMMUNITY

KIM-1–mediated phagocytosis reduces acute injury to the kidney

(2015) Li Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Phagocytosis of apoptotic cells in homeostasis

(2015) Sanja Arandjelovic et al.   NATURE IMMUNOLOGY

The macrophage soluble receptor AIM/Api6/CD5L displays a broad pathogen recognition spectrum and is involved in early response to microbial aggression

(2014) Vanesa G. Martinez et al.   Cellular & Molecular Immunology

Standardizing Scavenger Receptor Nomenclature

(2014) M. PrabhuDas et al.   JOURNAL OF IMMUNOLOGY

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

MafB promotes atherosclerosis by inhibiting foam-cell apoptosis

(2014) Michito Hamada et al.   Nature Communications

Circulating AIM Prevents Hepatocellular Carcinoma through Complement Activation

(2014) Natsumi Maehara et al.   Cell Reports

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Obesity-Associated Autoantibody Production Requires AIM to Retain the Immunoglobulin M Immune Complex on Follicular Dendritic Cells

(2013) Satoko Arai et al.   Cell Reports

Apoptosis inhibitor of macrophage (AIM) diminishes lipid droplet-coating proteins leading to lipolysis in adipocytes

(2012) Yoshihiro Iwamura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Epithelial cell-directed efferocytosis in the post-partum mammary gland is necessary for tissue homeostasis and future lactation

(2011) Melissa Sandahl et al.   BMC DEVELOPMENTAL BIOLOGY

The Conserved Scavenger Receptor Cysteine-Rich Superfamily in Therapy and Diagnosis

(2011) V. G. Martinez et al.   PHARMACOLOGICAL REVIEWS

Monocyte and Macrophage Abnormalities in Systemic Lupus Erythematosus

(2010) Yi Li et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Macrophage-Derived AIM Is Endocytosed into Adipocytes and Decreases Lipid Droplets via Inhibition of Fatty Acid Synthase Activity

(2010) Jun Kurokawa et al.   Cell Metabolism

Apoptotic Cell Recognition: Will the Real Phosphatidylserine Receptor(s) Please Stand up?

(2008) Donna L. Bratton et al.   CURRENT BIOLOGY

Kidney injury molecule–1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells

(2008) Takaharu Ichimura et al.   JOURNAL OF CLINICAL INVESTIGATION

Epithelial Cells Remove Apoptotic Epithelial Cells During Post-Lactation Involution of the Mouse Mammary Gland1

(2007) Jenifer Monks et al.   BIOLOGY OF REPRODUCTION